Elanco Receives USDA Approval for TruCan™ Ultra CIV H3N2/H3N8 (Canine Influenza Vaccine) Bringing to Market a High Standard of Respiratory Protection
- TruCan Ultra CIV is the only ½ mL bivalent Canine Influenza Virus (CIV) vaccine offering broad protection against H3N2 and H3N8.
- 100% virus neutralization against 33 current field isolates.1
- Unlike currently available products, only TruCan Ultra CIV demonstrates zero lung lesions in vaccinated dogs post H3N2 challenge.2,3,4
- TruCan Ultra CIV completes Elanco's extensive line of Tru Portfolio vaccines.
GREENFIELD, Ind., July 9, 2025 /PRNewswire/ -- Elanco Animal Health Incorporated (NYSE:ELAN) today announced the U.S. Department of Agriculture (USDA) has approved TruCan Ultra CIV H3N2/H3N8, a canine influenza vaccine designed to provide broad respiratory disease protection. The approval of TruCan Ultra CIV completes Elanco's Tru Portfolio of comfortable and convenient combination vaccines made with PureFil™ Technology, an exclusive process for creating highly purified vaccines designed to reduce adverse reactions and deliver better experiences.
In Canine Influenza Virus (CIV) studies, TruCan Ultra CIV was shown to be highly effective in protecting dogs' lungs and improving clinical signs:
- Zero vaccinated dogs developed lung lesions post H3N2 challenge2
- 100% neutralization of 33 currently circulating CIV field isolates1
- Proven to reduce viral shedding2,5
- Proven safe across multiple breed and ages in field safety study5
"With the recent USDA approval for TruCan Ultra CIV, Elanco continues to lead the charge in innovative animal health solutions," said Bobby Modi, Executive Vice President, U.S. Pet Health and Global Digital Transformation. "This vaccine not only offers broad protection against canine influenza but also integrates seamlessly into our Tru Portfolio. Our commitment to delivering safe, effective and advanced solutions reaffirms our position as a trusted partner in animal health, driving forward our mission to enrich lives through the health of animals."
Respiratory disease outbreaks can be devastating for patients, their families and veterinary clinics, sometimes leading to facility shutdowns and large financial impact. Canine Infectious Respiratory Disease Complex (CIRDC) is a collection of respiratory diseases of various causative agents, including CIV among others.
Certain breeds can be at a higher risk for severe symptoms associated with CIRDC, especially Brachycephalic dogs – dog breeds with short heads, flat faces and snub noses.6 These highly at-risk breeds, which includes French Bulldogs, Bulldogs, Pugs, Boston Terriers and more, continue to grow in popularity with six of the top 25 breeds in the U.S. being brachycephalic.7
Unfortunately, there is a relatively low rate of vaccination for CIV in the U.S. leaving these highly susceptible patients particularly at risk for developing infection when exposed to CIV.8 Patients with the highest risk factors include social dogs, dogs with pre-existing airway disease and those that are unvaccinated or incompletely vaccinated. Brachycephalics strongly benefit from added protection from respiratory disease as they can be life-threatening, with upper respiratory disorders being the cause of death in 17% of those breeds.6 It only takes one patient shedding CIV to spark an outbreak.
"With TruCan Ultra CIV, we are improving our ability to protect dogs from serious respiratory disease while remaining committed to helping provide a happier clinic experience for pets and their owners," said Dr. Jennifer Miller, technical veterinarian at Elanco. "This addition to our vaccine portfolio means our veterinarian customers can confidently offer a more complete set of immunizations tailored to the needs of all dogs, ensuring their long-term health and happiness."
Elanco's Tru Vaccine line is the first vaccine line recommended by Fear Free®, an organization whose mission is to prevent and alleviate fear, anxiety and stress in pets by inspiring and educating the people who care for them.
"Fear, anxiety and stress in pets can stem from many factors, including illness," said Dr. Marty Becker, Founder of Fear Free. "When veterinarians have effective tools to help protect pets from diseases like canine influenza, it can contribute to a smoother, less stressful experience for both pets and their people. Solutions like TruCan Ultra CIV support the goal of reducing fear, anxiety and stress by keeping pets healthier and more comfortable in the veterinary setting."
The approval of TruCan Ultra CIV is a key addition to completing Elanco's vaccine portfolio by addressing respiratory disease outbreaks. TruCan Ultra CIV is now available for pre-order and will ship within the next 30 business days.
Learn more about TruCan Ultra CIV at https://my.elanco.com/us/campaign/trucan-ultra.
*Drs. Becker and Reinero are consultants for Elanco Animal Health.
ABOUT ELANCO
Elanco Animal Health Incorporated (NYSE:ELAN) is a global leader in animal health dedicated to innovating and delivering products and services to prevent and treat disease in farm animals and pets, creating value for farmers, pet owners, veterinarians, stakeholders and society as a whole. With 70 years of animal health heritage, we are committed to breaking boundaries and going beyond to help our customers improve the health of animals in their care, while also making a meaningful impact on our local and global communities. At Elanco, we are driven by our vision of Food and Companionship Enriching Life and our purpose – all to Go Beyond for Animals, Customers, Society and Our People. Learn more at www.elanco.com.
1,2 Elanco Animal Health. Data on File.
3 USDA APHIS. https://www.aphis.usda.gov/sites/default/files/2024-09/165a-15p5r0.pdf
4 USDA APHIS. https://www.aphis.usda.gov/sites/default/files/2023-10/190-15q520.pdf
5 Elanco Animal Health. Data on File.
6 The Humane Society of the United States. https://www.humanesociety.org/resources/flat-face-dog-breeds-and-health-issues
7 American Kennel Club. Most Popular Dog Breeds of 2023 - American Kennel Club
8 Malter et al. Vaccine 40 (2022) 1001-1009.
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SOURCE Elanco Animal Health