Significant Growth Reported in Total Revenue (127%), Instrument Sales (178%), and BaroFold/UST Services (298%); Significant Decrease in Operating Loss (51%) Achieved

Investor Call Scheduled for Thursday, August 19, 2021 at 4:30 p.m. EDT

SOUTH EASTON, MA / ACCESSWIRE / August 19, 2021 / Pressure BioSciences, Inc. (OTCQB:PBIO) ("PBI" or the "Company"), a leader in the development and sale of broadly enabling, pressure-based instruments, consumables, and platform technology solutions to the worldwide biotechnology, biotherapeutics, nutraceuticals, cosmetics, agriculture, and food & beverage industries, today reported continued strong financial results for the second quarter ended June 30, 2021, provided a business update, and offered guidance for the remainder of FY 2021.

Financial Results: Q2 2021 vs. Q2 2020 (rounded to nearest hundred except earnings per share)

Total revenue for Q2 2021 was $608,900 compared to $268,200 for the Q2 2020, an increase of 127%.
Instrument sales for Q2 2021 were $337,400 compared to $121,400 for Q2 2020, an increase of 178%.
Consumable sales for Q2 2021 were $43,700 compared to $50,900 for Q2 2020, a decrease of 14%.
BaroFold/UST services in Q2 2021 were $136,000 compared to $34,200 for Q2 2020, an increase of 298%
Operating loss for Q2 2021 was $646,300 compared to $1,330,600 for Q2 2020, a decrease of 51%
Basic and diluted net loss per share was $(0.90) for Q2 2021 compared to $(1.70) for Q2 2020.

Financial Results: 1^st Half 2021 vs. 1^st Half 2020 (rounded to nearest hundred except earnings per share)

Total revenue for 1H 2021 was $1,168,800 compared to $522,000 for the 1H 2020, an increase of 124%.
Instrument sales for 1H 2021 were $656,900 compared to $216,700 for 1H 2020, an increase of 203%.
Consumable sales for 1H 2021 were $145,700 compared to $107,100 for 1H 2020, an increase of 36%
BaroFold/UST services in 1H 2021 were $142,100 compared to $44,000 for 1H 2020, an increase of 322%
Operating loss for 1H 2021 was $(1,721,400) compared to $(2,725,700) for 1H 2020, a decrease of 37%
Basic and diluted net loss per share was $(2.29) for 1H 2021 compared to $(3.34) for 1H 2020.

Mr. John B. Hollister, Director of Sales and Marketing for PBI, commented: "We are delighted to have followed our strong first quarter results with even stronger results in the second quarter. Requests for instrument systems have increased significantly since the beginning of the year, purchases of consumable products started to pick up appreciably near the end of the second quarter, and interest in our BaroFold services has leaped forward into exciting new growth opportunities. In particular, we are pleased to report that demand for our pressure-based instruments and services continued to strengthen throughout the quarter and the year-to-date. We are looking forward to a busy and highly successful second half of 2021."

Recent Operational and Technical Highlights

We formed PBI Agrochem, a wholly owned subsidiary, to integrate the assets of a global eco-friendly "green" agricultural products company, and to focus on the development of a new generation of products further enhanced by our revolutionary Ultra Shear Technology™ (UST™) platform.
We announced receipt of over $1,000,000 in orders for PBI Agrochem in just its first month of operations.
We set up a U.S. warehousing, processing, and product packaging facility for PBI Agrochem.
We continued to make measurable progress in the acquisition of assets of our targeted global eco-friendly agrochemical supplier. Their assets are expected to be accretive to PBI, with sustained profitable revenue growth beginning immediately after the close of the purchase.
We unveiled an aggressive "Growth Plan," including multiple important goals that we believe can be accomplished in 2021.
We reported that UST-enabled CBD nanoemulsions soared past our one-year product stability goal; results open explosive growth potential for water-soluble CBD (and other active ingredient infused) beverages worldwide.
We reported the successful nanoemulsification of Astaxanthin - one of the world's most potent antioxidants.
We were awarded three additional patents for our revolutionary UST platform (Japan, Australia, and China).

Mr. Richard T. Schumacher, President and CEO of PBI, commented: "Our Q1/Q2 2021 financial results clearly rank amongst the best first half results ever achieved by PBI. What makes them even more exciting is that revenue and operating income to date do not include any results from PBI Agrochem, as this subsidiary was just formed in July. We believe that once PBI Agrochem results are integrated with the results of the core business, the combination will be significantly accelerated in both revenue and operating income beyond any previous period. The success achieved to date in 2021, combined with the positive impacts of achieving even a few of the aggressive goals that we have set for the 2^nd half of 2021 makes this a terrific time to be a stakeholder in PBIO."

About Pressure BioSciences, Inc.

