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    Amendment: SEC Form SCHEDULE 13D/A filed by Jasper Therapeutics Inc.

    2/18/26 5:29:20 PM ET
    $JSPR
    Biotechnology: Biological Products (No Diagnostic Substances)
    Health Care
    Get the next $JSPR alert in real time by email



    SECURITIES AND EXCHANGE COMMISSION
    Washington, D.C. 20549


    SCHEDULE 13D

    Under the Securities Exchange Act of 1934

    (Amendment No. 4)


    Jasper Therapeutics, Inc.

    (Name of Issuer)


    Voting Common Stock, par value $0.0001 per share

    (Title of Class of Securities)


    471871202

    (CUSIP Number)


    Jeffrey Ferguson
    The Carlyle Group, 1001 Pennsylvania Avenue, NW, Suite 220S
    Washington, DC, 20004
    (202) 729-5626

    (Name, Address and Telephone Number of Person Authorized to Receive Notices and Communications)
    02/18/2026

    (Date of Event Which Requires Filing of This Statement)


    If the filing person has previously filed a statement on Schedule 13G to report the acquisition that is the subject of this Schedule 13D, and is filing this schedule because of §§ 240.13d-1(e), 240.13d-1(f) or 240.13d-1(g), check the following box. Checkbox not checked

    The information required on the remainder of this cover page shall not be deemed to be “filed” for the purpose of Section 18 of the Securities Exchange Act of 1934 (“Act”) or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).






    SCHEDULE 13D

    CUSIP No.
    471871202


    1 Name of reporting person

    The Carlyle Group Inc.
    2Check the appropriate box if a member of a Group (See Instructions)

    Checkbox not checked  (a)
    Checkbox not checked  (b)
    3SEC use only
    4 Source of funds (See Instructions)

    OO
    5 Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)

    Checkbox not checked
    6Citizenship or place of organization

    DELAWARE
    Number of Shares Beneficially Owned by Each Reporting Person With:
    7Sole Voting Power

    0.00
    8Shared Voting Power

    1,088,310.00
    9Sole Dispositive Power

    0.00
    10Shared Dispositive Power

    1,088,310.00
    11Aggregate amount beneficially owned by each reporting person

    1,088,310.00
    12Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)

    Checkbox not checked
    13Percent of class represented by amount in Row (11)

    3.8 %
    14Type of Reporting Person (See Instructions)

    CO



    SCHEDULE 13D

    CUSIP No.
    471871202


    1 Name of reporting person

    Carlyle Holdings I GP Inc.
    2Check the appropriate box if a member of a Group (See Instructions)

    Checkbox not checked  (a)
    Checkbox not checked  (b)
    3SEC use only
    4 Source of funds (See Instructions)

    OO
    5 Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)

    Checkbox not checked
    6Citizenship or place of organization

    DELAWARE
    Number of Shares Beneficially Owned by Each Reporting Person With:
    7Sole Voting Power

    0.00
    8Shared Voting Power

    1,088,310.00
    9Sole Dispositive Power

    0.00
    10Shared Dispositive Power

    1,088,310.00
    11Aggregate amount beneficially owned by each reporting person

    1,088,310.00
    12Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)

    Checkbox not checked
    13Percent of class represented by amount in Row (11)

    3.8 %
    14Type of Reporting Person (See Instructions)

    CO



    SCHEDULE 13D

    CUSIP No.
    471871202


    1 Name of reporting person

    Carlyle Holdings I GP Sub L.L.C.
    2Check the appropriate box if a member of a Group (See Instructions)

    Checkbox not checked  (a)
    Checkbox not checked  (b)
    3SEC use only
    4 Source of funds (See Instructions)

    OO
    5 Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)

    Checkbox not checked
    6Citizenship or place of organization

    DELAWARE
    Number of Shares Beneficially Owned by Each Reporting Person With:
    7Sole Voting Power

    0.00
    8Shared Voting Power

    1,088,310.00
    9Sole Dispositive Power

    0.00
    10Shared Dispositive Power

    1,088,310.00
    11Aggregate amount beneficially owned by each reporting person

    1,088,310.00
    12Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)

    Checkbox not checked
    13Percent of class represented by amount in Row (11)

    3.8 %
    14Type of Reporting Person (See Instructions)

    OO

    Comment for Type of Reporting Person:
    Limited Liability Company


    SCHEDULE 13D

    CUSIP No.
    471871202


    1 Name of reporting person

    Carlyle Holdings I L.P.
    2Check the appropriate box if a member of a Group (See Instructions)

