• Live Feeds
    • Press Releases
    • Insider Trading
    • FDA Approvals
    • Analyst Ratings
    • Insider Trading
    • SEC filings
    • Market insights
  • Analyst Ratings
  • Alerts
  • Subscriptions
  • AI SuperconnectorNEW
  • Settings
  • RSS Feeds
Quantisnow Logo
  • Live Feeds
    • Press Releases
    • Insider Trading
    • FDA Approvals
    • Analyst Ratings
    • Insider Trading
    • SEC filings
    • Market insights
  • Analyst Ratings
  • Alerts
  • Subscriptions
  • AI SuperconnectorNEW
  • Settings
  • RSS Feeds
PublishGo to AppAI Superconnector
    Quantisnow Logo

    © 2025 quantisnow.com
    Democratizing insights since 2022

    Services
    Live news feedsRSS FeedsAlertsPublish with Us
    Company
    AboutQuantisnow PlusContactJobsAI superconnector for talent & startupsNEW
    Legal
    Terms of usePrivacy policyCookie policy

    President, Orexin Program Accardi Mario Alberto sold $126,751 worth of Ordinary Shares (8,322 units at $15.23), decreasing direct ownership by 4% to 208,163 units (SEC Form 4)

    7/30/25 5:00:55 PM ET
    $CNTA
    Biotechnology: Pharmaceutical Preparations
    Health Care
    Get the next $CNTA alert in real time by email
    SEC FORM 4 SEC Form 4
    FORM 4 UNITED STATES SECURITIES AND EXCHANGE COMMISSION
    Washington, D.C. 20549

    STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

    Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
    or Section 30(h) of the Investment Company Act of 1940
    OMB APPROVAL
    OMB Number: 3235-0287
    Estimated average burden
    hours per response: 0.5
      
    Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
    X
    Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.
    1. Name and Address of Reporting Person*
    Accardi Mario Alberto

    (Last) (First) (Middle)
    C/O CENTESSA PHARMACEUTICALS PLC
    3RD FL., 1 ASHLEY RD, ALTRINCHAM

    (Street)
    CHESHIRE X0 WA14 2DT

    (City) (State) (Zip)
    2. Issuer Name and Ticker or Trading Symbol
    Centessa Pharmaceuticals plc [ CNTA ]
    5. Relationship of Reporting Person(s) to Issuer
    (Check all applicable)
    Director 10% Owner
    X Officer (give title below) Other (specify below)
    President, Orexin Program
    3. Date of Earliest Transaction (Month/Day/Year)
    07/29/2025
    4. If Amendment, Date of Original Filed (Month/Day/Year)
    6. Individual or Joint/Group Filing (Check Applicable Line)
    X Form filed by One Reporting Person
    Form filed by More than One Reporting Person
    Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
    1. Title of Security (Instr. 3) 2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4)
    Code V Amount (A) or (D) Price
    Ordinary Shares(1) 07/29/2025 S(2) 8,322 D $15.2308(3) 208,163 D
    Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
    (e.g., puts, calls, warrants, options, convertible securities)
    1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year) 3A. Deemed Execution Date, if any (Month/Day/Year) 4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 6. Date Exercisable and Expiration Date (Month/Day/Year) 7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4)
    Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
    Explanation of Responses:
    1. The Ordinary Shares may be represented by American Depositary Shares, each of which currently represents one Ordinary Share.
    2. The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on February 14, 2025.
    3. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $15.105 to $15.41, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.
    Remarks:
    /s/ Richard Menziuso, attorney-in-fact 07/30/2025
    ** Signature of Reporting Person Date
    Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
    * If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
    ** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
    Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
    Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.
    Get the next $CNTA alert in real time by email

    Crush Q3 2025 with the Best AI Superconnector

    Stay ahead of the competition with Standout.work - your AI-powered talent-to-startup matching platform.

    AI-Powered Inbox
    Context-aware email replies
    Strategic Decision Support
    Get Started with Standout.work

    Recent Analyst Ratings for
    $CNTA

    DatePrice TargetRatingAnalyst
    7/21/2025$30.00Buy
    Truist
    5/28/2025$35.00Buy
    Needham
    5/8/2025$30.00Buy
    Chardan Capital Markets
    3/31/2025$38.00Overweight
    Piper Sandler
    1/7/2025Buy
    TD Cowen
    9/20/2024$11.00 → $26.00Equal-Weight → Overweight
    Morgan Stanley
    9/19/2024$33.00Buy
    B. Riley Securities
    7/18/2024$14.00Outperform
    Oppenheimer
    More analyst ratings

    $CNTA
    Insider Trading

    Insider transactions reveal critical sentiment about the company from key stakeholders. See them live in this feed.

