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    Amendment: SEC Form SC 13G/A filed by Sagimet Biosciences Inc.

    11/14/24 4:27:19 PM ET
    $SGMT
    Biotechnology: Pharmaceutical Preparations
    Health Care
    Get the next $SGMT alert in real time by email
    SC 13G/A 1 tm2426483d5_sc13ga.htm SC 13G/A

     

     

     

    SCHEDULE 13G

     

    SECURITIES AND EXCHANGE COMMISSION
    WASHINGTON, DC 20549

     

    Under the Securities Exchange Act of 1934
    (Amendment No. 1)*

     

    Sagimet Biosciences Inc.

    (Name of Issuer)

     

    Series A Common Stock, par value $0.0001 per share

    (Title of Class of Securities)

     

    786700104

     

     

    (CUSIP Number)

     

    September 30, 2024

     

     

     

     

    (Date of Event which Requires Filing of this Statement)   

     

    Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

     

      x Rule 13d-1(b)

     

      ¨ Rule 13d-1(c)

     

      ¨ Rule 13d-1(d)

     

    *The remainder of this cover page shall be filled out for a reporting person’s initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter disclosures provided in a prior cover page.

     

    The information required on the remainder of this cover page shall not be deemed to be “filed” for the purpose of Section 18 of the Securities Exchange Act of 1934 (the “Act”) or otherwise subject to the liabilities of that section of the Act, but shall be subject to all other provisions of the Act (however, see the Notes).

     

     

     

     

     

     

    CUSIP No. 786700104

     

    1   NAMES OF REPORTING PERSONS

    Baker Bros. Advisors LP  
    2   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See Instructions)  (a) ¨     
     (b) ¨     
    3   SEC USE ONLY
     
    4   CITIZENSHIP OR PLACE OF ORGANIZATION

    Delaware  

    NUMBER OF
    SHARES
    BENEFICIALLY
    OWNED BY
    EACH
    REPORTING
    PERSON
    WITH
     
    5   SOLE VOTING POWER  

    1,538,489 (1)
    6   SHARED VOTING POWER  

    -0-  
    7   SOLE DISPOSITIVE POWER  

    1,538,489 (1)
    8   SHARED DISPOSITIVE POWER  

    -0-  

    9   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

    1,538,489 (1)
    10   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES
    (See Instructions)
    ¨     
    11   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

    4.99% (1)(2)
    12   TYPE OF REPORTING PERSON (See Instructions)  

    IA, PN 
             
               

     

      (1) Includes 156,591 shares of Series A Common Stock (“Common Stock”) of Sagimet Biosciences Inc. (the “Issuer”) issuable upon conversion of 156,591 shares of Series B Common Stock (as defined in Item 4 and subject to the limitations as described therein) directly held by the Funds (as defined in Item 4 below).
      (2)

    Based on 30,674,855 shares of Common Stock outstanding as of August 14, 2024, as reported in the Issuer’s Form S-3 filed with the Securities and Exchange Commission (“SEC”) on August 15, 2024.

     

     

     

     

    CUSIP No. 786700104

     

    1   NAMES OF REPORTING PERSONS

    Baker Bros. Advisors (GP) LLC
    2   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See Instructions)  (a) ¨     
     (b) ¨     
    3   SEC USE ONLY
     
    4   CITIZENSHIP OR PLACE OF ORGANIZATION

    Delaware  

    NUMBER OF
    SHARES
    BENEFICIALLY
    OWNED BY
    EACH
    REPORTING
    PERSON
    WITH
     
    5   SOLE VOTING POWER  

    1,538,489
    6   SHARED VOTING POWER  

    -0-  
    7   SOLE DISPOSITIVE POWER  

    1,538,489
    8   SHARED DISPOSITIVE POWER  

    -0-  

    9   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

    1,538,489
    10   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES
    (See Instructions)
    ¨     
    11   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

    4.99% (1)
    12   TYPE OF REPORTING PERSON (See Instructions)  

    HC, OO
             
               

     

    (1)Includes 156,591 shares of Common Stock issuable upon conversion of 156,591 shares of Series B Common Stock (as defined in Item 4 and subject to the limitations as described therein) directly held by the Funds (as defined in Item 4 below).
    (2)Based on 30,674,855 shares of Common Stock outstanding as of August 14, 2024, as reported in the Issuer’s Form S-3 filed with the SEC on August 15, 2024.

