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    Amendment: SEC Form S-1/A filed by HCW Biologics Inc.

    2/13/26 4:04:50 PM ET
    $HCWB
    Biotechnology: Pharmaceutical Preparations
    Health Care
    Get the next $HCWB alert in real time by email
    S-1/A 1 d55258ds1a.htm S-1/A S-1/A

    As filed with the Securities and Exchange Commission on February 13, 2026

    Registration No. 333-293396

     

     
     

    UNITED STATES

    SECURITIES AND EXCHANGE COMMISSION

    WASHINGTON, D.C. 20549

     

     

    Amendment No. 1

    to

    FORM S-1

    REGISTRATION STATEMENT

    UNDER

    THE SECURITIES ACT OF 1933

     

     

    HCW BIOLOGICS INC.

    (Exact name of Registrant as specified in its charter)

     

     

     

    Delaware   2834   82-5024477

    (State or Other Jurisdiction of

    Incorporation or Organization)

     

    Primary Standard Industrial

    Classification Code Number

     

    (I.R.S. Employer

    Identification Number)

    2929 N Commerce Parkway

    Miramar, FL 33025

    (954) 842-2024

    Address, including zip code, and telephone number, including area code, of Registrant’s principal executive offices

     

     

    Hing C. Wong, Ph.D.

    Chief Executive Officer

    HCW Biologics Inc.

    2929 N Commerce Parkway

    Miramar, FL 33025

    (954) 842-2024

    Name, Address Including Zip Code, and Telephone Number, Including Area Code, of Agent for Service

     

     

    With a copy to:

     

     

    James Groth, Esq.

    Clark Hill PLC

    130 E. Randolph St., Ste. 3900

    Chicago, IL 60601

    (312) 985-5900

     

    Yevgeniya (Jeny) Zarmon, Esq.

    Clark Hill PLC

    210 Carnegie Center, Suite 102

    Princeton, NJ 08540

    (609) 785-2918

     

    Barry I. Grossman, Esq.

    Matthew Bernstein, Esq.

    Ellenoff Grossman & Schole LLP

    1345 Avenue of the Americas

    New York, New York 10105

    Tel: (212) 370-1300

     

    Approximate Date of Commencement of Proposed Sale to the Public: As soon as practicable after this registration statement becomes effective.

    If any of the securities being registered on this Form are to be offered on a delayed or continuous basis pursuant to Rule 415 under the Securities Act of 1933, check the following box. ☒

    If this Form is filed to register additional securities for an offering pursuant to Rule 462(b) under the Securities Act, please check the following box and list the Securities Act registration statement number of the earlier effective registration statement for the same offering. ☐

    If this Form is a post-effective amendment filed pursuant to Rule 462(c) under the Securities Act, check the following box and list the Securities Act registration statement number of the earlier effective registration statement for the same offering. ☐

    If this Form is a post-effective amendment filed pursuant to Rule 462(d) under the Securities Act, check the following box and list the Securities Act registration statement number of the earlier effective registration statement for the same offering. ☐

    Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growth company. See the definitions of “large accelerated filer,” “accelerated filer,” “smaller reporting company” and “emerging growth company” in Rule 12b-2 of the Exchange Act.

     

    Large accelerated filer   ☐    Accelerated filer   ☐
    Non-accelerated filer   ☒    Smaller reporting company   ☒
         Emerging growth company   ☒

    If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act. ☐

     

     

    The registrant hereby amends this registration statement on such date or dates as may be necessary to delay its effective date until the registrant shall file a further amendment which specifically states that this registration statement shall thereafter become effective in accordance with Section 8(a) of the Securities Act or until the registration statement shall become effective on such date as the Securities and Exchange Commission, acting pursuant to Section 8(a) of the Securities Act, may determine.

     

     
     


    EXPLANATORY NOTE

    HCW Biologics Inc. is filing this Amendment No. 1 to its Registration Statement on Form S-1 (File No. 333-293396) as an exhibits-only filing. Accordingly, this Amendment consists only of the facing page, this explanatory note, Item 16(a) of Part II of the Registration Statement, the signature page to the Registration Statement and the filed exhibits. The remainder of the Registration Statement is unchanged and has therefore been omitted.


