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UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

___________________________________________________________________________________________

FORM 10-Q

___________________________________________________________________________________________

(Mark One)


☑			QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

For the quarterly period ended September 30, 2025


☐			TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

For the transition period from ______ to

Commission File Number: 001-38583

Crinetics Pharmaceuticals, Inc.

(Exact name of registrant as specified in its charter)


Delaware			26-3744114
(State or other jurisdiction of incorporation or organization)			(I.R.S. Employer Identification No.)

6055 Lusk Boulevard, San Diego, California			92121
(Address of principal executive offices)			(Zip code)

Registrant’s telephone number, including area code: (858) 450-6464

___________________________________________________________________________________________

Securities registered pursuant to Section 12(b) of the Act:

Title of each class

Trading
Symbol(s)

Name of each exchange on which registered

Common Stock, par value $0.001 per share

CRNX

Nasdaq Global Select Market

Indicate by check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports) and (2) has been subject to such filing requirements for the past 90 days. Yes ☑ No ☐

Indicate by check mark whether the registrant has submitted electronically every Interactive Data File required to be submitted pursuant to Rule 405 of Regulation S-T (§232.405 of this chapter) during the preceding 12 months (or for such shorter period that the registrant was required to submit such files). Yes ☑ No ☐

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growth company. See the definitions of “large accelerated filer,” “accelerated filer,” “smaller reporting company,” and “emerging growth company” in Rule 12b-2 of the Exchange Act.

Large accelerated filer

☑

Accelerated filer

☐

Non-accelerated filer

☐

Smaller reporting company

☐

Emerging growth company

☐

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ☐

Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Exchange Act). Yes ☐ No ☑

As of October 28, 2025, the registrant had 94,891,840 shares of common stock ($0.001 per share par value) outstanding.

CRINETICS PHARMACEUTICALS, INC. QUARTERLY REPORT ON FORM 10-Q

For the Quarter Ended September 30, 2025

TABLE OF CONTENTS


		Page
PART I – FINANCIAL INFORMATION
Item 1.	Condensed Consolidated Financial Statements (unaudited):	2
	Condensed Consolidated Balance Sheets	3
	Condensed Consolidated Statements of Operations and Comprehensive Loss	4
	Condensed Consolidated Statements of Stockholders’ Equity	5
	Condensed Consolidated Statements of Cash Flows	6
	Notes to Condensed Consolidated Financial Statements	7
Item 2.	Management’s Discussion and Analysis of Financial Condition and Results of Operations	18
Item 3.	Quantitative and Qualitative Disclosures About Market Risk	27
Item 4.	Controls and Procedures	27

PART II — OTHER INFORMATION
Item 1.	Legal Proceedings	28
Item 1A.	Risk Factors	28
Item 2.	Unregistered Sales of Equity Securities and Use of Proceeds	28
Item 3.	Defaults Upon Senior Securities
Item 4.	Mine Safety Disclosures	29
Item 5.	Other Information	29
Item 6.	Exhibits	29

S ignatures		30

Table of Contents

PART I — FINANCIAL INFORMATION

Item 1. Condensed Consolidated Financial Statements (Unaudited)

Table of Contents

Crinetics Pharmaceuticals, Inc.

Condensed Consolidated Balance Sheets

(in thousands, except per share data)


	September 30, 2025		December 31, 2024
	(Unaudited)
ASSETS
CURRENT ASSETS
Cash and cash equivalents	$	110,901	$	264,545
Restricted cash	500		500
Investment securities, amortized cost of $979,147 at September 30, 2025 and $1,088,561 at December 31, 2024	981,390		1,089,524
Prepaid expenses and other current assets	28,484		20,819
Total current assets	1,121,275		1,375,388
Property and equipment, net	14,377		12,068
Operating lease right-of-use assets	41,147		43,507
Restricted cash, net of current portion	800		800
Prepaid expenses and other assets, net of current portion	18,432		2,829
TOTAL ASSETS	$	1,196,031	$	1,434,592

LIABILITIES AND STOCKHOLDERS’ EQUITY
CURRENT LIABILITIES
Accounts payable and accrued expenses	$	33,674	$	21,469
Accrued compensation and related expenses	32,398		28,887
Deferred revenue	1,642		2,176
Operating lease liabilities	6,441		7,152
Total current liabilities	74,155		59,684
Operating lease liabilities, non-current	42,703		44,570
Deferred revenue, non-current	4,110		4,704
Other liabilities	2,894		829
TOTAL LIABILITIES	123,862		109,787
Commitments and contingencies (Note 6)
STOCKHOLDERS’ EQUITY
Preferred stock, $0.001 par; 10,000 shares authorized; no shares issued or outstanding at September 30, 2025 or December 31, 2024	—		—
Common stock and paid-in capital, $0.001 par; 200,000 shares authorized; 94,548 shares issued and outstanding at September 30, 2025; 92,926 shares issued and outstanding at December 31, 2024	2,364,699		2,275,952
Accumulated other comprehensive income	2,194		963
Accumulated deficit	(1,294,612)		(952,110)
Stock held in trust	(112)		—
TOTAL STOCKHOLDERS’ EQUITY	1,072,169		1,324,805
TOTAL LIABILITIES AND STOCKHOLDERS’ EQUITY	$	1,196,031	$	1,434,592

See the accompanying notes to these unaudited condensed consolidated financial statements.

