• Live Feeds
    • Press Releases
    • Insider Trading
    • FDA Approvals
    • Analyst Ratings
    • Insider Trading
    • SEC filings
    • Market insights
  • Analyst Ratings
  • Alerts
  • Subscriptions
  • AI SuperconnectorNEW
  • Settings
  • RSS Feeds
Quantisnow Logo
  • Live Feeds
    • Press Releases
    • Insider Trading
    • FDA Approvals
    • Analyst Ratings
    • Insider Trading
    • SEC filings
    • Market insights
  • Analyst Ratings
  • Alerts
  • Subscriptions
  • AI SuperconnectorNEW
  • Settings
  • RSS Feeds
PublishGo to AppAI Superconnector
    Quantisnow Logo

    © 2025 quantisnow.com
    Democratizing insights since 2022

    Services
    Live news feedsRSS FeedsAlertsPublish with Us
    Company
    AboutQuantisnow PlusContactJobsAI superconnector for talent & startupsNEWLLM Arena
    Legal
    Terms of usePrivacy policyCookie policy

    Arthur Tzianabos, Ph.D., June Lee, MD FACCP, and Joseph Loscalzo, MD, Ph.D. Join 5AM Ventures

    9/27/22 8:15:00 AM ET
    $AKUS
    $CINC
    $FIXX
    $IONS
    Specialty Chemicals
    Consumer Discretionary
    Biotechnology: Pharmaceutical Preparations
    Health Care
    Get the next $AKUS alert in real time by email

    SAN FRANCISCO and BOSTON, Sept. 27, 2022 (GLOBE NEWSWIRE) -- 5AM Ventures, a bicoastal venture capital firm, continues to attract preeminent talent as it celebrates 20 years of investing in early-stage life science companies. The firm is currently deploying capital in breakthrough science opportunities throughout North America and Europe from its $450 million 5AM Ventures VII fund and its $300 million 5AM Opportunities II fund, which has an additional mandate to invest in public market opportunities.

    5AM is pleased to announce the addition of two Venture Partners to the firm's investment team, and a Venture Advisor to the advisory team.

    Dr. Arthur Tzianabos has joined 5AM as a Venture Partner, bringing notable scientific and operational experience. Dr. Tzianabos recently served as President and CEO of 5AM portfolio company, Homology Medicines, Inc. (NASDAQ:FIXX) where he led the company from inception through a successful public offering. At Homology he took developmental candidates into gene editing and gene therapy clinical trials and struck many validating business development deals including the creation of a new company based on Homology's innovative AAV process development and manufacturing platform. Previously, Dr. Tzianabos was SVP of Research and Early Development at Shire PLC (acquired by Takeda, for $62B), where he was responsible for building the company's therapeutic pipeline and worked closely with the Venture group to invest in genetic medicines companies. Earlier, Dr. Tzianabos spent 13 years as a principal investigator and faculty member at Harvard Medical School. He is a member of the boards of directors for several companies, including Chair of 5AM's Homology Medicines and Akouos, Inc. (NASDAQ:AKUS). He serves on the Executive Committee of the Board of Directors for the Alliance for Regenerative Medicine and the Development Board for the University of New Hampshire's College of Life Sciences and Agriculture. Dr. Tzianabos received his B.S. in Biology from Boston College and his Ph.D. in Microbiology from the University of New Hampshire.

    Dr. June Lee, an eminent biotechnology industry operator, has joined 5AM as a Venture Partner. Dr. Lee was previously Chief Operating Officer, EVP and Chief Development Officer of MyoKardia (acquired by Bristol Myers Squibb for $13.1B) where she led development for its pipeline, including Camzyos to treat obstructive hyptertrophic cardiomyopathy, which the FDA approved this year. Prior to MyoKardia, Dr. Lee was a Professor of Medicine at UCSF School of Medicine, where she served as Director of Translational Research and built the Catalyst Program, an internal accelerator for early-stage technologies. Previously, Dr. Lee was the therapeutic area head in early clinical development at Genentech including programs in cardiovascular and metabolic diseases, infectious diseases, and respiratory diseases. Currently, she serves on the boards of leading biotech companies, including 5AM's CinCor Pharma, Inc. (NASDAQ:CINC). Dr. Lee received her undergraduate degree in Chemistry at the Johns Hopkins University, her medical degree at the School of Medicine at University of California, Davis, and completed clinical training in internal medicine and pulmonary and critical care at UCLA and UCSF.