    PART II

    Item 16. Exhibits.

    EXHIBIT INDEX

     

        

    Exhibit title

       Incorporated by reference      Filed or
    furnished
    herewith
     
    Exhibit No.    Form      File No.      Exhibit No.      Filing date  
     1.1    Form of Placement Agent Agreement      S-1        333-293396        1.1        2/11/2026     
     3.1    Amended and Restated Certificate of Incorporation      8-K        001-40591        3.1        07/26/2021     
     3.1a    Certificate of Amendment of Certificate of Incorporation, filed March 31, 2025.      8-K        001-40591        3.1a        04/01/2025     
     3.1b    Certificate of Correction of the Certificate of Amendment of Certificate of Incorporation, filed April 1, 2025.      8-K        001-40591        3.1b        04/01/2025     
     3.2    Amended and Restated Bylaws      8-K        001-40591        3.2        07/26/2021     
     4.1    Specimen Stock Certificate      S-1/A        333-256510        4.1        07/09/2021     
     4.2    Description of Securities      10-K        001-40591        4.2        03/29/2022     
     4.3    Form of New Warrant      8-K        001-40591        4.1        11/20/2025     
     4.4    Form of Pre-Funded Warrant Purchase Warrant      S-1        333-293396        4.4        2/11/2026     
     5.1    Opinion of Clark Hill PLC                  X  
    10.1    Form of Indemnification Agreement between HCW Biologics Inc. and each of its officers and directors.      S-1/A        333-256510        10.1        07/09/2021     
    10.2+    2019 Equity Incentive Plan, as amended, and forms of agreement thereunder.      S-1        333-256510        10.2        07/09/2021     
    10.3+    First Amendment to 2019 Equity Incentive Plan.      S-1        333-256510        10.3        07/09/2021     
    10.4+    2021 Equity Incentive Plan and forms of agreement thereunder      S-1        333-256510        10.4        07/09/2021     
    10.5+    Employment Agreement, dated July 6, 2021, between Peter Rhode and HCW Biologics Inc.      S-1        333-256510        10.6        07/09/2021     
    10.6+    Employment Agreement, dated October 9, 2019, between Rebecca Byam and HCW Biologics Inc.      S-1        333-256510        10.7        07/09/2021     
    10.7+    Non-Employee Director Compensation Policy.      S-1        333-256510        10.8        07/09/2021     
    10.8+    Employment Agreement, dated June 18, 2021, between Dr. Hing C. Wong and HCW Biologics Inc.      S-1        333-256510        10.13        07/09/2021     
    10.9+    Executive Incentive Bonus Plan      S-1        333-256510        10.11        07/09/2021     

     

    II-1


        