    Checkbox not checked  (a)
    Checkbox not checked  (b)
    3SEC use only
    4 Source of funds (See Instructions)

    OO
    5 Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)

    Checkbox not checked
    6Citizenship or place of organization

    DELAWARE
    Number of Shares Beneficially Owned by Each Reporting Person With:
    7Sole Voting Power

    0.00
    8Shared Voting Power

    1,088,310.00
    9Sole Dispositive Power

    0.00
    10Shared Dispositive Power

    1,088,310.00
    11Aggregate amount beneficially owned by each reporting person

    1,088,310.00
    12Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)

    Checkbox not checked
    13Percent of class represented by amount in Row (11)

    3.8 %
    14Type of Reporting Person (See Instructions)

    PN



    SCHEDULE 13D

    CUSIP No.
    471871202


    1 Name of reporting person

    CG Subsidiary Holdings L.L.C.
    2Check the appropriate box if a member of a Group (See Instructions)

    Checkbox not checked  (a)
    Checkbox not checked  (b)
    3SEC use only
    4 Source of funds (See Instructions)

    OO
    5 Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)

    Checkbox not checked
    6Citizenship or place of organization

    DELAWARE
    Number of Shares Beneficially Owned by Each Reporting Person With:
    7Sole Voting Power

    0.00
    8Shared Voting Power

    1,088,310.00
    9Sole Dispositive Power

    0.00
    10Shared Dispositive Power

    1,088,310.00
    11Aggregate amount beneficially owned by each reporting person

    1,088,310.00
    12Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)

    Checkbox not checked
    13Percent of class represented by amount in Row (11)

    3.8 %
    14Type of Reporting Person (See Instructions)

    OO

    Comment for Type of Reporting Person:
    Limited Liability Company


    SCHEDULE 13D

    CUSIP No.
    471871202


    1 Name of reporting person

    TC Group, L.L.C.
    2Check the appropriate box if a member of a Group (See Instructions)

    Checkbox not checked  (a)
    Checkbox not checked  (b)
    3SEC use only
    4 Source of funds (See Instructions)

    OO
    5 Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)

    Checkbox not checked
    6Citizenship or place of organization

    DELAWARE
    Number of Shares Beneficially Owned by Each Reporting Person With:
    7Sole Voting Power

    0.00
    8Shared Voting Power

    1,088,310.00
    9Sole Dispositive Power

    0.00
    10Shared Dispositive Power

    1,088,310.00
    11Aggregate amount beneficially owned by each reporting person

    1,088,310.00
    12Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)

    Checkbox not checked
    13Percent of class represented by amount in Row (11)

    3.8 %
    14Type of Reporting Person (See Instructions)

    OO

    Comment for Type of Reporting Person:
    Limited Liability Company


    SCHEDULE 13D

    CUSIP No.
    471871202


    1 Name of reporting person

    Carlyle Investment Management L.L.C.
    2Check the appropriate box if a member of a Group (See Instructions)

    Checkbox not checked  (a)
    Checkbox not checked  (b)
    3SEC use only
    4 Source of funds (See Instructions)

    OO
    5 Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)

    Checkbox not checked
    6Citizenship or place of organization

    DELAWARE
    Number of Shares Beneficially Owned by Each Reporting Person With:
    7Sole Voting Power

    0.00
    8Shared Voting Power

    1,088,310.00
    9Sole Dispositive Power

    0.00
    10Shared Dispositive Power

    1,088,310.00
    11Aggregate amount beneficially owned by each reporting person

    1,088,310.00
    12Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)

    Checkbox not checked
    13Percent of class represented by amount in Row (11)

    3.8 %
    14Type of Reporting Person (See Instructions)

    OO

    Comment for Type of Reporting Person:
    Limited Liability Company


    SCHEDULE 13D

    CUSIP No.
    471871202


    1 Name of reporting person

    Carlyle Genesis UK LLC
    2Check the appropriate box if a member of a Group (See Instructions)

    Checkbox not checked  (a)
    Checkbox not checked  (b)
    3SEC use only
    4 Source of funds (See Instructions)

    OO
    5 Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)

    Checkbox not checked
    6Citizenship or place of organization

    DELAWARE
    Number of Shares Beneficially Owned by Each Reporting Person With:
    7Sole Voting Power

    0.00
    8Shared Voting Power

    1,088,310.00
    9Sole Dispositive Power

    0.00
    10Shared Dispositive Power

    1,088,310.00
    11Aggregate amount beneficially owned by each reporting person

    1,088,310.00
    12Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)

