SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

SCHEDULE 13G

UNDER THE SECURITIES EXCHANGE ACT OF 1934

(Amendment No. 10)

aTYR PHARMA INC

(Name of Issuer)

COMMON STOCK

(Title of Class of Securities)

002120202

(CUSIP Number)

09/30/2025

(Date of Event Which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

Rule 13d-1(b)

Rule 13d-1(c)

Rule 13d-1(d)

SCHEDULE 13G

CUSIP No.

002120202

Names of Reporting Persons

Federated Hermes, Inc.

Check the appropriate box if a member of a Group (see instructions)

(a)

(b)

Sec Use Only

Citizenship or Place of Organization

PENNSYLVANIA

Number of Shares Beneficially Owned by Each Reporting Person With:

5	Sole Voting Power 10,544,437.00
6	Shared Voting Power 0.00
7	Sole Dispositive Power 10,544,437.00
8	Shared Dispositive Power 0.00

Aggregate Amount Beneficially Owned by Each Reporting Person

10,544,437.00

Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

Checkbox not checked

Percent of class represented by amount in row (9)

10.76 %

Type of Reporting Person (See Instructions)

SCHEDULE 13G

CUSIP No.

002120202

Names of Reporting Persons

Voting Shares Irrevocable Trust

Check the appropriate box if a member of a Group (see instructions)

(a)

(b)

Sec Use Only

Citizenship or Place of Organization

PENNSYLVANIA

Number of Shares Beneficially Owned by Each Reporting Person With:

5	Sole Voting Power 10,544,437.00
6	Shared Voting Power 0.00
7	Sole Dispositive Power 10,544,437.00
8	Shared Dispositive Power 0.00

Aggregate Amount Beneficially Owned by Each Reporting Person

10,544,437.00

Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

Checkbox not checked

Percent of class represented by amount in row (9)

10.76 %

Type of Reporting Person (See Instructions)

SCHEDULE 13G

CUSIP No.

002120202

Names of Reporting Persons

Thomas R. Donahue

Check the appropriate box if a member of a Group (see instructions)

(a)

(b)

Sec Use Only

Citizenship or Place of Organization

UNITED STATES

Number of Shares Beneficially Owned by Each Reporting Person With:

5	Sole Voting Power 0.00
6	Shared Voting Power 10,544,437.00
7	Sole Dispositive Power 0.00
8	Shared Dispositive Power 10,544,437.00

Aggregate Amount Beneficially Owned by Each Reporting Person

10,544,437.00

Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

Checkbox not checked

Percent of class represented by amount in row (9)

10.76 %

Type of Reporting Person (See Instructions)

SCHEDULE 13G

CUSIP No.

002120202

Names of Reporting Persons

Ann C. Donahue

Check the appropriate box if a member of a Group (see instructions)

(a)

(b)

Sec Use Only

Citizenship or Place of Organization

UNITED STATES

Number of Shares Beneficially Owned by Each Reporting Person With:

5	Sole Voting Power 0.00
6	Shared Voting Power 10,544,437.00
7	Sole Dispositive Power 0.00
8	Shared Dispositive Power 10,544,437.00

Aggregate Amount Beneficially Owned by Each Reporting Person

10,544,437.00

Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

Checkbox not checked

Percent of class represented by amount in row (9)

10.76 %

Type of Reporting Person (See Instructions)

SCHEDULE 13G

CUSIP No.

002120202

Names of Reporting Persons

J. Christopher Donahue

Check the appropriate box if a member of a Group (see instructions)

(a)

(b)

Sec Use Only

Citizenship or Place of Organization

UNITED STATES

Number of Shares Beneficially Owned by Each Reporting Person With:

5	Sole Voting Power 0.00
6	Shared Voting Power 10,544,437.00
7	Sole Dispositive Power 0.00
8	Shared Dispositive Power 10,544,437.00

Aggregate Amount Beneficially Owned by Each Reporting Person

10,544,437.00

Check box if the aggregate amount in row (9) excludes certain shares (See Instructions)

Checkbox not checked

Percent of class represented by amount in row (9)

10.76 %

Type of Reporting Person (See Instructions)

SCHEDULE 13G

Item 1.

(a)

Name of issuer:

aTYR PHARMA INC

(b)

Address of issuer's principal executive offices:

10240 Sorrento Valley Road, Suite 300 San Diego, CA 92121

Item 2.

(a)

Name of person filing:

Federated Hermes, Inc.

