Cognition Therapeutics Presents Results at AD/PD 2025 Showing Impact of Zervimesine (CT1812) on Alzheimer's Disease Processes

PURCHASE, N.Y., April 01, 2025 (GLOBE NEWSWIRE) -- Cognition Therapeutics, Inc., (the "Company" or "Cognition") (NASDAQ:CGTX), a clinical-stage company developing drugs that treat neurodegenerative disorders, presented biomarker results from the Phase 2 SHINE (COG0201) study of zervimesine (CT1812) in mild-to-moderate Alzheimer's disease at the AD/PD™ 2025 Alzheimer's & Parkinson's Diseases Conference taking place April 1-5, 2025 in Vienna, Austria.

In her presentation, Mary Hamby, Ph.D., VP of research at Cognition, compared changes in key proteins, called biomarkers, in the entire study population with changes observed in participants who began the study with lower levels of a protein called p-Tau217 in their blood. This protein, which can be measured with a blood test, has emerged as an indicator of Alzheimer's disease pathology. Analysis of this low-p-Tau217 subgroup was defined in the SHINE study design in order to examine the impact of zervimesine in people with less neurodegeneration.

In the overall study population, compared to participants treated with placebo, those who received zervimesine for six months had reductions in plasma biomarkers associated with Alzheimer's disease processes. Further analysis showed that the SHINE low-p-Tau217 subgroup experienced a pronounced reduction in these key plasma biomarkers compared to placebo.

Most notably, significant reductions were observed in the level of glial fibrillary acidic protein (GFAP), a protein associated with neuroinflammation. Neurofilament light (NfL), a protein associated with neurodegeneration was also reduced in participants treated with zervimesine compared to placebo. Similarly, amyloid beta (Aβ) and tau species (p-Tau217), which are proteins that build up in patients with Alzheimer's disease, were lower in participants treated with zervimesine for six months compared to placebo-treated individuals.

"The data that we are presenting at AD/PD this week show that changes in certain proteins correlate to the cognitive effect of zervimesine that we saw in the overall study population," explained Dr. Hamby. "Just as the cognitive effects were more pronounced in the SHINE low-p-Tau217 subgroup, the impact on biomarkers such as GFAP and NfL was also more pronounced in this patient population. Taken as a whole, these analyses support our understanding of zervimesine's mechanism of action in impacting disease and point to key biological underpinnings by which zervimesine may elicit its effect."

About Cognition Therapeutics, Inc.

Cognition Therapeutics, Inc., is a clinical-stage biopharmaceutical company discovering and developing innovative, small molecule therapeutics targeting age-related degenerative disorders of the central nervous system. We are currently investigating our lead candidate, zervimesine (CT1812), in clinical programs in dementia with Lewy bodies (DLB) and Alzheimer's disease, including the ongoing START study (NCT05531656) in early Alzheimer's disease. We believe zervimesine can regulate pathways that are impaired in these diseases though its interaction with the sigma-2 receptor, a mechanism that is functionally distinct from other approaches for the treatment of degenerative diseases. More about Cognition Therapeutics and our pipeline can be found at https://cogrx.com.

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