COLL - SEC Form 4 insider transactions

Director Freund John Gordon sold $681 worth of shares (20 units at $34.05), decreasing direct ownership by 0.02% to 83,952 units (SEC Form 4)

Director Bohlin Garen G was granted 8,741 shares, increasing direct ownership by 14% to 71,000 units (SEC Form 4)

Director Freund John Gordon was granted 8,741 shares, exercised 8,700 shares at a strike of $16.49 and sold $142,547 worth of shares (4,127 units at $34.54), increasing direct ownership by 19% to 83,972 units (SEC Form 4)

Director Paya Carlos V was granted 8,741 shares, increasing direct ownership by 45% to 28,323 units (SEC Form 4)

Director Lurker Nancy was granted 8,741 shares, increasing direct ownership by 49% to 26,758 units (SEC Form 4)

Director Balice-Gordon Rita J. was granted 8,741 shares, increasing direct ownership by 17% to 61,370 units (SEC Form 4)

Director Glancy Donovan Michael was granted 17,482 shares (SEC Form 4)

Director Santini Gino was granted 8,741 shares, increasing direct ownership by 9% to 103,783 units (SEC Form 4)

Director Lurker Nancy sold $161,861 worth of shares (4,500 units at $35.97), decreasing direct ownership by 20% to 18,017 units (SEC Form 4)

Director Bohlin Garen G exercised 8,700 shares at a strike of $16.49 and sold $323,491 worth of shares (8,700 units at $37.18) (SEC Form 4)

SEC Form 4 filed by Dieter David

SEC Form 4 filed by Dieter David

EVP & General Counsel Dieter David sold $228,110 worth of shares (6,224 units at $36.65), decreasing direct ownership by 6% to 91,047 units (SEC Form 4)

EVP & Chief Commercial Officer Dreyer Scott sold $2,019,437 worth of shares (49,976 units at $40.41), decreasing direct ownership by 41% to 71,770 units (SEC Form 4)

President and CEO Karnani Vikram was granted 111,795 shares and covered exercise/tax liability with 11,296 shares, increasing direct ownership by 103% to 197,864 units (SEC Form 4)

EVP & General Counsel Dieter David was granted 31,199 shares and covered exercise/tax liability with 2,781 shares, increasing direct ownership by 41% to 97,271 units (SEC Form 4)

EVP & Chief Commercial Officer Dreyer Scott was granted 49,725 shares and covered exercise/tax liability with 31,592 shares, increasing direct ownership by 18% to 121,746 units (SEC Form 4)

EVP and Chief Medical Officer Smith Thomas B was granted 37,042 shares and covered exercise/tax liability with 17,435 shares, increasing direct ownership by 28% to 90,651 units (SEC Form 4)

EVP & Chief Financial Officer Tupper Colleen was granted 59,155 shares and covered exercise/tax liability with 38,540 shares, increasing direct ownership by 16% to 147,282 units (SEC Form 4)

EVP & Chief Commercial Officer Dreyer Scott exercised 17,600 shares at a strike of $15.90 and sold $847,855 worth of shares (17,600 units at $48.17) (SEC Form 4)

Director Balice-Gordon Rita J. sold $171,673 worth of shares (3,650 units at $47.03), decreasing direct ownership by 6% to 52,629 units (SEC Form 4)

President and CEO Karnani Vikram covered exercise/tax liability with 8,983 shares, decreasing direct ownership by 8% to 96,989 units (SEC Form 4)

Director Fallon John A. exercised 34,853 shares at a strike of $12.41 and sold $1,645,536 worth of shares (34,853 units at $47.21) (SEC Form 4)

EVP & Chief Financial Officer Tupper Colleen sold $1,215,753 worth of shares (30,000 units at $40.53), decreasing direct ownership by 19% to 126,667 units (SEC Form 4)

EVP and Chief Medical Officer Smith Thomas B sold $671,576 worth of shares (17,478 units at $38.42), decreasing direct ownership by 20% to 70,264 units (SEC Form 4)

EVP & Chief Commercial Officer Dreyer Scott exercised 16,389 shares at a strike of $21.34 and sold $626,171 worth of shares (16,389 units at $38.21) (SEC Form 4)

Director Santini Gino sold $201,018 worth of shares (5,405 units at $37.19) and exercised 15,000 shares at a strike of $13.45, increasing direct ownership by 11% to 95,042 units (SEC Form 4)

EVP & Chief Commercial Officer Dreyer Scott exercised 4,861 shares at a strike of $21.34 and sold $184,881 worth of shares (4,861 units at $38.03) (SEC Form 4)

Large owner Rubric Capital Management Lp sold $946,250 worth of shares (25,000 units at $37.85) (SEC Form 4)

Director Freund John Gordon sold $400,641 worth of shares (11,659 units at $34.36) (SEC Form 4)

