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    SEC Form SC 13D/A filed by Incyte Corp. (Amendment)

    5/13/24 6:06:33 PM ET
    $INCY
    Biotechnology: Commercial Physical & Biological Resarch
    Health Care
    Get the next $INCY alert in real time by email
    SC 13D/A 1 tm2414337d1_sc13da.htm SC 13D/A

     

     

    UNITED STATES

    SECURITIES AND EXCHANGE COMMISSION

    WASHINGTON, DC 20549

     

    SCHEDULE 13D

    Under the Securities Exchange Act of 1934

     

    (Amendment No. 30)*

     

    Incyte Corporation

    (Name of Issuer)

     

    Common Stock, Par Value $0.001 Per Share

    (Title of Class of Securities)

     

    45337C102

    (CUSIP number)

     

    Alexandra A. Toohey

    Chief Financial Officer

    Baker Bros. Advisors LP

    860 Washington Street, 3rd Floor

    New York, NY 10014

    (212) 339-5690

    (Name, address and telephone number of person authorized to receive notices and communications)

     

    May 12, 2024

    (Date of event which requires filing of this statement)

     

    If the filing person has previously filed a statement on Schedule 13G to report the acquisition that is the subject of this Schedule 13D, and is filing this schedule because of Rule 13d-1(e), 13d-1(f) or 13d-1(g), check the following box ¨.

     

    (Continued on the following pages)

     

    Note: Schedules filed in paper format shall include a signed original and five copies of the schedule, including all exhibits. See Rule 13d-7 for other parties to whom copies are to be sent.

     

    *The remainder of this cover page shall be filled out for a reporting person's initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter disclosures provided in a prior cover page.

     

    The information required on the remainder of this cover page shall not be deemed to be "filed" for the purpose of Section 18 of the Securities Exchange Act of 1934 ("Act") or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).

     

     

     

     

     

    CUSIP No.    45337C102   Page   2   of  13   Pages

     

    1.

    NAMES OF REPORTING PERSONS

     

    Baker Bros. Advisors LP

    2.

    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*

     

    (a) ¨

    (b) ¨

    3.

    SEC USE ONLY

    4.

    SOURCE OF FUNDS*

    OO

    5. CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEM 2(d) or 2(e)  ¨
    6.

    CITIZENSHIP OR PLACE OF ORGANIZATION

    Delaware

    NUMBER OF
    SHARES
    BENEFICIALLY
    OWNED BY EACH
    REPORTING
    PERSON WITH
    7. SOLE VOTING POWER: 36,308,584 (1)
    8. SHARED VOTING POWER:  0
    9. SOLE DISPOSITIVE POWER:  36,308,584 (1)
    10. SHARED DISPOSITIVE POWER:  0

    11. AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON: 36,308,584 (1)
    12. CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES (See Instructions) ¨ 
    13.

    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

    16.1% (1)(2)

    14.

    TYPE OF REPORTING PERSON (See Instructions)

    IA, PN

    (1) Includes 111,414 shares of common stock (“Common Stock”) of Incyte Corporation (the “Issuer”) underlying 111,414 non-qualified options exercisable for Common Stock (“Stock Options”) and 2,505 shares of common stock underlying 2,505 restricted stock units (each, an “RSU”) which vest into Common Stock within 60 days of the date of this filing.

    (2) Based on 224,854,553 shares of Common Stock outstanding as of May 9, 2024, as reported in Exhibit 10.1 to the Issuer's Form 8-K filed with the Securities and Exchange Commission ("SEC") on May 13, 2024, and 111,414 shares of Common Stock underlying 111,414 Stock Options and 2,505 shares of Common Stock underlying 2,505 RSUs.

     

     

     

     

    CUSIP No.    45337C102   Page   3   of  13   Pages

     

    1.

    NAMES OF REPORTING PERSONS

     

    Baker Bros. Advisors (GP) LLC

    2.

    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*

     

    (a) ¨

    (b) ¨

    3.

    SEC USE ONLY

    4.

    SOURCE OF FUNDS*

    OO

    5. CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEM 2(d) or 2(e) ¨
    6.

    CITIZENSHIP OR PLACE OF ORGANIZATION

    Delaware

    NUMBER OF
    SHARES
    BENEFICIALLY
    OWNED BY EACH
    REPORTING
    PERSON WITH
    7. SOLE VOTING POWER: 36,308,584 (1)
    8. SHARED VOTING POWER:  0
    9. SOLE DISPOSITIVE POWER:  36,308,584 (1)
    10. SHARED DISPOSITIVE POWER:  0

    11. AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON: 36,308,584 (1)
    12. CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES (See Instructions) ¨ 
    13.

