SEC FORM 4

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FORM 4

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940

OMB APPROVAL

OMB Number:			3235-0287
Estimated average burden
hours per response:			0.5

Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.

1. Name and Address of Reporting Person^*

Labrucherie Gil M

(Last)

(First)

(Middle)

C/O SEPTERNA, INC.

250 EAST GRAND AVENUE

(Street)

SOUTH SAN FRANCISCO

94080

(City)

(State)

(Zip)

2. Issuer Name and Ticker or Trading Symbol
Septerna, Inc. [ SEPN ]

5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)

	Director	10% Owner
X	Officer (give title below)	Other (specify below)
	Chief Financial Officer

3. Date of Earliest Transaction (Month/Day/Year)
02/06/2026

4. If Amendment, Date of Original Filed (Month/Day/Year)

6. Individual or Joint/Group Filing (Check Applicable Line)

X	Form filed by One Reporting Person
	Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3)	2. Transaction Date (Month/Day/Year)	2A. Deemed Execution Date, if any (Month/Day/Year)	3. Transaction Code (Instr. 8)		4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5)			5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4)	6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
1. Title of Security (Instr. 3)	2. Transaction Date (Month/Day/Year)	2A. Deemed Execution Date, if any (Month/Day/Year)	Code	V	Amount	(A) or (D)	Price		6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Transaction Date (Month/Day/Year)	3A. Deemed Execution Date, if any (Month/Day/Year)	4. Transaction Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date (Month/Day/Year)		7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
1. Title of Derivative Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Transaction Date (Month/Day/Year)	3A. Deemed Execution Date, if any (Month/Day/Year)	Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares	8. Price of Derivative Security (Instr. 5)		10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
Stock Option (Right to Buy)	$25.41	02/06/2026		A		125,000		02/06/2026⁽¹⁾	02/05/2036	Common Stock	125,000	$0	125,000	D

Explanation of Responses:

1. 2/48th of the shares subject to such option shall vest and become exercisable on March 1, 2026 and the remaining shares subject to the option shall vest in 46 substantially equal monthly installments on each monthly anniversary thereafter, subject to the Reporting Person's continuous service to the Issuer on each such date.

Remarks:

Exhibit 24.2 - Substitute Power of Attorney

	/s/ Mark A. Wilson, Attorney-in-Fact	02/10/2026
	** Signature of Reporting Person	Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.