    Exhibit title

       Incorporated by reference      Filed or
    furnished
    herewith
     
    Exhibit No.    Form      File No.      Exhibit No.      Filing date  
    10.10†    Exclusive License Agreement, dated December 24, 2020, between HCW Biologics Inc. and Wugen, Inc.      S-1        333-256510        10.10        07/09/2021     
    10.11†    Master Services Agreement, dated March 14, 2019, between HCW Biologics Inc. and EirGenix, Inc.      S-1        333-256510        10.12        07/09/2021     
    10.12†#    Purchase and Sale Agreement, by and between HCW Biologics Inc. and Wai 3300 Corporate Way, LLC, dated May 27, 2022      10-Q        001-40591        10.1        08/12/2022     
    10.13    Capital on Demand Sales Agreement, dated August  19, 2022, by and between HCW Biologics Inc. and Jones Trading Institutional Services LLC      S-3        333-266991        1.2        08/19/2022     
    10.14#    Loan Agreement by and between HCW Biologics Inc. and Cogent Bank, dated August 15, 2022      10-Q        001-40591        10.1        11/07/2022     
    10.15#    Mortgage and Security Agreement by and between HCW Biologics Inc. and Cogent Bank, dated August 15, 2022      10-Q        001-40591        10.2        11/07/2022     
    10.16    Form of Subscription Agreement, dated February 20, 2024, by and between the Company and the Subscribers party thereto      8-K        001-40591        10.1        02/22/2024     
    10.17    Form of Subscription Agreement, dated February 20, 2024, by and between the Company and the Subscribers party thereto      10-Q        001-40591        10.5        05/15/2024     
    10.18    Form of Amended and Restated Senior Secured Note Purchase Agreement, dated July  2, 2024, by and between the Company and the Purchaser party thereto      10-Q        001-40591        10.1        08/14/2024     
    10.19    Form of Senior Secured Promissory Note by and between the Company and the Holder party thereof      10-Q        001-40591        10.2        08/14/2024     
    10.20    Form of Amended and Restated Pledge Agreement, dated July  2, 2024, by and among the Company, Escrow Agent and Noteholder parties thereto      10-Q        001-40591        10.3        08/14/2024     
    10.21    Form of Escrow Agreement, dated July 2, 2024, by and among the Company, Escrow Agent and Noteholder parties thereto      10-Q        001-40591        10.4        08/14/2024     
    10.22    Form of First Amendment to the Amended and Restated Senior Secured Note Purchase Agreement, dated September  30, 2024, by and between the Company and Purchaser parties thereto      10-Q        001-40591        10.5        11/14/2024     

     

    II-2


        

    Exhibit title

       Incorporated by reference      Filed or
    furnished
    herewith
     
    Exhibit No.    Form      File No.      Exhibit No.      Filing date  
    10.23†#    Settlement Agreement and Release, dated July  13, 2024, by and between the Company and Altor BioScience, LLC, NantCell, Inc., and ImmunityBio, Inc.      10-Q        001-40591        10.6        11/14/2024     
    10.24#    Placement Agency Agreement, dated November 18, 2024, between the Company and Maxim Group LLC.      8-K        001-40591        10.1        11/20/2024     
    10.25#    Securities Purchase Agreement, dated November 18, 2024, between the Company and Purchaser      8-K        001-40591        10.2        11/20/2024     
    10.26#    Equity Purchase Agreement, dated February 20, 2025, between the Company and Square Gate Master Fund—Series 4.      8-K        001-40591        10.1        02/21/2025     
    10.27    Registration Rights Agreement, dated February 20, 2025, between the Company and Square Gate Master Fund— Series 4.      8-K        001-40591        10.2        02/21/2025     
    10.28    Form of Promissory Note, dated May 8, 2025, between Company and Holder      10-Q        001-40591        10.4        05/15/2025     
    10.29    Form of Guaranty and Pledge Agreement dated May 8, 2025, between Dr. Hing C. Wong and Lender      10-Q        001-40591        10.5        05/15/2025     
    10.30    Form of Securities Purchase Agreement, dated May 13, 2025, between Company and Purchaser      8-K        001-40591        10.2        05/15/2025     
    10.31    Letter Agreement to the License, Research and Co-Development Agreement, dated March  17, 2025, between Company and WY Biotech Co. Ltd.      10-Q        001-40591        10.14        08/18/2025     
    10.32    Confirmation of Letter of Acceptance of Deliverable from Company by WY Biotech Co. Ltd., dated May 30, 2025      10-Q        001-40591        10.15        08/18/2025     
    10.33    Second Letter Agreement to the License, Research and Co-Development Agreement, dated July  13, 2025, between Company and WY Biotech Co. Ltd.      10-Q        001-40591        10.16        08/18/2025     
    10.34    Exclusive License Agreement 12-month Suspension, dated May 29, 2025, between the Company and Wugen, Inc.      10-Q        001-40591        10.17        08/18/2025     
    10.35    First Amendment to the Equity Purchase Agreement, dated August  14, 2025, between the Company and Square Gate Master Fund—Series 4.      8-K        001-40591        10.1        08/15/2025     

     

    II-3


        