    Dr. Joseph Loscalzo, a distinguished academic and industry leader, has joined 5AM as a Venture Advisor. Dr. Loscalzo is a Hersey professor at Harvard Medical School, Chair of the Department of Medicine, and Physician-in-Chief at Brigham and Women's Hospital. He previously served as Chief of Cardiology at Boston University in addition to being Chair of Medicine, Professor of Biochemistry, and Director of the Whitaker Cardiovascular Institute. Dr. Loscalzo has received numerous awards including election to the American Society for Clinical Investigation, the Association of American Physicians, and the Institute of Medicine of the National Academy of Sciences. His breadth of industry leadership experience includes serving as a board director at Leap Therapeutics, Inc. (NASDAQ:LPTX) and as board chair of Ionis Pharmaceuticals (NASDAQ:IONS). Dr. Loscalzo received his Ph.D. in Biochemistry and his M.D. from the University of Pennsylvania.

    ABOUT 5AM VENTURES

    Founded in 2002, 5AM Ventures is a leading venture capital firm focused on building next-generation life science companies. Based in San Francisco and Boston, 5AM takes a hands-on approach to investing and company building, often going beyond traditional board roles to leverage our diverse team of scientists, clinicians, drug developers and executives throughout a company's life. With more than $2.2 billion raised since inception, 5AM has invested globally in over 100 public and private companies. For more information, please visit www.5amventures.com.

    CONTACT

    5AM Ventures

    Britt Inga Emerson, Investor Relations Manager

    Email: [email protected]



    Primary Logo

    Get the next $AKUS alert in real time by email

    Crush Q3 2025 with the Best AI Superconnector

    Stay ahead of the competition with Standout.work - your AI-powered talent-to-startup matching platform.

    AI-Powered Inbox
    Context-aware email replies
    Strategic Decision Support
    Get Started with Standout.work

    Recent Analyst Ratings for
    $AKUS
    $CINC
    $FIXX
    $IONS

    CompanyDatePrice TargetRatingAnalyst
    Ionis Pharmaceuticals Inc.
    $IONS
    10/8/2025$80.00Neutral → Overweight
    Analyst
    Ionis Pharmaceuticals Inc.
    $IONS
    9/26/2025$65.00Sell → Neutral
    Goldman
    Ionis Pharmaceuticals Inc.
    $IONS
    9/3/2025$70.00Market Perform → Outperform
    BMO Capital Markets
    Ionis Pharmaceuticals Inc.
    $IONS
    7/31/2025$62.00Equal-Weight → Overweight
    Morgan Stanley
    Ionis Pharmaceuticals Inc.
    $IONS
    7/1/2025$57.00Equal Weight → Overweight
    Barclays
    Ionis Pharmaceuticals Inc.
    $IONS
    4/7/2025$45.00Buy
    H.C. Wainwright
    Ionis Pharmaceuticals Inc.
    $IONS
    3/31/2025$39.00Neutral
    Redburn Atlantic
    Leap Therapeutics Inc.
    $LPTX
    1/29/2025Buy → Neutral
    H.C. Wainwright
    More analyst ratings

    $AKUS
    $CINC
    $FIXX
    $IONS
    Insider Purchases

    Insider purchases reveal critical bullish sentiment about the company from key stakeholders. See them live in this feed.

    View All

    Director Hayden Michael R bought $477,900 worth of shares (15,000 units at $31.86), increasing direct ownership by 43% to 50,219 units (SEC Form 4)

    4 - IONIS PHARMACEUTICALS INC (0000874015) (Issuer)

    5/2/25 4:38:26 PM ET
    $IONS
    Biotechnology: Pharmaceutical Preparations
    Health Care

    Director Hayden Michael R bought $181,079 worth of shares (5,000 units at $36.22), increasing direct ownership by 17% to 35,219 units (SEC Form 4)

    4 - IONIS PHARMACEUTICALS INC (0000874015) (Issuer)

    12/26/24 4:57:52 PM ET
    $IONS
    Biotechnology: Pharmaceutical Preparations
    Health Care

    $AKUS
    $CINC
    $FIXX
    $IONS
    Press Releases

    Fastest customizable press release news feed in the world

    View All

    High Dose Regimen of Nusinersen Receives Positive CHMP Opinion for the Treatment of Spinal Muscular Atrophy