     

     

     

     

    CUSIP No. 786700104

     

    1   NAMES OF REPORTING PERSONS

    Felix J. Baker
    2   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See Instructions)  (a) ¨     
     (b) ¨     
    3   SEC USE ONLY
     
    4   CITIZENSHIP OR PLACE OF ORGANIZATION

    United States  

    NUMBER OF
    SHARES
    BENEFICIALLY
    OWNED BY
    EACH
    REPORTING
    PERSON
    WITH
     
    5   SOLE VOTING POWER  

    1,538,489
    6   SHARED VOTING POWER  

    -0-  
    7   SOLE DISPOSITIVE POWER  

    1,538,489
    8   SHARED DISPOSITIVE POWER  

    -0-  

    9   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

    1,538,489
    10   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES
    (See Instructions)
    ¨     
    11   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

    4.99% (1)
    12   TYPE OF REPORTING PERSON (See Instructions)  

    IN, HC
             
               

     

    (1)Includes 156,591 shares of Common Stock issuable upon conversion of 156,591 shares of Series B Common Stock (as defined in Item 4 and subject to the limitations as described therein) directly held by the Funds (as defined in Item 4 below).
    (2)Based on 30,674,855 shares of Common Stock outstanding as of August 14, 2024, as reported in the Issuer’s Form S-3 filed with the SEC on August 15, 2024.

     

     

     

     

    CUSIP No. 786700104

     

    1   NAMES OF REPORTING PERSONS

    Julian C. Baker
    2   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See Instructions)  (a) ¨     
     (b) ¨     
    3   SEC USE ONLY
     
    4   CITIZENSHIP OR PLACE OF ORGANIZATION

    United States  

    NUMBER OF
    SHARES
    BENEFICIALLY
    OWNED BY
    EACH
    REPORTING
    PERSON
    WITH
     
    5   SOLE VOTING POWER  

    1,538,489
    6   SHARED VOTING POWER  

    -0-  
    7   SOLE DISPOSITIVE POWER  

    1,538,489
    8   SHARED DISPOSITIVE POWER  

    -0-  

    9   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

    1,538,489
    10   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES
    (See Instructions)
    ¨     
    11   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

    4.99% (1)
    12   TYPE OF REPORTING PERSON (See Instructions)  

    IN, HC
             
               

     

    (1)Includes 156,591 shares of Common Stock issuable upon conversion of 156,591 shares of Series B Common Stock (as defined in Item 4 and subject to the limitations as described therein) directly held by the Funds (as defined in Item 4 below).
    (2)Based on 30,674,855 shares of Common Stock outstanding as of August 14, 2024, as reported in the Issuer’s Form S-3 filed with the SEC on August 15, 2024.

     

     

     

     

    Amendment No. 1 to Schedule 13G 

     

    This Amendment No. 1 to Schedule 13G amends and restates the previously filed Schedule 13G filed by Baker Bros. Advisors LP (the “Adviser"), Baker Bros. Advisors (GP) LLC (the “Adviser GP”), Julian C. Baker and Felix J. Baker (collectively, the "Reporting Persons"). Except as supplemented herein, such statements, as heretofore amended and supplemented, remain in full force and effect.

     

    Item 1(a) Name of Issuer:

     

    Sagimet Biosciences Inc. (the “Issuer”)

     

    Item 1(b) Address of Issuer’s Principal Executive Offices:

     

    155 Bovet Road, Suite 303

     

    San Mateo, California 94402

     

    Item 2(a) Name of Person Filing:

     

    This Amendment No. 1 is being filed jointly by the Reporting Persons.