Pressure BioSciences, Inc. (OTCQB:PBIO) is a leader in the development and sale of innovative, broadly enabling, pressure-based solutions for the worldwide life sciences industry. Our products are based on the unique properties of both constant (i.e., static) and alternating (i.e., pressure cycling technology, or PCT) hydrostatic pressure. PCT is a patented enabling technology platform that uses alternating cycles of hydrostatic pressure between ambient and ultra-high levels to control bio-molecular interactions safely and reproducibly (e.g., cell lysis, biomolecule extraction). Our primary focus is the development of PCT-based products for biomarker and target discovery, drug design and development, biotherapeutics characterization and quality control, soil & plant biology, forensics, and counter-bioterror applications. Additionally, major new market opportunities have emerged in the use of our pressure-based technologies in the following areas: (1) the use of our recently acquired, patented technology from BaroFold, Inc. (the "BaroFold" technology) to allow entry into the bio-pharma contract services sector, and (2) the use of our recently-patented, scalable, high-efficiency, pressure-based Ultra Shear Technology ("UST") platform to (i) create stable nanoemulsions of otherwise immiscible fluids (e.g., oils and water) and to (ii) prepare higher quality, homogenized, extended shelf-life or room temperature stable low-acid liquid foods that cannot be effectively preserved using existing non-thermal technologies.

Forward Looking Statements

This press release contains forward-looking statements. These statements relate to future events or our future financial performance and involve known and unknown risks, uncertainties and other factors that may cause our or our industry's actual results, levels of activity, performance, or achievements to be materially different from any future results, levels of activity, performance or achievements expressed, implied or inferred by these forward-looking statements. In some cases, you can identify forward-looking statements by terminology such as "may," "will," "should," "could," "would," "expects," "plans," "intends," "anticipates," "believes," estimates," "predicts," "projects," "potential" or "continue" or the negative of such terms and other comparable terminology. These statements are only predictions based on our current expectations and projections about future events. You should not place undue reliance on these statements. In evaluating these statements, you should specifically consider various factors. Actual events or results may differ materially. The Company's financial results for the three months ended March 31, 2021 may not necessarily be indicative of future results. These and other factors may cause our actual results to differ materially from any forward-looking statement. These risks, uncertainties, and other factors include, but are not limited to, the risks and uncertainties discussed under the heading "Risk Factors" in the Company's Annual Report on Form 10-K for the year ended December 31, 2020, and other reports filed by the Company from time to time with the SEC. The Company undertakes no obligation to update any of the information included in this release, except as otherwise required by law. Due to rounding, numbers presented throughout this and other documents may not add up precisely to the totals provided and percentages may not precisely reflect the absolute figures.

For more information about PBI and this press release, please click on the following website link:
http://www.pressurebiosciences.com
Please visit us on Facebook, LinkedIn, and Twitter.

Earnings Call

The Company will hold an Earnings Conference Call at 4:30 p.m. EDT on Thursday, August 19, 2021. To attend this teleconference via telephone, Dial-in: (844) 602-0380 (North America), (862) 298-0970 (International). Verbal Passcode: PBIO Second Quarter 2021 Financial Results Call. Replay Number (877) 481-4010 (North America), (919) 882-2331 (International). Replay ID Number: 42576. Teleconference Replay Available for 30 days.

Investor Contacts:

Richard T. Schumacher, President and CEO (508) 230-1828 (T)
John B. Hollister, Director of Marketing and Sales (508) 230-1829 (F)
Jeffrey N. Peterson, Chairman (650) 812-8121 (T)

PRESSURE BIOSCIENCES, INC. AND SUBSIDIARY
CONSOLIDATED STATEMENTS OF OPERATIONS
UNAUDITED

	For the Three Months Ended June 30,						For the Six Months Ended June 30,
	2021			2020			2021			2020
Revenue:
Products, services, other	$	608,927		$	268,154		$	1,168,801		$	522,027
Total revenue		608,927			268,154			1,168,801			522,027

Costs and expenses:
Cost of products and services		286,660			134,882			512,935			310,028
Research and development		256,507			294,602			556,450			560,292
Selling and marketing		92,813			162,098			186,141			351,214
General and administrative		619,286			1,007,215			1,634,716			2,026,225
Total operating costs and expenses		1,255,266			1,598,797			2,890,242			3,247,759

Operating loss		(646,339	)		(1,330,643	)		(1,721,441	)		(2,725,732	)

Other (expense) income:
Interest expense, net		(3,526,141	)		(1,724,879	)		(8,194,205	)		(3,296,679	)
Unrealized (loss) gain on investment in equity securities		(134,477	)		196,891			(242,380	)		346,262
Loss on extinguishment of liabilities		(498,226	)		(1,710,151	)		(1,223,385	)		(2,846,518	)
Other income		60,012			-			58,653			-
Total other expense		(4,098,832	)		(3,238,139	)		(9,601,317	)		(5,796,935	)