    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

    16.1% (1)(2)

    14.

    TYPE OF REPORTING PERSON (See Instructions)

    HC, OO

    (1) Includes 111,414 shares of Common Stock underlying 111,414 Stock Options and 2,505 shares of common stock underlying 2,505 RSUs which vest into Common Stock within 60 days of the date of this filing.

    (2) Based on 224,854,553 shares of Common Stock outstanding as of May 9, 2024, as reported in Exhibit 10.1 to the Issuer's Form 8-K filed with the SEC on May 13, 2024, and 111,414 shares of Common Stock underlying 111,414 Stock Options and 2,505 shares of Common Stock underlying 2,505 RSUs.

     

     

     

     

    CUSIP No.    45337C102   Page   4   of  13   Pages

     

    1.

    NAMES OF REPORTING PERSONS

     

    Julian C. Baker

    2.

    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*

     

    (a) ¨

    (b) ¨

    3.

    SEC USE ONLY

    4.

    SOURCE OF FUNDS*

    OO

    5. CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEM 2(d) or 2(e) ¨ 
    6.

    CITIZENSHIP OR PLACE OF ORGANIZATION

    United States

    NUMBER OF
    SHARES
    BENEFICIALLY
    OWNED BY EACH
    REPORTING
    PERSON WITH
    7. SOLE VOTING POWER: 36,666,662 (1)
    8. SHARED VOTING POWER:  0
    9. SOLE DISPOSITIVE POWER:  36,666,662 (1)
    10. SHARED DISPOSITIVE POWER:  0

    11. AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON: 36,666,662 (1)
    12. CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES (See Instructions) ¨ 
    13.

    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

    16.3% (1)(2)

    14.

    TYPE OF REPORTING PERSON (See Instructions)

    IN, HC

    (1) Includes 111,414 shares of Common Stock underlying 111,414 Stock Options and 2,505 shares of common stock underlying 2,505 RSUs which vest into Common Stock within 60 days of the date of this filing.

    (2) Based on 224,854,553 shares of Common Stock outstanding as of May 9, 2024, as reported in Exhibit 10.1 to the Issuer's Form 8-K filed with the SEC on May 13, 2024, and 111,414 shares of Common Stock underlying 111,414 Stock Options and 2,505 shares of Common Stock underlying 2,505 RSUs.

     

     

     

     

    CUSIP No.    45337C102   Page   5   of  13   Pages

     

    1.

    NAMES OF REPORTING PERSONS

     

    Felix J. Baker

    2.

    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*

     

    (a) ¨

    (b) ¨

    3.

    SEC USE ONLY

    4.

    SOURCE OF FUNDS (See Instructions)

    OO

    5. CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEM 2(d) or 2(e) ¨
    6.

    CITIZENSHIP OR PLACE OF ORGANIZATION

    United States

    NUMBER OF
    SHARES
    BENEFICIALLY
    OWNED BY EACH
    REPORTING
    PERSON WITH
    7. SOLE VOTING POWER: 36,669,079 (1)
    8. SHARED VOTING POWER:  0
    9. SOLE DISPOSITIVE POWER:  36,669,079 (1)
    10. SHARED DISPOSITIVE POWER:  0

    11. AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON: 36,669,079 (1)
    12. CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES (See Instructions) ¨
    13.

    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

    16.3% (1)(2)

    14.

    TYPE OF REPORTING PERSON (See Instructions)

    IN, HC

    (1) Includes 111,414 shares of Common Stock underlying 111,414 Stock Options and 2,505 shares of common stock underlying 2,505 RSUs which vest into Common Stock within 60 days of the date of this filing.

    (2) Based on 224,854,553 shares of Common Stock outstanding as of May 9, 2024, as reported in Exhibit 10.1 to the Issuer's Form 8-K filed with the SEC on May 13, 2024, and 111,414 shares of Common Stock underlying 111,414 Stock Options and 2,505 shares of Common Stock underlying 2,505 RSUs.

     

     

     

     

    CUSIP No.    45337C102   Page   6   of  13   Pages

     

    1.

    NAMES OF REPORTING PERSONS

     

    FBB2, LLC

    2.

    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*

     

    (a) ¨

    (b) ¨

    3.

    SEC USE ONLY

    4.

    SOURCE OF FUNDS (See Instructions)

    OO

    5. CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEM 2(d) or 2(e) ¨
    6.

    CITIZENSHIP OR PLACE OF ORGANIZATION

    Delaware

    NUMBER OF
    SHARES
    BENEFICIALLY
    OWNED BY EACH
    REPORTING
    PERSON WITH
    7. SOLE VOTING POWER: 14,755
    8. SHARED VOTING POWER:  0
    9. SOLE DISPOSITIVE POWER:  14,755
    10. SHARED DISPOSITIVE POWER:  0

    11. AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON: 14,755
    12. CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES (See Instructions) ¨
    13.