(b)

Address or principal business office or, if none, residence:

1001 Liberty Avenue, Pittsburgh, PA 15222-3779

(c)

Citizenship:

Pennsylvania

(d)

Title of class of securities:

COMMON STOCK

(e)

CUSIP No.:

002120202

Item 3.

If this statement is filed pursuant to §§ 240.13d-1(b) or 240.13d-2(b) or (c), check whether the person filing is a:

(a)

Broker or dealer registered under section 15 of the Act (15 U.S.C. 78o);

(b)

Bank as defined in section 3(a)(6) of the Act (15 U.S.C. 78c);

(c)

Insurance company as defined in section 3(a)(19) of the Act (15 U.S.C. 78c);

(d)

Investment company registered under section 8 of the Investment Company Act of 1940 (15 U.S.C. 80a-8);

(e)

An investment adviser in accordance with § 240.13d-1(b)(1)(ii)(E);

(f)

An employee benefit plan or endowment fund in accordance with § 240.13d-1(b)(1)(ii)(F);

(g)

A parent holding company or control person in accordance with § 240.13d-1(b)(1)(ii)(G);

(h)

A savings associations as defined in Section 3(b) of the Federal Deposit Insurance Act (12 U.S.C. 1813);

(i)

A church plan that is excluded from the definition of an investment company under section 3(c)(14) of the Investment Company Act of 1940 (15 U.S.C. 80a-3);

(j)

A non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J). If filing as a non-U.S. institution in accordance with § 240.13d-1(b)(1)(ii)(J),
please specify the type of institution:

(k)

Group, in accordance with Rule 240.13d-1(b)(1)(ii)(K).

Item 4.

Ownership

(a)

Amount beneficially owned:

10,544,437

(b)

Percent of class:

10.76 %

(c)

Number of shares as to which the person has:

(i) Sole power to vote or to direct the vote:

10,544,437

(ii) Shared power to vote or to direct the vote:

(iii) Sole power to dispose or to direct the disposition of:

10,544,437

(iv) Shared power to dispose or to direct the disposition of:

Item 5.

Ownership of 5 Percent or Less of a Class.

Item 6.

Ownership of more than 5 Percent on Behalf of Another Person.

Not Applicable

Item 7.

Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding Company or Control Person.

If a parent holding company has filed this schedule, pursuant to Rule 13d-1(b)(ii)(G), so indicate under Item 3(g) and attach an exhibit stating the identity and the Item 3 classification of the relevant subsidiary. If a parent holding company has filed this schedule pursuant to Rule 13d-1(c) or Rule 13d-1(d), attach an exhibit stating the identification of the relevant subsidiary.

See Exhibit "1" Attached

Item 8.

Identification and Classification of Members of the Group.

Not Applicable

Item 9.

Notice of Dissolution of Group.

Not Applicable

Item 10.

Certifications:

By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were acquired and are held in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11. By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11.

SIGNATURE

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

Federated Hermes, Inc.

Signature:	/s/J. Christopher Donahue
Name/Title:	J. Christopher Donahue, as President of Federated Hermes, Inc.
Date:	10/07/2025

Voting Shares Irrevocable Trust

Signature:	/s/Thomas R. Donahue
Name/Title:	Thomas R. Donahue, as Trustee of Voting Shares Irrevocable Trust
Date:	10/07/2025

Signature:	/s/Ann C. Donahue
Name/Title:	Ann C. Donahue, as Trustee of Voting Shares Irrevocable Trust
Date:	10/07/2025

Signature:	/s/J. Christopher Donahue
Name/Title:	J. Christopher Donahue, as Trustee of Voting Shares Irrevocable Trust
Date:	10/07/2025

Thomas R. Donahue

Signature:	/s/Thomas R. Donahue
Name/Title:	Thomas R. Donahue
Date:	10/07/2025

Ann C. Donahue

Signature:	/s/Ann C. Donahue
Name/Title:	Ann C. Donahue
Date:	10/07/2025

J. Christopher Donahue

Signature:	/s/J. Christopher Donahue
Name/Title:	J. Christopher Donahue
Date:	10/07/2025

Comments accompanying signature: SEE EXHIBITS 2 AND 3 ATTACHED Exhibit Information EXHIBIT 1 ITEM 3 CLASSIFICATION OF REPORTING PERSONS EXHIBIT 2 AGREEMENT FOR JOINT FILING OF SCHEDULE 13G EXHIBIT 3 POWER OF ATTORNEY

Amendment: SEC Form SCHEDULE 13G/A filed by aTyr Pharma Inc.