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☒			QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934


☐			TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934


Delaware			90-1024039
(State or other jurisdiction of incorporation or organization)			(I.R.S. Employer Identification No.)
611 Gateway Boulevard, Suite 273 South San Francisco, California			94080
(Address of principal executive offices)			(Zip Code)
Registrant’s telephone number, including area code: (415) 910-5717


		Page
PART I.	FINANCIAL INFORMATION
Item 1.	Financial Statements (Unaudited)	1
	Condensed Consolidated Balance Sheets	1
	Condensed Consolidated Statements of Operations and Comprehensive Loss	2
	Condensed Consolidated Statements of Stockholders’ Equity	3
	Condensed Consolidated Statements of Cash Flows	4
	Notes to Unaudited Condensed Consolidated Financial Statements	5
Item 2.	Management’s Discussion and Analysis of Financial Condition and Results of Operations	24
Item 3.	Quantitative and Qualitative Disclosures About Market Risk	31
Item 4.	Controls and Procedures	31

PART II.	OTHER INFORMATION
Item 1.	Legal Proceedings	32
Item 1A.	Risk Factors	32
Item 2.	Unregistered Sales of Equity Securities and Use of Proceeds	32
Item 3.	Defaults Upon Senior Securities	32
Item 4.	Mine Safety Disclosures	32
Item 5.	Other Information	32
Item 6.	Exhibits	33
Signatures		34


Abbreviated Term			Defined Term

AIDE			Autologous Intracellular Drug Encapsulation
ASC			Accounting Standards Codification
ASU			Accounting Standards Update
A-T			Ataxia-Telangiectasia
ATTeST			Ataxia Telangiectasia Trial with the eDSP System
the Code			Internal Revenue Code of 1986, as amended
CODM			Chief Operating Decision Maker
COVID-19			Coronavirus disease
Credits			Tax credits
CRO			Contract Research Organization
CTR			European Union pharmaceutical legislation known as the Clinical Trials Regulation
Debt Agreement			Unsecured line of credit agreement between EryDel and the European Investment Bank, which the Company guaranteed on October 20, 2023 in connection with the EryDel Acquisition
DMD			Duchenne muscular dystrophy
DSP			Dexamethasone Sodium Phosphate
EC			European Commission
EryDel			Quince Therapeutics, S.p.A (previously named EryDel S.p.A.)
eDSP			Encapsulated dexamethasone sodium phosphate encapsulated in patient's own red blood cells (previously referred to as EryDex)
eDSP System			Automated combination product to encapsulate dexamethasone sodium phosphate in red blood cells
EIB			European Investment Bank
EU			European Union
EIB Loan			Unsecured line of credit between EryDel and the European Investment Bank
Exchange Act			Securities Exchange Act of 1934, as amended
FASB			Financial Accounting Standards Board
FDA			United States Food and Drug Administration
GAAP			generally accepted accounting principles in the United States
GMP			Good Manufacturing Practice
HHS			United States Department of Health and Human Services
ICARS			International Cooperative Ataxia Rating Scale
IPR&D			In-process Research and Development
IRA			Inflation Reduction Act of 2022
Lighthouse			Lighthouse Pharmaceuticals, Inc.
MAA			Marketing Authorization Application
MDR			Medical Devices Regulation 2017/745
MPEEM			Multi-Period Excess Earnings Method
Nasdaq			The Nasdaq Stock Market LLC
NDA			New Drug Application


NEAT			eDSP Phase 3 Clinical Trial (Neurological Effects of eDSP on Subjects with A-T)
Novosteo			Novosteo, Inc.
OLE			Open-Label Extension Clinical Trial
PD			Pharmacodynamic
PK			Pharmacokinetic
PRF			Purdue Research Foundation
R&D			Research and Development
RBC			Red Blood Cell
RSA			Restricted Stock Awards
RSU			Restricted Stock Units
SAE			Serious Adverse Event
Sarbanes-Oxley Act			The Sarbanes-Oxley Act of 2002
SEC			United States Securities and Exchange Commission
Securities Act			Securities Act of 1933
SPA			Special Protocol Assessment



	March 31, 2025		December 31, 2024
ASSETS
Current assets:
Cash and cash equivalents	$	7,771	$	6,212
Short-term investments	23,828		34,572
Prepaid expenses and other current assets	2,230		3,252
Total current assets	33,829		44,036
Property and equipment, net	448		315
Operating lease right-of-use assets	493		498
Intangible assets	62,365		60,045
Other assets	9,954		9,584
Total assets	$	107,089	$	114,478