Net loss		(4,745,171	)		(4,568,782	)		(11,322,758	)		(8,522,667	)
Deemed dividends on beneficial conversion feature		-			-			(57,884	)		-
Preferred stock dividends		(404,171	)		(396,970	)		(807,386	)		(721,556	)
Net loss attributable to common stockholders	$	(5,149,342	)	$	(4,965,752	)	$	(12,188,028	)	$	(9,244,223	)
Basic and diluted net loss per share attributable to common stockholders	$	(0.90	)	$	(1.70	)	$	(2.29	)	$	(3.34	)

Weighted average common stock shares outstanding used in the basic and diluted net loss per share calculation		5,748,711			2,914,659			5,312,172			2,765,132

PRESSURE BIOSCIENCES, INC. AND SUBSIDIARY
CONSOLIDATED BALANCE SHEETS

	Unaudited
	June 30, 2021			December 31, 2020
ASSETS
CURRENT ASSETS
Cash and cash equivalents	$	46,625		$	18,540
Accounts receivable		629,766			131,228
Inventories, net of $342,496 reserve at June 30, 2021 and December 31, 2020		492,095			592,767
Prepaid expenses and other current assets		219,161			314,936
Total current assets		1,387,647			1,057,471
Investment in equity securities		274,621			517,001
Property and equipment, net		7,431			16,490
Right of use asset leases		189,808			221,432
Intangible assets, net		447,115			490,385
TOTAL ASSETS	$	2,306,622		$	2,302,779
LIABILITIES AND STOCKHOLDERS' DEFICIT
CURRENT LIABILITIES
Accounts payable	$	628,835		$	771,945
Accrued employee compensation		420,510			417,578
Accrued professional fees and other		2,163,563			2,037,806
Other current liabilities		8,165,281			6,330,722
Deferred revenue		49,189			47,328
Convertible debt, net of unamortized discounts of $2,353,152 and $3,948,167, respectively		10,909,314			7,545,670
Other debt, net of unamortized discounts of $5,495 and $0, respectively		1,363,931			1,135,469
Operating lease liability		69,204			65,193
Other related party debt		184,600			166,000
Total current liabilities		23,954,427			18,517,711
LONG TERM LIABILITIES
Long term debt		527,038			527,039
Operating lease liability - long term		120,604			156,239
Deferred revenue		7,446			19,382
TOTAL LIABILITIES		24,609,515			19,220,371
COMMITMENTS AND CONTINGENCIES
STOCKHOLDERS' DEFICIT
Series D Convertible Preferred Stock, $.01 par value; 850 shares authorized; 300 shares issued and outstanding on June 30, 2021 and December 31, 2020, respectively (Liquidation value of $300,000)		3			3
Series G Convertible Preferred Stock, $.01 par value; 240,000 shares authorized; 80,570 shares issued and outstanding on June 30, 2021 and December 31, 2020, respectively		806			806
Series H Convertible Preferred Stock, $.01 par value; 10,000 shares authorized; 10,000 shares issued and outstanding on June 30, 2021 and December 31, 2020, respectively		100			100
Series H2 Convertible Preferred Stock, $.01 par value; 21 shares authorized; 21 shares issued and outstanding on June 30, 2021 and December 31, 2020, respectively		-			-
Series J Convertible Preferred Stock, $.01 par value; 6,250 shares authorized; 3,458 shares issued and outstanding on June 30, 2021 and December 31, 2020, respectively		35			35
Series K Convertible Preferred Stock, $.01 par value; 15,000 shares authorized; 6,880 shares issued and outstanding on June 30, 2021 and December 31, 2020, respectively		68			68
Series AA Convertible Preferred Stock, $.01 par value; 10,000 shares authorized; 8,083 and 8,043 shares issued and outstanding on June 30, 2021 and December 31, 2020, respectively		81			81
Common stock, $.01 par value; 100,000,000 shares authorized; 6,260,884 and 4,168,324 shares issued and outstanding on June 30, 2021 and December 31, 2020 respectively		62,608			41,683
Warrants to acquire common stock		30,911,495			29,192,471
Additional paid-in capital		55,317,862			50,312,968
Accumulated deficit		(108,595,951	)		(96,465,807	)
Total stockholders' deficit		(22,302,893	)		(16,917,592	)
TOTAL LIABILITIES AND STOCKHOLDERS' DEFICIT	$	2,306,622		$	2,302,779

SOURCE: Pressure BioSciences Inc.

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Pressure BioSciences, Inc. Reports Strong Second Quarter 2021 Financial Results