tm2618428-2_424b5 - none

424B5 1 tm2618428-2_424b5.htm 424B5 tm2618428-2_424b5 - none - 5.7969207s

Filed pursuant to Rule 424(b)(5)

Registration No. 333-284168

Prospectus supplement
(To prospectus dated January 7, 2025)

4,945,055 Ordinary Shares

We are offering 4,945,055 ordinary shares, nominal value €0.05 per share, pursuant to this prospectus supplement and the accompanying prospectus.

Our ordinary shares are listed on The Nasdaq Global Select Market, or Nasdaq, under the symbol “QURE.” On June 23, 2026, the last reported sale price of our ordinary shares on Nasdaq was $49.04 per ordinary share.

Investing in our ordinary shares involves significant risks. See “Risk Factors” beginning on page S-7 of this prospectus supplement as well as the documents incorporated by reference into this prospectus supplement and the accompanying prospectus for a discussion of the factors you should consider before deciding to purchase our securities.

Neither the Securities and Exchange Commission nor any state securities commission has approved or disapproved of these securities or passed upon the adequacy or accuracy of this prospectus supplement or the accompanying prospectus. Any representation to the contrary is a criminal offense.

	Per ordinary share			Total
Public offering price		$	45.50		$	225,000,003
Underwriting discounts and commissions(1)		$	2.73		$	13,500,000
Proceeds to uniQure N.V. (before expenses)		$	42.77		$	211,500,003

(1)

See “Underwriting” beginning on page S-25 of this prospectus supplement for additional information regarding total underwriting compensation.

Delivery of our ordinary shares is expected to be made on or about June 25, 2026. We have granted the underwriters an option for a period of 30 days to purchase up to an additional 741,758 ordinary shares at the public offering price less the underwriting discounts and commissions.

Joint Bookrunning Managers

Leerink Partners

Stifel

Guggenheim Securities

RBC Capital Markets

Lead Manager

H.C. Wainwright & Co.

The date of this prospectus supplement is June 23, 2026.

	Page
ABOUT THIS PROSPECTUS SUPPLEMENT		S-ii
SPECIAL CAUTIONARY NOTE REGARDING FORWARD-LOOKING STATEMENTS		S-iv
ENFORCEMENT OF CIVIL LIABILITIES		S-vi
PROSPECTUS SUPPLEMENT SUMMARY		S-1
THE OFFERING		S-5
RISK FACTORS		S-7
USE OF PROCEEDS		S-11
DIVIDEND POLICY		S-12
DILUTION		S-13
MATERIAL DUTCH AND U.S. FEDERAL INCOME TAX CONSIDERATIONS		S-15
UNDERWRITING		S-25
LEGAL MATTERS		S-31
EXPERTS		S-32
WHERE YOU CAN FIND MORE INFORMATION		S-33
INCORPORATION OF CERTAIN INFORMATION BY REFERENCE		S-34

	Page
ABOUT THIS PROSPECTUS		1
THE COMPANY		2
RISK FACTORS		3
SPECIAL NOTE REGARDING FORWARD-LOOKING STATEMENTS		4
USE OF PROCEEDS		6
DESCRIPTION OF ORDINARY SHARES AND ARTICLES OF ASSOCIATION		7
DESCRIPTION OF DEBT SECURITIES		13
DESCRIPTION OF WARRANTS		19
DESCRIPTION OF RIGHTS		20
DESCRIPTION OF UNITS		21
CONVERTIBLE OR EXCHANGEABLE SECURITIES		22
FORM, EXCHANGE AND TRANSFER		23
BOOK-ENTRY PROCEDURES AND SETTLEMENT		24
PLAN OF DISTRIBUTION		26
LEGAL MATTERS		29
EXPERTS		30
WHERE YOU CAN FIND MORE INFORMATION		31
INCORPORATION OF CERTAIN INFORMATION BY REFERENCE		32

Public offering price per ordinary share			$	45.50
Net tangible book value per ordinary share as of March 31, 2026	$	0.74
Increase per ordinary share attributable to new investors		3.04
As adjusted net tangible book value per ordinary share as of March 31, 2026 after giving effect to this offering				3.78
Dilution per ordinary share to new investors purchasing ordinary shares in this offering			$	41.72

Underwriter	Number of Ordinary Shares
Leerink Partners LLC		2,076,923
Stifel, Nicolaus & Company, Incorporated		1,186,813
Guggenheim Securities, LLC		1,087,912
RBC Capital Markets, LLC		445,055
H.C. Wainwright & Co., LLC		148,352
Total		4,945,055

	Per Ordinary Share			Total
	Per Ordinary Share			Without Option			With Option
Initial public offering price		$	45.50		$	225,000,003		$	258,749,992
Underwriting discounts and commissions		$	2.73		$	13,500,000		$	15,525,000
Proceeds, before expenses, to us		$	42.77		$	211,500,003		$	243,224,992

SEC Form 424B5 filed by uniQure N.V.