    Positive CHMP opinion is based on data from the DEVOTE study which evaluated the high dose regimen of nusinersen in treatment-naive participants and those transitioning from the currently approved 12mg dose regimen1Final European Commission decision expected in January 2026SMA is a rare, genetic, neuromuscular disease that affects individuals of all ages2 CAMBRIDGE, Mass., Nov. 17, 2025 (GLOBE NEWSWIRE) -- Biogen Inc. (NASDAQ:BIIB) today announced the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) adopted a positive opinion recommending by consensus the approval of the high dose regimen of nusinersen for the treatment of 5q spinal muscular a

    11/17/25 6:00:00 AM ET
    $BIIB
    $IONS
    Biotechnology: Biological Products (No Diagnostic Substances)
    Health Care
    Biotechnology: Pharmaceutical Preparations

    Biogen Completes Acquisition of Alcyone Therapeutics

    CAMBRIDGE, Mass., Nov. 14, 2025 (GLOBE NEWSWIRE) -- Biogen Inc. (NASDAQ:BIIB) has completed the acquisition of Alcyone Therapeutics, a clinical-stage biotechnology company known for its innovative CNS therapy delivery solutions, such as the ThecaFlex DRx™ drug delivery system. ThecaFlex DRx™ is an investigational implantable device designed to provide an alternative to repeat lumbar punctures in chronic intrathecal administration of medicines, which could ease both patient experience and accessibility for a broader population of people living with neurologic disorders. ThecaFlex DRx™ has been in development since 2019, with the PIERRE and PIERRE-PK clinical studies for nusinersen curren

    11/14/25 4:05:00 PM ET
    $BIIB
    $IONS
    Biotechnology: Biological Products (No Diagnostic Substances)
    Health Care
    Biotechnology: Pharmaceutical Preparations

    DAWNZERA™ (donidalorsen) receives positive opinion from CHMP, recommended for approval in EU for hereditary angioedema (HAE)

    Recommendation based on breadth of clinical evidence demonstrating significant HAE attack rate reduction with DAWNZERA European Commission decision expected in Q1 2026 Ionis Pharmaceuticals, Inc. (NASDAQ:IONS) and Otsuka Pharmaceutical Co., Ltd. (Otsuka) today announced that the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency has adopted a positive opinion of DAWNZERA™ (donidalorsen) for the routine prevention of recurrent attacks of hereditary angioedema (HAE) in adults and adolescents aged 12 years and older. The positive opinion is now referred to the European Commission (EC) for an approval decision. "We believe the positive opinion from t

    11/14/25 7:00:00 AM ET
    $IONS
    Biotechnology: Pharmaceutical Preparations
    Health Care

    $AKUS
    $CINC
    $FIXX
    $IONS
    Analyst Ratings

    Analyst ratings in real time. Analyst ratings have a very high impact on the underlying stock. See them live in this feed.

    View All

    Ionis Pharma upgraded by Analyst with a new price target

    Analyst upgraded Ionis Pharma from Neutral to Overweight and set a new price target of $80.00

    10/8/25 8:16:23 AM ET
    $IONS
    Biotechnology: Pharmaceutical Preparations
    Health Care

    Ionis Pharma upgraded by Goldman with a new price target

    Goldman upgraded Ionis Pharma from Sell to Neutral and set a new price target of $65.00

    9/26/25 8:00:14 AM ET
    $IONS
    Biotechnology: Pharmaceutical Preparations
    Health Care

    Ionis Pharma upgraded by BMO Capital Markets with a new price target

    BMO Capital Markets upgraded Ionis Pharma from Market Perform to Outperform and set a new price target of $70.00

    9/3/25 8:16:13 AM ET
    $IONS
    Biotechnology: Pharmaceutical Preparations
    Health Care

    $AKUS
    $CINC
    $FIXX
    $IONS
    Insider Trading

    Insider transactions reveal critical sentiment about the company from key stakeholders. See them live in this feed.