    Checkbox not checked
    13Percent of class represented by amount in Row (11)

    3.8 %
    14Type of Reporting Person (See Instructions)

    OO

    Comment for Type of Reporting Person:
    Limited Liability Company


    SCHEDULE 13D

    CUSIP No.
    471871202


    1 Name of reporting person

    Abingworth LLP
    2Check the appropriate box if a member of a Group (See Instructions)

    Checkbox not checked  (a)
    Checkbox not checked  (b)
    3SEC use only
    4 Source of funds (See Instructions)

    OO
    5 Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)

    Checkbox not checked
    6Citizenship or place of organization

    UNITED KINGDOM
    Number of Shares Beneficially Owned by Each Reporting Person With:
    7Sole Voting Power

    0.00
    8Shared Voting Power

    1,088,310.00
    9Sole Dispositive Power

    0.00
    10Shared Dispositive Power

    1,088,310.00
    11Aggregate amount beneficially owned by each reporting person

    1,088,310.00
    12Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)

    Checkbox not checked
    13Percent of class represented by amount in Row (11)

    3.8 %
    14Type of Reporting Person (See Instructions)

    PN



    SCHEDULE 13D

    CUSIP No.
    471871202


    1 Name of reporting person

    Abingworth Bioventures VII LP
    2Check the appropriate box if a member of a Group (See Instructions)

    Checkbox not checked  (a)
    Checkbox not checked  (b)
    3SEC use only
    4 Source of funds (See Instructions)

    OO
    5 Check if disclosure of legal proceedings is required pursuant to Items 2(d) or 2(e)

    Checkbox not checked
    6Citizenship or place of organization

    UNITED KINGDOM
    Number of Shares Beneficially Owned by Each Reporting Person With:
    7Sole Voting Power

    0.00
    8Shared Voting Power

    1,088,310.00
    9Sole Dispositive Power

    0.00
    10Shared Dispositive Power

    1,088,310.00
    11Aggregate amount beneficially owned by each reporting person

    1,088,310.00
    12Check if the aggregate amount in Row (11) excludes certain shares (See Instructions)

    Checkbox not checked
    13Percent of class represented by amount in Row (11)

    3.8 %
    14Type of Reporting Person (See Instructions)

    PN



    SCHEDULE 13D

    Item 1.Security and Issuer
    (a)Title of Class of Securities:

    Voting Common Stock, par value $0.0001 per share
    (b)Name of Issuer:

    Jasper Therapeutics, Inc.
    (c)Address of Issuer's Principal Executive Offices:

    2200 Bridge Pkwy, Suite #102, Redwood City, CALIFORNIA , 94065.
    Item 1 Comment:
    Explanatory Note This Amendment No. 4 to Schedule 13D ("Amendment No. 4") amends and supplements the Schedule 13D originally filed with the United States Securities and Exchange Commission (the "SEC") on October 4, 2021 (as amended to date, the "Schedule 13D"), relating to the shares of voting common stock, par value $0.0001 per share (the "Common Stock"), of Jasper Therapeutics, Inc., a Delaware corporation (the "Issuer"). Capitalized terms used herein without definition shall have the meanings set forth in the Schedule 13D.
    Item 5.Interest in Securities of the Issuer
    (a)
    Item 5 of the Schedule 13D is hereby amended and restated in its entirety as follows: The following sets forth, as of the date of this Schedule 13D, the aggregate number of shares of Common Stock and percentage of Common Stock beneficially owned by each of the Reporting Persons, based on 27,984,039 shares of Common Stock outstanding as of November 6, 2025, as disclosed in the Issuer's Quarterly Report on Form 10-Q filed with the SEC on November 10, 2025. Abingworth Bioventures VII LP is the beneficial owner of 1,088,310 shares of Common Stock, or approximately 3.8% of the shares of Common Stock outstanding, which include (i) 1,066,189 shares of Common Stock held of record by Abingworth Bioventures VII LP, (ii) 2,117 shares of Common Stock held for the benefit of Abingworth Bioventures VII LP and (iii) 20,004 shares of Common Stock underlying stock options held for the benefit of Abingworth Bioventures VII LP. The Carlyle Group Inc., which is a publicly traded entity listed on Nasdaq, is the sole shareholder of Carlyle Holdings I GP Inc., which is the sole member of Carlyle Holdings I GP Sub L.L.C., which is the general partner of Carlyle Holdings I L.P., which, with respect to the securities reported herein, is the managing member of CG Subsidiary Holdings L.L.C., which is the managing member of TC Group, L.L.C., which is the managing member of Carlyle Investment Management, L.L.C., which is the sole member of Carlyle Genesis UK LLC, which is the principal member of Abingworth LLP. Abingworth Bioventures VII LP has delegated to Abingworth LLP all investment and dispositive power over the securities held of record by Abingworth Bioventures VII LP. Accordingly, each of the foregoing entities may be deemed to share beneficial ownership of the securities held of record by Abingworth Bioventures VII LP, but each disclaims beneficial ownership of such securities.
    (b)
    Sole power to vote or to direct the vote: 0 Shared power to vote or to direct the vote: 1,088,310 Sole power to dispose or to direct the disposition: 0 Shared power to dispose or to direct the disposition: 1,088,310
    (c)
    During the past 60 days, the Reporting Persons have not effected any transactions with respect to the Common Stock.
    (d)
    None.
    (e)
    As of the date hereof, the Reporting Persons ceased to be the beneficial owners of more than five percent of the outstanding shares of Common Stock.

