SEC FORM 3

SEC FORM 3 SEC Form 3

FORM 3

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person^*

Griffiths Richard Ian

(Last)

(First)

(Middle)

FLOOR 1 LIBERATION STATION, ESPLANADE

(Street)

ST HELIER

JE2 3AS

(City)

(State)

(Zip)

2. Date of Event Requiring Statement (Month/Day/Year)
01/02/2025

3. Issuer Name and Ticker or Trading Symbol
Silence Therapeutics plc [ SLN ]

4. Relationship of Reporting Person(s) to Issuer
(Check all applicable)

Director	X	10% Owner
Officer (give title below)		Other (specify below)

5. If Amendment, Date of Original Filed (Month/Day/Year)

6. Individual or Joint/Group Filing (Check Applicable Line)

X	Form filed by One Reporting Person
	Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Beneficially Owned
1. Title of Security (Instr. 4)	2. Amount of Securities Beneficially Owned (Instr. 4)	3. Ownership Form: Direct (D) or Indirect (I) (Instr. 5)	4. Nature of Indirect Beneficial Ownership (Instr. 5)

Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 4)	2. Date Exercisable and Expiration Date (Month/Day/Year)		3. Title and Amount of Securities Underlying Derivative Security (Instr. 4)		4. Conversion or Exercise Price of Derivative Security	5. Ownership Form: Direct (D) or Indirect (I) (Instr. 5)	6. Nature of Indirect Beneficial Ownership (Instr. 5)
1. Title of Derivative Security (Instr. 4)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares	4. Conversion or Exercise Price of Derivative Security	5. Ownership Form: Direct (D) or Indirect (I) (Instr. 5)	6. Nature of Indirect Beneficial Ownership (Instr. 5)
American Depositary Shares	⁽¹⁾	⁽¹⁾	Ordinary Shares	19,221,525	⁽¹⁾	I	By Ora Capital Limited⁽²⁾
American Depositary Shares	⁽¹⁾	⁽¹⁾	Ordinary Shares	1,815,522	⁽¹⁾	I	By Sarossa Plc⁽³⁾
American Depositary Shares	⁽¹⁾	⁽¹⁾	Ordinary Shares	1,500,000	⁽¹⁾	I	By Cream Capital Limited⁽⁴⁾
American Depositary Shares	⁽¹⁾	⁽¹⁾	Ordinary Shares	300,000	⁽¹⁾	I	By Blake Holdings Limited⁽⁵⁾
American Depositary Shares	⁽¹⁾	⁽¹⁾	Ordinary Shares	360,000	⁽¹⁾	I	By Ora Ventures Limited⁽⁶⁾
American Depositary Shares	⁽¹⁾	⁽¹⁾	Ordinary Shares	190,500	⁽¹⁾	I	By Pinkey's Limited⁽⁷⁾
American Depositary Shares	⁽¹⁾	⁽¹⁾	Ordinary Shares	3,878,454	⁽¹⁾	D

Explanation of Responses:

1. Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date.

2. The securities are held by Ora Capital Limited ("Ora Capital"). Mr. Griffiths is a director and the controlling shareholder of Ora Capital. Mr. Griffiths disclaims beneficial ownership of these securities except to the extent of his proportionate pecuniary interest therein.

3. The securities are held by Sarossa Plc ("Sarossa"). Mr. Griffiths is a director and the controlling shareholder of Sarossa. Mr. Griffiths disclaims beneficial ownership of these securities except to the extent of his proportionate pecuniary interest therein.

4. The securities are held by Cream Capital Limited ("Cream"). Mr. Griffiths is a director and the controlling shareholder of Cream. Mr. Griffiths disclaims beneficial ownership of these securities except to the extent of his proportionate pecuniary interest therein.

5. The securities are held by Blake Holdings Limited ("Blake"). Mr. Griffiths is a director and the controlling shareholder of Blake. Mr. Griffiths disclaims beneficial ownership of these securities except to the extent of his proportionate pecuniary interest therein.

6. The securities are held by Ora Ventures Limited ("Ora Ventures"). Mr. Griffiths is a director and the controlling shareholder of Ora Ventures. Mr. Griffiths disclaims beneficial ownership of these securities except to the extent of his proportionate pecuniary interest therein.

7. The securities are held by Pinkey's Limited ("Pinkey's"). Mr. Griffiths is a controlling shareholder of Pinkey's. Mr. Griffiths disclaims beneficial ownership of these securities except to the extent of his proportionate pecuniary interest therein.

	/s/ Richard Ian Griffiths	01/02/2025
	** Signature of Reporting Person	Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 5 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.