    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

    0.01% (1)

    14.

    TYPE OF REPORTING PERSON (See Instructions)

    OO

    (1)Based on 224,854,553 shares of Common Stock outstanding as of May 9, 2024, as reported in Exhibit 10.1 to the Issuer's Form 8-K filed with the SEC on May 13, 2024.

     

     

     

     

    CUSIP No.    45337C102   Page   7   of  13   Pages

     

    1.

    NAMES OF REPORTING PERSONS

     

    FBB3 LLC

    2.

    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*

     

    (a) ¨

    (b) ¨

    3.

    SEC USE ONLY

    4.

    SOURCE OF FUNDS (See Instructions)

    OO

    5. CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEM 2(d) or 2(e) ¨
    6.

    CITIZENSHIP OR PLACE OF ORGANIZATION

    Delaware

    NUMBER OF
    SHARES
    BENEFICIALLY
    OWNED BY EACH
    REPORTING
    PERSON WITH
    7. SOLE VOTING POWER: 31,140
    8. SHARED VOTING POWER:  0
    9. SOLE DISPOSITIVE POWER:  31,140
    10. SHARED DISPOSITIVE POWER:  0

    11. AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON: 31,140
    12. CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES (See Instructions) ¨
    13.

    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

    0.01% (1)

    14.

    TYPE OF REPORTING PERSON (See Instructions)

    OO

    (1)

    Based on 224,854,553 shares of Common Stock outstanding as of May 9, 2024, as reported in Exhibit 10.1 to the Issuer's Form 8-K filed with the SEC on May 13, 2024.

     

     

     

     

    CUSIP No.    45337C102   Page   8   of  13   Pages

     

    1.

    NAMES OF REPORTING PERSONS

     

    FBB Associates

    2.

    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*

     

    (a) ¨

    (b) ¨

    3.

    SEC USE ONLY

    4.

    SOURCE OF FUNDS (See Instructions)

    OO

    5. CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEM 2(d) or 2(e) ¨
    6.

    CITIZENSHIP OR PLACE OF ORGANIZATION

    New York

    NUMBER OF
    SHARES
    BENEFICIALLY
    OWNED BY EACH
    REPORTING
    PERSON WITH
    7. SOLE VOTING POWER: 33,410
    8. SHARED VOTING POWER:  0
    9. SOLE DISPOSITIVE POWER:  33,410
    10. SHARED DISPOSITIVE POWER:  0

    11. AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON: 33,410
    12. CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES (See Instructions) ¨
    13.

    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

    0.01% (1)

    14.

    TYPE OF REPORTING PERSON (See Instructions)

    PN, OO

    (1) Based on 224,854,553 shares of Common Stock outstanding as of May 9, 2024, as reported in Exhibit 10.1 to the Issuer's Form 8-K filed with the SEC on May 13, 2024.

     

     

     

     

    Amendment No. 30 to Schedule 13D

     

    This Amendment No. 30 to Schedule 13D amends and supplements the statements on the previously filed Schedule 13D, as amended, filed by Baker Bros. Advisors LP (the “Adviser”), Baker Bros. Advisors (GP) LLC (the “Adviser GP”), Julian C. Baker, Felix J. Baker, FBB2, LLC (“FBB2”), FBB3 LLC (“FBB3”) and FBB Associates (“FBB”). Except as supplemented herein, such statements, as hereto amended and supplemented, remain in full force and effect. Information given in response to each item shall be deemed incorporated by reference in all other items, as applicable. Each capitalized term used but not defined herein has the meaning ascribed to such term in the Schedule 13D, as amended.

     

    The Adviser GP is the sole general partner of the Adviser. Pursuant to management agreements, as amended, among the Adviser, Baker Brothers Life Sciences, L.P. (“Life Sciences”), and 667, L.P. (“667”, and together with Life Sciences, the “Funds”), and their respective general partners, the Funds’ respective general partners relinquished to the Adviser all discretion and authority with respect to the investment and voting power of the securities held by the Funds, and thus the Adviser has complete and unlimited discretion and authority with respect to the Funds’ investments and voting power over investments.

     

    Item 4. Purpose of the Transaction.

     

    Item 4 of Amendment No. 30 is supplemented and superseded, as the case may be, as follows:

     

    Tender Offer

     

    On May 13, 2024, Incyte Corporation (the “Issuer”) announced its intention to conduct a public modified Dutch auction self-tender offer for up to $1.672 billion in consideration (the “Total Consideration”) of shares of its common stock (“Common Stock”), at prices ranging from $52.00 to $60.00 per share (the “Price Range”), subject to the other terms and conditions as determined by the Issuer’s Board of Directors (the “Board”) (such offer, the “Tender Offer”).