        SIGNATURE 
     
    After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

     
    The Carlyle Group Inc.
     
    Signature:/s/ Anne K. Frederick
    Name/Title:Anne K. Frederick, Corporate Secretary
    Date:02/18/2026
     
    Carlyle Holdings I GP Inc.
     
    Signature:/s/ Anne K. Frederick
    Name/Title:Anne K. Frederick, Managing Director
    Date:02/18/2026
     
    Carlyle Holdings I GP Sub L.L.C.
     
    Signature:By: Carlyle Holdings I GP Inc., its sole member, /s/ Anne K. Frederick
    Name/Title:Anne K. Frederick, Managing Director
    Date:02/18/2026
     
    Carlyle Holdings I L.P.
     
    Signature:/s/ Anne K. Frederick
    Name/Title:Anne K. Frederick, Managing Director
    Date:02/18/2026
     
    CG Subsidiary Holdings L.L.C.
     
    Signature:/s/ Anne K. Frederick
    Name/Title:Anne K. Frederick, Managing Director
    Date:02/18/2026
     
    TC Group, L.L.C.
     
    Signature:/s/ Anne K. Frederick
    Name/Title:Anne K. Frederick, Managing Director
    Date:02/18/2026
     
    Carlyle Investment Management L.L.C.
     
    Signature:/s/ Anne K. Frederick
    Name/Title:Anne K. Frederick, Managing Director
    Date:02/18/2026
     
    Carlyle Genesis UK LLC
     
    Signature:By: Carlyle Investment Management L.L.C., its sole member, /s/ Anne K. Frederick
    Name/Title:Anne K. Frederick, Managing Director
    Date:02/18/2026
     
    Abingworth LLP
     
    Signature:/s/ Emma O'Reilly
    Name/Title:Emma O'Reilly, Authorized Signatory
    Date:02/18/2026
     
    Abingworth Bioventures VII LP
     
    Signature:/s/ Emma O'Reilly
    Name/Title:Emma O'Reilly, Authorized Signatory
    Date:02/18/2026
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    Reductions in airway hyperresponsiveness and suppressed eosinophilic response at both 6 weeks and 12 weeks observed after a single 180mg dose of Briquilimab in the ETESIAN Study Preliminary data from ETESIAN study supports further development of briquilimab in asthma Jasper also announces completion of internal BEACON study investigation noting no deviations or issues with drug product utilized Jasper to host conference call and webinar today at 8:00 a.m. ET REDWOOD CITY, Calif., Dec. 02, 2025 (GLOBE NEWSWIRE) -- Jasper Therapeutics, Inc. (NASDAQ:JSPR) (Jasper), a clinical stage biotechnology company focused on development of briquilimab, a novel antibody therapy targeting KIT (CD117)

    12/2/25 7:00:00 AM ET
    $JSPR
    Biotechnology: Biological Products (No Diagnostic Substances)
    Health Care

    Jasper Therapeutics Reports Positive Data from 180mg Cohort in SPOTLIGHT Study of Briquilimab in Chronic Inducible Urticaria

    11 of 12 participants (92%) enrolled in the 180mg cohort achieved a complete response 12 of 12 participants (100%) in the 180mg cohort achieved a clinical response Tryptase levels below the lower limit of quantification observed in 10 of 12 participants (83%) No serious adverse events and no grade 3 or higher adverse events reported in the 180mg cohort Company to host conference call and webinar on Monday, June 16, at 8:00 a.m. EDT REDWOOD CITY, Calif., June 14, 2025 (GLOBE NEWSWIRE) -- Jasper Therapeutics, Inc. (NASDAQ:JSPR) (Jasper), a clinical stage biotechnology company focused on development of briquilimab, a novel antibody therapy targeting KIT (CD117) to address mast cell drive

    6/14/25 10:00:23 AM ET
    $JSPR
    Biotechnology: Biological Products (No Diagnostic Substances)
    Health Care

    $JSPR
    Large Ownership Changes

    This live feed shows all institutional transactions in real time.

