SC 13G/A 1 b021221a.htm SCHEDULE 13G (AMENDMENT #1)

240.13d-102 Schedule 13G - Information to be included in statements filed

pursuant to 240.13d-1(b), (c), and (d) and amendments thereto

filed pursuant to 240.13d-2.

Securities and Exchange Commission, Washington, D.C. 20549

Schedule 13G

Under the Securities Exchange Act of 1934

(Amendment No. 1)*

(Name of Issuer)

Bicycle Therapeutics plc.

(Title of Class of Securities)

Ordinary shares, nominal value £0.01 per share¹

(CUSIP Number)

088786108²

(Date of Event Which Requires Filing of this Statement)

December 31, 2020

Check the appropriate box to designate the rule pursuant to which this

Schedule is filed:

[ ] Rule 13d-1(b)

[ x ] Rule 13d-1(c)

[ ] Rule 13d-1(d)

*The remainder of this cover page shall be filled out for a reporting person's
initial filing on this form with respect to the subject class of securities, and
for any subsequent amendment containing information which would alter the
disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be
deemed to be “filed” for the purpose of Section 18 of the Securities Exchange
Act of 1934 (“Act”) or otherwise subject to the liabilities of that section of the Act
but shall be subject to all other provisions of the Act (however, see the Notes).

¹ The holdings reported herein are held in the form of American Depositary Shares
("ADS"), which each represent one ordinary share, nominal value £0.01 per share of
the Issuer (“Ordinary Shares”).

² The CUSIP Number listed throughout this filing is the CUSIP assigned to the ADS
of the Issuer.

CUSIP No. 088786108
(1) Names of reporting persons Point72 Asset Management, L.P.
(2) Check the appropriate box if a member of a group	(a)
(see instructions)	(b)X
(3) SEC use only
(4) Citizenship or place of organization Delaware
Number of shares beneficially owned by each reporting person with:
(5) Sole voting power 0
(6) Shared voting power 1,437,576* (see Item 4)
(7) Sole dispositive power 0
(8) Shared dispositive power 1,437,576* (see Item 4)
(9) Aggregate amount beneficially owned by each reporting person 1,437,576* (see Item 4)
(10) Check if the aggregate amount in Row (9) excludes certain shares (see instructions)
(11) Percent of class represented by amount in Row (9) 6.7% (see Item 4)
(12) Type of reporting person (see instructions) PN

*Consists of 1,437,576 American Depositary Shares, representing 1,437,576 Ordinary Shares.

CUSIP No. 088786108
(1) Names of reporting persons Point72 Capital Advisors, Inc.
(2) Check the appropriate box if a member of a group	(a)
(see instructions)	(b)X
(3) SEC use only
(4) Citizenship or place of organization Delaware
Number of shares beneficially owned by each reporting person with:
(5) Sole voting power 0
(6) Shared voting power 1,437,576* (see Item 4)
(7) Sole dispositive power 0
(8) Shared dispositive power 1,437,576* (see Item 4)
(9) Aggregate amount beneficially owned by each reporting person 1,437,576* (see Item 4)
(10) Check if the aggregate amount in Row (9) excludes certain shares (see instructions)
(11) Percent of class represented by amount in Row (9) 6.7% (see Item 4)
(12) Type of reporting person (see instructions) CO

*Consists of 1,437,576 American Depositary Shares, representing 1,437,576 Ordinary Shares

CUSIP No. 088786108
(1) Names of reporting persons Steven A. Cohen
(2) Check the appropriate box if a member of a group	(a)
(see instructions)	(b)X
(3) SEC use only
(4) Citizenship or place of organization United States
Number of shares beneficially owned by each reporting person with:
(5) Sole voting power 0
(6) Shared voting power 1,437,576* (see Item 4)
(7) Sole dispositive power 0
(8) Shared dispositive power 1,437,576* (see Item 4)
(9) Aggregate amount beneficially owned by each reporting person 1,437,576* (see Item 4)
(10) Check if the aggregate amount in Row (9) excludes certain shares (see instructions)
(11) Percent of class represented by amount in Row (9) 6.7% (see Item 4)
(12) Type of reporting person (see instructions) IN

*Consists of 1,437,576 American Depositary Shares, representing 1,437,576 Ordinary Shares.

Item 1(a) Name of issuer:

Bicycle Therapeutics plc

Item 1(b) Address of issuer's principal executive offices:

B900, Babraham Research Campus, Cambridge, United Kingdom CB22 3AT

2(a) Name of person filing:

The holdings of the Issuer’s ordinary shares, nominal value £0.01 per share (“Ordinary Shares”)
reported herein are held in the form of American Depositary Shares (“ADS”), which each
represent one Ordinary Share. This statement is filed by: (i) Point72 Asset Management, L.P.
(“Point72 Asset Management”) with respect to Ordinary Shares held, in the form of ADSs, by
certain investment funds it manages; (ii) Point72 Capital Advisors, Inc. (“Point72 Capital
Advisors Inc.”) with respect to Ordinary Shares held, in the form of ADSs, by certain investment
funds managed by Point72 Asset Management; and (iii) Steven A. Cohen (“Mr. Cohen”) with
respect to Ordinary Shares held, in the form of ADSs, beneficially owned by Point72 Asset
Management and Point72 Capital Advisors Inc.

