APLT - SEC Form 4 insider transactions

Director Kanter Stacy J. returned 22,500 shares to the company, closing all direct ownership in the company (SEC Form 4)

Chief Commercial Officer Hooks Corwin Dale was granted 312,500 shares and returned 862,500 shares to the company, closing all direct ownership in the company (SEC Form 4)

Officer Chinoporos Constantine was granted 437,500 shares and returned 1,000,000 shares to the company, closing all direct ownership in the company (SEC Form 4)

Director Skyler Jay S returned 22,500 shares to the company, closing all direct ownership in the company (SEC Form 4)

Chief Financial Officer Funtleyder Leslie D. was granted 1,187,500 shares and returned 2,375,000 shares to the company, closing all direct ownership in the company (SEC Form 4)

Chief Medical Officer Bailey Evan Prescott returned 1,235,915 shares to the company and was granted 437,500 shares, closing all direct ownership in the company (SEC Form 4)

Director Lerner Teena returned 22,500 shares to the company, closing all direct ownership in the company (SEC Form 4)

Chief Financial Officer Funtleyder Leslie D. was granted 150,000 shares, increasing direct ownership by 13% to 1,340,459 units (SEC Form 4)

Director Kanter Stacy J. sold $4,816 worth of shares (43,000 units at $0.11), decreasing direct ownership by 40% to 65,000 units (SEC Form 4)

Chief Financial Officer Funtleyder Leslie D. was granted 150,000 shares, increasing direct ownership by 14% to 1,190,459 units (SEC Form 4)

Chief Financial Officer Funtleyder Leslie D. was granted 300,000 shares, increasing direct ownership by 47% to 937,121 units (SEC Form 4)

Chief Medical Officer Bailey Evan Prescott was granted 300,000 shares, increasing direct ownership by 55% to 841,669 units (SEC Form 4)

SEC Form 4 filed by Director Lerner Teena

SEC Form 4 filed by Director Skyler Jay S

SEC Form 4 filed by Director Kanter Stacy J.

Chief Commercial Officer Hooks Corwin Dale was granted 250,000 shares, increasing direct ownership by 83% to 550,000 units (SEC Form 4)

Officer Funtleyder Leslie D. was granted 350,000 shares, increasing direct ownership by 90% to 740,459 units (SEC Form 4)

Officer Chinoporos Constantine was granted 350,000 shares, increasing direct ownership by 129% to 621,436 units (SEC Form 4)

Chief Medical Officer Perfetti Riccardo sold $4,561 worth of shares (10,366 units at $0.44), decreasing direct ownership by 1% to 890,409 units (SEC Form 4)

Officer Funtleyder Leslie D. sold $6,381 worth of shares (14,502 units at $0.44), decreasing direct ownership by 4% to 390,459 units (SEC Form 4)

Officer Chinoporos Constantine sold $197 worth of shares (447 units at $0.44), decreasing direct ownership by 0.16% to 271,436 units (SEC Form 4)

Officer Funtleyder Leslie D. sold $14,000 worth of shares (22,950 units at $0.61), decreasing direct ownership by 5% to 404,961 units (SEC Form 4)

Chief Medical Officer Perfetti Riccardo sold $52,508 worth of shares (86,078 units at $0.61), decreasing direct ownership by 9% to 900,775 units (SEC Form 4)

Officer Chinoporos Constantine sold $17,151 worth of shares (28,117 units at $0.61), decreasing direct ownership by 9% to 271,883 units (SEC Form 4)

Executive Chairman Johnson John was granted 500,000 shares (SEC Form 4)

Officer Funtleyder Leslie D. was granted 150,000 shares, increasing direct ownership by 54% to 427,911 units (SEC Form 4)

Chief Financial Officer Funtleyder Leslie D. sold $78,880 worth of shares (13,530 units at $5.83), decreasing direct ownership by 5% to 277,911 units (SEC Form 4)

Chief Medical Officer Perfetti Riccardo sold $132,230 worth of shares (22,681 units at $5.83), decreasing direct ownership by 2% to 986,853 units (SEC Form 4)

President and CEO Shendelman Shoshana gifted 747,886 shares, received a gift of 747,886 shares and sold $4,712,049 worth of shares (777,014 units at $6.06), decreasing direct ownership by 14% to 4,690,839 units (SEC Form 4)