     

    Stock Purchase Agreement

     

    On May 12, 2024, the Funds, together with FBB, FBB2, FBB3, Felix J. Baker, and Julian C. Baker (collectively, with the Funds, the “Seller Affiliates”) entered into a Stock Purchase Agreement with the Issuer (the “Stock Purchase Agreement”) pursuant to which, subject to the completion of the Tender Offer and other terms and conditions stated in the Stock Purchase Agreement, the Funds agreed to sell to the Issuer and the Issuer agreed to purchase from the Funds an aggregate number of shares of Common Stock of the Issuer equal to the total number of shares of Common Stock held by the Seller Affiliates as of May 9, 2024, multiplied by the quotient of the total number of shares acquired by the Issuer in the Tender Offer and 188,020,620 (representing the outstanding shares of Common Stock owned by all stockholders of the Issuer other than the Seller Affiliates as of May 9, 2024). The per share purchase price for such shares shall be the price per share paid by the Issuer for the shares of Common Stock tendered by the holders of Common Stock in the Tender Offer.

     

    Pursuant to the Stock Purchase Agreement, each Seller Affiliate agreed that such Seller Affiliate and its respective affiliates will: (1) not, directly or indirectly, purchase any shares of the Issuer’s Common Stock until eleven business days following the expiration date of the Tender Offer; (2) not tender any shares of Common Stock in the Tender Offer, or, until the first trading day after the Issuer publicly announces the final results of the Tender Offer, sell any shares of Common Stock; and (3) use commercially reasonable efforts to ensure that each of the conditions to closing of the Stock Purchase Agreement is satisfied. Pursuant to the Stock Purchase Agreement, the Issuer agreed not to reduce the Price Range or the Total Consideration in the Tender Offer without the prior written consent of the Seller Affiliates.

     

     

     

     

    The Issuer or the Seller Affiliates may terminate the Stock Purchase Agreement if: (1) the Tender Offer is not commenced by May 27, 2024; (2) the Tender Offer is terminated without the purchase of any shares of Common Stock; or (3) if the Tender Offer is not consummated by August 12, 2024, provided that the Issuer may not terminate the Stock Purchase Agreement under clause (3) unless the Tender Offer is terminated. The transactions contemplated by the Stock Purchase Agreement are expected to close on the eleventh business day following the expiration date of the Tender Offer, or at such other later date as the Issuer and Seller Affiliates otherwise agree.

     

    The foregoing description of the Stock Purchase Agreement is qualified in its entirety by reference to the full text of the Stock Purchase Agreement, which is incorporated by reference as Exhibit 99.1 and is incorporated herein by reference.

     

    The Funds hold securities of the Issuer for investment purposes. Subject to the terms of the Stock Purchase Agreement, the Reporting Persons or their affiliates may purchase additional securities of the Issuer or dispose of securities in varying amounts and at varying times depending upon the Reporting Persons’ continuing assessments of pertinent factors, including the availability of shares of Common Stock or other securities for purchase at particular price levels, the business prospects of the Issuer, other business investment opportunities, economic conditions, stock market conditions, money market conditions, the attitudes and actions of the Board and management of the Issuer, the availability and nature of opportunities to dispose of securities of the Issuer and other plans and requirements of the particular persons. The Reporting Persons may discuss items of mutual interest with the Issuer’s management, other members of the Board and other investors, which could include items in subparagraphs (a) through (j) of Item 4 Schedule 13D.

     

    Depending upon their assessments of the above factors, the Reporting Persons or their affiliates may change their present intentions as stated above and they may make suggestions to the management of the Issuer regarding financing, and, subject to the terms of the Stock Purchase Agreement, may acquire additional securities of the Issuer, including shares of Common Stock (by means of open market purchases, privately negotiated purchases, exercise of some or all of the Stock Options (as defined in Item 5), vesting of restricted stock units (each, an “RSU”) or otherwise) or may dispose of some or all of the securities of the Issuer, including shares of Common Stock, under their control.

     

    Except as otherwise disclosed herein, at the present time, the Reporting Persons do not have any plans or proposals with respect to any extraordinary corporate transaction involving the Issuer including, without limitation, those matters described in subparagraphs (a) through (j) of Item 4 of Schedule 13D.

      

    Item 5. Interest in Securities of the Issuer.

