SEC FORM 4

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FORM 4

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940

OMB APPROVAL

OMB Number:			3235-0287
Estimated average burden
hours per response:			0.5

Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.

1. Name and Address of Reporting Person^*

Khan Ruhi Ahmad

(Last)

(First)

(Middle)

C/O CARIBOU BIOSCIENCES, INC.

2929 7TH STREET, SUITE 105

(Street)

BERKELEY

94710

(City)

(State)

(Zip)

2. Issuer Name and Ticker or Trading Symbol
Caribou Biosciences, Inc. [ CRBU ]

5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)

	Director	10% Owner
X	Officer (give title below)	Other (specify below)
	Chief Business Officer

3. Date of Earliest Transaction (Month/Day/Year)
02/20/2024

4. If Amendment, Date of Original Filed (Month/Day/Year)

6. Individual or Joint/Group Filing (Check Applicable Line)

X	Form filed by One Reporting Person
	Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3)	2. Transaction Date (Month/Day/Year)	2A. Deemed Execution Date, if any (Month/Day/Year)	3. Transaction Code (Instr. 8)		4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5)			5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4)	6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
1. Title of Security (Instr. 3)	2. Transaction Date (Month/Day/Year)	2A. Deemed Execution Date, if any (Month/Day/Year)	Code	V	Amount	(A) or (D)	Price		6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
Common Stock	02/20/2024		A		33,000⁽¹⁾	A	$0	33,000	D

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Transaction Date (Month/Day/Year)	3A. Deemed Execution Date, if any (Month/Day/Year)	4. Transaction Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date (Month/Day/Year)		7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
1. Title of Derivative Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Transaction Date (Month/Day/Year)	3A. Deemed Execution Date, if any (Month/Day/Year)	Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares	8. Price of Derivative Security (Instr. 5)		10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
Option to purchase Common Stock	$6.81	02/20/2024		A		153,000		⁽²⁾	02/19/2034	Common Stock	153,000	$0	153,000	D

Explanation of Responses:

1. This reflects restricted stock units ("RSUs") that vest in four equal annual installments beginning on February 20, 2025, subject to the reporting person's continued services to the Issuer through the applicable vesting dates. The RSUs will be settled in stock within 30 days after each vesting date.

2. 25% of the options will vest upon the one-year anniversary of the grant date, February 20, 2025, and 1/48th will vest monthly thereafter over the 36-month period following the one-year cliff, subject to the reporting person's continued service to the Issuer through the applicable vesting dates.

Remarks:

	/s/ Barbara G. McClung, as attorney-in-fact	02/22/2024
	** Signature of Reporting Person	Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.

