Trilivy™ is designed to address the challenges of metabolic dysfunction
Clients on Trilivy's Reset 5 & 1 Plan who work with a coach lose up to 10 times more weight and 17 times more fat compared to self-directed approaches*

Baltimore, MD, Sept. 29, 2026 (GLOBE NEWSWIRE) -- A weight loss plateau is one of the most common reasons people abandon a structured weight loss effort altogether. The body stops losing weight when metabolic dysfunction interferes with the fat-burning process, and without a framework built to identify what's happening beneath the surface, a stall can look like failure rather than a solvable metabolic pattern. Trilivy™, a science-backed, coach-guided comprehensive metabolic health system, points to five metabolic and behavioral factors behind why plateaus happen and why they tend to compound with each subsequent attempt.

"Body composition research points to a consistent pattern: when lean mass isn’t protected during weight loss, resting metabolic rate can be affected. Repeated cycles of weight loss may compound those changes, which is why body composition should be addressed from the first week," said Satya Jonnalagadda, PhD, MBA, RD, Vice President, Scientific & Clinical Affairs at Trilivy, who leads the company's scientific and clinical research strategy.

A Weight Loss Plateau Reflects a Metabolic Problem

Five reasons weight loss plateaus occur are highlighted below.

1. Lean Mass Is Lost Alongside Fat, Lowering the Metabolic Rate

When weight loss happens without a structured nutrition (protein) and lifestyle framework, the body breaks down lean tissue as well as fat to meet its energy needs. Lean mass, around 50% of which is muscle, makes up the body's non-fat composition and it is metabolically active. As it declines, so does resting metabolic rate, which is the number of calories the body burns at rest. Protecting lean mass prevents the metabolic rate suppression that makes later progress more challenging.

2. Visceral Fat Disrupts the Metabolic Environment

Visceral fat is a metabolically active tissue that releases inflammatory molecules and hormones affecting insulin sensitivity and energy regulation. As visceral fat accumulates, it changes the way the metabolism works, making the body progressively more insulin resistant and less efficient at burning fat for fuel. This determines whether the metabolic environment supports continued fat loss.

3. A Weight Loss Plateau in the First Four Weeks Predicts the Long-term Outcome

How a person responds in the first four weeks of a weight loss program is a strong predictor of the final outcome. A secondary data analysis found that what happens in the first four weeks of a weight loss program predicts the final outcome, and individuals who stall early need additional support rather than an entirely new protocol.¹ A plateau acts as a signal, and the presence of a coach can help catch this signal early on to redirect it.

4. No Accountability Layer Means No Behavioral Correction at the Plateau

Without a structured accountability layer, there is no mechanism to catch a stall early or correct course before it takes hold. The presence of one-on-one support gives an individual a way to identify the pattern behind a plateau and stay engaged through the period when adherence typically breaks down, rather than abandoning the effort altogether.

5. Body Composition Is the Signal That Matters During a Metabolic Reset

Body composition, specifically a reduction in visceral fat levels and lean mass retention, reflects what is biologically changing in the metabolic environment. Individuals may not see external progress even while visceral fat is actively being reduced, and without body composition data, that stall can read as failure.

How Trilivy's Metabolic Synchronization® Addresses Weight Loss Plateaus

Trilivy is built around Metabolic Synchronization®, a breakthrough science that reverses metabolic dysfunction through targeted metabolic reset.

Key Facts:

14% reduction in visceral fat and 98% of lean mass retained at 16 weeks among individuals on the Trilivy Reset 5 & 1 Plan*
Coach-supported participants lost up to 10 times more weight and 17 times more fat than those following the same plan without a coach*

The metabolic variables that drive a plateau, including visceral fat accumulation, lean mass loss, and suppressed resting metabolic rate, respond to structured intervention. A plan that measures and protects those variables creates the conditions for progress beyond the stall.

FAQs

Question: What does a metabolic reset involve in a weight loss program?

Answer: A metabolic reset targets the body composition variables that drive weight loss stalls, specifically visceral fat reduction and lean mass preservation. Programs built around this framework adjust resting metabolic rate by protecting lean tissue during the fat loss phase, rather than allowing muscle depletion to suppress metabolism further.

Question: What makes a weight loss program effective for someone who has already hit a plateau?

Answer: Plateau-specific effectiveness requires addressing the metabolic conditions that caused the stall. Tracking visceral fat and lean mass retention alongside body weight can identify whether metabolic progress is continuing even when external changes are difficult to see. But lasting progress also depends on the habits that support metabolic health: consistent nutrition, movement, sleep, and other healthy routines. Community and human connection can help reinforce those habits. Together, these factors can help inform the next intervention step.

Question: What does a weight loss program need to include to help someone keep weight off long-term?

Answer: Long-term weight management requires protecting lean mass during the weight loss phase, since lean tissue supports resting metabolic rate after the deficit ends. Look for programs that pair structured nutrition with one-on-one behavioral accountability since the behavioral layer addresses the adherence patterns that determine whether results last beyond the active program. A combination of nutrition, lifestyle and behavior modifications, and exercise can contribute to weight management.

Trilivy™ recommends that you contact your healthcare provider before starting and throughout your weight loss journey.

* Arterburn LM, et al. Randomized controlled trial assessing two commercial weight loss programs in adults with overweight or obesity. Obesity Science & Practice. 2019. https://onlinelibrary.wiley.com/doi/10.1002/osp4.312. In a clinical study, individuals on the Reset 5 & 1 Plan experienced a reduction of 14% visceral fat and 98% of lean mass was retained at 16 weeks. Those on the Reset 5 & 1 Plan with the support of a coach lost up to 10x more weight and 17x more fat than those who tried to lose weight on their own.

¹ Coleman CD, Guarneiri LL, Kiel JR, et al. Importance of early weight loss and other predictors of lower weight loss in a commercial program: a secondary data analysis. Obesity Science and Practice. 2024;10(1):e724. doi: 10.1002/osp4.724.

About Medifast and Trilivy

Medifast (NYSE:MED) is the health and wellness company known for its science-backed comprehensive metabolic health system, Trilivy. Designed to address the challenges of metabolic dysfunction, the company’s holistic approach integrates science-backed plans and products, personal 1:1 coaching, a supportive community, and behavioral science support to develop healthy habits.

Driven to improve metabolic health through advanced science and comprehensive behavioral support, Medifast has introduced Metabolic Synchronization®, a breakthrough science that targets metabolic dysfunction through a comprehensive system focused on fat loss, lean mass preservation, and long-term health. Trilivy's comprehensive three-phase metabolic health system is designed to help people reset their metabolism, refine their health, and renew their lives. By integrating science, coaching, and healthy habits into a single approach, Trilivy helps people look, feel, and live better.

Backed by more than 45 years of clinical heritage, Medifast continues to advance its mission of lifelong transformation through metabolic science and human connection™. For more information, visit trilivyhealth.com and medifastinc.com.

Sarah Evans, CEO
Zen Media
sarah@zenmedia.com