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	MANAGEMENT INFORMATION CIRCULAR AND PROXY STATEMENT					1
	SOLICITATION OF PROXIES					1
	Instructions for Attending the Virtual Meeting					1
	APPOINTMENT OF PROXY HOLDERS					4
	REVOCABILITY OF PROXY					4
	VOTING OF SHARES REPRESENTED BY MANAGEMENT PROXIES					4
	VOTING SHARES AND THE PRINCIPAL HOLDERS THEREOF					5
	ADVICE TO BENEFICIAL HOLDERS OF SECURITIES					6
	BUSINESS OF THE MEETING					6
	Audited Consolidated Financial Statements and Auditors’ Report					7
	Election of Directors					7
	Appointment and Remuneration of the Auditors					14
	Advisory Vote on Named Executive Officer Compensation					14
	Advisory Vote on the Frequency of Advisory Votes on Named Executive Officer Compensation					15
	OTHER MATTERS COMING BEFORE THE MEETING					15
	STATEMENT OF EXECUTIVE COMPENSATION					15
	Compensation Discussion and Analysis					15
	Raise Funding (full year)
	Summary Compensation Table					20
	Outstanding Equity Awards at Fiscal Year End (NEOs)					22
	Incentive Plan Awards — Value Vested or Earned During the Year (NEOs)					23
	Securities Authorized for Issuance under Equity Compensation Plan					24
	The 2020 Omnibus Plan					24
	Pension Benefit Plans					30
	Termination of Employment, Change of Control and Employment Contracts					30
	Directors’ and Officers’ Liability Insurance					31
	Director Compensation					32
	Outstanding Option-Based Awards and Share Based Awards — Directors					34
	Incentive Plan Awards — Value Vested or Earned During the Year — Directors					35
	INDEBTEDNESS OF DIRECTORS AND EXECUTIVE OFFICERS					35
	INTERESTS OF INFORMED PERSONS IN MATERIAL TRANSACTIONS					35
	INTERESTS OF CERTAIN PERSONS AND COMPANIES IN MATTERS TO BE ACTED UPON					36
	CORPORATE GOVERNANCE DISCLOSURE					37
	Board of Directors					37
	Board Composition; Term of Office					38
	Director Independence					38
	Board and Committee Meetings Held for the Year Ended December 31, 2020					38
	Attendance of Directors for the Year Ended December 31, 2020					39
	Directorships					39
	Orientation and Continuing Education					40

	Ethical Business Conduct					40
	Communication with the Directors of Trillium					40
	Nomination of Directors					41
	Corporate Governance and Nominating Committee					41
	Compensation Committee					42
	Audit Committee					42
	Other Committees					43
	Assessments					43
	Director Tenure					43
	Diversity					44
	ADDITIONAL INFORMATION					48
	DIRECTORS’ APPROVAL					49
	Schedule A — CORPORATE GOVERNANCE GUIDELINES					1

Name Present Office Held Province/State and Country of Residence/ Age as of April 28, 2021	Principal Business Activities, Other Principal Directorships and Function	Director Since	Number of Common Shares
Luke Beshar Director(1)(3) New Jersey, USA Age: 62	Mr. Beshar is an independent biotechnology consultant and financial expert. Mr. Beshar is a former chief financial officer of various public and private companies and has more than 30 years of general and financial management experience. Mr. Beshar has served as a director of REGENXBIO Inc., a publicly held gene therapy company, since May 2015 and is currently chair of its audit committee. Mr. Beshar has served as a director of Protara Therapeutics, Inc., a publicly held company focused on immune-oncology and rare diseases, since October 2018 and is currently chairman of its board of directors and chair of its nominating and corporate governance committee. Mr. Beshar was most recently the Executive/Senior Vice President and Chief Financial Officer of NPS Pharmaceuticals, Inc., a global biopharmaceutical company from November 2007 to February 2015. Mr. Beshar served as Executive Vice President and Chief Financial Officer of Cambrex Corporation, a life sciences company, from December 2002 to November 2007. Mr. Beshar began his career with Arthur Andersen & Co. in 1980 and is a Certified Public Accountant. Mr. Beshar holds a B.S. degree in Accounting and Finance from Michigan State University and is a graduate of The Executive Program at the Darden Graduate School of Business at the University of Virginia. As an independent director, Mr. Beshar supervises our management and helps to ensure compliance with our corporate governance policies and standards. We believe Mr. Beshar is qualified to serve on our Board because of his experience in the life sciences industry and financial expertise.	March 10, 2014	Nil
Jan Skvarka Director, President and Chief Executive Officer Massachusetts, USA Age: 54	Dr. Skvarka has been the President and Chief Executive Officer of Trillium since September 25, 2019. Prior to joining Trillium, Dr. Skvarka served as the President and CEO of Tal Medical, a clinical-stage neuroscience company in Boston, Massachusetts, from 2014 until 2018. Before Tal, Dr. Skvarka spent 14 years with Bain & Company, Boston as a healthcare consultant. He was partner in the Healthcare practice from 2007 until 2013, with a focus on pharmaceutical, biotechnology and medical technology companies. Earlier in his career, Dr. Skvarka worked in the corporate finance arm of Price Waterhouse in London, UK and Vienna, Austria.	September 25, 2019	Nil