6c:["$","div",null,{"className":"mb-4 flex items-center gap-3","children":[["$","$L78",null,{"item":{"id":5285896,"title":"Khan Ruhi Ahmad was granted 33,000 shares (SEC Form 4)","summary":"4 - Caribou Biosciences, Inc. (0001619856) (Issuer)","link":"https://www.sec.gov/Archives/edgar/data/control/000162828024006425/0001628280-24-006425-index.htm","imgUrl":"https://www.sec.gov/files/sec-logo.png","publishedAt":"2024-02-22 22:21:46.000000","discoveredAt":"2024-02-22 22:22:22.172395","parser":6,"category":16,"text":null,"html":"$79","companies":[{"id":69084,"ticker":"CRBU","name":"Caribou Biosciences Inc.","website":null,"sector":"Health Care","industry":"Biotechnology: Biological Products (No Diagnostic Substances)"}]},"showLabel":true}],"$L7a","$L7b","$L7c"]}] 6d:["$","div",null,{"className":"flex flex-col items-start gap-2 sm:flex-row sm:gap-3","children":[["$","div",null,{"className":"flex shrink-0 -space-x-1.5 sm:pt-1.5","children":[[["$","div","69084",{"className":"relative h-7 w-7 shrink-0 overflow-hidden rounded-md border border-border bg-surface ring-2 ring-background sm:h-11 sm:w-11","title":"CRBU","children":["$","$L7d",null,{"website":null,"ticker":"CRBU","name":"Caribou Biosciences Inc.","size":"md","chromeless":true}]}]],null]}],["$","div",null,{"className":"min-w-0","children":[["$","h1",null,{"className":"font-display max-w-[62ch] text-balance text-[32px] leading-[1.08] text-foreground sm:text-[44px]","children":"Khan Ruhi Ahmad was granted 33,000 shares (SEC Form 4)"}],["$","div",null,{"className":"mt-4 flex flex-wrap items-center gap-x-2 gap-y-1 text-[13px] text-muted-foreground","children":[["$","span",null,{"children":"By"}],["$","$L2d",null,{"ref":"$undefined","prefetch":false,"href":"/","rel":"publisher author","className":"font-medium text-foreground transition-colors hover:text-brand-glow","children":["Quantisnow",["$","$L30",null,{}]]}],["$","span",null,{"className":"text-dim-foreground","children":"·"}],["$","span",null,{"className":"text-dim-foreground","children":"Wall Street's wire, on your screen."}]]}]]}]]}] 6e:["$","div",null,{"className":"mt-7 flex flex-wrap items-center gap-x-4 gap-y-2 border-y border-hairline py-3.5","children":[["$","div",null,{"className":"flex flex-wrap items-center gap-1.5","children":[["$","$L2d","69084",{"ref":"$undefined","prefetch":false,"href":"/company/CRBU","className":"inline-flex h-7 items-center gap-1.5 rounded-full border border-hairline-strong bg-surface/60 px-3 text-[13px] font-medium text-foreground transition-colors hover:border-brand/50","children":[[["$","span",null,{"className":"font-mono","children":"CRBU"}],["$","span",null,{"className":"font-normal text-dim-foreground","children":"Caribou Biosciences Inc."}]],["$","$L30",null,{}]]}]]}],["$","div",null,{"className":"ml-auto flex flex-wrap gap-1.5","children":[["$","span","Health Care",{"className":"text-[13px] text-dim-foreground","children":"Health Care"}]]}]]}] 6f:["$","$L7f",null,{"insightId":"5285896","iso":"2024-02-22 22:21:46.000000"}] 82:T43de, SEC FORM 4 SEC Form 4

FORM 4

OMB APPROVAL

OMB Number:			3235-0287
Estimated average burden
hours per response:			0.5

Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

1. Name and Address of Reporting Person^*

Khan Ruhi Ahmad

(Last)

(First)

(Middle)

C/O CARIBOU BIOSCIENCES, INC.

2929 7TH STREET, SUITE 105

(Street)

BERKELEY

94710

(City)

(State)

(Zip)

2. Issuer Name and Ticker or Trading Symbol
Caribou Biosciences, Inc. [ CRBU ]

5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)

	Director	10% Owner
X	Officer (give title below)	Other (specify below)
	Chief Business Officer

3. Date of Earliest Transaction (Month/Day/Year)
02/20/2024

4. If Amendment, Date of Original Filed (Month/Day/Year)

6. Individual or Joint/Group Filing (Check Applicable Line)

X	Form filed by One Reporting Person
	Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3)	2. Transaction Date (Month/Day/Year)	2A. Deemed Execution Date, if any (Month/Day/Year)	3. Transaction Code (Instr. 8)		4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5)			5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4)	6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
1. Title of Security (Instr. 3)	2. Transaction Date (Month/Day/Year)	2A. Deemed Execution Date, if any (Month/Day/Year)	Code	V	Amount	(A) or (D)	Price		6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
Common Stock	02/20/2024		A		33,000⁽¹⁾	A	$0	33,000	D

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Transaction Date (Month/Day/Year)	3A. Deemed Execution Date, if any (Month/Day/Year)	4. Transaction Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date (Month/Day/Year)		7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
1. Title of Derivative Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Transaction Date (Month/Day/Year)	3A. Deemed Execution Date, if any (Month/Day/Year)	Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares	8. Price of Derivative Security (Instr. 5)		10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
Option to purchase Common Stock	$6.81	02/20/2024		A		153,000		⁽²⁾	02/19/2034	Common Stock	153,000	$0	153,000	D

Explanation of Responses:

Remarks:

	/s/ Barbara G. McClung, as attorney-in-fact	02/22/2024
	** Signature of Reporting Person	Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
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