     

    Item 5 of this Amendment No. 30 is amended and restated as follows:

     

    (a) and (b) Items 7 through 11 and 13 of each of the cover pages of this Amendment No. 30 are incorporated herein by reference. Set forth below is the aggregate number of shares of Common Stock directly held by each of the Funds and the percentage of the Issuer’s outstanding shares of Common Stock such holdings represent. The information set forth below is based on 224,854,553 shares of Common Stock outstanding as of May 9, 2024, as reported in Exhibit 10.1 to the Issuer’s Form 8-K filed with the Securities and Exchange Commission on May 13, 2024. Such percentage figures are calculated in accordance with Rule 13d-3 under the Securities Exchange Act of 1934, as amended.

     

    Holder  Shares of Common Stock   Percent of Class Outstanding 
    667, L.P.   2,734,189    1.2%
    Baker Brothers Life Sciences, L.P.   33,212,097    14.8%
    Total   35,946,286    16.0%

     

    The Adviser GP, Felix J. Baker and Julian C. Baker as managing members of the Adviser GP, and the Adviser may be deemed to be beneficial owners of securities of the Issuer directly held by the Funds.

     

     

     

     

    Julian C. Baker and Felix J. Baker are also the sole managers of FBB2 and FBB3 and by policy they do not transact in or vote the securities of the Issuer held by FBB2 and FBB3.

     

    Julian C. Baker and Felix J. Baker are also the sole partners of FBB and as such may be deemed to be beneficial owners of securities owned by FBB and may be deemed to have the power to vote or direct the vote and dispose or direct the disposition of those securities.

     

    In connection with his service on the Issuer’s Board, Julian C. Baker holds options to purchase Common Stock of the Issuer (“Stock Options”), RSUs, Common Stock and Common Stock received from the exercise of Stock Options as disclosed in previous amendments to this Schedule 13D.

     

    Julian C. Baker serves on the Board as a representative of the Funds. The policy of the Funds and the Adviser does not permit managing members of the Adviser GP or full-time employees of the Adviser to receive compensation for serving as a director of the Issuer. Therefore, Julian C. Baker has no pecuniary interest in the Stock Options, Common Stock, RSUs or Common Stock received from the exercise of Stock Options or vesting of RSUs received as directors’ compensation. The Funds are instead entitled to the pecuniary interest in the Stock Options, Common Stock, RSUs and Common Stock received from the exercise of Stock Options and vesting of RSUs received as directors’ compensation.

     

    The Adviser has voting and investment power over the Stock Options, RSUs, Common Stock and Common Stock underlying such Stock Options and Common Stock received from the exercise of Stock Options by Julian C. Baker received as directors’ compensation. The Adviser GP, and Felix J. Baker and Julian C. Baker as managing members of the Adviser GP, may be deemed to have the power to vote or direct the vote of and the power to dispose or direct the disposition of the Stock Options, RSUs, Common Stock, Common Stock received from the exercise of Stock Options and Common Stock underlying such Stock Options held by Julian C. Baker received as director’s compensation.

     

    (c) Except as disclosed herein or in any previous amendments to this Schedule 13D, none of the Reporting Persons or their affiliates has effected any other transactions in securities of the Issuer during the past 60 days.

     

    (d) Certain securities of the Issuer are held directly by 667, a limited partnership the sole general partner of which is Baker Biotech Capital, L.P., a limited partnership the sole general partner of which is Baker Biotech Capital (GP), LLC. Julian C. Baker and Felix J. Baker are the controlling members of Baker Biotech Capital (GP), LLC.

     

    Certain securities of the Issuer are held directly by Life Sciences, a limited partnership the sole general partner of which is Baker Brothers Life Sciences Capital, L.P., a limited partnership the sole general partner of which is Baker Brothers Life Sciences Capital (GP), LLC. Julian C. Baker and Felix J. Baker are the controlling members of Baker Brothers Life Sciences Capital (GP), LLC.

     

    (e) Not applicable.

     

    Item 6. Contracts, Arrangements, Understandings or Relationships with Respect to the Securities of the Issuer.

     

    Item 6 of this Schedule 13D is hereby supplemented and amended, as the case may be, as follows:

     

    The disclosure in Item 4 is incorporated by reference herein.

     

     

     

     

    The Stock Purchase Agreement is incorporated by reference as Exhibit 99.1 and is incorporated by reference herein.

     

    Item 7. Material to be Filed as Exhibits.

     

    Exhibit  Description
    99.1  Stock Purchase Agreement, dated May 12, 2024, by and among Incyte Corporation, Baker Brothers Life Sciences, L.P., 667, L.P., Felix J. Baker, Julian C. Baker, FBB2, LLC, FBB 3 LLC, and FBB Associates (incorporated by reference to Exhibit 10.1 to the Issuer’s Current Report on Form 8-K, filed with the SEC on May 13, 2024).