Name Present Office Held / Officer since / Age			Principal Business Activities and Function
Robert Uger Chief Scientific Officer Ontario, Canada April 9, 2013 Age: 50			Dr. Uger has been the Chief Scientific Officer of Trillium since April 9, 2013 and was the Vice President, Research of Trillium Privateco prior thereto from 2003. As Chief Scientific Officer, Dr. Uger is responsible for developing and implementing our scientific direction, and oversees both internal product development and external research and development programs. Dr. Uger also served on the board of directors from April 29, 2019 to February 6, 2020.
Ingmar Bruns Chief Medical Officer Massachusetts, USA November 2, 2020 Age: 46			Dr. Bruns has been the Chief Medical Officer of Trillium since November 2, 2020. Previously, Dr. Bruns was the senior vice president and head of clinical development at Pieris Pharmaceuticals from October 2017 to November 2020, and from July 2013 through October 2017, Dr. Bruns led clinical development of several oncology assets at Bayer Pharmaceuticals. As Chief Medical Officer, Dr. Bruns is responsible for the design and execution of our clinical and regulatory strategy.
James Parsons Chief Financial Officer Ontario, Canada August 25, 2011 Age: 55			Mr. Parsons has been the Chief Financial Officer of Trillium since August 25, 2011 and was also the Director, Finance of Trillium Privateco. He was previously the Vice President, Finance of DiaMedica Inc. from October 2010 to May 2014. Mr. Parsons sits on the board of Sernova Corp and DiaMedica Therapeutics, Inc. As Chief Financial Officer, Mr. Parsons is responsible for financial and risk management, investor relations, corporate governance and administration.
Penka Petrova Chief Development Officer Ontario, Canada May 29, 2015 Age: 53			Dr. Petrova has been the Chief Development Officer of Trillium since May 29, 2015 and was the Vice President, Drug Development from April 2013 to May 2015. Dr. Petrova joined Trillium Privateco in 2003. As Chief Development Officer, Dr. Petrova is responsible for managing our formal drug development efforts, including all outsourced activities to contract manufacturers and contract research organizations.
Rosemary Harrison Senior Vice President, Corporate Development and Strategy Massachusetts, USA November 5, 2020 Age: 38			Dr. Harrison has been the Senior Vice President, Corporate Development and Strategy of Trillium since November 5, 2020. Previously, Dr. Harrison served in roles within RA Capital Management and as head of rare diseases at Imbria Pharmaceuticals. From 2015 to 2018, Dr. Harrison was head of portfolio management and strategic planning at the Novartis Institutes for Biomedical Research. As Senior Vice President, Corporate Development and Strategy, Dr. Harrison is responsible for business development and strategic partnerships.

	December 31, 2020 ($)		December 31, 2019 ($)
Executive Compensation – Related Fees(1)		135,000		18,387
All Other Fees(2)		57,000		1,731
Total Fees		192,000		20,118

Anaptys Bio	Arcus Biosciences	Calithera Biosciences
CASI Pharmaceuticals	Concert Pharmaceuticals	Five Prime Therapeutics
G1 Therapeutics	Jounce Therapeutics	KalVista Pharmaceuticals
Kura Oncology	Magenta Therapeutics	MEI Pharma
Molecular Templates	Replimune Group	Scholar Rock
Syndax Pharmaceuticals	Syros Pharmaceuticals	Voyager Therapeutics
ZIOPHARM Oncology

Compensation Element			Purpose
Salary			Cash payment designed to attract and retain key employees. Salary level takes into consideration the current competitive market conditions, experience, proven or expected performance, and the particular skills of the NEO.
Short-Term Incentive			Cash payment designed to align NEO performance with strategy, to reward the achievement of key milestones and to provide a competitive level of compensation. Short-term incentive awards for target performance are set as a percentage of salary, with actual awards based

Compensation Element			Purpose
			on performance relative to specific targets. Target awards for each of the NEOs are as follows: • CEO 50% of salary • Other NEOs 35% to 40% of salary
Long-Term Incentive			Award of stock options designed to align NEO compensation with long-term shareholder interests and to provide a competitive level of compensation.
Benefits and Group Registered Retirement Savings Plans			Competitive benefits designed to attract and retain key employees.

