MANE - SEC Form 4 insider transactions

Director Montanova Capital, Llc sold $80,437,500 worth of shares (750,000 units at $107.25) and converted options into 300,000 shares (SEC Form 4)

Chief Technical Officer Durso Timothy August exercised 3,452 shares at a strike of $12.19 and sold $4,690,005 worth of shares (43,500 units at $107.82), decreasing direct ownership by 34% to 78,142 units (SEC Form 4)

Chief Executive Officer Waldman Reid Alexander sold $7,280,713 worth of shares (67,500 units at $107.86) and exercised 3,452 shares at a strike of $12.19, decreasing direct ownership by 27% to 170,824 units (SEC Form 4)

Director Childs John W sold $10,711,700 worth of shares (100,000 units at $107.12) (SEC Form 4)

SEC Form 4 filed by Director Suvretta Capital Management, Llc

SEC Form 4 filed by Director Pance Katarina

Director Grant-Kels Jane M. converted options into 2,455 shares (SEC Form 4)

SEC Form 4 filed by Director Friedman David Matthew

SEC Form 4 filed by General Counsel Greco Michael V.

SEC Form 4 filed by Chief Commercial Officer Neumann Mark

SEC Form 4 filed by Chief Financial Officer Carrano Dominic Gabriel

Chief Technical Officer Durso Timothy August converted options into 1,473 shares, increasing direct ownership by 1% to 118,190 units (SEC Form 4)

Chief Executive Officer Waldman Reid Alexander converted options into 1,437 shares, increasing direct ownership by 0.62% to 234,872 units (SEC Form 4)