SEC FORM 4

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FORM 4

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940

OMB APPROVAL

OMB Number:			3235-0287
Estimated average burden
hours per response:			0.5

Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

1. Name and Address of Reporting Person^*

GUGGENHIME ANDREW

(Last)

(First)

(Middle)

C/O CARIBOU BIOSCIENCES, INC.

2929 7TH STREET, SUITE 105

(Street)

BERKELEY

94710

(City)

(State)

(Zip)

2. Issuer Name and Ticker or Trading Symbol
Caribou Biosciences, Inc. [ CRBU ]

5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)

X	Director	10% Owner
	Officer (give title below)	Other (specify below)

3. Date of Earliest Transaction (Month/Day/Year)
02/21/2023

4. If Amendment, Date of Original Filed (Month/Day/Year)

6. Individual or Joint/Group Filing (Check Applicable Line)

X	Form filed by One Reporting Person
	Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3)	2. Transaction Date (Month/Day/Year)	2A. Deemed Execution Date, if any (Month/Day/Year)	3. Transaction Code (Instr. 8)		4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5)			5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4)	6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
1. Title of Security (Instr. 3)	2. Transaction Date (Month/Day/Year)	2A. Deemed Execution Date, if any (Month/Day/Year)	Code	V	Amount	(A) or (D)	Price		6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Transaction Date (Month/Day/Year)	3A. Deemed Execution Date, if any (Month/Day/Year)	4. Transaction Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date (Month/Day/Year)		7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
1. Title of Derivative Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Transaction Date (Month/Day/Year)	3A. Deemed Execution Date, if any (Month/Day/Year)	Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares	8. Price of Derivative Security (Instr. 5)		10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
Option to purchase Common Stock	$6.12	02/21/2023		A		21,500		⁽¹⁾	02/20/2033	Common Stock	21,500	$0	21,500	D

Explanation of Responses:

1. One-twelfth of the shares subject to this option will vest on each monthly anniversary of the grant date such that the option will be fully vested on February 21, 2024, subject to the reporting person continuing to provide service to the Issuer through each such vesting date.

Remarks:

	/s/ Barbara G. McClung, as attorney-in-fact	02/23/2023
	** Signature of Reporting Person	Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.