    View All

    General Counsel Hussain Iqbal J exercised 6,000 units of Ordinary Shares at a strike of $5.84 and sold $103,380 worth of Ordinary Shares (6,000 units at $17.23) (SEC Form 4)

    4 - Centessa Pharmaceuticals plc (0001847903) (Issuer)

    8/15/25 6:13:20 PM ET
    $CNTA
    Biotechnology: Pharmaceutical Preparations
    Health Care

    President, Orexin Program Accardi Mario Alberto covered exercise/tax liability with 597 units of Ordinary Shares, decreasing direct ownership by 0.29% to 207,566 units (SEC Form 4)

    4 - Centessa Pharmaceuticals plc (0001847903) (Issuer)

    8/1/25 5:00:11 PM ET
    $CNTA
    Biotechnology: Pharmaceutical Preparations
    Health Care

    President, Orexin Program Accardi Mario Alberto sold $126,751 worth of Ordinary Shares (8,322 units at $15.23), decreasing direct ownership by 4% to 208,163 units (SEC Form 4)

    4 - Centessa Pharmaceuticals plc (0001847903) (Issuer)

    7/30/25 5:00:55 PM ET
    $CNTA
    Biotechnology: Pharmaceutical Preparations
    Health Care

    $CNTA
    SEC Filings

    View All

    Amendment: SEC Form SCHEDULE 13G/A filed by Centessa Pharmaceuticals plc

    SCHEDULE 13G/A - Centessa Pharmaceuticals plc (0001847903) (Subject)

    8/12/25 9:01:47 AM ET
    $CNTA
    Biotechnology: Pharmaceutical Preparations
    Health Care

    SEC Form 10-Q filed by Centessa Pharmaceuticals plc

    10-Q - Centessa Pharmaceuticals plc (0001847903) (Filer)

    8/12/25 7:13:54 AM ET
    $CNTA
    Biotechnology: Pharmaceutical Preparations
    Health Care

    Centessa Pharmaceuticals plc filed SEC Form 8-K: Results of Operations and Financial Condition, Financial Statements and Exhibits

    8-K - Centessa Pharmaceuticals plc (0001847903) (Filer)

    8/12/25 7:07:33 AM ET
    $CNTA
    Biotechnology: Pharmaceutical Preparations
    Health Care

    $CNTA
    Insider Purchases

    Insider purchases reveal critical bullish sentiment about the company from key stakeholders. See them live in this feed.

    View All

    Director Goyal Arjun bought $5,865,242 worth of Ordinary Shares (462,585 units at $12.68) (SEC Form 4)

    4 - Centessa Pharmaceuticals plc (0001847903) (Issuer)

    5/19/25 5:49:01 PM ET
    $CNTA
    Biotechnology: Pharmaceutical Preparations
    Health Care

    $CNTA
    Press Releases

    Fastest customizable press release news feed in the world

    View All

    Centessa Pharmaceuticals Reports Financial Results and Business Highlights for the Second Quarter of 2025

    Advancing a broad, potential best-in-class orexin receptor 2 (OX2R) agonist franchise, with key data readouts expected this year ORX750 Phase 2a CRYSTAL-1 study for the treatment of narcolepsy type 1 (NT1), narcolepsy type 2 (NT2) and idiopathic hypersomnia (IH) on track with data expected in all three indications this year with first-in-class potential in NT2 and IH ORX142 Phase 1 clinical trial for the treatment of select neurological and neurodegenerative disorders underway with data in acutely sleep-deprived healthy volunteers expected this year ORX489 in IND-enabling studies for the treatment of neuropsychiatric disorders BOSTON and LONDON, Aug. 12, 2025 (GLOBE NEWSWIRE) -- Cent

    8/12/25 7:00:26 AM ET
    $CNTA
    Biotechnology: Pharmaceutical Preparations
    Health Care

    Centessa Pharmaceuticals Announces Clearance of Investigational New Drug Application (IND) for ORX142, a Novel Orexin Receptor 2 (OX2R) Agonist; Clinical Data in Acutely Sleep-Deprived Healthy Volunteers Planned for this Year

    BOSTON and LONDON, June 16, 2025 (GLOBE NEWSWIRE) -- Centessa Pharmaceuticals plc (NASDAQ:CNTA), a clinical-stage pharmaceutical company, today announced that the U.S. Food and Drug Administration (FDA) has cleared the IND to initiate a Phase 1 clinical study of ORX142 in healthy volunteers. ORX142 is an investigational, novel, highly potent and selective OX2R agonist being developed for the treatment of select neurological and neurodegenerative disorders. ORX142 is the second drug candidate from the Company's multi-asset orexin franchise. "The clearance of our IND to initiate clinical studies of ORX142 represents a significant milestone, signaling the beginning of an exciting new phase i