     

     

     

       

    SIGNATURE

     

    After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

     

    May 13, 2024

     

     

    BAKER BROS. ADVISORS LP

     

    By: Baker Bros. Advisors (GP) LLC, its general partner

         
      By: /s/ Scott L. Lessing
        Name: Scott L. Lessing
    Title: President

     

      BAKER BROS. ADVISORS (GP) LLC
         
      By: /s/ Scott L. Lessing
        Name: Scott L. Lessing
    Title: President

     

      /s/ Julian C. Baker
      Julian C. Baker
       
      /s/ Felix J. Baker
      Felix J. Baker

     

      FBB Associates
         
      By: /s/ Julian C. Baker
        Name: Julian C. Baker
    Title: Partner

     

      FBB2, LLC
         
      By: /s/ Julian C. Baker
        Name: Julian C. Baker
    Title: Manager

     

      FBB3 LLC
         
      By: /s/ Julian C. Baker
        Name: Julian C. Baker
    Title: Manager

     

     

     

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    Recent Analyst Ratings for
    $INCY

    DatePrice TargetRatingAnalyst
    8/6/2025$89.00Equal Weight → Overweight
    Wells Fargo
    8/1/2025$90.00Overweight
    Barclays
    6/16/2025$107.00Hold → Buy
    Stifel
    3/18/2025Buy → Neutral
    Guggenheim
    3/18/2025Outperform → Mkt Perform
    William Blair
    12/17/2024$77.00Neutral
    UBS
    10/29/2024$68.00 → $90.00Neutral → Buy
    BofA Securities
    10/1/2024$84.00Outperform
    Wolfe Research
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    $INCY
    Press Releases

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    Incyte to Present at Upcoming Investor Conferences

    Incyte (NASDAQ:INCY) announced today that it will present at the following investor conferences during the month of September: Cantor Global Healthcare Conference on Wednesday, September 3, 2025 at 8:00 am (EDT) Well Fargo Healthcare Conference on Thursday, September 4, 2025 at 8:45 am (EDT) Morgan Stanley 23rd Annual Global Healthcare Conference on Tuesday, September 9, 2025 at 10:00 am (EDT) The presentations will be webcast live and can be accessed at Investor.Incyte.com and will be available for replay for 30 days. About Incyte A global biopharmaceutical company on a mission to Solve On., Incyte follows the science to find solutions for patients with unmet medical needs.

    8/19/25 8:00:00 AM ET
    $INCY
    Biotechnology: Commercial Physical & Biological Resarch
    Health Care

    Incyte Announces Departure of Chief Financial Officer Christiana Stamoulis

    - Company initiates search for successor and reaffirms full year financial guidance Incyte (NASDAQ:INCY) today announced that Christiana Stamoulis will step down from her role as Executive Vice President and Chief Financial Officer (CFO) to pursue another opportunity, effective September 16, 2025. Ms. Stamoulis will remain with the Company until then to support a smooth transition. The Company has initiated the process of appointing a successor. "Since joining Incyte in 2019, Christiana has been an invaluable part of the leadership team. I would like to take this opportunity to thank Christiana for her many contributions, and wish her well in her future endeavors," said Bill Meury, Pres

    8/5/25 4:05:00 PM ET
    $INCY
    Biotechnology: Commercial Physical & Biological Resarch
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    Knight Therapeutics and Incyte Amend Supply and Distribution Agreement to Add Retifanlimab and Axatilimab in Latin America

    MONTREAL, Aug. 04, 2025 (GLOBE NEWSWIRE) -- Knight Therapeutics Inc., (TSX:GUD) ("Knight") a pan-American (ex-USA) specialty pharmaceutical company, announced today that it has expanded its existing relationship and amended its agreement with Incyte Biosciences International Sàrl, the Swiss-based affiliate of Incyte (NASDAQ:INCY), for the exclusive rights to distribute retifanlimab (sold as ZYNYZ® in the United States and Europe) and axatilimab (sold as NIKTIMVO™ in the United States) in Latin America. Under the terms of the amended agreement Incyte will be responsible for the development, manufacture and supply to Knight of retifanlimab and axatilimab, and Knight will be responsible for

    8/4/25 4:30:00 PM ET
    $INCY
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    $INCY
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    Incyte upgraded by Wells Fargo with a new price target

    Wells Fargo upgraded Incyte from Equal Weight to Overweight and set a new price target of $89.00

    8/6/25 7:56:54 AM ET
    $INCY
    Biotechnology: Commercial Physical & Biological Resarch
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    Barclays initiated coverage on Incyte with a new price target

