SPRB - SEC Form 4 insider transactions

SEC Form 4 filed by Chief Commercial Officer Hooks Corwin Dale

Interim Chief Medical Officer Ways Douglas Kirk converted options into 1,250 shares (SEC Form 4)

CHIEF EXECUTIVE OFFICER Szwarcberg Javier B. was granted 4,690 shares, increasing direct ownership by 33% to 19,004 units (SEC Form 4)

PRESIDENT AND CFO Gharib Samir M. converted options into 1,009 shares and covered exercise/tax liability with 362 shares, increasing direct ownership by 8% to 8,263 units (SEC Form 4)

CHIEF EXECUTIVE OFFICER Szwarcberg Javier B. converted options into 2,676 shares and covered exercise/tax liability with 1,360 shares, increasing direct ownership by 10% to 14,314 units (SEC Form 4)

SEC Form 4 filed by Director Spiegelman Daniel K

SEC Form 4 filed by Executive Chairman Grey Michael G

SEC Form 4 filed by PRESIDENT AND CFO Gharib Samir M.

SEC Form 4 filed by CHIEF EXECUTIVE OFFICER Szwarcberg Javier B.

SEC Form 4 filed by Director Simpson Camilla V

SEC Form 4 filed by Director Barretto-Ko Percival

SEC Form 4 filed by Director Walbert Keli

PRESIDENT AND CFO Gharib Samir M. converted options into 2,414 shares and covered exercise/tax liability with 864 shares, increasing direct ownership by 26% to 7,616 units (SEC Form 4)

CHIEF EXECUTIVE OFFICER Szwarcberg Javier B. converted options into 6,146 shares and covered exercise/tax liability with 2,622 shares, increasing direct ownership by 37% to 12,998 units (SEC Form 4)

PRESIDENT AND CFO Gharib Samir M. converted options into 2,053 shares and covered exercise/tax liability with 661 shares, increasing direct ownership by 30% to 6,066 units (SEC Form 4)

CHIEF EXECUTIVE OFFICER Szwarcberg Javier B. converted options into 4,784 shares and covered exercise/tax liability with 1,539 shares, increasing direct ownership by 52% to 9,474 units (SEC Form 4)

SEC Form 4 filed by Director Spiegelman Daniel K

SEC Form 4 filed by Director Simpson Camilla V

SEC Form 4 filed by Executive Chairman Grey Michael G

SEC Form 4 filed by Director Barretto-Ko Percival

SEC Form 4 filed by Director Aynechi Tiba

SEC Form 4 filed by Interim Chief Medical Officer Ways Kirk

SEC Form 4 filed by Director Muralidhar Bali

CHIEF MEDICAL OFFICER Charlton Ralph William Iii converted options into 164,750 shares and covered exercise/tax liability with 58,784 shares, increasing direct ownership by 191% to 161,339 units (SEC Form 4)

PRESIDENT AND CFO Gharib Samir M. converted options into 229,750 shares and covered exercise/tax liability with 81,976 shares, increasing direct ownership by 73% to 350,550 units (SEC Form 4)

CHIEF EXECUTIVE OFFICER Szwarcberg Javier B. converted options into 559,500 shares and covered exercise/tax liability with 199,630 shares, increasing direct ownership by 335% to 467,191 units (SEC Form 4)

SEC Form 4 filed by Ways Kirk

SEC Form 4 filed by Spiegelman Daniel K

SEC Form 4 filed by Simpson Camilla V

SEC Form 4 filed by Muralidhar Bali

SEC Form 4 filed by Grey Michael G

SEC Form 4 filed by Barretto-Ko Percival

SEC Form 4 filed by Aynechi Tiba

Novo Holdings A/S sold $350,951 worth of shares (465,021 units at $0.75), decreasing direct ownership by 15% to 2,550,000 units (SEC Form 4)

Novo Holdings A/S sold $1,358,804 worth of shares (1,794,999 units at $0.76), decreasing direct ownership by 37% to 3,015,021 units (SEC Form 4)

Novo Holdings A/S sold $1,698,902 worth of shares (1,912,316 units at $0.89), decreasing direct ownership by 28% to 4,810,020 units (SEC Form 4)

SEC Form 4 filed by Charlton Ralph William Iii

SEC Form 4 filed by Gharib Samir M.

SEC Form 4 filed by Szwarcberg Javier B.

Charlton Ralph William Iii was granted 9,361 shares, increasing direct ownership by 20% to 55,373 units (SEC Form 4)

Gharib Samir M. was granted 11,255 shares, increasing direct ownership by 6% to 202,776 units (SEC Form 4)

Charlton Ralph William Iii converted options into 31,750 shares and covered exercise/tax liability with 10,980 shares, increasing direct ownership by 82% to 46,012 units (SEC Form 4)

Gharib Samir M. converted options into 112,250 shares and covered exercise/tax liability with 36,095 shares, increasing direct ownership by 66% to 191,521 units (SEC Form 4)

Szwarcberg Javier B. converted options into 111,000 shares and covered exercise/tax liability with 38,384 shares, increasing direct ownership by 209% to 107,321 units (SEC Form 4)

SEC Form 4 filed by Szwarcberg Javier B.

SEC Form 4 filed by Gharib Samir M.

SEC Form 4 filed by Charlton Ralph William Iii

SEC Form 4 filed by Szwarcberg Javier B.

SEC Form 4 filed by Gharib Samir M.

SEC Form 4 filed by Ways Kirk

SEC Form 4 filed by Spiegelman Daniel K

SEC Form 4 filed by Simpson Camilla V

SEC Form 4 filed by O'Donnell Niall

SEC Form 4 filed by Muralidhar Bali

SEC Form 4 filed by Grey Michael G

SEC Form 4 filed by Aynechi Tiba

SEC Form 4 filed by Barretto-Ko Percival

SEC Form 4 filed by O'Donnell Niall

SEC Form 4: Novo Holdings A/S bought $6,999,360 worth of shares (2,208,000 units at $3.17), increasing direct ownership by 49% to 6,722,336 units

SEC Form 4: Charlton Ralph William Iii was granted 12,864 shares