Praxis Precision Medicines, Inc., a clinical-stage biopharmaceutical company, develops therapies for central nervous system disorders characterized by neuronal imbalance. Its lead product candidates include PRAX-114, an extrasynaptic-preferring GABAA receptor positive allosteric modulator that is in Phase IIa clinical trial for the treatment of major depressive disorder and perimenopausal depression; and PRAX-944, a selective small molecule inhibitor of T-type calcium channels, which is in Phase IIa clinical trial for the treatment of essential tremor. The company is also developing PRAX-562, a persistent sodium current blocker that is in Phase I clinical trial to treat severe pediatric epilepsy and adult cephalgia; PRAX-222, an antisense oligonucleotide for patients with gain-of-function (GOF) SCN2A epilepsy; and KCNT1 program for the treatment of KCNT1 GOF epilepsy. It has a cooperation and license agreement with RogCon Inc.; a license agreement Purdue Neuroscience Company; a research collaboration, option, and license agreement with Ionis Pharmaceuticals, Inc.; and collaboration with The Florey Institute to develop three novel ASOs. The company was incorporated in 2015 and is based in Cambridge, Massachusetts.
IPO Year: 2020
Exchange: NASDAQ
Website: praxismedicines.com
| Date | Price Target | Rating | Analyst |
|---|---|---|---|
| 6/2/2025 | $97.00 | Outperform | Oppenheimer |
| 5/7/2025 | $80.00 | Buy | Chardan Capital Markets |
| 3/3/2025 | $120.00 → $105.00 | Buy | H.C. Wainwright |
| 2/11/2025 | $111.00 | Buy | Deutsche Bank |
| 8/5/2024 | $134.00 | Outperform | Oppenheimer |
| 6/24/2024 | $145.00 | Buy | Needham |
| 6/18/2024 | $155.00 | Buy | Guggenheim |
| 5/1/2024 | $117.00 | Outperform | Robert W. Baird |
| 9/19/2023 | $10.00 | Buy | Truist |
| 6/6/2022 | $4.00 | Outperform → Neutral | Wedbush |
4 - Praxis Precision Medicines, Inc. (0001689548) (Issuer)
Oppenheimer resumed coverage of Praxis Precision Medicines with a rating of Outperform and set a new price target of $97.00
Chardan Capital Markets initiated coverage of Praxis Precision Medicines with a rating of Buy and set a new price target of $80.00
H.C. Wainwright reiterated coverage of Praxis Precision Medicines with a rating of Buy and set a new price target of $105.00 from $120.00 previously
Deutsche Bank initiated coverage of Praxis Precision Medicines with a rating of Buy and set a new price target of $111.00
Oppenheimer initiated coverage of Praxis Precision Medicines with a rating of Outperform and set a new price target of $134.00
Needham initiated coverage of Praxis Precision Medicines with a rating of Buy and set a new price target of $145.00
Guggenheim initiated coverage of Praxis Precision Medicines with a rating of Buy and set a new price target of $155.00
Robert W. Baird initiated coverage of Praxis Precision Medicines with a rating of Outperform and set a new price target of $117.00
Truist initiated coverage of Praxis Precision Medicines with a rating of Buy and set a new price target of $10.00
Wedbush downgraded Praxis Precision Medicines from Outperform to Neutral and set a new price target of $4.00
4 - Praxis Precision Medicines, Inc. (0001689548) (Issuer)
4 - Praxis Precision Medicines, Inc. (0001689548) (Issuer)
4 - Praxis Precision Medicines, Inc. (0001689548) (Issuer)
4 - Praxis Precision Medicines, Inc. (0001689548) (Issuer)
4 - Praxis Precision Medicines, Inc. (0001689548) (Issuer)
4 - Praxis Precision Medicines, Inc. (0001689548) (Issuer)
4 - Praxis Precision Medicines, Inc. (0001689548) (Issuer)
4 - Praxis Precision Medicines, Inc. (0001689548) (Issuer)
4 - Praxis Precision Medicines, Inc. (0001689548) (Issuer)
4 - Praxis Precision Medicines, Inc. (0001689548) (Issuer)
BOSTON, June 04, 2025 (GLOBE NEWSWIRE) -- Praxis Precision Medicines, Inc. (NASDAQ:PRAX), a clinical-stage biopharmaceutical company translating genetic insights into the development of therapies for central nervous system (CNS) disorders characterized by neuronal excitation-inhibition imbalance, today announced that on June 2, 2025, the Compensation Committee of Praxis' Board of Directors granted a restricted stock unit award covering 750 shares of its common stock to one new non-executive employee under the Praxis Precision Medicines, Inc. 2024 Inducement Plan (the 2024 Inducement Plan). The restricted stock unit award was granted as inducement material to the employee's entering into em
BOSTON, May 20, 2025 (GLOBE NEWSWIRE) -- Praxis Precision Medicines, Inc. (NASDAQ:PRAX), a clinical-stage biopharmaceutical company translating genetic insights into the development of therapies for central nervous system (CNS) disorders characterized by neuronal excitation-inhibition imbalance, today announced that it will be participating in three upcoming investor conferences: Praxis management will be participating in a fireside chat at the H.C. Wainwright 3rd Annual BioConnect Investor Conference, taking place at NASDAQ on Tuesday, May 20th, at 9:30am ET. A webcast of the fireside chat will be available through this link.Praxis management will also be participating in the Mizuho
