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Compare · SLNO vs SMLR

SLNO vs SMLR

Side-by-side comparison of Soleno Therapeutics Inc. (SLNO) and Semler Scientific Inc. (SMLR): market cap, price performance, sector, and recent activity on the wire.

Summary

  • Both SLNO and SMLR operate in Biotechnology: Electromedical & Electrotherapeutic Apparatus (Health Care), so they compete in similar markets.
  • SLNO is the larger of the two at $2.72B, about 5.8x SMLR ($470.7M).
  • Over the past year, SLNO is down 29.4% and SMLR is down 37.1% - SLNO leads by 7.7 points.
  • SLNO has hit the wire 12 times in the past 4 weeks while SMLR has been quiet.
  • SLNO has more recent analyst coverage (12 ratings vs 6 for SMLR).
PerformanceSLNO-36.63%SMLR-37.13%
2025-08-12+0.00%2026-04-30
MetricSLNOSMLR
Company
Soleno Therapeutics Inc.
Semler Scientific Inc.
Price
$52.80+0.02%
$20.34-5.02%
Market cap
$2.72B
$470.7M
1M return
+57.85%
+16.67%
1Y return
-29.41%
-37.13%
Industry
Biotechnology: Electromedical & Electrotherapeutic Apparatus
Biotechnology: Electromedical & Electrotherapeutic Apparatus
Exchange
NASDAQ
NASDAQ
IPO
2014
News (4w)
12
0
Recent ratings
12
6
SLNO

Soleno Therapeutics Inc.

Soleno Therapeutics, Inc., a clinical-stage biopharmaceutical company, focuses on the development and commercialization of novel therapeutics for the treatment of rare diseases. Its lead candidate is Diazoxide Choline Controlled-Release (DCCR), a once-daily oral tablet for the treatment of Prader-Willi Syndrome (PWS), is being evaluated in a Phase III clinical development program. The company was formerly known as Capnia, Inc. and changed its name to Soleno Therapeutics, Inc. in May 2017. Soleno Therapeutics has collaboration with Vanderbilt University to discover and develop next generation K(ATP) channel activators for the treatment of rare diseases. Soleno Therapeutics, Inc. was incorporated in 1999 and is headquartered in Redwood City, California.

SMLR

Semler Scientific Inc.

Semler Scientific, Inc. develops, manufactures, and markets proprietary products that assist healthcare providers to evaluate and treat patients with chronic diseases in the United States. The company's products include QuantaFlo, a four-minute in-office blood flow test that enables healthcare providers to use blood flow measurements as part of their examinations of a patient's vascular condition. Its products serve cardiologists, internists, nephrologists, endocrinologists, podiatrists, and family practitioners, as well as healthcare insurance plans, integrated delivery networks, independent physician groups, and companies contracting with the healthcare industry, such as risk assessment groups. The company offers its products through salespersons and distributors. Semler Scientific, Inc. was incorporated in 2007 and is headquartered in Santa Clara, California.