Q1 & Q2 2020 Corporate Objectives	Weight	Achievements at year end
Raise Funding (full year)	33.3%	The objective was achieved above target at 50%.
Execute TTI-621 & TTI-622 Studies	16.7%	The objective was achieved on target at 16.7%.

Q3 & Q4 2020 Corporate Objectives	Weight	Achievements at year end
Execute TTI-621 & TTI-622 Studies	16.7%	The objective was achieved above target at 25%.
Execute CMC campaigns	16.7%	The objective was achieved above target at 25%.
Prepare clinical development plan by a certain date	16.7%	This objective was below target at 8.3%.

Name	Option Awards										Stock Awards
	Number of securities underlying unexercised options (#)				Option exercise price ($) USD(2)			Option expiration date	Value of unexercised in-the- money options ($)(3)		Number of shares or units of stock that have not vested (#)		Market or payout value of shares or units of stock that have not vested ($)		Market or payout value of vested share-based awards not paid out or distributed ($)
	Exercisable		Unexercisable(1)		Option exercise price ($) USD(2)			Option expiration date	Value of unexercised in-the- money options ($)(3)		Number of shares or units of stock that have not vested (#)
Jan Skvarka President & CEO and Director		398,437		876,563		$	0.41	September 25, 2029		18,232,500		—		—		—
		175,000		65,000		$	0.29	November 7, 2029		3,460,800		—		—		—
		—		600,000		$	12.03	December 23, 2030		1,608,000		—		—		—
Robert Kirkman(4) Former Executive Chairman		—		—			—	—		—		—		—		3,353,880
Robert Uger Chief Scientific Officer		29,073		—		$	14.54	November 19, 2025		4,942		—		—		—
		29,073		—		$	10.75	May 27, 2026		115,129		—		—		—
		4,954		1,474		$	9.62	November 9, 2027		32,719		—		—		—
		34,939		32,145		$	3.23	November 8, 2028		770,124		—		—		—
		34,559		93,046		$	0.29	November 7, 2029		1,840,064		—		—		—
		—		250,000		$	12.03	December 23, 2030		670,000

Name and Principal Position	Year		Salary ($)		Bonus ($)(1)		Stock Awards ($)		Option Awards ($)(2)		Non-Equity Incentive Plan Compensation ($)				Nonqualified Deferred Compensation Earnings		Pension Value ($)		All other Compensation ($)		Total Compensation ($)
Name and Principal Position	Year		Salary ($)		Bonus ($)(1)		Stock Awards ($)		Option Awards ($)(2)		Annual Incentive Plans(3)		Long-Term Incentive Plans		Nonqualified Deferred Compensation Earnings		Pension Value ($)		All other Compensation ($)		Total Compensation ($)
Jan Skvarka(4) President & CEO and Director		2020		500,000		—		—		5,982,600		312,500		—		—		—		—		6,795,100
Jan Skvarka(4) President & CEO and Director		2019		132,673		25,000		—		1,072,335		82,920		—		—		—		—		1,312,928
Robert Kirkman(5) Former Executive Chairman		2020		81,250		—		—		—		—		—		—		—		—		81,250
Robert Kirkman(5) Former Executive Chairman		2019		219,158		—		132,720		—		—		—		—		—		—		351,878
Robert Uger(6) Chief Scientific Officer		2020		271,696		194,250		—		2,492,750		118,867		—		—		—		10,918(9)		3,088,481
		2019		319,303		—		—		99,723		115,024		—		—		—		—		534,050
		2018		268,979		—		—		323,993		54,132		—		—		—		—		647,105
Ingmar Bruns(7) Chief Medical Officer		2020		73,333		120,000		—		4,655,200		36,667		—		—		—		—		4,885,200
Yaping Shou(8) Former Chief Medical Officer		2020		333,333		300,000		—		—		—		—		—		—		267,798		901,131
		2019		400,000		50,000		—		112,417		175,000		—		—		—		—		787,417
		2018		224,357		50,000		—		1,026,408		44,992		—		—		—		—		1,345,757
James Parsons(6) Chief Financial Officer		2020		252,525		180,375		—		1,794,780		110,480		—		—		—		—		2,338,160
		2019		244,361		—		—		90,205		106,908		—		—		—		—		441,474
		2018		250,000		—		—		289,281		50,312		—		—		—		—		589,593
Penka Petrova(6) Chief Development Officer		2020		252,525		180,375		—		1,395,940		110,480		—		—		—		10,148(9)		1,949,468
		2019		244,361		—		—		90,205		106,908		—		—		—		—		441,474
		2018		250,000		—		—		289,281		50,312		—		—		—		—		589,593