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    SEC Form SC 13G/A filed by Eton Pharmaceuticals, Inc. (Amendment)

    6/17/21 4:40:55 PM ET
    $ETON
    Biotechnology: Pharmaceutical Preparations
    Health Care
    Get the next $ETON alert in real time by email
    SC 13G/A 1 formsc13ga.htm

     

     

     

    UNITED STATES
    SECURITIES AND EXCHANGE COMMISSION

    Washington, D.C. 20549

     

    SCHEDULE 13G/A

     

    Under the Securities Exchange Act of 1934

     

    (Amendment No. 3)

     

    ETON PHARMACEUTICALS, INC.

     

    (Name of Issuer)

     

    Common Stock, par value $0.001 per share

     

    (Title of Class of Securities)

     

    29772L108

     

    (CUSIP Number)

     

    December 31, 2020

     

    (Date of Event Which Requires Filing of this Statement)

     

    Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

     

      [  ] Rule 13d-1(b)
         
      [X]  Rule 13d-1(c)
         
      [  ] Rule 13d-1(d)

     

    * The remainder of this cover page shall be filled out for a reporting person’s initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter the disclosures provided in a prior cover page.

     

    The information required in the remainder of this cover page shall not be deemed to be “filed” for the purpose of Section 18 of the Securities Exchange Act of 1934 (“Act”) or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).

     

     

     

     

     

     

    CUSIP No. 29772L108 13G/A Page 2 of 9 Pages

     

       NAMES OF REPORTING PERSONS
       Opaleye Management Inc.
       
    1

    I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

    20-5648796

       
       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS)
       
       (a) [  ]
    2  (b) [  ]
       SEC USE ONLY
       
    3  
       CITIZENSHIP OR PLACE OF ORGANIZATION
       
    4  Massachusetts

    NUMBER OF SHARES
    BENEFICIALLY OWNED
    BY EACH REPORTING
    PERSON WITH:
       SOLE VOTING POWER
       
    5  0
       SHARED VOTING POWER
       
    6  3,692,700
       SOLE DISPOSITIVE POWER
       
    7  0
       SHARED DISPOSITIVE POWER
       
    8  3,692,700

       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
       
    9  3,692,700
       CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS)
       
    10  [  ]
       PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
       
    11  15.07% *
       TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)
       
    12  CO

     

    * Based upon 24,507,616 shares of common stock issued and outstanding on March 31, 2021 as reported by the Issuer on its Form 10-Q filed with the Securities and Exchange Commission on May 13, 2021. This calculation does not include the exercise or conversion of outstanding securities of the Issuer. As disclosed on the Form 4 filed by Opaleye Management Inc. on October 16, 2020, two transactions were completed on such date that required a Schedule 13G/A filing.

     

     

     

     

    CUSIP No. 29772L108 13G/A Page 3 of 9 Pages

     

       NAMES OF REPORTING PERSONS
    1

    I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

     

      Opaleye, L.P.

       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS)
       
       (a) [  ]
    2  (b) [  ]
       SEC USE ONLY
       
    3  
       CITIZENSHIP OR PLACE OF ORGANIZATION
       
    4  Delaware

    NUMBER OF SHARES
    BENEFICIALLY OWNED
    BY EACH REPORTING
    PERSON WITH:
       SOLE VOTING POWER
       
    5  0
       SHARED VOTING POWER
       
    6  3,692,700
       SOLE DISPOSITIVE POWER
       
    7  0
       SHARED DISPOSITIVE POWER
       
    8  3,692,700

       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
       
    9  3,692,700
       CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS)
       
    10  [  ]
       PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
       
    11  15.07% *
       TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)
       
    12  PN

     

    * Based upon 24,507,616 shares of common stock issued and outstanding on March 31, 2021 as reported by the Issuer on its Form 10-Q filed with the Securities and Exchange Commission on May 13, 2021. This calculation does not include the exercise or conversion of outstanding securities of the Issuer. As disclosed on the Form 4 filed by Opaleye Management Inc. on October 16, 2020, two transactions were completed on such date that required a Schedule 13G/A filing.