    Exhibit title

       Incorporated by reference      Filed or
    furnished
    herewith
     
    Exhibit No.    Form      File No.      Exhibit No.     Filing date  
    10.36    Second Amendment to Amended and Restated Senior Secured Note Purchase Agreement and Related Agreements, dated May  1, 2025, between Company and Holder      10-Q        001-40591        10.12       08/18/2025     
    10.37    Form of Common Stock Warrant dated May 7, 2025, between Company and Holder      10-Q        001-40591        10.13       08/18/2025     
    10.38    Exclusive License Agreement 12-month Suspension, dated May  29, 2025, between the Company and Wugen, Inc.      10-Q        001-40591        10.17       08/18/2025     
    10.39    Form of Inducement Agreement between the Company and Armistice Capital Management, LLC      8-K        001-40591        10.1       11/20/2025     
    10.40†#    Amended and Restated License, Research and Co-Development Agreement, dated November  17, 2025, between Beijing Trimmune Biotech Co., Ltd., and the Company      S-1        333-293396        10.40       2/11/2026     
    10.41    Form of Securities Purchase Agreement      S-1        333-293396        10.41       2/11/2026     
    10.42    Form of Lock Up Agreement      S-1        333-293396        10.42       2/11/2026     
    10.43†#    Amendment 1 to Amended and Restated License, Research and Co-Development Agreement, dated January 27, 2026 between Beijing Trimmune Biotech Co., Ltd., and the Company      S-1        333-293396        10.43       2/11/2026     
    10.44†#    Shareholder Purchase Agreement, dated October  10, 2025, between co-founders of Beijing Trimmune Biotech Co., Ltd., including the Company      S-1        333-293396        10.44       2/11/2026     
    23.1a    Consent of Independent Registered Public Accounting Firm (Grant Thornton, Predecessor)      S-1        333-293396        23.1 (a)      2/11/2026     
    23.1b    Consent of Independent Registered Public Accounting Firm (Crowe, Successor)      S-1        333-293396        23.1 (b)      2/11/2026     
    23.2*    Opinion of Clark Hill PLC              
    97.1    HCW Biologics Inc. Compensation Recovery Policy      10-K        001-40591        97.1       04/01/2024     
    99.1    Audit Committee Charter of the Registrant      S-1        333-293396        99.1       2/11/2026     
    99.2    Compensation Committee Charter of the Registrant      S-1        333-293396        99.2       2/11/2026     
    99.3    HCW Biologics Inc. Related Party Transaction Policy      S-1        333-293396        99.3       2/11/2026     
    107    Filing Fee Table      S-1        333-293396        107       2/11/2026     

     

    *

    Opinion of Clark Hill PLC to be filed by amendment

    †

    Certain portions of this document that constitute confidential information have been redacted in accordance with Regulation S-K, Item 60 1(b)(10).

    +

    Indicates management contract or compensatory plan.

    #

    Certain information in this document has been excluded pursuant to Item 601(a)(5) or (a)(6) of Regulation S-K. The Registrant agrees to furnish supplementally such information to the SEC upon request.

     

    II-4


    SIGNATURES

    Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this registration statement on Form S-1 to be signed on its behalf by the undersigned, in the city of Miramar, State of Florida, on February 13, 2026.

     

    HCW BIOLOGICS INC.
    By:   /s/ Hing C. Wong
    Name:   Hing C. Wong
    Title:   Founder & Chief Executive Officer

    POWER OF ATTORNEY

    Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this registration statement on Form S-1 to be signed on its behalf by the undersigned, thereunto duly authorized.

