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    SEC Form SC 13G/A filed by Zai Lab Limited (Amendment)

    2/14/23 6:24:55 AM ET
    $ZLAB
    Biotechnology: Pharmaceutical Preparations
    Health Care
    Get the next $ZLAB alert in real time by email
    SC 13G/A 1 dp188767_sc13ga-4.htm FORM SC 13G/A

     

    UNITED STATES
    SECURITIES AND EXCHANGE COMMISSION
    Washington, D.C. 20549

     

    SCHEDULE 13G/A

     

    (Amendment No. 4)*

     

    Under the Securities Exchange Act of 1934

     

    Zai Lab Limited

    (Name of Issuer)

     

    Ordinary shares, par value US$0.000006 per share

    (Title of Class of Securities)

     

    98887Q104**

    (CUSIP Number)

     

    December 31, 2022

    (Date of Event which Requires Filing of this Statement)

     

    Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

     

      ☐ Rule 13d-1(b)

     

      ☐ Rule 13d-1(c)

     

      ☒ Rule 13d-1(d)

     

    *The remainder of this cover page shall be filled out for a reporting person's initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter disclosures provided in a prior cover page.

     

    **There is no CUSIP number assigned to the Ordinary Shares. CUSIP number 98887Q104 has been assigned to the American Depositary Shares (“ADSs”) of the Issuer, which are quoted on the Nasdaq Stock Exchange under the symbol “ZLAB.” Each ADS represents 10 Ordinary Shares.

     

    The information required on the remainder of this cover page shall not be deemed to be "filed" for the purpose of Section 18 of the Securities Exchange Act of 1934 ("Act") or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).

     

     

     

    CUSIP No. 98887Q104

     

    1. 

    NAMES OF REPORTING PERSON

     

    Qiming Corporate GP IV, Ltd.

    2.

    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
    (see instructions)

     

    (a)       ☐

    (b)       ☐

    3.

    SEC USE ONLY

     

    4.

    CITIZENSHIP OR PLACE OF ORGANIZATION

     

    Cayman Islands

    NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH 5.

    SOLE VOTING POWER

     

    79,229,320(1)

    6.

    SHARED VOTING POWER

     

    None

    7. 

    SOLE DISPOSITIVE POWER

     

    79,229,320(1)

    8. 

    SHARED DISPOSITIVE POWER

     

    None

    9. 

    AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     

    79,229,320(1)

    10.

    CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES 

     

    (see instructions) ☐

    11. 

    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

     

    8.1%(2)

    12.

    TYPE OF REPORTING PERSON (see instructions)

     

    CO

     

    (1) As of the date of this 13G/A filing, Qiming Corporate GP IV, Ltd. is the general partner of Qiming Managing Directors Fund IV, L.P. and Qiming GP IV, L.P. Qiming Managing Directors Fund IV, L.P. holds approximately 3.06% of the equity interest of QM11 Limited. Qiming GP IV, L.P. is the general partner of Qiming Venture Partners IV, L.P., which holds approximately 96.94% of the equity interest of QM11 Limited. QM11 Limited is the owner of 79,229,320 Ordinary Shares (in the form of ADSs and 66,549,320 Ordinary Shares).

     

    (2) The percentage is calculated based upon an aggregate of 979,087,430 Ordinary Shares outstanding as of December 31, 2022, which is based on the information disclosed by the Issuer on January 6, 2023.

     

    2 

     

    CUSIP No. 98887Q104

     

    1.

    NAMES OF REPORTING PERSON

     

    Qiming Managing Directors Fund IV, L.P. 

    2.

    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
    (see instructions)

     

    (a)☐

    (b)☐

    3.

    SEC USE ONLY

     

    4.

    CITIZENSHIP OR PLACE OF ORGANIZATION

     

    Cayman Islands

    NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH 5.

    SOLE VOTING POWER

     

    None

    6.

    SHARED VOTING POWER

     

    2,425,051(3) 

    7.

    SOLE DISPOSITIVE POWER

     

    None

    8.

    SHARED DISPOSITIVE POWER

     

    2,425,051(3) 

    9.

    AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     

    ‎2,425,051(3) 

    10.

    CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES 

     

    (see instructions) ☐

    11.

    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

     

    ‎0.3%(4)‎

    12.

    TYPE OF REPORTING PERSON (see instructions)

     

    PN

     

    (3) As of the date of this 13G/A filing, Qiming Managing Directors Fund IV, L.P. holds approximately 3.06% of the equity interest of QM11 Limited, which is the owner of 79,229,320 Ordinary Shares (in the form of ADSs and 66,549,320 Ordinary Shares).

     

    (4) The percentage is calculated based upon an aggregate of 979,087,430 Ordinary Shares outstanding as of December 31, 2022, which is based on the information disclosed by the Issuer on January 6, 2023. 

     

    3 

     

    CUSIP No. 98887Q104

     

    1.

    NAMES OF REPORTING PERSON

     

    Qiming GP IV, L.P.

    2.

    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
    (see instructions)

     

    (a)☐

    (b)☐

    3.

    SEC USE ONLY

     

    4.

    CITIZENSHIP OR PLACE OF ORGANIZATION

     

    Cayman Islands

    NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH 5.

    SOLE VOTING POWER

     

    None

    6.

    SHARED VOTING POWER

     

    76,804,269(5)

    7.

    SOLE DISPOSITIVE POWER

     

    None

    8.

    SHARED DISPOSITIVE POWER

     

    ‎76,804,269(5)

    9.

    AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     

    76,804,269(5)

    10.

    CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES 

     

    (see instructions) ☐

    11.

    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

     

    7.8%(6)‎

    12.

    TYPE OF REPORTING PERSON (see instructions)

     

    PN

     

    (5) As of the date of this 13G/A filing, Qiming GP IV, L.P. is the general partner of Qiming Venture Partners IV, L.P., which owns approximately 96.94% of the equity interest of QM11 Limited, which is the owner of 79,229,320 Ordinary Shares (in the form of ADSs and 66,549,320 Ordinary Shares).

     

    (6) The percentage is calculated based upon an aggregate of 979,087,430 Ordinary Shares outstanding as of December 31, 2022, which is based on the information disclosed by the Issuer on January 6, 2023. 

     

    4 

     

    CUSIP No. 98887Q104

     

    1.

    NAMES OF REPORTING PERSON

     

    Qiming Venture Partners IV, L.P.

    2.

    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
    (see instructions)

     

    (a)☐

    (b)☐

    3.

    SEC USE ONLY

     

    4.

    CITIZENSHIP OR PLACE OF ORGANIZATION

     

    Cayman Islands

    NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH 5.

    SOLE VOTING POWER

     

    None

    6.

    SHARED VOTING POWER

     

    76,804,269(7)

    7.

    SOLE DISPOSITIVE POWER

     

    None

    8.

    SHARED DISPOSITIVE POWER

     

    76,804,269(7)

    9.

    AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     

    76,804,269(7)

    10.

    CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES 

     

    (see instructions) ☐

    11.

    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

     

    7.8%(8)‎

    12.

    TYPE OF REPORTING PERSON (see instructions)

     

    PN

     

    (7) As of the date of this 13G/A filing, Qiming Venture Partners IV, L.P. holds approximately 96.94% of the equity interest of QM11 Limited, which is the owner of 79,229,320 Ordinary Shares (in the form of ADSs and 66,549,320 Ordinary Shares).

     

    (8) The percentage is calculated based upon an aggregate of 979,087,430 Ordinary Shares outstanding as of December 31, 2022, which is based on the information disclosed by the Issuer on January 6, 2023.

     

    5 

     

    CUSIP No. 98887Q104

     

    1.

    NAMES OF REPORTING PERSON

     

    QM11 Limited

    2.

    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
    (see instructions)

     

    (a)☐

    (b)☐

    3.SEC USE ONLY

     

    4.

    CITIZENSHIP OR PLACE OF ORGANIZATION

     

    Hong Kong

    NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH 5.

    SOLE VOTING POWER

     

    79,229,320

    6.

    SHARED VOTING POWER

     

    None

    7.

    SOLE DISPOSITIVE POWER

     

    79,229,320

    8.