    6/16/25 9:00:37 AM ET
    $CNTA
    Biotechnology: Pharmaceutical Preparations
    Health Care

    Centessa Pharmaceuticals to Participate in Upcoming Investor Conferences

    BOSTON and LONDON, May 19, 2025 (GLOBE NEWSWIRE) -- Centessa Pharmaceuticals plc (NASDAQ:CNTA), a clinical-stage pharmaceutical company that aims to discover and develop transformational medicines for patients, today announced that members of its management team will participate in the following investor conferences: Event: Jefferies 2025 Global Healthcare Conference Date: June 4, 2025Fireside Chat: 11:40 AM ET Event: Goldman Sachs 46th Annual Global Healthcare ConferenceDate: June 10, 2025Fireside Chat: 9:20 AM ET Access to the live webcasts of these events, as well as archived recordings, will be available under the "Events and Publications" tab on the investor

    5/19/25 8:00:00 AM ET
    $CNTA
    Biotechnology: Pharmaceutical Preparations
    Health Care

    $CNTA
    Analyst Ratings

    Analyst ratings in real time. Analyst ratings have a very high impact on the underlying stock. See them live in this feed.

    View All

    Truist initiated coverage on Centessa Pharmaceuticals with a new price target

    Truist initiated coverage of Centessa Pharmaceuticals with a rating of Buy and set a new price target of $30.00

    7/21/25 8:31:29 AM ET
    $CNTA
    Biotechnology: Pharmaceutical Preparations
    Health Care

    Needham initiated coverage on Centessa Pharmaceuticals with a new price target

    Needham initiated coverage of Centessa Pharmaceuticals with a rating of Buy and set a new price target of $35.00

    5/28/25 9:07:36 AM ET
    $CNTA
    Biotechnology: Pharmaceutical Preparations
    Health Care

    Chardan Capital Markets initiated coverage on Centessa Pharmaceuticals with a new price target

    Chardan Capital Markets initiated coverage of Centessa Pharmaceuticals with a rating of Buy and set a new price target of $30.00

    5/8/25 8:28:10 AM ET
    $CNTA
    Biotechnology: Pharmaceutical Preparations
    Health Care

    $CNTA
    Large Ownership Changes

    This live feed shows all institutional transactions in real time.

    View All

    Amendment: SEC Form SC 13G/A filed by Centessa Pharmaceuticals plc

    SC 13G/A - Centessa Pharmaceuticals plc (0001847903) (Subject)

    11/14/24 5:43:48 PM ET
    $CNTA
    Biotechnology: Pharmaceutical Preparations
    Health Care

    Amendment: SEC Form SC 13G/A filed by Centessa Pharmaceuticals plc

    SC 13G/A - Centessa Pharmaceuticals plc (0001847903) (Subject)

    11/14/24 4:20:32 PM ET
    $CNTA
    Biotechnology: Pharmaceutical Preparations
    Health Care

    SEC Form SC 13G/A filed by Centessa Pharmaceuticals plc (Amendment)

    SC 13G/A - Centessa Pharmaceuticals plc (0001847903) (Subject)

    2/14/24 5:37:34 PM ET
    $CNTA
    Biotechnology: Pharmaceutical Preparations
    Health Care

    $CNTA
    Leadership Updates

    Live Leadership Updates

    View All

    Centessa Pharmaceuticals Announces Appointment of Stephen Kanes, MD PhD, as Chief Medical Officer

    BOSTON and LONDON, Jan. 08, 2025 (GLOBE NEWSWIRE) -- Centessa Pharmaceuticals plc (NASDAQ:CNTA), a clinical stage pharmaceutical company with a mission to discover, develop and ultimately deliver medicines that are transformational for patients, today announced the appointment of Stephen Kanes MD PhD, as Chief Medical Officer (CMO). Dr. Kanes is a neuropsychiatrist, with a career in neuroscience, clinical psychiatry, and neuroscience drug development spanning more than 30 years.  "Centessa is rapidly advancing a potential best-in-class and first-in-class portfolio of orexin receptor 2 (OX2R) agonists with a robust series of clinical milestones anticipated this year," said Saurabh Saha MD

    1/8/25 7:05:00 AM ET
    $CNTA
    Biotechnology: Pharmaceutical Preparations
    Health Care

    Centessa Pharmaceuticals Strengthens Executive Leadership with Appointment of John Crowley CPA, as Chief Financial Officer and Gregory Weinhoff MD MBA, as Chief Business Officer