     

     

     

     

    CUSIP No. 29772L108 13G/A Page 4 of 9 Pages

     

       NAMES OF REPORTING PERSONS
    1

    I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

     

     James Silverman

       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS)
       
       (a) [  ]
    2  (b) [  ]
       SEC USE ONLY
       
    3  
       CITIZENSHIP OR PLACE OF ORGANIZATION
       
    4  United States

    NUMBER OF SHARES
    BENEFICIALLY OWNED
    BY EACH REPORTING
    PERSON WITH:
       SOLE VOTING POWER
       
    5  0
       SHARED VOTING POWER
       
    6  3,692,700
       SOLE DISPOSITIVE POWER
       
    7  0
       SHARED DISPOSITIVE POWER
       
    8  3,692,700

       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
       
    9  3,692,700
       CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS)
       
    10  [  ]
       PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
       
    11  15.07% *
       TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)
       
    12  IN

     

    * Based upon 24,507,616 shares of common stock issued and outstanding on March 31, 2021 as reported by the Issuer on its Form 10-Q filed with the Securities and Exchange Commission on May 13, 2021. This calculation does not include the exercise or conversion of outstanding securities of the Issuer. As disclosed on the Form 4 filed by Opaleye Management Inc. on October 16, 2020, two transactions were completed on such date that required a Schedule 13G/A filing.

     

     

     

     

    CUSIP No. 29772L108 13G/A Page 5 of 9 Pages

     

    Item 1(a).   Name of Issuer:
         
        The name of the issuer is Eton Pharmaceuticals, Inc. (the “Company”).
         
    Item 1(b).   Address of Issuer’s Principal Executive Offices:
         
        The Company’s principal executive offices are located at 21925 W. Field Parkway, Suite 235, Deer Park, Illinois 60010
         
    Item 2(a).   Name of Person Filing.
         
        This statement is filed by the entities and persons listed below, who are collectively referred to herein as “Reporting Persons” with respect to the shares of common stock of the Company:
         
        Opaleye Fund
         
        Opaleye, L.P. (the “Opaleye Fund”), a private fund formed in the state of Delaware.
         
        Investment Manager
         
        Opaleye Management Inc. (the “Investment Manager”), with respect to the common shares held by the Opaleye Fund, a private fund to which the Investment Manager serves as investment manager. The Investment Manager also serves as a portfolio manager for a separate managed account (the “Managed Account”) and may be deemed to indirectly beneficially own securities owned by the Managed Account. The Investment Manager disclaims beneficial ownership of the shares held by the Managed Account.
         
        Reporting Individual
         
        Mr. James Silverman (the “Reporting Individual”), with respect to the shares of common stock held by the Opaleye Fund. Mr. Silverman is the President of the Investment Manager.
         
    Item 2(b).   Address of Principal Business Office or, if None, Residence.
         
        One Boston Place, 26th Floor
        Boston, Massachusetts 02108
         
    Item 2(c).   Citizenship.
         
        Citizenship is set forth in Row 4 of the cover page for each Reporting Person and is incorporated herein by reference for each such Reporting Person.
         
    Item 2(d).   Title of Class of Securities.
         
        Common Stock, $0.001 par value per share
         
    Item 2(e).   CUSIP Number.
         
        29772L108

     

     

     

     

    CUSIP No. 29772L108 13G/A Page 6 of 9 Pages

     

    Item 3. If This Statement is Filed Pursuant to Rule 13d-1(b), or 13d-2(b) or (c), Check Whether the Person Filing is a:

     

    (a) [  ] Broker or dealer registered under Section 15 of the Exchange Act.
         
    (b) [  ] Bank as defined in Section 3(a)(6) of the Exchange Act.

     

    (c) [  ] Insurance company as defined in Section 3(a)(19) of the Exchange Act.
         
    (d) [  ] Investment company registered under Section 8 of the Investment Company Act.
         
    (e) [  ] An investment adviser in accordance with Rule 13d-1(b)(1)(ii)(E);
         
    (f) [  ] An employee benefit plan or endowment fund in accordance with Rule 13d-1(b)(1)(ii)(F);
         
    (g) [  ] A parent holding company or control person in accordance with Rule 13d-1(b)(1)(ii)(G);
         
    (h) [  ] A savings association as defined in Section 3(b) of the Federal Deposit Insurance Act;
         
    (i) [  ] A church plan that is excluded from the definition of an investment company under Section 3(c)(14) of the Investment Company Act;
         
    (j) [  ] A non-U.S. institution in accordance with Rule 13d-1(b)(1)(ii)(J);
         
    (k) [  ] Group, in accordance with Rule 13d-1(b)(1)(ii)(K).

     

    If filing as a non-U.S. institution in accordance with Rule 13d-1(b)(1)(ii)(J), please specify the type of institution:

     

     

     

    Item 4. Ownership.