    SHARED DISPOSITIVE POWER

     

    None

    9.

    AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     

    79,229,320

    10.

    CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES 

     

    (see instructions) ☐

    11.

    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

     

    8.1%(9) 

    12.

    TYPE OF REPORTING PERSON (see instructions)

     

    CO

     
    (9) The percentage is calculated based upon an aggregate of 979,087,430 Ordinary Shares outstanding as of December 31, 2022, which is based on the information disclosed by the Issuer on January 6, 2023.

    6 

     

    Item 1.

     

      (a) Name of Issuer

     

    Zai Lab Limited (the “Issuer”)

     

      (b) Address of Issuer’s Principal Executive Offices

     

    The Issuer’s principal executive offices are located at 4560 Jinke Road, Bldg.1, 4F, Pudong, Shanghai, China 201210 and 314 Main Street 4th Floor, Suite 100 Cambridge, MA, USA 02142.

     

    Item 2.

     

      (a) Name of Person Filing

     

    Qiming Corporate GP IV, Ltd.

    Qiming Managing Directors Fund IV, L.P.

    Qiming GP IV, L.P.

    Qiming Venture Partners IV, L.P.

    QM11 Limited

     

      (b) Address of the Principal Office or, if None, Residence

     

    The registered address of each of Qiming Corporate GP IV, Ltd., Qiming Managing Directors Fund IV, L.P., Qiming GP IV, L.P. and Qiming Venture Partners IV, L.P. is M&C Corporate Services Limited, P.O. Box 309GT, Ugland House, South Church Street, George Town, Grand Cayman, Cayman Islands.

     

    The registered address of QM11 Limited is Units 4205-06, 42nd Floor, Gloucester Tower, the Landmark, 15 Queen’s Road Central, Hong Kong.

     

      (c) Citizenship

     

    Qiming Corporate GP IV, Ltd., Qiming Managing Directors Fund IV, L.P., Qiming GP IV, L.P. and Qiming Venture Partners IV, L.P. are organized in Cayman Islands.

     

    QM11 Limited is a company organized in Hong Kong.

     

      (d) Title of Class of Securities

     

    Ordinary Shares, par value of $0.000006 per share (the "Ordinary Shares").

     

      (e) CUSIP Number

     

    There is no CUSIP number assigned to the Ordinary Shares. CUSIP number 98887Q104 has been assigned to the American Depositary Shares (“ADSs”) of the Issuer, which are quoted on the Nasdaq Stock Exchange under the symbol “ZLAB.” Each ADS represents 10 Ordinary Shares.

     

    Item 3. Statement is filed pursuant to §§240.13d-1(b) or 240.13d-2(b) or (c):

     

    Not applicable.

     

    Item 4. Ownership.

     

    7 

     

    The information required by Items 4(a) - (c) is set forth in Rows 5 - 11 of the cover page for each Reporting Person and is incorporated herein by reference.

     

    Item 5. Ownership of Five Percent or Less of a Class.

     

    Not applicable.

     

    Item 6. Ownership of More than Five Percent on Behalf of Another Person.

     

    Not applicable.

     

    Item 7. Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on By the Parent Holding Company.

     

    Not applicable.

     

    Item 8. Identification and Classification of Members of the Group.

     

    Not applicable.

     

    Item 9. Notice of Dissolution of Group.

     

    Not applicable.

     

    Item 10. Certification.

     

    Not applicable.

     

    8 

     

    SIGNATURE

     

    After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

     

    Dated: February 14, 2023

     

      Qiming Corporate GP IV, Ltd.
       
       
      By: /s/ Grace Lee
        Name: Grace Lee
        Title: Authorized Signatory

     

     

     

    Qiming Managing Directors Fund IV, L.P.

    By: Qiming Corporate GP IV, Ltd.,

    its General Partner

       
       
      By: /s/ Grace Lee
        Name: Grace Lee
        Title: Authorized Signatory

     

     

     

    Qiming GP IV, L.P.

    By: Qiming Corporate GP IV, Ltd.,

    its General Partner

       
       
      By: /s/ Grace Lee
        Name: Grace Lee
        Title: Authorized Signatory

     

     

     

    Qiming Venture Partners IV, L.P.