     

    Signature

      

    Title

     

    Date

    /s/ Scott T. Garrett

    Scott T. Garrett

      

    Chairman of the Board of Directors

     

    February 13, 2026

    /s/ Rebecca Byam

    Rebecca Byam

      

    Chief Financial Officer

     

    February 13, 2026

    /s/ Hing C. Wong

    Hing C. Wong

      

    Chief Executive Officer

     

    February 13, 2026

    /s/ Rick S. Greene

    Rick S. Greene

      

    Director

     

    February 13, 2026

    /s/ Lisa M. Giles

    Lisa M. Giles

      

    Director

     

    February 13, 2026

     

    By:   /s/ Hing C. Wong
      Hing C. Wong, Attorney-in-Fact

     

    II-5

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    MIRAMAR, Fla., April 01, 2024 (GLOBE NEWSWIRE) -- HCW Biologics Inc. (the "Company" or "HCW Biologics") (NASDAQ:HCWB), a clinical-stage biopharmaceutical company focused on discovering and developing novel immunotherapies to lengthen healthspan by disrupting the link between inflammation and age-related diseases, today reported financial results and recent business highlights for its fourth quarter and fiscal year ended December 31, 2023.  Dr. Hing C. Wong, Founder and CEO of HCW Biologics, stated, "These are exciting times at HCW Biologics. We achieved two major clinical milestones, with the completion of the Phase 1 clinical study to evaluate HCW9218 in solid tumors and the Phase 1b stu

    4/1/24 4:10:32 PM ET
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    Biotechnology: Pharmaceutical Preparations
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    $HCWB
    Large Ownership Changes

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    Amendment: SEC Form SC 13D/A filed by HCW Biologics Inc.

    SC 13D/A - HCW Biologics Inc. (0001828673) (Subject)

    11/22/24 4:53:35 PM ET
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    Biotechnology: Pharmaceutical Preparations
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    $HCWB
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    HCW Biologics Reports Second Quarter 2025 Business Highlights and Financial Results

    MIRAMAR, Fla., Aug. 18, 2025 (GLOBE NEWSWIRE) -- HCW Biologics Inc. (the "Company" or "HCW Biologics") (NASDAQ:HCWB), a clinical-stage biopharmaceutical company focused on discovering and developing novel immunotherapies to lengthen health span by disrupting the link between inflammation and age-related diseases, today reported financial results and recent business highlights for its second quarter ended June 30, 2025.  On May 15, 2025, the Company closed an equity offering with gross proceeds of $5.0 million with a single institutional investor. Dr. Hing Wong, Founder and CEO, stated, "We are pleased to have completed a successful $5.0 million equity offering in a challenging market with

    8/18/25 2:44:03 PM ET
    $HCWB
    Biotechnology: Pharmaceutical Preparations
    Health Care

    HCW Biologics Reports Second Quarter 2022 Financial Results And Recent Business Highlights

    MIRAMAR, Fla., Aug. 12, 2022 (GLOBE NEWSWIRE) -- HCW Biologics Inc. (the "Company" or "HCW Biologics") (NASDAQ:HCWB), a clinical-stage biopharmaceutical company focused on discovering and developing novel immunotherapies to lengthen healthspan by disrupting the link between chronic, low-grade inflammation and age-related diseases, today reported financial results and recent business highlights for its second quarter ended June 30, 2022. "We have achieved several milestones in the first half of 2022, and some important pieces of our strategic plan have fallen into place. First, we are now a clinical-stage company, with the entry of our lead product candidate, HCW9218, into the clinic in a

    8/12/22 7:00:00 AM ET
    $HCWB
    Biotechnology: Pharmaceutical Preparations
    Health Care

    HCW Biologics Reports First Quarter 2022 Financial Results and Recent Business Highlights

    MIRAMAR, Fla., May 13, 2022 (GLOBE NEWSWIRE) -- HCW Biologics Inc. (the "Company" or "HCW Biologics") (NASDAQ:HCWB), a biopharmaceutical company focused on discovering and developing novel immunotherapies to lengthen health span by disrupting the link between chronic, low-grade inflammation and age-related diseases, today reported financial results and recent business highlights for its first quarter ended March 31, 2022. "We continue to successfully execute our clinical development strategy which is based on our unique approach toward inflammaging," stated Hing C. Wong, Founder and CEO of HCW Biologics Inc. "HCW Biologics is developing immunotherapeutics that do not treat a single indica

    5/13/22 7:15:00 AM ET
    $HCWB
    Biotechnology: Pharmaceutical Preparations
    Health Care