LIABILITIES AND STOCKHOLDERS’ EQUITY
Current liabilities:
Accounts payable	$	3,008	$	2,903
Accrued expenses and other current liabilities	5,348		4,375
Total current liabilities	8,356		7,278
Long-term debt	15,266		14,321
Long-term operating lease liabilities	383		394
Long-term contingent consideration	58,615		56,691
Deferred tax liabilities	5,172		4,963
Other long-term liabilities	716		685
Total liabilities	88,508		84,332
Stockholders’ equity:
Preferred stock, $0.001 par value, 10,000,000 authorized, no shares issued and outstanding as of March 31, 2025 and December 31, 2024, respectively.	—		—
Common stock, $0.001 par value, 100,000,000 shares authorized, 44,089,142 and 44,001,643 issued and outstanding as of March 31, 2025 and December 31, 2024, respectively.	44		44
Additional paid in capital	408,082		406,609
Accumulated other comprehensive income (loss)	1,957		(35)
Accumulated deficit	(391,502)		(376,472)
Total stockholders’ equity	18,581		30,146
Total liabilities and stockholders’ equity	$	107,089	$	114,478


	Three Months Ended March 31,
		2025		2024
Operating expenses:
Research and development		$	8,145	$	3,702
General and administrative		4,789		4,971
Fair value adjustment for contingent consideration		1,924		2,545
Total operating expenses		14,858		11,218
Loss from operations		(14,858)		(11,218)
Fair value adjustment for long-term debt		(444)		(388)
Interest income		406		887
Other expense, net		(87)		(399)
Net loss before provision for income taxes		(14,983)		(11,118)
Income tax expense		(47)		(31)
Net loss		(15,030)		(11,149)
Other comprehensive loss:
Foreign currency translation adjustments		2,045		(1,229)
Unrealized gain (loss) on available-for-sale securities		(53)		7
Total comprehensive loss		$	(13,038)	$	(12,371)
Net loss per share - basic and diluted		$	(0.34)	$	(0.26)
Weighted average shares of common stock outstanding - basic and diluted		43,941,185		43,010,212


For the three months ended March 31, 2025 and 2024
	Common Stock			Additional Paid in		Accumulated Other Comprehensive Income / (Loss)		Accumulated Deficit		Total Stockholders' Equity
	Shares	Amount
Balance as of December 31, 2024	44,001,643	$	44	$	406,609	$	(35)	$	(376,472)	$	30,146
Issuance of common stock on exercise of stock options	87,499	—		87		—		—		87
Stock based compensation	—	—		1,386		—		—		1,386
Foreign currency translation adjustment	—	—		—		2,045		—		2,045
Unrealized gain (loss) on available for sale investments	—	—		—		(53)		—		(53)
Net loss	—	—		—		—		(15,030)		(15,030)
Balance as of March 31, 2025	44,089,142	$	44	$	408,082	$	1,957	$	(391,502)	$	18,581

Balance as of December 31, 2023	42,973,215	$	43	$	401,638	$	3,047	$	(319,644)	$	85,084
Issuance of common stock on exercise of stock options	242,018	—		190		—		—		190
Stock based compensation	—	—		1,274		—		—		1,274
Foreign currency translation adjustment	—	—		—		(1,229)		—		(1,229)
Unrealized gain (loss) on available for sale investments	—	—		—		7		—		7
Net loss	—	—		—		—		(11,149)		(11,149)
Balance as of March 31, 2024	43,215,233	$	43	$	403,102	$	1,825	$	(330,793)	$	74,177


	Fair Value Measurements as of March 31, 2025
	Total		Level 1		Level 2		Level 3
Assets:
Money market funds	$	5,685	$	5,685	$	—	$	—

Government and agency notes	23,828		—		23,828		—
Total Assets	$	29,513	$	5,685	$	23,828	$	—
Liabilities:
Contingent consideration	58,615		—		—		58,615
Long-term debt	15,266		—		—		15,266
Total	$	73,881	$	—	$	—	$	73,881


	March 31, 2025	December 31, 2024
Expected timing of milestones completion dates	2026 - 2038	2026 - 2038
Discount rate	14.5%	14.5%
Probability of achievement	1% - 56.5%	1% - 56.5%


	Fair Value Measurements as of December 31, 2024
	Total		Level 1		Level 2		Level 3
Assets:
Money market funds	$	3,702	$	3,702	$	—	$	—

Government and agency notes	34,572		—		34,572		—
Total Assets	$	38,274	$	3,702	$	34,572	$	—
Liabilities:
Contingent consideration	56,691		—		—		56,691
Long-term debt	14,321		—		—		14,321
Total	$	71,012	$	—	$	—	$	71,012


	2025		2024



Beginning contingent consideration balance, December 31	$	56,691	$	57,706
Change in fair value of contingent consideration	1,924		2,545
Ending contingent consideration balance, March 31	$	58,615	$	60,251


	(in thousands)



Balance as of December 31, 2024	$	14,321
Change in fair value	444
Interest payment	(54)
Due to foreign currency translation	555
Balance as of March 31, 2025	$	15,266


	March 31, 2025		December 31, 2024
Cash and cash equivalents:
Cash	$	2,086	$	2,510
Money market funds	5,685		3,702

Total cash and cash equivalents	$	7,771	$	6,212

Short-term investments:

Government and agency notes	23,828		34,572
Total short-term investments	$	23,828	$	34,572