6b:["$","div",null,{"className":"mb-4 flex items-center gap-3","children":[["$","$L77",null,{"item":{"id":6385121,"title":"SEC Form 4 filed by Chief Financial Officer Labrucherie Gil M","summary":"4 - Septerna, Inc. (0001984086) (Issuer)","link":"https://www.sec.gov/Archives/edgar/data/control/000119312526045109/0001193125-26-045109-index.htm","imgUrl":"https://www.sec.gov/files/sec-logo.png","publishedAt":"2026-02-11 00:10:50.000000","discoveredAt":"2026-02-11 00:11:13.176145","parser":6,"category":16,"text":null,"html":"$78","companies":[{"id":71170,"ticker":"SEPN","name":"Septerna Inc.","website":null,"sector":"Health Care","industry":"Biotechnology: Pharmaceutical Preparations"}]},"showLabel":true}],"$L79","$L7a","$L7b"]}] 6c:["$","div",null,{"className":"flex flex-col items-start gap-2 sm:flex-row sm:gap-3","children":[["$","div",null,{"className":"flex shrink-0 -space-x-1.5 sm:pt-1.5","children":[[["$","div","71170",{"className":"relative h-7 w-7 shrink-0 overflow-hidden rounded-md border border-border bg-surface ring-2 ring-background sm:h-11 sm:w-11","title":"SEPN","children":["$","$L7c",null,{"website":null,"ticker":"SEPN","name":"Septerna Inc.","size":"md","chromeless":true}]}]],null]}],["$","div",null,{"className":"min-w-0","children":[["$","h1",null,{"className":"font-display max-w-[62ch] text-balance text-[32px] leading-[1.08] text-foreground sm:text-[44px]","children":"SEC Form 4 filed by Chief Financial Officer Labrucherie Gil M"}],["$","div",null,{"className":"mt-4 flex flex-wrap items-center gap-x-2 gap-y-1 text-[13px] text-muted-foreground","children":[["$","span",null,{"children":"By"}],["$","$L2d",null,{"ref":"$undefined","prefetch":false,"href":"/","rel":"publisher author","className":"font-medium text-foreground transition-colors hover:text-brand-glow","children":["Quantisnow",["$","$L30",null,{}]]}],["$","span",null,{"className":"text-dim-foreground","children":"·"}],["$","span",null,{"className":"text-dim-foreground","children":"Wall Street's wire, on your screen."}]]}]]}]]}] 6d:["$","div",null,{"className":"mt-7 flex flex-wrap items-center gap-x-4 gap-y-2 border-y border-hairline py-3.5","children":[["$","div",null,{"className":"flex flex-wrap items-center gap-1.5","children":[["$","$L2d","71170",{"ref":"$undefined","prefetch":false,"href":"/company/SEPN","className":"inline-flex h-7 items-center gap-1.5 rounded-full border border-hairline-strong bg-surface/60 px-3 text-[13px] font-medium text-foreground transition-colors hover:border-brand/50","children":[[["$","span",null,{"className":"font-mono","children":"SEPN"}],["$","span",null,{"className":"font-normal text-dim-foreground","children":"Septerna Inc."}]],["$","$L30",null,{}]]}]]}],["$","div",null,{"className":"ml-auto flex flex-wrap gap-1.5","children":[["$","span","Health Care",{"className":"text-[13px] text-dim-foreground","children":"Health Care"}]]}]]}] 6e:["$","$L7e",null,{"insightId":"6385121","iso":"2026-02-11 00:10:50.000000"}] 81:T4000, SEC FORM 4 SEC Form 4

FORM 4

OMB APPROVAL

OMB Number:			3235-0287
Estimated average burden
hours per response:			0.5

Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

1. Name and Address of Reporting Person^*

Labrucherie Gil M

(Last)

(First)

(Middle)

C/O SEPTERNA, INC.

250 EAST GRAND AVENUE

(Street)

SOUTH SAN FRANCISCO

94080

(City)

(State)

(Zip)

2. Issuer Name and Ticker or Trading Symbol
Septerna, Inc. [ SEPN ]

5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)

	Director	10% Owner
X	Officer (give title below)	Other (specify below)
	Chief Financial Officer

3. Date of Earliest Transaction (Month/Day/Year)
02/06/2026

4. If Amendment, Date of Original Filed (Month/Day/Year)

6. Individual or Joint/Group Filing (Check Applicable Line)

X	Form filed by One Reporting Person
	Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3)	2. Transaction Date (Month/Day/Year)	2A. Deemed Execution Date, if any (Month/Day/Year)	3. Transaction Code (Instr. 8)		4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5)			5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4)	6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
1. Title of Security (Instr. 3)	2. Transaction Date (Month/Day/Year)	2A. Deemed Execution Date, if any (Month/Day/Year)	Code	V	Amount	(A) or (D)	Price		6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Transaction Date (Month/Day/Year)	3A. Deemed Execution Date, if any (Month/Day/Year)	4. Transaction Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date (Month/Day/Year)		7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
1. Title of Derivative Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Transaction Date (Month/Day/Year)	3A. Deemed Execution Date, if any (Month/Day/Year)	Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares	8. Price of Derivative Security (Instr. 5)		10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
Stock Option (Right to Buy)	$25.41	02/06/2026		A		125,000		02/06/2026⁽¹⁾	02/05/2036	Common Stock	125,000	$0	125,000	D

Explanation of Responses:

Remarks:

Exhibit 24.2 - Substitute Power of Attorney

	/s/ Mark A. Wilson, Attorney-in-Fact	02/10/2026
	** Signature of Reporting Person	Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
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