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    Amendment: SEC Form SC 13G/A filed by Jasper Therapeutics Inc.

    SC 13G/A - Jasper Therapeutics, Inc. (0001788028) (Subject)

    11/14/24 6:01:49 PM ET
    $JSPR
    Biotechnology: Biological Products (No Diagnostic Substances)
    Health Care

    Amendment: SEC Form SC 13G/A filed by Jasper Therapeutics Inc.

    SC 13G/A - Jasper Therapeutics, Inc. (0001788028) (Subject)

    11/14/24 3:32:57 PM ET
    $JSPR
    Biotechnology: Biological Products (No Diagnostic Substances)
    Health Care

    Amendment: SEC Form SC 13G/A filed by Jasper Therapeutics Inc.

    SC 13G/A - Jasper Therapeutics, Inc. (0001788028) (Subject)

    11/4/24 12:05:53 PM ET
    $JSPR
    Biotechnology: Biological Products (No Diagnostic Substances)
    Health Care

    $JSPR
    Leadership Updates

    Live Leadership Updates

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    Jasper Therapeutics Announces Appointment of Svetlana Lucas Ph.D., to its Board of Directors

    REDWOOD CITY, Calif., June 19, 2024 (GLOBE NEWSWIRE) -- Jasper Therapeutics, Inc. (NASDAQ:JSPR) (Jasper), a clinical stage biotechnology company focused on development of briquilimab, a novel antibody therapy targeting c-Kit (CD117) to address mast cell driven diseases such as chronic spontaneous urticaria (CSU), chronic inducible urticaria (CIndU) and asthma, today announced the appointment of Svetlana Lucas, Ph.D., to Jasper's Board of Directors (the Board), effective as of June 18, 2024. Separately, Anna French, D. Phil., stepped down from the Board, effective as of June 18, 2024. "We are pleased to welcome Svetlana, an experienced and accomplished biopharmaceutical executive, to our B

    6/19/24 8:00:00 AM ET
    $JSPR
    Biotechnology: Biological Products (No Diagnostic Substances)
    Health Care

    Jasper Therapeutics Announces Appointment of Thomas G. Wiggans as Chairperson of the Board of Directors

    REDWOOD CITY, Calif., Nov. 01, 2023 (GLOBE NEWSWIRE) -- Jasper Therapeutics, Inc. (NASDAQ:JSPR) (Jasper), a biotechnology company focused on the development of briquilimab, a novel antibody therapy targeting c-Kit (CD117) to address mast cell driven diseases such as chronic spontaneous urticaria (CSU) and chronic inducible urticaria (CIndU), as well as lower to intermediate risk myelodysplastic syndromes (LR-MDS) and novel stem cell transplant conditioning regimens, today announced the appointment of Thomas G. Wiggans, a veteran biopharmaceutical executive, as Chairperson of Jasper's Board of Directors (the Board), effective immediately. Bill Lis is stepping down as Chairperson and will re

    11/1/23 8:00:00 AM ET
    $DERM
    $JSPR
    Biotechnology: Pharmaceutical Preparations
    Health Care
    Biotechnology: Biological Products (No Diagnostic Substances)

    Jasper Therapeutics Strengthens Management Team with Key Appointments

    Patricia Carlos Appointed Senior Vice President of Regulatory Affairs and Quality Annette Marcantonio Appointed Vice President of Clinical Operations REDWOOD CITY, Calif., Aug. 02, 2023 (GLOBE NEWSWIRE) -- Jasper Therapeutics, Inc. (NASDAQ:JSPR) (Jasper), a biotechnology company focused on the development of briquilimab, a novel antibody therapy targeting c-Kit (CD117) to address diseases such as chronic spontaneous urticaria (CSU), lower to intermediate risk myelodysplastic syndromes (LR-MDS) as well as novel stem cell transplant conditioning regimes, today announced the appointment of two seasoned pharma industry executives to its regulatory affairs, quality and clinical operations

    8/2/23 8:00:00 AM ET
    $JSPR
    Biotechnology: Biological Products (No Diagnostic Substances)
    Health Care