BOSTON, May 05, 2025 (GLOBE NEWSWIRE) -- Praxis Precision Medicines, Inc. (NASDAQ:PRAX), a clinical-stage biopharmaceutical company translating genetic insights into the development of therapies for central nervous system (CNS) disorders characterized by neuronal excitation-inhibition imbalance, hosted a virtual investor event on its clinical programs in developmental and epileptic encephalopathies (DEEs) on Friday, May 2, 2025. "We were excited to highlight the significant opportunity in DEEs and progress Praxis is making in this field," said Marcio Souza, president and chief executive officer of Praxis. "Relutrigine continues to show tremendous promise to broadly address the DEE market
BOSTON, May 02, 2025 (GLOBE NEWSWIRE) -- Praxis Precision Medicines, Inc. (NASDAQ:PRAX), a clinical-stage biopharmaceutical company translating genetic insights into the development of therapies for central nervous system (CNS) disorders characterized by neuronal excitation-inhibition imbalance, today announced that on May 1, 2025, the Compensation Committee of Praxis' Board of Directors granted restricted stock unit awards covering an aggregate of 3,688 shares of its common stock to five new non-executive employees under the Praxis Precision Medicines, Inc. 2024 Inducement Plan (the 2024 Inducement Plan). The restricted stock units were granted as inducements material to the employees' en
On track for six major study readouts across four programs over the next 12 months Ready to initiate pivotal studies in two developmental and epileptic encephalopathy (DEE) programs in mid-year 2025: EMERALD for broad DEEs with relutrigine and EMBRAVE3 for SCN2A GoF with elsunersen Vormatrigine continues to generate a best-in-class safety profile with new data demonstrating no food effect and higher dosing tolerability Praxis to host a virtual investor event on Friday, May 2, 2025 to discuss its DEE portfolio [registration link] Cash and investments of $472 million as of March 31, 2025, maintains runway into 2028 BOSTON, May 02, 2025 (GLOBE NEWSWIRE) -- Praxis Precision Medicines, Inc
BOSTON, April 08, 2025 (GLOBE NEWSWIRE) -- Praxis Precision Medicines, Inc. (NASDAQ:PRAX), a clinical-stage biopharmaceutical company translating genetic insights into the development of therapies for central nervous system (CNS) disorders characterized by neuronal excitation-inhibition imbalance, today announced that it will be hosting a virtual investor event on Friday, May 2, 2025 from 10:00 a.m. to 11:30 a.m. EDT. The webinar, hosted by the Praxis management team, will focus on the company's clinical programs in developmental and epileptic encephalopathies (DEEs) including: The EMBOLD study evaluating relutrigine for SCN2A and SCN8A DEEsThe EMERALD study evaluating relutrigine for br
BOSTON, April 03, 2025 (GLOBE NEWSWIRE) -- Praxis Precision Medicines, Inc. (NASDAQ:PRAX), a clinical-stage biopharmaceutical company translating genetic insights into the development of therapies for central nervous system (CNS) disorders characterized by neuronal excitation-inhibition imbalance, today announced that it will be participating in two upcoming investor conferences this April: Praxis management will be presenting a corporate overview at the 24th Annual Needham Virtual Healthcare Conference, taking place virtually on Monday, April 7, 2025 at 11:00a.m. EDT. A live webcast of the event will be available through this link.Praxis management will also be participating in the Piper
BOSTON, April 03, 2025 (GLOBE NEWSWIRE) -- Praxis Precision Medicines, Inc. (NASDAQ:PRAX), a clinical-stage biopharmaceutical company translating genetic insights into the development of therapies for central nervous system (CNS) disorders characterized by neuronal excitation-inhibition imbalance, today announced that on April 1, 2025, the Compensation Committee of Praxis' Board of Directors granted restricted stock unit awards covering an aggregate of 8,763 shares of its common stock to four new non-executive employees under the Praxis Precision Medicines, Inc. 2024 Inducement Plan (the 2024 Inducement Plan). The restricted stock units were granted as inducements material to the employees
BOSTON, March 24, 2025 (GLOBE NEWSWIRE) -- Praxis Precision Medicines, Inc. (NASDAQ:PRAX), a clinical-stage biopharmaceutical company translating genetic insights into the development of therapies for central nervous system (CNS) disorders characterized by neuronal excitation-inhibition imbalance, today announced that that it will present data from its four late-stage programs in epilepsy and movement disorders at the American Academy of Neurology (AAN) 2025 Annual Meeting taking place from April 5 to 9, 2025 in San Diego, California. "Praxis's innovative pipeline continues to rapidly advance, with four late-stage programs poised to transform patient care," said Steven Petrou, Chief Scien
BOSTON, March 04, 2025 (GLOBE NEWSWIRE) -- Praxis Precision Medicines, Inc. (NASDAQ:PRAX), a clinical-stage biopharmaceutical company translating genetic insights into the development of therapies for central nervous system (CNS) disorders characterized by neuronal excitation-inhibition imbalance, today announced that on March 3, 2025, the Compensation Committee of Praxis' Board of Directors granted non-qualified stock option awards to purchase an aggregate of 2,000 shares of its common stock and restricted stock unit awards covering an aggregate of 7,288 shares of its common stock to six new non-executive employees under the Praxis Precision Medicines, Inc. 2024 Inducement Plan (the 2024