SC 13G 1 d9763989_13g.htm

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

WASHINGTON, DC 20549

SCHEDULE 13G

Under the Securities Exchange Act of 1934

(Amendment No.)*

Syros Pharmaceuticals, Inc.

(Name of Issuer)

Common Stock, $0.001 par value

(Title of Class of Securities)

87184Q206

(CUSIP Number)

September 16, 2022

(Date of Event Which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

[_] Rule 13d-1(b)

[X] Rule 13d-1(c)

[_] Rule 13d-1(d)

__________

*The remainder of this cover page shall be filled out for a reporting person's initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter the disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed to be "filed" for the purpose of Section 18 of the Securities Exchange Act of 1934 ("Act") or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).

CUSIP No.

87184Q206

1.	NAME OF REPORTING PERSONS
	I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

	Avidity Partners Management LP

2.	CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS)
		(a) [_]
		(b) [X]

3.	SEC USE ONLY



4.	CITIZENSHIP OR PLACE OF ORGANIZATION

	Delaware

NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH

5.	SOLE VOTING POWER

	0

6.	SHARED VOTING POWER

	2,120,000

7.	SOLE DISPOSITIVE POWER

	0

8.	SHARED DISPOSITIVE POWER

	2,120,000

9.	AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

	2,120,000

10.	CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS)
		[_]


11.	PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

	9.9%¹

12.	TYPE OF REPORTING PERSON (SEE INSTRUCTIONS) IA, PN

________________

¹ The percentage of ownership based on approximately 20.3 million shares of Common Stock of the Company outstanding as of September 16, 2022, as reported on the Issuer’s press release on September 16, 2022, located at: https://ir.syros.com/press-releases/detail/260/syros-announces-closing-of-merger-with-tyme-technologies.

CUSIP No.

87184Q206

1.	NAME OF REPORTING PERSONS
	I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

	Avidity Partners Management (GP) LLC

2.	CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS)
		(a) [_]
		(b) [X]

3.	SEC USE ONLY


4.	CITIZENSHIP OR PLACE OF ORGANIZATION

	Delaware

NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH

5.	SOLE VOTING POWER

	0

6.	SHARED VOTING POWER

	2,120,000

7.	SOLE DISPOSITIVE POWER

	0

8.	SHARED DISPOSITIVE POWER

	2,120,000

9.	AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

	2,120,000

10.	CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS)
		[_]


11.	PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

	9.9%²

12.	TYPE OF REPORTING PERSON (SEE INSTRUCTIONS) OO

________________

² The percentage of ownership based on approximately 20.3 million shares of Common Stock of the Company outstanding as of September 16, 2022, as reported on the Issuer’s press release on September 16, 2022, located at: https://ir.syros.com/press-releases/detail/260/syros-announces-closing-of-merger-with-tyme-technologies.

CUSIP No.

87184Q206

1.	NAME OF REPORTING PERSONS
	I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

	Avidity Capital Partners Fund (GP) LP

2.	CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS)
		(a) [_]
		(b) [X]

3.	SEC USE ONLY


4.	CITIZENSHIP OR PLACE OF ORGANIZATION

	Delaware

NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH

5.	SOLE VOTING POWER

	0

6.	SHARED VOTING POWER

	2,120,000

7.	SOLE DISPOSITIVE POWER

	0

8.	SHARED DISPOSITIVE POWER

	2,120,000

9.	AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

	2,120,000

10.	CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS)
		[_]


11.	PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

	9.9%³

12.	TYPE OF REPORTING PERSON (SEE INSTRUCTIONS) OO, PN

________________

³ The percentage of ownership based on approximately 20.3 million shares of Common Stock of the Company outstanding as of September 16, 2022, as reported on the Issuer’s press release on September 16, 2022, located at: https://ir.syros.com/press-releases/detail/260/syros-announces-closing-of-merger-with-tyme-technologies.

CUSIP No.