    Barclays initiated coverage of Incyte with a rating of Overweight and set a new price target of $90.00

    8/1/25 8:13:12 AM ET
    $INCY
    Biotechnology: Commercial Physical & Biological Resarch
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    Incyte upgraded by Stifel with a new price target

    Stifel upgraded Incyte from Hold to Buy and set a new price target of $107.00

    6/16/25 7:42:04 AM ET
    $INCY
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    FDA Approval for JAKAFI issued to INCYTE CORP

    Submission status for INCYTE CORP's drug JAKAFI (SUPPL-25) with active ingredient RUXOLITINIB PHOSPHATE has changed to 'Approval' on 09/27/2021. Application Category: NDA, Application Number: 202192, Application Classification: Labeling

    9/28/21 5:20:01 AM ET
    $INCY
    Biotechnology: Commercial Physical & Biological Resarch
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    FDA Approval for JAKAFI issued to INCYTE CORP

    Submission status for INCYTE CORP's drug JAKAFI (SUPPL-23) with active ingredient RUXOLITINIB PHOSPHATE has changed to 'Approval' on 09/22/2021. Application Category: NDA, Application Number: 202192, Application Classification: Efficacy

    9/23/21 5:11:12 AM ET
    $INCY
    Biotechnology: Commercial Physical & Biological Resarch
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    FDA Approval for OPZELURA issued to INCYTE CORP

    Submission status for INCYTE CORP's drug OPZELURA (ORIG-1) with active ingredient RUXOLITINIB has changed to 'Approval' on 09/21/2021. Application Category: NDA, Application Number: 215309, Application Classification: Type 10 - New Indication Submitted as Distinct NDA - Not Consolidated

    9/22/21 11:16:23 AM ET
    $INCY
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    EVP & General Counsel Denton Sheila A. exercised 598 shares at a strike of $58.06 and sold $45,310 worth of shares (598 units at $75.77) (SEC Form 4)

    4 - INCYTE CORP (0000879169) (Issuer)

    8/6/25 4:03:10 PM ET
    $INCY
    Biotechnology: Commercial Physical & Biological Resarch
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    New insider Mayes Patrick A claimed ownership of 67,388 shares (SEC Form 3)

    3 - INCYTE CORP (0000879169) (Issuer)

    8/5/25 4:03:49 PM ET
    $INCY
    Biotechnology: Commercial Physical & Biological Resarch
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    EVP & Chief Medical Officer Stein Steven H sold $251,786 worth of shares (3,706 units at $67.94), decreasing direct ownership by 3% to 102,886 units (SEC Form 4)

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    7/23/25 3:56:25 PM ET
    $INCY
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    SEC Form 144 filed by Incyte Corp.

    144 - INCYTE CORP (0000879169) (Subject)

    8/12/25 4:21:26 PM ET
    $INCY
    Biotechnology: Commercial Physical & Biological Resarch
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    Incyte Corp. filed SEC Form 8-K: Leadership Update

    8-K - INCYTE CORP (0000879169) (Filer)

    8/7/25 9:08:14 AM ET
    $INCY
    Biotechnology: Commercial Physical & Biological Resarch
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    SEC Form 10-Q filed by Incyte Corp.

    10-Q - INCYTE CORP (0000879169) (Filer)

    7/29/25 4:01:59 PM ET
    $INCY
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    SEC Form SC 13G filed by Incyte Corp.

    SC 13G - INCYTE CORP (0000879169) (Subject)

    10/17/24 9:39:00 AM ET
    $INCY
    Biotechnology: Commercial Physical & Biological Resarch
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    Amendment: SEC Form SC 13D/A filed by Incyte Corp.

    SC 13D/A - INCYTE CORP (0000879169) (Subject)

    6/14/24 6:23:05 PM ET
    $INCY
    Biotechnology: Commercial Physical & Biological Resarch
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    SEC Form SC 13D/A filed by Incyte Corp. (Amendment)

    SC 13D/A - INCYTE CORP (0000879169) (Subject)

    5/13/24 6:06:33 PM ET
    $INCY
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    Incyte Appoints Bill Meury Chief Executive Officer; Hervé Hoppenot to Retire

    - Three-decade industry leader, former CEO of Karuna and Anthos and Chief Commercial Officer of Allergan, Bill Meury, joins Incyte as President and CEO - Hervé Hoppenot to retire after 11 years of leading Incyte through major expansion - Julian Baker elected Chairman of the Board of Directors Incyte (NASDAQ:INCY) today announced that the Company's Board of Directors has unanimously appointed Bill Meury as President and Chief Executive Officer (CEO) and a member of the Company's Board of Directors, effective immediately. Bill Meury succeeds Hervé Hoppenot who will retire from the Company after 11 years of service. Mr. Hoppenot will serve as an advisor to the CEO and will remain as a

