Pre-market movers - July 27, 2026

Here is how US equities are shaping up pre-market on July 27, 2026. The names below show the widest percentage moves against yesterday's close, giving a quick read on where retail and institutional attention is concentrating before the opening bell.

BIOTW leads pre-market gainers, climbing +720.55% to $0.06. STAK at +602.27% and LVWR at +89.61% round out the early movers. The remaining 7 names in the top 10 are up an average of 53.93% heading into the open.

VYNE Therapeutics Inc. (VYNE) leads pre-market losers, falling +98.90% to $0.51. SXTC at -80.82% and CISS at -45.94% round out the early movers. The remaining 7 names in the top 10 are down an average of 40.11% heading into the open.

Pre-market action does not always carry into the regular session - gaps often fade once liquidity returns - but outsized moves here frequently trace back to overnight filings, earnings, analyst actions, or macro headlines worth checking on each ticker's wire.