Table of Contents

Crinetics Pharmaceuticals, Inc.

Condensed Consolidated Statements of Operations and Comprehensive Loss

(in thousands, except per share data)

(unaudited)


	Three months ended September 30,				Nine months ended September 30,
	2025		2024		2025		2024
Revenues	$	143	$	—	$	1,535	$	1,039
Operating expenses:
Research and development	90,464		61,905		247,005		173,590
Selling, general and administrative	52,265		25,892		137,633		71,558
Total operating expenses	142,729		87,797		384,638		245,148
Loss from operations	(142,586)		(87,797)		(383,103)		(244,109)
Other income (expense):
Interest income	12,544		11,006		40,833		27,067
Other expense, net	(49)		(37)		(232)		(301)
Total other income, net	12,495		10,969		40,601		26,766
Loss before equity method investment	(130,091)		(76,828)		(342,502)		(217,343)
Loss on equity method investment	—		—		—		(470)
Net loss	$	(130,091)	$	(76,828)	$	(342,502)	$	(217,813)
Net loss per share:
Net loss per share — basic and diluted	$	(1.38)	$	(0.96)	$	(3.66)	$	(2.82)
Weighted average shares — basic and diluted	94,215		80,091		93,707		77,173
Other comprehensive income (loss):
Unrealized gain on investment securities	$	594	$	2,228	$	1,280	$	1,061
Unrealized loss on foreign currency	(21)		—		(49)		—
Total other comprehensive income	573		2,228		1,231		1,061
Comprehensive loss	$	(129,518)	$	(74,600)	$	(341,271)	$	(216,752)

See the accompanying notes to these unaudited condensed consolidated financial statements.

Table of Contents

Crinetics Pharmaceuticals, Inc.

Condensed Consolidated Statements of Stockholders’ Equity

(in thousands)

(unaudited)


	Common Stock Shares	Common Stock and Paid-In Capital		Accumulated Other Comprehensive Income (loss)		Accumulated Deficit		Stock Held in Trust		Total Stockholders’ Equity
Balance at July 1, 2025	94,126	$	2,334,538	$	1,621	$	(1,164,521)	$	(112)	$	1,171,526
Exercise of stock options	417	7,452		—		—		—		7,452
Issuance of common stock upon vesting of restricted stock units	5	—		—		—		—		—
Stock-based compensation	—	22,702		—		—		—		22,702
Other	—	7		—		—		—		7
Other comprehensive income	—	—		573		—		—		573
Net loss	—	—		—		(130,091)		—		(130,091)
Balance at September 30, 2025	94,548	$	2,364,699	$	2,194	$	(1,294,612)	$	(112)	$	1,072,169

Balance at January 1, 2025	92,926	$	2,275,952	$	963	$	(952,110)	$	—	$	1,324,805
Exercise of stock options	1,095	16,433		—		—		—		16,433
Stock issued under Employee Stock Purchase Plan	115	2,880		—		—		—		2,880
Issuance of common stock upon vesting of restricted stock units	412	—		—		—		—		—
Stock-based compensation	—	69,304		—		—		—		69,304
Stock held in trust under deferred compensation plan	—	112		—		—		(112)		—
Other	—	18		—		—		—		18
Other comprehensive income	—	—		1,231		—		—		1,231
Net loss	—	—		—		(342,502)		—		(342,502)
Balance at September 30, 2025	94,548	$	2,364,699	$	2,194	$	(1,294,612)	$	(112)	$	1,072,169

Balance at July 1, 2024	79,322	$	1,625,640	$	(190)	$	(794,687)	$	—	$	830,763
Exercise of stock options	585	10,374		—		—		—		10,374
Issuance of common stock, net of transaction costs	929	48,296		—		—		—		48,296
Issuance of common stock upon vesting of restricted stock units	5	—		—		—		—		—
Stock-based compensation	—	18,147		—		—		—		18,147
Other comprehensive income	—	—		2,228		—		—		2,228
Net loss	—	—		—		(76,828)		—		(76,828)
Balance at September 30, 2024	80,841	$	1,702,457	$	2,038	$	(871,515)	$	—	$	832,980

Balance on January 1, 2024	68,175	$	1,191,831	$	977	$	(653,702)	$	—	$	539,106
Issuance of common stock, net of transaction costs	10,486	427,200		—		—		—		427,200
Exercise of stock options	1,816	30,858		—		—		—		30,858
Stock issued under Employee Stock Purchase Plan	115	2,027		—		—		—		2,027
Issuance of common stock upon vesting of restricted stock units	249	—		—		—		—		—
Stock-based compensation	—	50,541		—		—		—		50,541
Other comprehensive income	—	—		1,061		—		—		1,061
Net loss	—	—		—		(217,813)		—		(217,813)
Balance at September 30, 2024	80,841	$	1,702,457	$	2,038	$	(871,515)	$	—	$	832,980

See the accompanying notes to these unaudited condensed consolidated financial statements.

Table of Contents

Crinetics Pharmaceuticals, Inc.

Condensed Consolidated Statements of Cash Flows

(in thousands)

(unaudited)


	Nine months ended
	September 30,
	2025		2024
CASH FLOWS FROM OPERATING ACTIVITIES
Net loss	$	(342,502)	$	(217,813)
Adjustments to reconcile net loss to net cash used in operating activities:
Stock-based compensation	69,304		50,541
Depreciation and amortization	2,896		1,997