Lilly announces more than $1.2 billion investment in Puerto Rico facility to boost oral medicine manufacturing capacity in the United States

Company plans to create 100 manufacturing jobs and up to 1,000 construction jobs

INDIANAPOLIS, Oct. 29, 2025 /PRNewswire/ -- Eli Lilly and Company (NYSE:LLY) announced today a planned investment of more than $1.2 billion to expand and modernize its Lilly del Caribe manufacturing site in Carolina, Puerto Rico. This new investment will integrate advanced technologies and expand production capacity within the existing campus to support the company's growing portfolio of oral solid medicines in cardiometabolic health, neuroscience, oncology and immunology.

The enhanced facility will be among those that will manufacture orforglipron, Lilly's first oral, small molecule GLP-1 receptor agonist, which the company expects to submit to global regulatory agencies for obesity by the end of this year. This strategic expansion underscores Puerto Rico's role in Lilly's historic manufacturing agenda as a part of the previously announced $50 billion capital investment commitment to expand U.S. manufacturing capacity. The company recently shared plans to build sites in Texas and Virginia, with two additional locations to be announced in the next few months. These new sites are part of Lilly's broader efforts to expand existing U.S. manufacturing sites to increase capacity.

"After sixty years, Lilly del Caribe continues to play an important role in making life-changing medicines for people in the U.S. and beyond," said Edgardo Hernandez, executive vice president and president of Lilly Manufacturing Operations. "Our continued investments in capacity, infrastructure, advanced technologies and highly specialized jobs will further cement the site's significance in Lilly's global manufacturing network. Our progress builds on the dedication and expertise of our local team, helping us deliver new medicines for patients around the world."

This facility will deploy highly advanced technologies in oral solid medicine manufacturing, including dock-to-dock automation and material flow, paperless manufacturing, process analytical technology and spray-dried dispersion, which allows oral medicines to be effectively absorbed.

Lilly estimates that the project will generate up to 1,000 construction jobs and 100 additional high-tech manufacturing positions. The company supports local bioscience growth by offering scholarships for students in engineering, science, technology and business administration.

"This announcement reflects the very essence of our public policy, which is to position Puerto Rico as a strategic hub for advanced manufacturing, innovation and national economic security," said Jenniffer Gonzalez-Colon, Governor of Puerto Rico. "Lilly's multimillion-dollar expansion is a resounding vote of confidence in our people, our infrastructure and our long-term competitiveness within the U.S. supply chain. It demonstrates that global companies can continue to grow and thrive here, while Puerto Rico contributes in a meaningful way to the resilience of the nation's most critical industries." 

"This historic investment stands as proof of what can be achieved when the private sector and government work hand in hand toward a shared vision of competitiveness and economic growth," said Sebastian Negron Reichard, Secretary of the Department of Economic Development and Commerce, Puerto Rico. "For over sixty years, Lilly has trusted Puerto Rico, its people, its talent and its potential. Today, that trust translates into new capacity, advanced technologies, investment and long-term economic value for our island. This is exactly the kind of partnership that defines our economic development strategy and strengthens Puerto Rico's position as a global leader in life sciences manufacturing."

Construction on the expanded oral solid medicine product manufacturing facility is estimated to begin in 2026, with plans to start producing medicine by the end of 2028. 

About Lilly

Lilly is a medicine company turning science into healing to make life better for people around the world. We've been pioneering life-changing discoveries for nearly 150 years, and today our medicines help tens of millions of people across the globe. Harnessing the power of biotechnology, chemistry and genetic medicine, our scientists are urgently advancing new discoveries to solve some of the world's most significant health challenges: redefining diabetes care; treating obesity and curtailing its most devastating long-term effects; advancing the fight against Alzheimer's disease; providing solutions to some of the most debilitating immune system disorders; and transforming the most difficult-to-treat cancers into manageable diseases. With each step toward a healthier world, we're motivated by one thing: making life better for millions more people. That includes delivering innovative clinical trials that reflect the diversity of our world and working to ensure our medicines are accessible and affordable. To learn more, visit Lilly.com and Lilly.com/news, or follow us on Facebook, Instagram, and LinkedIn. C-LLY

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Cautionary Statement Regarding Forward-Looking Statements

This press release contains forward-looking statements (as that term is defined in the Private Securities Litigation Reform Act of 1995) including about planned capital investments in new manufacturing capacity, production and delivery of medicines, hiring and related initiatives and reflects Lilly's current beliefs and expectations. However, as with any such undertaking, there are substantial risks and uncertainties in the manufacturing process, development and commercialization of pharmaceutical products any of which could impact the overall commercial success of our products, and as related to cost, completion timing, expected capacity, personnel, and other factors which could impact expected benefits of the capacity expansion and related initiatives. For further discussion of risks and uncertainties relevant to Lilly's business that could cause actual results to differ from Lilly's expectations, see Lilly's Form 10-K and Form 10-Q filings with the United States Securities and Exchange Commission. Except as required by law, Lilly undertakes no duty to update forward-looking statements to reflect events after the date of this release. 

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SOURCE Eli Lilly and Company