SEC FORM 4

SEC FORM 4SEC Form 4

FORM 4

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940

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Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.

1. Name and Address of Reporting Person^*

Harrison Seth Loring

(Last)

(First)

(Middle)

C/O STOKE THERAPEUTICS, INC.

45 WIGGINS AVENUE

(Street)

BEDFORD

MASSACHUSETTS

01730

(City)

(State)

(Zip)

UNITED STATES

(Country)

2. Issuer Name and Ticker or Trading Symbol
Stoke Therapeutics, Inc. [ STOK ]

5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)

X	Director	10% Owner
	Officer (give title below)	Other (specify below)

2a. Foreign Trading Symbol

3. Date of Earliest Transaction (Month/Day/Year)
07/16/2026

6. Individual or Joint/Group Filing (Check Applicable Line)

X	Form filed by One Reporting Person
	Form filed by More than One Reporting Person

4. If Amendment, Date of Original Filed (Month/Day/Year)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3)	2. Transaction Date (Month/Day/Year)	2A. Deemed Execution Date, if any (Month/Day/Year)	3. Transaction Code (Instr. 8)		4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5)			5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4)	6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
1. Title of Security (Instr. 3)	2. Transaction Date (Month/Day/Year)	2A. Deemed Execution Date, if any (Month/Day/Year)	Code	V	Amount	(A) or (D)	Price		6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Transaction Date (Month/Day/Year)	3A. Deemed Execution Date, if any (Month/Day/Year)	4. Transaction Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date (Month/Day/Year)		7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
1. Title of Derivative Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Transaction Date (Month/Day/Year)	3A. Deemed Execution Date, if any (Month/Day/Year)	Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares	8. Price of Derivative Security (Instr. 5)		10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
Stock Option (Right to Buy)	$28.8	07/16/2026		G⁽¹⁾			29,555	⁽²⁾	09/09/2029	Common Stock	29,555	$0	0	D
Stock Option (Right to Buy)	$28.8	07/16/2026		G⁽¹⁾		29,555		⁽²⁾	09/09/2029	Common Stock	29,555	$0	29,555	I	By Trust⁽³⁾
Stock Option (Right to Buy)	$26.53	07/16/2026		G⁽¹⁾			14,777	⁽⁴⁾	06/02/2030	Common Stock	14,777	$0	0	D
Stock Option (Right to Buy)	$26.53	07/16/2026		G⁽¹⁾		14,777		⁽⁴⁾	06/02/2030	Common Stock	14,777	$0	14,777	I	By Trust⁽³⁾
Stock Option (Right to Buy)	$40.37	07/16/2026		G⁽¹⁾			11,650	⁽⁵⁾	06/07/2031	Common Stock	11,650	$0	0	D
Stock Option (Right to Buy)	$40.37	07/16/2026		G⁽¹⁾		11,650		⁽⁵⁾	06/07/2031	Common Stock	11,650	$0	11,650	I	By Trust⁽³⁾
Stock Option (Right to Buy)	$12.96	07/16/2026		G⁽¹⁾			21,000	⁽⁶⁾	06/06/2032	Common Stock	21,000	$0	0	D
Stock Option (Right to Buy)	$12.96	07/16/2026		G⁽¹⁾		21,000		⁽⁶⁾	06/06/2032	Common Stock	21,000	$0	21,000	I	By Trust⁽³⁾
Stock Option (Right to Buy)	$12.46	07/16/2026		G⁽¹⁾			19,441	⁽⁷⁾	06/12/2033	Common Stock	19,441	$0	0	D
Stock Option (Right to Buy)	$12.46	07/16/2026		G⁽¹⁾		19,441		⁽⁷⁾	06/12/2033	Common Stock	19,441	$0	19,441	I	By Trust⁽³⁾
Stock Option (Right to Buy)	$16.41	07/16/2026		G⁽¹⁾			7,639	⁽⁸⁾	06/04/2034	Common Stock	7,639	$0	0	D
Stock Option (Right to Buy)	$16.41	07/16/2026		G⁽¹⁾		7,639		⁽⁸⁾	06/04/2034	Common Stock	7,639	$0	7,639	I	By Trust⁽³⁾
Stock Option (Right to Buy)	$10.9	07/16/2026		G⁽¹⁾			29,747	⁽⁹⁾	06/02/2035	Common Stock	29,747	$0	0	D
Stock Option (Right to Buy)	$10.9	07/16/2026		G⁽¹⁾		29,747		⁽⁹⁾	06/02/2035	Common Stock	29,747	$0	29,747	I	By Trust⁽³⁾
Stock Option (Right to Buy)	$29.46	07/16/2026		G⁽¹⁾			17,786	⁽¹⁰⁾	06/02/2036	Common Stock	17,786	$0	0	D
Stock Option (Right to Buy)	$29.46	07/16/2026		G⁽¹⁾		17,786		⁽¹⁰⁾	06/02/2036	Common Stock	17,786	$0	17,786	I	By Trust⁽³⁾

Explanation of Responses:

1. The reported transaction represents a gift, for no consideration, of shares of the Issuer's Common Stock, which is exempt from short-swing profit liability pursuant to Rule 16b-5 under the Exchange Act of 1934, as amended.

2. This option is fully vested and exercisable. Pursuant to the grant agreement between the Issuer and the reporting person, the award became fully vested on March 21, 2022.

3. The securities are directly held by the East Pillar 2026 Irrevocable Trust (the "Trust"). The reporting person is a member of the board of managers of the Trust's trustee and may be deemed to exercise voting discretion, as well as shared investment discretion, in such capacity. The reporting person and certain of his immediate family members are beneficiaries of the Trust.

4. This option is fully vested and exercisable. Pursuant to the grant agreement between the Issuer and the reporting person, the award became fully vested on June 3, 2021.

5. This option is fully vested and exercisable. Pursuant to the grant agreement between the Issuer and the reporting person, the award became fully vested on June 8, 2022.

6. This option is fully vested and exercisable. Pursuant to the grant agreement between the Issuer and the reporting person, the award became fully vested on June 7, 2023.

7. This option is fully vested and exercisable. Pursuant to the grant agreement between the Issuer and the reporting person, the award became fully vested on June 13, 2024.

8. This option is fully vested and exercisable. Pursuant to the grant agreement between the Issuer and the reporting person, the award became fully vested on June 3, 2025.

9. This option is fully vested and exercisable. Pursuant to the grant agreement between the Issuer and the reporting person, the award became fully vested on June 3, 2026.

10. The option shall vest in full on the earlier of: (i) June 3, 2027 or (ii) the date of the Issuer's next annual meeting of its stockholders, subject to the reporting person's continued service to the Issuer on the vesting date.

	/s/ Jonathan Allan, Attorney-in-Fact	07/17/2026
	** Signature of Reporting Person	Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.
* Form 4: SEC 1474 (03-26)