     

    Item 2(b) Address of Principal Business Office or, if None, Residence:

     

    The business address of each of the Reporting Persons is:

     

    c/o Baker Bros. Advisors LP

     

    860 Washington Street, 3rd Floor

     

    New York, NY 10014

     

    (212) 339-5690

     

    Item 2(c) Citizenship:

     

    The Adviser is a limited partnership organized under the laws of the State of Delaware. The Adviser GP is a limited liability company organized under the laws of the State of Delaware. The citizenship of each of Julian C. Baker and Felix J. Baker is the United States of America.

     

    Item 2(d) Title of Class of Securities:

     

    Series A Common Stock, $0.0001 par value per share (“Common Stock”)

     

    Item 2(e) CUSIP Number:

     

    786700104

     

     

     

    Item 3 If this statement is filed pursuant to §§240.13d-1(b) or (c), check whether the person filing is a:

     

    (a) ¨ Broker or dealer registered under Section 15 of the Exchange Act.

     

    (b) ¨ Bank as defined in section 3(a)(6) of the Exchange Act.

     

    (c) ¨ Insurance company as defined in section 3(a)(19) of the Exchange Act.

     

    (d) ¨ Investment company registered under section 8 of the Investment Company Act of 1940.

     

    (e) x An investment adviser in accordance with Rule 13d-1(b)(1)(ii)(E).

     

    (f) ¨ An employee benefit plan or endowment fund in accordance with Rule 13d-1(b)(1)(ii)(F).

     

    (g) x A parent holding company or control person in accordance with Rule 13d-1(b)(1)(ii)(G).

     

    (h) ¨ A savings association as defined in Section 3(b) of the Federal Deposit Insurance Act.

     

    (i) ¨ A church plan that is excluded from the definition of an investment company under section 3(c)(14) of the Investment Company Act of 1940.

     

    (j) ¨ Group, in accordance with Rule 13d-1(b)(1)(ii)(J).

     

    Item 4 Ownership:

     

    Items 5 through 9 and 11 of each of the cover pages to this Schedule 13G are incorporated herein by reference. Set forth below is the aggregate number of shares of Common Stock of the Issuer directly held by each of 667, L.P. (“667”) and Baker Brothers Life Sciences, L.P. (“Life Sciences”, and together with 667, the “Funds”), which may be deemed to be indirectly beneficially owned by the Reporting Persons, as well as shares of Common Stock that may be acquired upon the conversion of Series B Common Stock (as defined below), subject to the limitations on conversion described below.

     

    The information set forth below is based upon 30,674,855 shares of Common Stock outstanding as of August 14, 2024, as reported in the Issuer’s Form S-3 filed with the Securities and Exchange Commission on August 15, 2024. Such percentage figures are calculated in accordance with Rule 13d-3 under the Securities Exchange Act of 1934, as amended (the “Exchange Act”).

     

     

     

    Name     Number of
    Shares
    of Common
    Stock
    we own or have
    the right to
    acquire
    within 60 days
        Percent of
    Class
    Outstanding
     
    667, L.P.       117,375       0.38 %
    Baker Brothers Life Sciences, L.P.       1,421,114       4.61 %
    Total       1,538,489       4.99 %

     

    The Funds hold shares of a common stock equivalent with no voting rights that are convertible into shares of Common Stock on a 1-for-1 basis (“Series B Common Stock”). However, the shares of Series B Common Stock are not convertible to the extent that after giving effect to such attempted conversion the holders thereof and their affiliates and any other persons whose beneficial ownership of securities would be aggregated with the holders’ pursuant to Section 13(d) would beneficially own in the aggregate, for purposes of Rule 13d-3 under the Exchange Act, more than 4.99% of the outstanding Common Stock of the Issuer (“Series B Beneficial Ownership Limitation”). As a result of the Series B Beneficial Ownership Limitation, the number of shares of Common Stock that may be issued upon conversion of the shares of Series B Common Stock by the above holders may change depending upon changes in the outstanding shares of Common Stock. By written notice to the Issuer, the Funds may increase or decrease the Series B Beneficial Ownership Limitation applicable to that Fund to any other percentage, provided that any such increase or decrease will not be effective until the 61st day after such notice is delivered to the Issuer. As a result of these restrictions, the number of shares of Common Stock that may be issued upon conversion of the Series B Common Stock by the above holders may change depending upon changes in the outstanding Common Stock.