    6/26/25 7:30:00 AM ET
    $INCY
    Biotechnology: Commercial Physical & Biological Resarch
    Health Care

    Galapagos appoints Dr. Susanne Schaffert as non-executive independent Director to its Board

    Mechelen, Belgium; 12 June 2023, 22:01 CET; Galapagos NV ((Euronext &, NASDAQ:GLPG) today announced that during its meeting of 12 June 2023, the Board of Directors co-opted Dr. Susanne Schaffert as non-executive independent Director. Dr. Schaffert replaces Dr. Rajesh Parekh who stepped down on 10 June 2023. After an extraordinary 27-year career at Novartis in various global roles, including commercialization, market access, investor relations, business development & licensing, acquisitions and company integration, Dr. Schaffert retired in 2022 as President of Novartis Oncology and Member of the Novartis Executive Committee. In that role, Dr. Schaffert ran a global $15 billion business acr

    6/12/23 4:01:00 PM ET
    $GLPG
    $INCY
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    Incyte Names New Member to Its Board of Directors

    Incyte (NASDAQ:INCY) announces the appointment of Susanne Schaffert, Ph.D., as a new member of its Board of Directors. "On behalf of the Incyte Board of Directors, I am happy to welcome Susanne. Her extensive commercial, development and industry experience will greatly complement our Board and we look forward to Susanne's contributions to our continued growth and future success," said Hervé Hoppenot, Chief Executive Officer, Incyte. "I am very excited for the opportunity to join the Incyte Board of Directors and helping the organization in its commitment to leading scientific innovation and developing new medicines for patients in need. I look forward to being part of this dynamic Company

    10/4/22 8:00:00 AM ET
    $INCY
    Biotechnology: Commercial Physical & Biological Resarch
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    $INCY
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    Incyte Reports 2025 Second Quarter Financial Results and Provides Updates on Key Clinical Programs

    – Total revenues of $1,216 million in the second quarter (Q2'25) (+16% Y/Y); total product revenues of $1,059 million in Q2'25 (+17%Y/Y) – Jakafi® (ruxolitinib) net product revenues of $764 million in Q2'25 (+8% Y/Y); raising full year 2025 guidance to a new range of $3,000 - $3,050 million [previously $2,950 - $3,000 million] – Opzelura® (ruxolitinib) cream net product revenues of $164 million in Q2'25 (+35% Y/Y) – Niktimvo™ (axatilimab-csfr) net product revenues of $36 million in the second quarter, demonstrating strong commercial execution; raising full year 2025 Other Oncology guidance to a new range of $500 - $520 million [previously $415 - $455 million] – Zynyz® (retifanlimab-

    7/29/25 7:00:00 AM ET
    $INCY
    Biotechnology: Commercial Physical & Biological Resarch
    Health Care

    Incyte to Report Second Quarter Financial Results

    Incyte (NASDAQ:INCY) announced today that it has scheduled its second quarter financial results conference call and webcast for 8:00 a.m. ET on Tuesday, July 29, 2025. The schedule for the press release and conference call/webcast is as follows: Q2 2025 Press Release: July 29, 2025 at 7:00 a.m. ET Q2 2025 Conference Call: July 29, 2025 at 8:00 a.m. ET Domestic Dial-In Number: 877-407-3042 International Dial-In Number: 201-389-0864 Conference ID Number: 13754581 If you are unable to participate, a replay of the conference call will be available for thirty days. The replay dial-in number for the U.S. is 877-660-6853 and the dial-in number for international callers is 201-6

    7/10/25 8:00:00 AM ET
    $INCY
    Biotechnology: Commercial Physical & Biological Resarch
    Health Care

    Positive Late-Breaking Data for Incyte's First-in-Class mutCALR-targeted therapy INCA033989 in Essential Thrombocythemia Presented at EHA2025

    Data demonstrates the potential for INCA033989 to modify disease by directly inhibiting and eliminating oncogenic mutCALR cells, while sparing healthy cells and restoring normal blood cell production In high-risk patients with essential thrombocythemia (ET) with a CALR mutation (mutCALR), 86% of INCA033989-treated patients at doses 400 mg and above achieved a complete or partial hematologic response with the majority (82%) realizing a complete response A reduction in peripheral blood mutCALR variant allele frequency (VAF) was observed in 89% of evaluable patients correlating with hematologic response Initial results demonstrate a favorable safety profile – no dose limiting toxicit

    6/15/25 3:15:00 AM ET
    $INCY
    Biotechnology: Commercial Physical & Biological Resarch
    Health Care