     

    (a) Amount beneficially owned:
       
      Opaleye Management Inc. — 3,692,700 shares of common stock*
      Opaleye, L.P. — 3,692,700 shares of common stock*
      James Silverman — 3,692,700 shares of common stock*

     

    * Includes 141,600 common shares held by the Managed Account

     

    (b) Percent of class:
       
      Opaleye Management Inc. — 15.07%**
      Opaleye, L.P. — 15.07%**
      James Silverman — 15.07%**

     

    ** Based upon 24,507,616 shares of common stock issued and outstanding on March 31, 2021 as reported by the Issuer on its Form 10-Q filed with the Securities and Exchange Commission on May 13, 2021. This calculation does not include the exercise or conversion of outstanding securities of the Issuer.

     

     

     

     

    CUSIP No. 29772L108 13G/A Page 7 of 9 Pages

     

    (c) Number of shares as to which the person has:
         
      (i) Sole power to vote or to direct the vote:
         
        Opaleye Management Inc. — 0 shares
        Opaleye, L.P. — 0 shares
        James Silverman — 0 shares
         
      (ii) Shared power to vote or to direct the vote:
         
        Opaleye Management Inc. — 3,692,700 shares of common stock*
        Opaleye, L.P. — 3,692,700 shares of common stock*
        James Silverman — 3,692,700 shares of common stock*
         
      * Includes 141,600 common shares held by the Managed Account
         
      (iii) Sole power to dispose or to direct the disposition of:
         
        Opaleye Management Inc. — 0 shares
        Opaleye, L.P. — 0 shares
        James Silverman — 0 shares
         
      (iv) Shared power to dispose or to direct the disposition of:
         
        Opaleye Management Inc. — 3,692,700 shares of common stock
        Opaleye, L.P. — 3,692,700 shares of common stock
        James Silverman — 3,692,700 shares of common stock
         
      * Includes 141,600 common shares held by the Managed Account

     

    Item 5. Ownership of Five Percent or Less of a Class.

     

    Not applicable.

     

    Item 6. Ownership of More than Five Percent on Behalf of Another Person.

     

    Not applicable.

     

    Item 7. Identification and Classification of the Subsidiary Which Acquired the Security Being Reported by the Parent Holding Company or Control Person.

     

    Not applicable.

     

    Item 8. Identification and Classification of Members of the Group.

     

    Not applicable.

     

    Item 9. Notice of Dissolution of Group.

     

    Not applicable.

     

     

     

     

    CUSIP No. 29772L108 13G/A Page 8 of 9 Pages

     

    Item 10. Certification.

     

    By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect.

     

     

     

     

    CUSIP No. 29772L108 13G/A Page 9 of 9 Pages

     

    SIGNATURE

     

    After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

     

    Date: June 16, 2021 By: /s/ James Silverman
        James Silverman
         
      Opaleye, L.P.
         
    Date: June 16, 2021 By: /s/ James Silverman
      Name: James Silverman
      Title: Managing Member of Opaleye
        GP LLC, the General Partner of
        Opaleye, L.P.
         
      Opaleye Management Inc.
         
    Date: June 16, 2021 By: /s/ James Silverman
      Name: James Silverman
      Title: President

     

     

     

     

    JOINT FILING AGREEMENT

     

    This Joint Filing Agreement, dated June 16, 2021, is entered into by and among Opaleye Management Inc., a Massachusetts corporation, Opaleye, L.P., a Delaware limited partnership and James Silverman, an individual (collectively referred to herein as (the “Filers”)). Each of the Filers may be required to file with the U.S. Securities and Exchange Commission a statement on Schedule 13G with respect to shares of common stock, $0.001 par value per share, of Eton Pharmaceuticals, Inc. beneficially owned by them from time to time. Pursuant to and in accordance with Rule 13(d)(1)(k) promulgated under the Securities Exchange Act of 1934, as amended, the Filers hereby agree to file a single statement on Schedule 13G and/or 13D (and any amendments thereto) on behalf of each of such parties, and hereby further agree to file this Joint Filing Agreement as an exhibit to such statement, as required by such rule. This Joint Filing Agreement may be terminated by any of the Filers upon one week’s prior written notice or such lesser period of notice as the Filers may mutually agree.

     

    DATED: June 16, 2021

     

      By: /s/ James Silverman
        James Silverman
         
      Opaleye, L.P.
         