    View All

    Director Wender Joseph H exercised 16,000 shares at a strike of $24.42 (SEC Form 4)

    4 - IONIS PHARMACEUTICALS INC (0000874015) (Issuer)

    11/20/25 5:12:23 PM ET
    $IONS
    Biotechnology: Pharmaceutical Preparations
    Health Care

    Director Herman Joan E exercised 44,000 shares at a strike of $57.40 and sold $3,173,830 worth of shares (44,000 units at $72.13) (SEC Form 4)

    4 - IONIS PHARMACEUTICALS INC (0000874015) (Issuer)

    11/20/25 5:12:11 PM ET
    $IONS
    Biotechnology: Pharmaceutical Preparations
    Health Care

    SEC Form 4 filed by CEO,CFO,Pres.,GC,Treas.&Sec. Onsi Douglas E

    4 - CYPHERPUNK TECHNOLOGIES INC. (0001509745) (Issuer)

    11/13/25 5:02:26 PM ET
    $LPTX
    Biotechnology: Pharmaceutical Preparations
    Health Care

    $AKUS
    $CINC
    $FIXX
    $IONS
    SEC Filings

    View All

    Ionis Pharmaceuticals Inc. filed SEC Form 8-K: Entry into a Material Definitive Agreement

    8-K - IONIS PHARMACEUTICALS INC (0000874015) (Filer)

    11/17/25 4:06:20 PM ET
    $IONS
    Biotechnology: Pharmaceutical Preparations
    Health Care

    SEC Form DEFA14A filed by Leap Therapeutics Inc.

    DEFA14A - LEAP THERAPEUTICS, INC. (0001509745) (Filer)

    11/12/25 4:10:30 PM ET
    $LPTX
    Biotechnology: Pharmaceutical Preparations
    Health Care

    Leap Therapeutics Inc. filed SEC Form 8-K: Entry into a Material Definitive Agreement

    8-K - LEAP THERAPEUTICS, INC. (0001509745) (Filer)

    11/12/25 4:06:53 PM ET
    $LPTX
    Biotechnology: Pharmaceutical Preparations
    Health Care

    $AKUS
    $CINC
    $FIXX
    $IONS
    Large Ownership Changes

    This live feed shows all institutional transactions in real time.

    View All

    Amendment: SEC Form SC 13G/A filed by Ionis Pharmaceuticals Inc.

    SC 13G/A - IONIS PHARMACEUTICALS INC (0000874015) (Subject)

    11/14/24 8:34:57 PM ET
    $IONS
    Biotechnology: Pharmaceutical Preparations
    Health Care

    Amendment: SEC Form SC 13G/A filed by Ionis Pharmaceuticals Inc.

    SC 13G/A - IONIS PHARMACEUTICALS INC (0000874015) (Subject)

    11/14/24 1:28:29 PM ET
    $IONS
    Biotechnology: Pharmaceutical Preparations
    Health Care

    SEC Form SC 13G filed by Leap Therapeutics Inc.

    SC 13G - LEAP THERAPEUTICS, INC. (0001509745) (Subject)

    11/14/24 6:07:56 AM ET
    $LPTX
    Biotechnology: Pharmaceutical Preparations
    Health Care

    $AKUS
    $CINC
    $FIXX
    $IONS
    Financials

    Live finance-specific insights

    View All

    Biogen Completes Acquisition of Alcyone Therapeutics

    CAMBRIDGE, Mass., Nov. 14, 2025 (GLOBE NEWSWIRE) -- Biogen Inc. (NASDAQ:BIIB) has completed the acquisition of Alcyone Therapeutics, a clinical-stage biotechnology company known for its innovative CNS therapy delivery solutions, such as the ThecaFlex DRx™ drug delivery system. ThecaFlex DRx™ is an investigational implantable device designed to provide an alternative to repeat lumbar punctures in chronic intrathecal administration of medicines, which could ease both patient experience and accessibility for a broader population of people living with neurologic disorders. ThecaFlex DRx™ has been in development since 2019, with the PIERRE and PIERRE-PK clinical studies for nusinersen curren

    11/14/25 4:05:00 PM ET
    $BIIB
    $IONS
    Biotechnology: Biological Products (No Diagnostic Substances)
    Health Care
    Biotechnology: Pharmaceutical Preparations

    Cypherpunk Technologies (formerly Leap Therapeutics) Reports Third Quarter 2025 Financial Results

    CAMBRIDGE, Mass., Nov. 12, 2025 /PRNewswire/ -- Cypherpunk Technologies Inc., previously known as Leap Therapeutics, Inc. (NASDAQ:LPTX), a company developing novel therapies for patients with cancer and implementing a digital asset treasury strategy focused on Zcash, today reported financial results for the third quarter of 2025 and a corporate update. As announced earlier today, the Company has changed its name to "Cypherpunk Technologies Inc." from "Leap Therapeutics, Inc." to reflect the strategic focus on acquiring the digital asset, ZEC, participating in the development of Zcash, and the values of privacy and liberty. The Company will begin trading on the Nasdaq Capital Market under the