87184Q206

1.	NAME OF REPORTING PERSONS
	I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

	Avidity Capital Partners (GP) LLC

2.	CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS)
		(a) [_]
		(b) [X]

3.	SEC USE ONLY


4.	CITIZENSHIP OR PLACE OF ORGANIZATION

	Delaware

NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH

5.	SOLE VOTING POWER

	0

6.	SHARED VOTING POWER

	2,120,000

7.	SOLE DISPOSITIVE POWER

	0

8.	SHARED DISPOSITIVE POWER

	2,120,000

9.	AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

	2,120,000

10.	CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS)
		[_]


11.	PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

	9.9%⁴

12.	TYPE OF REPORTING PERSON (SEE INSTRUCTIONS) OO

________________

⁴ The percentage of ownership based on approximately 20.3 million shares of Common Stock of the Company outstanding as of September 16, 2022, as reported on the Issuer’s press release on September 16, 2022, located at: https://ir.syros.com/press-releases/detail/260/syros-announces-closing-of-merger-with-tyme-technologies.

CUSIP No.

87184Q206

1.	NAME OF REPORTING PERSONS
	I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

	Avidity Private Master Fund I LP

2.	CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS)
		(a) [_]
		(b) [X]

3.	SEC USE ONLY


4.	CITIZENSHIP OR PLACE OF ORGANIZATION

	Cayman Islands

NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH

5.	SOLE VOTING POWER

	0

6.	SHARED VOTING POWER

	1,169,610

7.	SOLE DISPOSITIVE POWER

	0

8.	SHARED DISPOSITIVE POWER

	1,169,610

9.	AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

	1,169,610

10.	CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS)
		[_]


11.	PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

	5.6%⁵

12.	TYPE OF REPORTING PERSON (SEE INSTRUCTIONS) OO, PN

________________

⁵ The percentage of ownership based on approximately 20.3 million shares of Common Stock of the Company outstanding as of September 16, 2022, as reported on the Issuer’s press release on September 16, 2022, located at: https://ir.syros.com/press-releases/detail/260/syros-announces-closing-of-merger-with-tyme-technologies.

CUSIP No.

87184Q206

1.	NAME OF REPORTING PERSONS
	I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

	David Witzke

2.	CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS)
		(a) [_]
		(b) [X]

3.	SEC USE ONLY



4.	CITIZENSHIP OR PLACE OF ORGANIZATION

	United States of America

NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH

5.	SOLE VOTING POWER

	0

6.	SHARED VOTING POWER

	2,120,000

7.	SOLE DISPOSITIVE POWER

	0

8.	SHARED DISPOSITIVE POWER

	2,120,000

9.	AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

	2,120,000

10.	CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS)
		[_]


11.	PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

	9.9%⁶

12.	TYPE OF REPORTING PERSON (SEE INSTRUCTIONS) IN

________________

⁶ The percentage of ownership based on approximately 20.3 million shares of Common Stock of the Company outstanding as of September 16, 2022, as reported on the Issuer’s press release on September 16, 2022, located at: https://ir.syros.com/press-releases/detail/260/syros-announces-closing-of-merger-with-tyme-technologies.

CUSIP No.

87184Q206

1.	NAME OF REPORTING PERSONS
	I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

	Michael Gregory

2.	CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS)
		(a) [_]
		(b) [X]

3.	SEC USE ONLY



4.	CITIZENSHIP OR PLACE OF ORGANIZATION

	United States of America

NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH

5.	SOLE VOTING POWER

	0

6.	SHARED VOTING POWER

	2,120,000

7.	SOLE DISPOSITIVE POWER

	0

8.	SHARED DISPOSITIVE POWER

	2,120,000

9.	AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

	2,120,000

10.	CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS)
		[_]


11.	PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

	9.9%⁷

12.	TYPE OF REPORTING PERSON (SEE INSTRUCTIONS) IN

________________

⁷ The percentage of ownership based on approximately 20.3 million shares of Common Stock of the Company outstanding as of September 16, 2022, as reported on the Issuer’s press release on September 16, 2022, located at: https://ir.syros.com/press-releases/detail/260/syros-announces-closing-of-merger-with-tyme-technologies.

Item 1.	(a).	Name of Issuer:

		Syros Pharmaceuticals, Inc.

(b).

Address of issuer's principal executive offices:

35 CambridgePark Drive, 4^th Floor

Cambridge, Massachusetts 02140

United States of America

Item 2.

(a).

Name of person filing:

Avidity Partners Management LP

Avidity Partners Management (GP) LLC

Avidity Capital Partners Fund (GP) LP

Avidity Capital Partners (GP) LLC

Avidity Private Master Fund I LP

David Witzke

Michael Gregory

(b).

Address or principal business office or, if none, residence:

Avidity Partners Management LP

SEC Form SC 13G filed by Syros Pharmaceuticals Inc.