     

     

     

    Pursuant to the management agreements, as amended, among the Adviser, the Funds and their respective general partners, the Funds’ respective general partners relinquished to the Adviser all discretion and authority with respect to the investment and voting power of the securities held by the Funds, and thus the Adviser has complete and unlimited discretion and authority with respect to the Funds’ investments and voting power over investments.

     

    The Adviser GP is the sole general partner of the Adviser. The Adviser GP, Felix J. Baker and Julian C. Baker as managing members of the Adviser GP, and the Adviser may be deemed to be beneficial owners of securities of the Issuer directly held by the Funds.

     

    Item 5 Ownership of Five Percent or Less of a Class:

     

    If this statement is being filed to report the fact that as of the date hereof the reporting person has ceased to be the beneficial owner of more than five percent of the class of securities, check the following x.

     

    Item 6 Ownership of More than Five Percent on Behalf of Another Person:

     

    N/A

     

    Item 7 Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding Company or Control Person:

     

    The information in Item 4 is incorporated herein by reference.

     

    Item 8 Identification and Classification of Members of the Group:

     

    N/A

     

    Item 9 Notice of Dissolution of Group:

     

    N/A

     

    Item 10 Certification:

     

    By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were acquired and are held in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect.

     

     

     

    SIGNATURE

     

    After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

     

    November 14, 2024

     

     

    BAKER BROS. ADVISORS LP

     

    By: Baker Bros. Advisors (GP) LLC, its general partner

         
      By: /s/ Scott L. Lessing
        Name: Scott L. Lessing
        Title: President

     

      BAKER BROS. ADVISORS (GP) LLC
         
      By: /s/ Scott L. Lessing
        Name: Scott L. Lessing
        Title: President

     

      /s/ Julian C. Baker
      Julian C. Baker
       
      /s/ Felix J. Baker
      Felix J. Baker

     

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    Denifanstat Phase 2b FASCINATE-2 clinical trial 52-week data was presented in June at the European Association for the Study of the Liver (EASL) Congress Preparations are ongoing to initiate a Phase 3 clinical development program for denifanstat in patients with metabolic dysfunction-associated steatohepatitis (MASH) in the second half of 2024 Two biotechnology industry leaders, Anne Phillips and Jennifer Jarrett, joined the Board of Directors effective August 1, 2024 Anticipated cash runway through 2025 with cash, cash equivalents and marketable securities totaling $188.5 million as of June 30, 2024 SAN MATEO, Calif., Aug. 14, 202

    8/14/24 8:00:00 AM ET
    $SGMT
    Biotechnology: Pharmaceutical Preparations
    Health Care

    Sagimet Biosciences to Host Conference Call and Webcast to Discuss Recently Presented Data from ITT and F3 Patient Population in Phase 2b FASCINATE-2 Clinical Trial of Denifanstat

    SAN MATEO, Calif., June 10, 2024 (GLOBE NEWSWIRE) -- Sagimet Biosciences Inc. ((Sagimet, NASDAQ:SGMT), a clinical-stage biopharmaceutical company developing novel fatty acid synthase (FASN) inhibitors designed to target dysfunctional metabolic and fibrotic pathways, today announced that it will host a conference call and webcast on Thursday, June 13, 2024, at 9.30 AM PT / 12:30 PM ET. The event will feature Rohit Loomba, M.D., M.H.Sc., Professor of Medicine, Chief, Division of Gastroenterology and Hepatology, and Director, MASLD Research Center, University of California San Diego, who was the Principal Investigator on the Phase 2b FASCINATE-2 clinical trial and serves as a scientific advi

    6/10/24 8:00:00 AM ET
    $SGMT
    Biotechnology: Pharmaceutical Preparations
    Health Care