    11/12/25 8:00:00 AM ET
    $LPTX
    Biotechnology: Pharmaceutical Preparations
    Health Care

    Ionis reports third quarter 2025 financial results and highlights progress on key programs

    - TRYNGOLZA® generated $32 million in net product sales in the third quarter 2025 - - DAWNZERA™ (donidalorsen) launch off to encouraging start - - Olezarsen significantly reduced triglycerides and acute pancreatitis events in severe hypertriglyceridemia (sHTG) in landmark Phase 3 studies; sNDA submission on track by year-end – - Positive pivotal zilganersen results in Alexander disease position Ionis for first independent neurology launch in 2026 - - Increasing 2025 financial guidance driven by continued strength across the business – Ionis Pharmaceuticals, Inc. (NASDAQ:IONS) (the "Company") today reported financial results and provided key updates for the third quarter ended Sept

    10/29/25 7:00:00 AM ET
    $IONS
    Biotechnology: Pharmaceutical Preparations
    Health Care

    $AKUS
    $CINC
    $FIXX
    $IONS
    Leadership Updates

    Live Leadership Updates

    View All

    Leap Therapeutics Rebrands as Cypherpunk; Expands Leadership Team to Drive New Zcash Treasury Strategy

    Khing Oei appointed Chairman of the Board; Will McEvoy appointed Chief Investment Officer and Member of the Board; Cypherpunk Technologies Inc. announces acquisition of 203,775.27 ZEC. CAMBRIDGE, Mass., Nov. 12, 2025 /PRNewswire/ -- Leap Therapeutics, Inc. (NASDAQ:LPTX) today announced it will change its name to Cypherpunk Technologies Inc., and unveiled a digital asset treasury strategy to accumulate Zcash's native coin, ZEC. Cypherpunk has to date used $50 million of proceeds from the previously announced private placement to purchase 203,775.27 ZEC at an average purchase price of $245.37 per ZEC. In addition, the company also plans to change its ticker symbol to (NASDAQ:CYPH) as part of t

    11/12/25 7:00:00 AM ET
    $LPTX
    Biotechnology: Pharmaceutical Preparations
    Health Care

    Alltrna Announces Updates to Its Board of Directors

    Chris Schade appointed as Board ChairpersonLynne Parshall, Robert Plenge, M.D., Ph.D., and Nancy Simonian, M.D., appointed to Board of DirectorsCAMBRIDGE, Mass., July 17, 2024 /PRNewswire/ -- Alltrna, a Flagship Pioneering company unlocking transfer RNA (tRNA) biology and pioneering tRNA therapeutics to regulate the protein universe and resolve disease, today announced the appointment of Chris Schade, Growth Partner at Flagship Pioneering, as Chairperson of the Board, succeeding Noubar Afeyan, Ph.D., Co-Founder of Alltrna and Founder and CEO of Flagship Pioneering. In addition, Alltrna also announced the appointments to the company's Board of Directors of Lynne Parshall, founding Chief Opera

    7/17/24 8:00:00 AM ET
    $APRE
    $CYTK
    $EVLO
    Biotechnology: Pharmaceutical Preparations
    Health Care
    Medical/Dental Instruments
    Biotechnology: Biological Products (No Diagnostic Substances)

    Contineum Therapeutics Announces Appointment of Sarah Boyce to Board of Directors

    Contineum Therapeutics, Inc. (NASDAQ:CTNM), a clinical stage biopharmaceutical company focused on discovering and developing novel, oral small molecule therapies that target biological pathways associated with specific clinical impairments for the treatment of neuroscience, inflammation and immunology (NI&I) indications, today announced the appointment of Sarah Boyce, President and Chief Executive Officer of Avidity Biosciences, Inc. (NASDAQ:RNA), as an independent member of its Board of Directors. Ms. Boyce brings over 25 years of global commercial and clinical development expertise in the life sciences industry to Contineum's board. Ms. Boyce has extensive expertise in global pharmaceut

    6/24/24 4:05:00 PM ET
    $CTNM
    $IONS
    $NVS
    Biotechnology: Pharmaceutical Preparations
    Health Care
    Major Pharmaceuticals
    Medicinal Chemicals and Botanical Products