Director Freund John Gordon exercised 15,000 shares at a strike of $13.45 and sold $202,149 worth of shares (6,601 units at $30.62), increasing direct ownership by 13% to 70,658 units (SEC Form 4)

Director Fallon John A. was granted 9,791 shares, increasing direct ownership by 18% to 64,634 units (SEC Form 4)

Director Lurker Nancy was granted 9,791 shares, increasing direct ownership by 77% to 22,517 units (SEC Form 4)

Director Bohlin Garen G was granted 9,791 shares, increasing direct ownership by 19% to 62,259 units (SEC Form 4)

Director Balice-Gordon Rita J. was granted 9,791 shares, increasing direct ownership by 21% to 56,279 units (SEC Form 4)

Director Freund John Gordon was granted 9,791 shares, increasing direct ownership by 19% to 62,259 units (SEC Form 4)

Director Santini Gino was granted 9,791 shares, increasing direct ownership by 13% to 85,447 units (SEC Form 4)

Director Paya Carlos V was granted 19,582 shares (SEC Form 4)

EVP & Chief Financial Officer Tupper Colleen sold $228,250 worth of shares (7,602 units at $30.02), decreasing direct ownership by 5% to 156,667 units (SEC Form 4)

EVP & Chief Commercial Officer Dreyer Scott sold $624,794 worth of shares (20,808 units at $30.03), decreasing direct ownership by 17% to 103,613 units (SEC Form 4)

EVP & General Counsel Dieter David was granted 68,449 shares (SEC Form 4)

Amendment: EVP & Chief Commercial Officer Dreyer Scott sold $461,672 worth of shares (15,387 units at $30.00), decreasing direct ownership by 11% to 126,676 units (SEC Form 4)

EVP & Chief Financial Officer Tupper Colleen sold $29,313 worth of shares (977 units at $30.00), decreasing direct ownership by 0.59% to 164,269 units (SEC Form 4)

EVP & Chief Commercial Officer Dreyer Scott sold $67,661 worth of shares (2,255 units at $30.00), decreasing direct ownership by 2% to 124,421 units (SEC Form 4)

EVP & Chief Commercial Officer Dreyer Scott sold $461,672 worth of shares (15,387 units at $30.00), decreasing direct ownership by 11% to 126,676 units (SEC Form 4)

EVP & Chief Financial Officer Tupper Colleen sold $313,413 worth of shares (10,445 units at $30.01), decreasing direct ownership by 6% to 165,246 units (SEC Form 4)

EVP & Chief Financial Officer Tupper Colleen sold $103,591 worth of shares (3,453 units at $30.00), decreasing direct ownership by 2% to 175,691 units (SEC Form 4)

EVP & Chief Commercial Officer Dreyer Scott sold $169,299 worth of shares (5,643 units at $30.00), decreasing direct ownership by 4% to 142,063 units (SEC Form 4)

EVP and General Counsel Kuhlmann Shirley R. sold $2,426,634 worth of shares (86,067 units at $28.19) and exercised 40,000 shares at a strike of $24.03, decreasing direct ownership by 30% to 108,137 units (SEC Form 4)

EVP and Chief Medical Officer Smith Thomas B was granted 39,075 shares and covered exercise/tax liability with 5,897 shares, increasing direct ownership by 61% to 87,742 units (SEC Form 4)

Director Heffernan Michael Thomas was granted 4,820 shares, increasing direct ownership by 11% to 50,328 units (SEC Form 4)

EVP & Chief Commercial Officer Dreyer Scott covered exercise/tax liability with 29,623 shares and was granted 71,427 shares, increasing direct ownership by 39% to 147,706 units (SEC Form 4)

EVP & Chief Financial Officer Tupper Colleen was granted 78,725 shares and covered exercise/tax liability with 30,426 shares, increasing direct ownership by 37% to 179,144 units (SEC Form 4)

EVP and General Counsel Kuhlmann Shirley R. covered exercise/tax liability with 34,975 shares and was granted 69,995 shares, increasing direct ownership by 29% to 154,204 units (SEC Form 4)

Director Lurker Nancy was granted 12,726 shares (SEC Form 4)

EVP and General Counsel Kuhlmann Shirley R. sold $908,628 worth of shares (27,500 units at $33.04) and exercised 27,500 shares at a strike of $21.34 (SEC Form 4)

President and CEO Karnani Vikram was granted 105,972 shares (SEC Form 4)

EVP and Chief Medical Officer Smith Thomas B sold $351,320 worth of shares (9,593 units at $36.62), decreasing direct ownership by 15% to 53,816 units (SEC Form 4)

EVP and General Counsel Kuhlmann Shirley R. sold $773,792 worth of shares (20,225 units at $38.26), decreasing direct ownership by 15% to 119,184 units (SEC Form 4)

Kuhlmann Shirley R. sold $814,180 worth of shares (25,000 units at $32.57), decreasing direct ownership by 15% to 139,409 units (SEC Form 4)