2(b) Address or principal business office or, if none, residence:

The address of the principal business office of Point72 Asset Management,
Point72 Capital Advisors Inc., and Mr. Cohen is 72 Cummings Point Road,
Stamford, CT 06902.

2(c) Citizenship:

Point72 Asset Management is a Delaware limited partnership. Point72 Capital Advisors Inc. is a
Delaware corporation. Mr. Cohen is a United States citizen.

2(d) Title of class of securities:

Ordinary Shares, nominal value £0.01 per share.

2(e) CUSIP Number:

088786108

Item 3.

Not applicable

Item 4. Ownership

As of the close of business on December 31, 2020:

1. Point72 Asset Management, L.P.

(a) Amount beneficially owned: 1,437,576

(b) Percent of class: 6.7%

(i) Sole power to vote or to direct the vote: 0

(ii) Shared power to vote or to direct the vote: 1,437,576

(iii) Sole power to dispose or to direct the disposition of: 0

(iv) Shared power to dispose or to direct the disposition of: 1,437,576

2. Point72 Capital Advisors, Inc.

(a) Amount beneficially owned: 1,437,576

(b) Percent of class: 6.7%

(i) Sole power to vote or to direct the vote: 0

(ii) Shared power to vote or to direct the vote: 1,437,576

(iii) Sole power to dispose or to direct the disposition of: 0

(iv) Shared power to dispose or to direct the disposition of: 1,437,576

3. Steven A. Cohen

(a) Amount beneficially owned: 1,437,576

(b) Percent of class: 6.7%

(i) Sole power to vote or to direct the vote: 0

(ii) Shared power to vote or to direct the vote: 1,437,576

(iii) Sole power to dispose or to direct the disposition of: 0

(iv) Shared power to dispose or to direct the disposition of: 1,437,576

Point72 Asset Management, Point72 Capital Advisors Inc., and Mr. Cohen own
directly no ADSs or Ordinary Shares. Pursuant to an investment management agreement,
Point72 Asset Management maintains investment and voting power with respect to the
securities held by certain investment funds it manages. Point72 Capital Advisors Inc. is the
general partner of Point72 Asset Management. Mr. Cohen controls each of Point72 Asset
Management and Point72 Capital Advisors Inc. As of December 31, 2020, by reason of the
provisions of Rule 13d-3 of the Securities Exchange Act of 1934, as amended, each of Point72
Asset Management, Point72 Capital Advisors Inc. and Mr. Cohen may be deemed to beneficially
own 1,437,576 Ordinary Shares (constituting approximately 6.7% of the Ordinary Shares
outstanding). Each of Point72 Asset Management, Point72 Capital Advisors Inc., and Mr. Cohen
disclaims beneficial ownership of any of the securities covered by this statement.

Item 5. Ownership of 5 Percent or Less of a Class.

If this statement is being filed to report the fact that as of the date hereof

the reporting person has ceased to be the beneficial owner of more than

5 percent of the class of securities, check the following [].

Item 6. Ownership of More than 5 Percent on Behalf of Another Person.

Not applicable

Item 7. Identification and Classification of the Subsidiary Which Acquired

the Security Being Reporting on by the Parent Holding Company or Control

Person.

Not applicable

Item 8. Identification and Classification of Members of the Group

Not applicable

Item 9. Notice of Dissolution of Group.

Not applicable

Item 10. Certifications

By signing below I certify that, to the best of my knowledge and belief,

the securities referred to above were not acquired and are not held for the purpose

of or with the effect of changing or influencing the control of the issuer of

the securities and were not acquired and are not held in connection with or

as a participant in any transaction having that purpose or effect, other than activities
solely in connection with a nomination under§ 240.14a-11.

Signature. After reasonable inquiry and to the best of my knowledge and belief,

I certify that the information set forth in this statement is true, complete

and correct.

Dated: February 16, 2021

POINT72 ASSET MANAGEMENT, L.P.

By: /s/ Jason M. Colombo

Name: Jason M. Colombo

Title: Authorized Person

POINT72 CAPITAL ADVISORS, INC.

By: /s/ Jason M. Colombo

Name: Jason M. Colombo

Title: Authorized Person

STEVEN A. COHEN

By: /s/ Jason M. Colombo

Name: Jason M. Colombo

Title: Authorized Person

SEC Form SC 13G/A filed