President and CEO Shendelman Shoshana sold $266,954 worth of shares (61,795 units at $4.32), decreasing direct ownership by 2% to 3,756,019 units (SEC Form 4)

Chief Medical Officer Perfetti Riccardo sold $95,053 worth of shares (22,003 units at $4.32), decreasing direct ownership by 2% to 1,009,534 units (SEC Form 4)

Chief Financial Officer Funtleyder Leslie D. sold $73,354 worth of shares (16,980 units at $4.32), decreasing direct ownership by 6% to 291,441 units (SEC Form 4)

Kanter Stacy J. was granted 45,000 shares, increasing direct ownership by 71% to 108,000 units (SEC Form 4)

Skyler Jay S was granted 45,000 shares, increasing direct ownership by 225% to 65,000 units (SEC Form 4)

Marcus Joel S was granted 45,000 shares, increasing direct ownership by 10% to 498,414 units (SEC Form 4)

Lerner Teena was granted 45,000 shares, increasing direct ownership by 74% to 105,422 units (SEC Form 4)

Alexandria Real Estate Equities, Inc. sold $1,267,500 worth of shares (300,000 units at $4.22) (SEC Form 4)

Hooks Corwin Dale was granted 300,000 shares (SEC Form 4)

Shendelman Shoshana sold $1,717,108 worth of shares (318,573 units at $5.39), decreasing direct ownership by 8% to 3,817,814 units (SEC Form 4)

Perfetti Riccardo sold $597,234 worth of shares (110,804 units at $5.39), decreasing direct ownership by 10% to 1,031,537 units (SEC Form 4)

Hansard Adam sold $263,415 worth of shares (48,871 units at $5.39), decreasing direct ownership by 6% to 732,919 units (SEC Form 4)

Funtleyder Leslie D. sold $154,839 worth of shares (28,727 units at $5.39), decreasing direct ownership by 9% to 308,421 units (SEC Form 4)

Chinoporos Constantine was granted 300,000 shares (SEC Form 4)

Shendelman Shoshana was granted 1,540,000 shares, increasing direct ownership by 59% to 4,136,387 units (SEC Form 4)

Perfetti Riccardo was granted 450,000 shares, increasing direct ownership by 65% to 1,142,341 units (SEC Form 4)

Hansard Adam was granted 400,000 shares, increasing direct ownership by 105% to 781,790 units (SEC Form 4)

Shendelman Shoshana sold $7,817 worth of shares (3,968 units at $1.97), decreasing direct ownership by 0.15% to 2,596,387 units (SEC Form 4)

Perfetti Riccardo sold $3,119 worth of shares (1,583 units at $1.97), decreasing direct ownership by 0.23% to 692,341 units (SEC Form 4)

Hansard Adam sold $1,901 worth of shares (965 units at $1.97), decreasing direct ownership by 0.25% to 381,790 units (SEC Form 4)

Alexandria Real Estate Equities, Inc. acquired 575,000 shares and disposed of 575,000 shares (SEC Form 4)

Funtleyder Leslie D. was granted 300,000 shares, increasing direct ownership by 808% to 337,148 units (SEC Form 4)

Alexandria Real Estate Equities, Inc. sold $572,204 worth of shares (247,258 units at $2.31) (SEC Form 4)

Alexandria Real Estate Equities, Inc. sold $781,221 worth of shares (327,742 units at $2.38) (SEC Form 4)

Alexandria Real Estate Equities, Inc. disposed of 1,600,000 shares and acquired 1,600,000 shares (SEC Form 4)

Shendelman Shoshana sold $312,206 worth of shares (115,632 units at $2.70), decreasing direct ownership by 4% to 2,600,355 units (SEC Form 4)

Perfetti Riccardo sold $29,516 worth of shares (10,932 units at $2.70), decreasing direct ownership by 2% to 693,924 units (SEC Form 4)

Hansard Adam sold $26,244 worth of shares (9,720 units at $2.70), decreasing direct ownership by 2% to 382,755 units (SEC Form 4)

SEC Form 4: Marcus Joel S exercised 12,375 shares at a strike of $1.05, increasing direct ownership by 3% to 453,414 units

SEC Form 4 filed by Skyler Jay S

SEC Form 4 filed by Marcus Joel S