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    Amendment: SEC Form SCHEDULE 13D/A filed by Arrowhead Pharmaceuticals Inc.

    8/15/25 5:28:19 PM ET
    $ARWR
    Biotechnology: Pharmaceutical Preparations
    Health Care
    Get the next $ARWR alert in real time by email



    SECURITIES AND EXCHANGE COMMISSION
    Washington, D.C. 20549


    SCHEDULE 13D

    Under the Securities Exchange Act of 1934

    (Amendment No. 1)


    ARROWHEAD PHARMACEUTICALS, INC.

    (Name of Issuer)


    Common stock, par value $0.001 per share (the "Common Stock")

    (Title of Class of Securities)


    04280A100

    (CUSIP Number)


    Cristin Rothfuss
    215 First Street,
    Cambridge, MA, 02142
    (617) 274-4000

    (Name, Address and Telephone Number of Person Authorized to Receive Notices and Communications)
    08/13/2025

    (Date of Event Which Requires Filing of This Statement)


    If the filing person has previously filed a statement on Schedule 13G to report the acquisition that is the subject of this Schedule 13D, and is filing this schedule because of §§ 240.13d-1(e), 240.13d-1(f) or 240.13d-1(g), check the following box. Checkbox not checked

    The information required on the remainder of this cover page shall not be deemed to be “filed” for the purpose of Section 18 of the Securities Exchange Act of 1934 (“Act”) or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).






    SCHEDULE 13D

    CUSIP No.
    04280A100


    1 Name of reporting person

    Sarepta Therapeutics, Inc.
    2Check the appropriate box if a member of a Group (See Instructions)

    Checkbox not checked  (a)
    Checkbox not checked  (b)
    3SEC use only
    4 Source of funds (See Instructions)

    WC
    5 Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)

    Checkbox not checked
    6Citizenship or place of organization

    DELAWARE
    Number of Shares Beneficially Owned by Each Reporting Person With:
    7Sole Voting Power

    0.00
    8Shared Voting Power

    0.00
    9Sole Dispositive Power

    0.00
    10Shared Dispositive Power

    0.00
    11Aggregate amount beneficially owned by each reporting person

    0.00
    12Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)

    Checkbox not checked
    13Percent of class represented by amount in Row (11)

    0.00 %
    14Type of Reporting Person (See Instructions)

    CO



    SCHEDULE 13D

    CUSIP No.
    04280A100


    1 Name of reporting person

    Sarepta Therapeutics Investments, Inc.
    2Check the appropriate box if a member of a Group (See Instructions)

    Checkbox not checked  (a)
    Checkbox not checked  (b)
    3SEC use only
    4 Source of funds (See Instructions)

    WC
    5 Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)

    Checkbox not checked
    6Citizenship or place of organization

    DELAWARE
    Number of Shares Beneficially Owned by Each Reporting Person With:
    7Sole Voting Power

    0.00
    8Shared Voting Power

    0.00
    9Sole Dispositive Power

    0.00
    10Shared Dispositive Power

    0.00
    11Aggregate amount beneficially owned by each reporting person

    0.00
    12Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)

    Checkbox not checked
    13Percent of class represented by amount in Row (11)

    0.00 %
    14Type of Reporting Person (See Instructions)

    CO



    SCHEDULE 13D

    Item 1.Security and Issuer
    (a)Title of Class of Securities:

    Common stock, par value $0.001 per share (the "Common Stock")
    (b)Name of Issuer:

    ARROWHEAD PHARMACEUTICALS, INC.
    (c)Address of Issuer's Principal Executive Offices:

    177 E COLORADO BLVD, Suite 700, Pasadena, CALIFORNIA , 91105.
    Item 1 Comment:
    This Amendment No. 1 to Schedule 13D (this "Amendment") amends the Schedule 13D (the "Original Schedule 13D") filed on February 14, 2025. Items 4, 5, 6 and 7 of the Original Schedule 13D are hereby amended and supplemented to the extent hereinafter expressly set forth. Except as amended hereby, the original disclosure set forth in the Original Schedule 13D shall remain unchanged. All capitalized terms used and not expressly defined herein have the respective meanings ascribed to such terms in the Original Schedule 13D.
    Item 4.Purpose of Transaction
     
    Item 4 of the Original Schedule 13D is hereby amended by adding the following: On August 13, 2025, Sarepta Investments sold 9,265,312 shares of the Issuer's Common Stock at a price of $18.79 per share in a privately negotiated block trade pursuant to Rule 144 of the Securities Act of 1933, as amended (the "Secondary Sale"). Also on August 13, 2025, concurrently with the Secondary Sale, Sarepta, Sarepta Investments and the Issuer entered into a Letter Agreement (the "Letter Agreement") pursuant to which the Issuer agreed to redeem and acquire from Sarepta Investments 2,660,989 shares of the Issuer's Common Stock (the "Redemption") in satisfaction of the obligation of Sarepta to pay the Issuer $49,999,983.31 of the DM1 First Development Milestone Payment (as such term is defined in Section 8.3.1(a)(i) of the Collaboration Agreement). The foregoing description of the Letter Agreement is not complete and is subject to and qualified in its entirety by reference to the full text of such agreement, which is attached as Exhibit 99.5 hereto and incorporated herein by reference.
    Item 5.Interest in Securities of the Issuer
    (a)
    Item 5 is hereby amended and restated in its entirety as follows: On the date of this Amendment, the Reporting Persons beneficially own 0 shares of Common Stock, representing 0.0% of the Issuer's Common Stock outstanding.
    (b)
    0
    (c)
    Other than the sale of 9,265,312 shares of the Issuer's Common Stock pursuant to the Secondary Sale and 2,660,989 shares of the Issuer's Common Stock pursuant to the Redemption, in each case, at a price of $18.79 per share, as further described in Item 4, there have been no transactions in the securities of the Issuer effected by the Reporting Persons in the last 60 days.
    (d)
    Not applicable
    (e)
    The Reporting Persons ceased to be the beneficial owners of more than 5% of the shares of the Issuer's Common Stock as of August 13, 2025.
    Item 6.Contracts, Arrangements, Understandings or Relationships With Respect to Securities of the Issuer
     
    Item 6 is hereby amended and restated in its entirety as follows: Except as disclosed in the Original Schedule 13D and in Item 4 of this Amendment, there are no contracts, arrangements, understandings or relationships (legal or otherwise) to which any Reporting Person is a party with respect to the securities of the Issuer.
    Item 7.Material to be Filed as Exhibits.
     
    Item 7 is hereby amended to include the following exhibit: Exhibit 99.5 Letter Agreement, dated as of August 13, 2025 among Arrowhead Pharmaceuticals, Inc., Sarepta Therapeutics, Inc. and Sarepta Therapeutics Investments, Inc.

        SIGNATURE 
     
    After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

     
    Sarepta Therapeutics, Inc.
     
    Signature:/s/ Ryan Wong
    Name/Title:Ryan Wong, Executive Vice President, Chief Financial Officer
    Date:08/15/2025
     
    Sarepta Therapeutics Investments, Inc.
     
    Signature:/s/ Joe Bratica
    Name/Title:Joe Bratica, President
    Date:08/15/2025
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