    BOSTON and LONDON, June 10, 2024 (GLOBE NEWSWIRE) -- Centessa Pharmaceuticals plc (NASDAQ:CNTA), a clinical-stage pharmaceutical company that aims to discover and develop medicines that are transformational for patients, today announced that John Crowley CPA, has been appointed Chief Financial Officer, and Gregory Weinhoff MD MBA, former Chief Financial Officer, has been appointed to the newly created role of Chief Business Officer, effective June 10, 2024. "With all three of our core programs in the clinic, we believe we have solidified a strong foundation and are poised for our next exciting chapter as a company. To best position Centessa for this pivotal time, we've added key new talen

    6/10/24 7:00:00 AM ET
    $CNTA
    Biotechnology: Pharmaceutical Preparations
    Health Care

    Centessa Pharmaceuticals Announces Additions to Senior Leadership Team

    BOSTON and LONDON, Oct. 03, 2023 (GLOBE NEWSWIRE) -- Centessa Pharmaceuticals plc (NASDAQ:CNTA), a clinical-stage pharmaceutical company that aims to discover and develop medicines that are transformational for patients, today announced the appointment of April Dovholuk and Ellie Im, MD to Centessa's executive team as Senior Vice President of Development Operations and Senior Vice President of Clinical Development, Oncology, respectively. In these newly created roles, Ms. Dovholuk will lead both Centessa's global Clinical Trials and Development Operations teams, and Dr. Im will manage clinical development of the Company's Oncology programs based on the LockBody® technology platform. "We a

    10/3/23 8:00:00 AM ET
    $CNTA
    Biotechnology: Pharmaceutical Preparations
    Health Care

    $CNTA
    Financials

    Live finance-specific insights

    View All

    Centessa Pharmaceuticals Reports Financial Results and Business Highlights for the Second Quarter of 2025

    Advancing a broad, potential best-in-class orexin receptor 2 (OX2R) agonist franchise, with key data readouts expected this year ORX750 Phase 2a CRYSTAL-1 study for the treatment of narcolepsy type 1 (NT1), narcolepsy type 2 (NT2) and idiopathic hypersomnia (IH) on track with data expected in all three indications this year with first-in-class potential in NT2 and IH ORX142 Phase 1 clinical trial for the treatment of select neurological and neurodegenerative disorders underway with data in acutely sleep-deprived healthy volunteers expected this year ORX489 in IND-enabling studies for the treatment of neuropsychiatric disorders BOSTON and LONDON, Aug. 12, 2025 (GLOBE NEWSWIRE) -- Cent

    8/12/25 7:00:26 AM ET
    $CNTA
    Biotechnology: Pharmaceutical Preparations
    Health Care

    Centessa Pharmaceuticals Reports Financial Results and Business Highlights for the First Quarter of 2025

    Advancing a broad, potential best-in-class orexin receptor 2 (OX2R) agonist franchise, with key data readouts expected this year ORX750 Phase 2a CRYSTAL-1 study for the treatment of narcolepsy type 1 (NT1), narcolepsy type 2 (NT2) and idiopathic hypersomnia (IH) on track with data expected across all three indications this year with first-in-class potential in NT2 and IHORX142 on track to initiate first-in-human studies for the treatment of neurological and neurodegenerative disorders with clinical data in acutely sleep-deprived healthy volunteers planned for this yearORX489 advancing in IND-enabling studies for the treatment of neuropsychiatric disorders BOSTON and LONDON, May 14, 20

    5/14/25 7:00:53 AM ET
    $CNTA
    Biotechnology: Pharmaceutical Preparations
    Health Care

    Centessa Pharmaceuticals Reports Financial Results and Business Highlights for the Third Quarter of 2023

    SerpinPC: Ongoing registrational PRESent-2 and PRESent-3 studies for the treatment of hemophilia B; New data from ongoing Phase 2a study accepted for poster presentation at American Society of Hematology (ASH) Annual Meeting in December 2023 ORX750: Preclinical data supporting potential best-in-class profile for the treatment of narcolepsy and other sleep-wake disorders presented at World Sleep Congress; Advancing in IND-enabling studies; Clinical proof of concept data planned for 2024LockBody® Technology Platform: Ongoing Phase 1/2a study of LB101 (PD-L1xCD47) for the treatment of solid tumors BOSTON and LONDON, Nov. 13, 2023 (GLOBE NEWSWIRE) -- Centessa Pharmaceuticals plc (NASDAQ:CNTA

    11/13/23 4:05:10 PM ET
    $CNTA
    Biotechnology: Pharmaceutical Preparations
    Health Care