    By: Qiming GP IV, L.P.,

    its General Partner

    By: Qiming Corporate GP IV, Ltd.,

    General Partner of Qiming GP IV., L.P.

       
       
      By: /s/ Grace Lee
        Name: Grace Lee
        Title: Authorized Signatory

     

     

      QM11 Limited
       
       
      By: /s/ Grace Lee
        Name: Grace Lee
        Title: Director

    9 

     

    JOINT FILING AGREEMENT

     

    In accordance with Rule 13d-1(k) under the Securities Exchange Act of 1934, as amended, each of the undersigned agrees that (i) this statement on Schedule 13G has been adopted and filed on behalf of each of them and (ii) all future amendments to such statement on Schedule 13G will, unless written notice to the contrary is delivered as described below, be jointly filed on behalf of each of them. This agreement may be terminated with respect to the obligations to jointly file future amendments to such statement on Schedule 13G as to any of the undersigned upon such person giving written notice thereof to each of the other persons signatory hereto, at the principal office thereof.

     

    Dated: February 13, 2019

     

      Qiming Corporate GP IV, Ltd.
       
       
      By: /s/ Grace Lee
        Name: Grace Lee
        Title: Authorized Signatory

     

     

     

    Qiming Managing Directors Fund IV, L.P.

    By: Qiming Corporate GP IV, Ltd.,

    its General Partner

       
       
      By: /s/ Grace Lee
        Name: Grace Lee
        Title: Authorized Signatory

     

     

     

    Qiming GP IV, L.P.

    By: Qiming Corporate GP IV, Ltd.,

    its General Partner

       
       
      By: /s/ Grace Lee
        Name: Grace Lee
        Title: Authorized Signatory

     

     

     

    Qiming Venture Partners IV, L.P.

    By: Qiming GP IV, L.P.,

    its General Partner

    By: Qiming Corporate GP IV, Ltd.,

    General Partner of Qiming GP IV., L.P.

       
       
      By: /s/ Grace Lee
        Name: Grace Lee
        Title: Authorized Signatory

     

     

      QM11 Limited
       
       
      By: /s/ Grace Lee
        Name: Grace Lee
        Title: Director

    10 

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    $ZLAB
    Biotechnology: Pharmaceutical Preparations
    Health Care

    Zai Lab to Announce Second Quarter 2025 Financial Results and Recent Corporate Updates on August 7, 2025

    - Company to host conference call and webcast on August 7, 2025, at 8:00 a.m. ET (8:00 p.m. HKT) Zai Lab Limited (NASDAQ:ZLAB, HKEX: 9688)) today announced that it will report its second quarter 2025 financial results and provide recent corporate updates on August 7, 2025, before the opening of U.S. equity markets. The announcement will be followed by a conference call and webcast at 8:00 a.m. ET (8:00 p.m. HKT). Conference Call and Webcast Information Listeners may access the live webcast by visiting the Company's website at http://ir.zailaboratory.com. Participants must register in advance of the conference call. Details are as follows: Registration link for webcast (preferred):

    7/10/25 7:30:00 AM ET
    $ZLAB
    Biotechnology: Pharmaceutical Preparations
    Health Care

    Zai Lab Presents Positive Phase 1 Data for ZL-1310, a DLL3-Targeted ADC, Demonstrating Robust Anti-Tumor Activity and Safety in Patients with Extensive-Stage Small Cell Lung Cancer at 2025 ASCO Annual Meeting

    - Clinically meaningful anti-tumor activity of ZL-1310 observed in heavily pretreated population of patients with small cell lung cancer (SCLC) across dose escalation and expansion cohorts - In second-line (2L) SCLC, objective response rate (ORR) was 67% across all dose levels (n=33) and 79% at 1.6 mg/kg dose (n=14) - Median duration of response has not yet been reached, with 29 of 38 responders remaining on study; 27 of 31 patients with stable disease remaining on study, the majority of whom had tumor regressions - ZL-1310 demonstrated a well-tolerated safety profile at target doses of less than 2.0 mg/kg, with Grade ≥3 treatment-related adverse events (TRAEs) of 6%, and no drug disc

    6/2/25 7:00:00 AM ET
    $ZLAB
    Biotechnology: Pharmaceutical Preparations
    Health Care

    $ZLAB
    Large Ownership Changes

    This live feed shows all institutional transactions in real time.