65:["$","div",null,{"className":"mb-4 flex items-center gap-3","children":[["$","$L71",null,{"item":{"id":4110586,"title":"SEC Form 4 filed by Guggenhime Andrew","summary":"4 - Caribou Biosciences, Inc. (0001619856) (Issuer)","link":"https://www.sec.gov/Archives/edgar/data/control/000161985623000022/0001619856-23-000022-index.htm","imgUrl":"https://www.sec.gov/files/sec-logo.png","publishedAt":"2023-02-23 22:10:32.000000","discoveredAt":"2023-02-23 22:14:52.998387","parser":6,"category":16,"text":null,"html":"$72","companies":[{"id":69084,"ticker":"CRBU","name":"Caribou Biosciences Inc.","website":null,"sector":"Health Care","industry":"Biotechnology: Biological Products (No Diagnostic Substances)"}]},"showLabel":true}],"$L73","$L74","$L75"]}] 66:["$","div",null,{"className":"flex flex-col items-start gap-2 sm:flex-row sm:gap-3","children":[["$","div",null,{"className":"flex shrink-0 -space-x-1.5 sm:pt-1.5","children":[[["$","div","69084",{"className":"relative h-7 w-7 shrink-0 overflow-hidden rounded-md border border-border bg-surface ring-2 ring-background sm:h-11 sm:w-11","title":"CRBU","children":["$","$L76",null,{"website":null,"ticker":"CRBU","name":"Caribou Biosciences Inc.","size":"md","chromeless":true}]}]],null]}],["$","div",null,{"className":"min-w-0","children":[["$","h1",null,{"className":"font-display max-w-[62ch] text-balance text-[32px] leading-[1.08] text-foreground sm:text-[44px]","children":"SEC Form 4 filed by Guggenhime Andrew"}],["$","div",null,{"className":"mt-4 flex flex-wrap items-center gap-x-2 gap-y-1 text-[13px] text-muted-foreground","children":[["$","span",null,{"children":"By"}],["$","$L2c",null,{"ref":"$undefined","prefetch":false,"href":"/","rel":"publisher author","className":"font-medium text-foreground transition-colors hover:text-brand-glow","children":["Quantisnow",["$","$L2f",null,{}]]}],["$","span",null,{"className":"text-dim-foreground","children":"·"}],["$","span",null,{"className":"text-dim-foreground","children":"Wall Street's wire, on your screen."}]]}]]}]]}] 67:["$","div",null,{"className":"mt-7 flex flex-wrap items-center gap-x-4 gap-y-2 border-y border-hairline py-3.5","children":[["$","div",null,{"className":"flex flex-wrap items-center gap-1.5","children":[["$","$L2c","69084",{"ref":"$undefined","prefetch":false,"href":"/company/CRBU","className":"inline-flex h-7 items-center gap-1.5 rounded-full border border-hairline-strong bg-surface/60 px-3 text-[13px] font-medium text-foreground transition-colors hover:border-brand/50","children":[[["$","span",null,{"className":"font-mono","children":"CRBU"}],["$","span",null,{"className":"font-normal text-dim-foreground","children":"Caribou Biosciences Inc."}]],["$","$L2f",null,{}]]}]]}],["$","div",null,{"className":"ml-auto flex flex-wrap gap-1.5","children":[["$","span","Health Care",{"className":"text-[13px] text-dim-foreground","children":"Health Care"}]]}]]}] 68:["$","$L78",null,{"insightId":"4110586","iso":"2023-02-23 22:10:32.000000"}] 7b:T3da0, SEC FORM 4 SEC Form 4

FORM 4

OMB APPROVAL

OMB Number:			3235-0287
Estimated average burden
hours per response:			0.5

Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

1. Name and Address of Reporting Person^*

GUGGENHIME ANDREW

(Last)

(First)

(Middle)

C/O CARIBOU BIOSCIENCES, INC.

2929 7TH STREET, SUITE 105

(Street)

BERKELEY

94710

(City)

(State)

(Zip)

2. Issuer Name and Ticker or Trading Symbol
Caribou Biosciences, Inc. [ CRBU ]

5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)

X	Director	10% Owner
	Officer (give title below)	Other (specify below)

3. Date of Earliest Transaction (Month/Day/Year)
02/21/2023

4. If Amendment, Date of Original Filed (Month/Day/Year)

6. Individual or Joint/Group Filing (Check Applicable Line)

X	Form filed by One Reporting Person
	Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3)	2. Transaction Date (Month/Day/Year)	2A. Deemed Execution Date, if any (Month/Day/Year)	3. Transaction Code (Instr. 8)		4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5)			5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4)	6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
1. Title of Security (Instr. 3)	2. Transaction Date (Month/Day/Year)	2A. Deemed Execution Date, if any (Month/Day/Year)	Code	V	Amount	(A) or (D)	Price		6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Transaction Date (Month/Day/Year)	3A. Deemed Execution Date, if any (Month/Day/Year)	4. Transaction Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date (Month/Day/Year)		7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
1. Title of Derivative Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Transaction Date (Month/Day/Year)	3A. Deemed Execution Date, if any (Month/Day/Year)	Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares	8. Price of Derivative Security (Instr. 5)		10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
Option to purchase Common Stock	$6.12	02/21/2023		A		21,500		⁽¹⁾	02/20/2033	Common Stock	21,500	$0	21,500	D

Explanation of Responses:

Remarks:

	/s/ Barbara G. McClung, as attorney-in-fact	02/23/2023
	** Signature of Reporting Person	Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
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