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UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

SCHEDULE 14A

PROXY STATEMENT PURSUANT TO SECTION 14(a) OF THE

SECURITIES EXCHANGE ACT OF 1934

Filed by the Registrant ☒
Filed by a party other than the Registrant ☐

Check the appropriate box:


☐	Preliminary Proxy Statement
☐	Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2))
☒	Definitive Proxy Statement
☐	Definitive Additional Materials
☐	Soliciting Material Pursuant to §240.14a-11(c) or §240.14a-2

ALX Oncology Holdings Inc.

(Name of Registrant as Specified In Its Charter)

Payment of Filing Fee (Check all boxes that apply):


☒	No fee required.
☐	Fee paid previously with preliminary materials.
☐	Fee computed on table in exhibit required by Item 25(b) per Exchange Act Rules 14a-6(i)(1) and 0-11

April 21, 2025

Dear Stockholder:

We are pleased to invite you to attend the 2025 Annual Meeting of Stockholders (the Annual Meeting) of ALX Oncology Holdings Inc. (ALX or the Company), which will be conducted via a live webcast on Wednesday, June 11, 2025 at 1:00 p.m. Pacific Time. The Annual Meeting will be held in a virtual format only. You will be able to attend the Annual Meeting by visiting www.virtualshareholdermeeting.com/ALXO2025, where you will be able to listen to the meeting live, submit questions and vote online by entering the control number located on your proxy card.

The attached Notice of Annual Meeting of Stockholders and Proxy Statement contain details of the business to be conducted at the Annual Meeting.

Whether or not you attend the virtual Annual Meeting, it is important that your shares be represented and voted at the meeting. Therefore, we urge you to promptly vote and submit your proxy via the Internet, by phone, or by signing, dating and returning the enclosed proxy card in the enclosed envelope. If you decide to attend the Annual Meeting, you will be able to change your vote or revoke your proxy, even if you have previously submitted your proxy.

On behalf of the Company’s Board of Directors, we would like to thank you for your continued support of and interest in ALX.

Sincerely,




Corey Goodman, Ph.D.		Jason Lettmann
Chairman of the Board of Directors		Chief Executive Officer and Director

ALX ONCOLOGY HOLDINGS INC.

323 Allerton Avenue

South San Francisco, California 94080

NOTICE OF ANNUAL MEETING OF STOCKHOLDERS


Time and Date	Wednesday, June 11, 2025 at 1:00 p.m. Pacific Time
Place	The Annual Meeting will be a completely virtual meeting of stockholders, to be conducted via a live webcast. You will be able to attend the Annual Meeting virtually, submit questions and vote online during the meeting by visiting www.virtualshareholdermeeting.com/ALXO2025.
Items of Business	• To elect two Class II directors to serve until the 2028 annual meeting of stockholders or until their successors are duly elected and qualified; • To conduct an advisory vote to approve the compensation of our named executive officers (NEOs); • To ratify the appointment of KPMG LLP as our independent registered public accounting firm for our fiscal year ending December 31, 2025; and • To transact such other business as may properly come before the Annual Meeting or any adjournments or postponements thereof.
Record Date	Tuesday, April 15, 2025 (the Record Date). Only stockholders of record at the close of business on the Record Date are entitled to receive notice of, and to vote at, the Annual Meeting.

YOUR VOTE IS IMPORTANT. Whether or not you plan to attend the Annual Meeting virtually, we urge you to submit your vote via the Internet, telephone or mail as soon as possible to ensure your shares are represented. For additional instructions for each of these voting options, please refer to the proxy card. Returning the proxy does not deprive you of your right to attend the Annual Meeting and to vote your shares at the Annual Meeting. The proxy statement explains proxy voting and the matters to be voted on in more detail.

Important Notice Regarding the Availability of Proxy Materials for the Annual Meeting to Be Held on June 11, 2025. Our proxy statement and Annual Report to Stockholders are being made available on or about April 21, 2025 on our investor relations website at https://ir.alxoncology.com/ under “Financials & Filings.” We are providing access to our proxy materials over the Internet under the rules adopted by the Securities and Exchange Commission.

By order of the Board of Directors,

Jason Lettmann

Chief Executive Officer and Director

South San Francisco, California

April 21, 2025

This proxy statement is being mailed to stockholders on or about April 21, 2025.

TABLE OF CONTENTS


	Page
QUESTIONS AND ANSWERS ABOUT THE ANNUAL MEETING	1
BOARD OF DIRECTORS AND CORPORATE GOVERNANCE	9
Director Nominees	9
Continuing Directors	10
Family Relationships	12
Director Independence	12
Board Leadership Structure	13
Board Diversity	13
Role of the Board in Risk Oversight	14
Environmental, Social and Governance (ESG) Practices	14
Committees of our Board of Directors	15
Attendance at Board and Stockholder Meetings	17
Compensation Committee Interlocks and Insider Participation	17
Considerations in Evaluating Director Nominees	17
Stockholder Recommendations for Nominations to the Board of Directors	18
Communications with the Board of Directors	19
Corporate Governance Guidelines and Code of Business Conduct and Ethics	19
Director Compensation	19
PROPOSAL NO. 1 ELECTION OF DIRECTORS	23
Nominees	23
Vote Required	23
PROPOSAL NO. 2 ADVISORY VOTE ON THE COMPENSATION OF OUR NAMED EXECUTIVE OFFICERS
Vote Required
PROPOSAL NO. 3 RATIFICATION OF APPOINTMENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM	25
Fees Paid to the Independent Registered Public Accounting Firm	25
Auditor Independence	25
Audit Committee Policy on Pre-Approval of Audit and Permissible Non-Audit Services of Independent Registered Public Accounting Firm	26
Vote Required	26
AUDIT COMMITTEE REPORT	27
EXECUTIVE OFFICERS	28
EXECUTIVE COMPENSATION	30
Named Executive Officers	30
Summary	30
Compensation Philosophy	31
“Say-on-Pay” Voting	31
Compensation Determination Process	31
Pay Components	32
Severance and Change in Control Protections	33
Other Compensation	34
Additional Policies and Practices	35
Summary Compensation Table	35
Outstanding Equity Awards at 2024 Year-End	36
Executive Employment Letter Agreements	38
Change in Control and Severance Agreements	40


Executive Incentive Compensation Plan	42
2025 Inducement Equity Incentive Plan	43
Equity Compensation Plan Information	43
Compensation Recovery (Clawback)	44
Insider Trading Policy	44
Pay Versus Performance	44
Description of Relationship Between Compensation Actually Paid and Company Total Shareholder Return (or TSR)	46
Description of Relationship Between NEO Compensation Actually Paid and Net Income/(Loss)	47
SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT	48
CERTAIN RELATIONSHIPS, RELATED PARTY AND OTHER TRANSACTIONS	51
Investors’ Rights Agreement	51
venBio Consulting Agreement	51
Tallac Therapeutics Agreements	51
ScalmiBio Milestone Payments	52
Indemnification Agreements	52
Related-Party Transaction Policy	52
OTHER MATTERS	53
Delinquent Section 16(a) Reports	53
Fiscal Year 2024 Annual Report and SEC Filings	53

ALX ONCOLOGY HOLDINGS INC.

PROXY STATEMENT

FOR THE 2025 ANNUAL MEETING OF STOCKHOLDERS

To Be Held at 1:00 p.m. Pacific Time on Wednesday, June 11, 2025

This proxy statement and the enclosed form of proxy are furnished in connection with the solicitation of proxies by our