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    SEC Form SC 13G filed by Zai Lab Limited

    SC 13G - Zai Lab Ltd (0001704292) (Subject)

    11/14/24 11:11:39 AM ET
    $ZLAB
    Biotechnology: Pharmaceutical Preparations
    Health Care

    Amendment: SEC Form SC 13G/A filed by Zai Lab Limited

    SC 13G/A - Zai Lab Ltd (0001704292) (Subject)

    11/8/24 10:52:38 AM ET
    $ZLAB
    Biotechnology: Pharmaceutical Preparations
    Health Care

    SEC Form SC 13G/A filed by Zai Lab Limited (Amendment)

    SC 13G/A - Zai Lab Ltd (0001704292) (Subject)

    6/6/24 9:54:34 AM ET
    $ZLAB
    Biotechnology: Pharmaceutical Preparations
    Health Care

    $ZLAB
    Leadership Updates

    Live Leadership Updates

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    Zai Lab Announces Dr. Harald Reinhart to Retire as Head of Global Development for Neuroscience, Autoimmune and Infectious Diseases; Dr. Rafael Amado to be Appointed President, Head of Global R&D

      Zai Lab Limited (NASDAQ:ZLAB, HKEX: 9688))) announced today that following a distinguished career, Harald Reinhart, M.D., President, Head of Global Development, Neuroscience, Autoimmune and Infectious Diseases (NSAiID) of Zai Lab, will retire at the end of June, after which he will serve as a senior advisor for the Company. Rafael Amado, M.D., President, Head of Global Oncology Research and Development of Zai Lab, will expand his role and assume responsibility for all of the Company's Global R&D upon Dr. Reinhart's retirement. "Harald has devoted nearly 50 years to treating patients, first as a physician and later discovering and developing innovative therapies to bring to patients in

    6/11/24 4:05:00 PM ET
    $ZLAB
    Biotechnology: Pharmaceutical Preparations
    Health Care

    Zai Lab Appoints Michel Vounatsos To Its Board of Directors

    SHANGHAI and CAMBRIDGE, Mass., Jan. 09, 2023 (GLOBE NEWSWIRE) -- Zai Lab Limited (NASDAQ:ZLAB, HKEX: 9688))) today announced that Michel Vounatsos has been appointed to its Board of Directors, effective January 7, 2023. Mr. Vounatsos brings to the Board extensive global leadership and management experience in the biopharmaceutical industry, including more than 25 years of service at leading companies. His expertise includes significant commercial experience in China and worldwide in the areas of primary care and neuroscience. "We are delighted to welcome Michel Vounatsos to the Zai Lab Board of Directors," said Dr. Samantha Du, Founder, Chairperson, and CEO of Zai Lab. "Michel has a wealt

    1/9/23 7:30:00 AM ET
    $ZLAB
    Biotechnology: Pharmaceutical Preparations
    Health Care

    Zai Lab Announces the Appointment of Dr. Rafael G. Amado as President, Head of Global Oncology Research and Development

    SHANGHAI and CAMBRIDGE, Mass., Jan. 03, 2023 (GLOBE NEWSWIRE) -- Zai Lab Limited (NASDAQ:ZLAB, HKEX: 9688))) a patient-focused, innovative, commercial-stage, global biopharmaceutical company, today announced the appointment of Rafael G. Amado, M.D. as President, Head of Global Oncology Research and Development, effective December 30, 2022. Dr. Amado brings to Zai Lab deep expertise in the field of oncology and significant global biopharmaceutical R&D leadership. "We are pleased to welcome Rafael to our executive leadership team," said Dr. Samantha Du, Founder, Chairperson, and CEO of Zai Lab. "Rafael's experience leading worldwide discovery and clinical development for a number of oncolog

    1/3/23 8:30:00 AM ET
    $ZLAB
    Biotechnology: Pharmaceutical Preparations
    Health Care