      By: /s/ James Silverman
      Name: James Silverman
      Title: Managing Member of
        Opaleye GP LLC, the General Partner
        of Opaleye, L.P.
         
      Opaleye Management Inc.
         
      By: /s/ James Silverman
      Name: James Silverman
      Title: President

     

     

     

     

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    Q1 2025 revenue of $17.3 million, with product sales of $14.0 million, representing 76% growth over Q1 2024 and the 17th straight quarter of sequential product sales growthQ1 2025 basic and fully diluted GAAP EPS of $(0.06), Non-GAAP fully diluted EPS of $0.07, and Adjusted EBITDA of $3.7 millionRelaunched pediatric endocrinology biologic INCRELEX® in the U.S. and out-licensed international rightsEstablished Wilson disease franchise with the acquisition and relaunch of GALZIN® (zinc acetate) capsules and the introduction of product candidate ET-700Announced positive pivotal clinical study results for ET-600 and submitted its New Drug Application (NDA) to the U.S. Food and Drug Administration

    5/13/25 4:01:00 PM ET
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    Large Ownership Changes

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    SEC Form SC 13G filed by Eton Pharmaceuticals Inc.

    SC 13G - Eton Pharmaceuticals, Inc. (0001710340) (Subject)

    12/9/24 4:04:43 PM ET
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    Biotechnology: Pharmaceutical Preparations
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    Amendment: SEC Form SC 13G/A filed by Eton Pharmaceuticals Inc.

    SC 13G/A - Eton Pharmaceuticals, Inc. (0001710340) (Subject)

    9/12/24 4:05:13 PM ET
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    Biotechnology: Pharmaceutical Preparations
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    SEC Form SC 13D/A filed by Eton Pharmaceuticals Inc. (Amendment)

    SC 13D/A - Eton Pharmaceuticals, Inc. (0001710340) (Subject)

    4/30/24 7:00:15 AM ET
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    Biotechnology: Pharmaceutical Preparations
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    Leadership Updates

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    Eton Pharmaceuticals Appoints Ipek Erdogan-Trinkaus as Chief Commercial Officer

    Ms. Erdogan-Trinkaus brings a wealth of commercial leadership and expertise in sales and marketing from her tenure at leading global pharmaceutical companies and across the broader health and wellness sector, including significant experience in the pediatric endocrinology specialty. DEER PARK, Ill., Dec. 03, 2024 (GLOBE NEWSWIRE) -- Eton Pharmaceuticals, Inc ("Eton" or the "Company") (NASDAQ:ETON), an innovative pharmaceutical company focused on developing and commercializing treatments for rare diseases, today announced the appointment of Ipek Erdogan-Trinkaus as Chief Commercial Officer (CCO). Ms. Erdogan-Trinkaus brings to the Company broad commercial experience in the pharmaceutical

    12/3/24 6:50:00 AM ET
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    Eton Pharmaceuticals Appoints James Gruber as Chief Financial Officer

    DEER PARK, Ill., April 11, 2022 (GLOBE NEWSWIRE) -- Eton Pharmaceuticals, Inc (NASDAQ:ETON), an innovative pharmaceutical company focused on developing and commercializing treatments for rare diseases, today announced the appointment of James Gruber as Chief Financial Officer, effective immediately. He succeeds Wilson Troutman, who is retiring. Mr. Troutman will remain with the company through the end of May to ensure a smooth transition. "We are pleased to welcome James to the Eton team. He brings a wealth of experience managing the finance and accounting activities for some of the most successful companies in the industry. We look forward to benefiting from his financial expertise as we

    4/11/22 4:01:00 PM ET
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    Biotechnology: Pharmaceutical Preparations
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    Small Pharma Strengthens Board With Appointment of Paul Maier as Independent Director

    LONDON, Nov. 18, 2021 (GLOBE NEWSWIRE) -- Small Pharma Inc. (TSXV:DMT) (OTCQB:DMTTF) (the "Company" or "Small Pharma"), a neuropharmaceutical company focused on psychedelic-assisted therapies, announces that Mr. Paul Maier has been appointed as a non-executive independent director of the board of directors of the Company (the "Board"). He will hold office as an independent director until the next annual meeting of shareholders, or until his successor has been elected or appointed. Mr. Maier has also been appointed as a member of the Audit Committee and Corporate Governance and Nominating Committee and Chair of the Compensation Committee. Mr. Maier joins Small Pharma with over 30 years' ex

    11/18/21 2:04:01 PM ET
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    Biotechnology: Pharmaceutical Preparations
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