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Compare · LYRA vs SYK

LYRA vs SYK

Side-by-side comparison of Lyra Therapeutics Inc. (LYRA) and Stryker Corporation (SYK): market cap, price performance, sector, and recent activity on the wire.

Summary

  • Both LYRA and SYK operate in Medical/Dental Instruments (Health Care), so they compete in similar markets.
  • SYK is the larger of the two at $125.43B, about 2755.8x LYRA ($45.5M).
  • Over the past year, LYRA is down 89.9% and SYK is down 10.8% - SYK leads by 79.2 points.
  • SYK has been more active in the news (5 items in the past 4 weeks vs 4 for LYRA).
  • SYK has more recent analyst coverage (25 ratings vs 7 for LYRA).
PerformanceLYRA-89.93%SYK-10.77%
2025-04-28+0.00%2026-04-24
MetricLYRASYK
Company
Lyra Therapeutics Inc.
Stryker Corporation
Price
$0.49-61.33%
$327.50-0.63%
Market cap
$45.5M
$125.43B
1M return
+0.00%
-0.03%
1Y return
-89.93%
-10.77%
Industry
Medical/Dental Instruments
Medical/Dental Instruments
Exchange
NASDAQ
NYSE
IPO
2020
News (4w)
4
5
Recent ratings
7
25
LYRA

Lyra Therapeutics Inc.

Lyra Therapeutics, Inc., a clinical-stage therapeutics company, focuses on the development and commercialization of novel integrated drug and delivery solutions for the localized treatment of patients with ear, nose, and throat diseases. The company's XTreo technology platform is designed to deliver medicines directly to the affected tissue for sustained periods with a single administration. Its product candidates include LYR-210, an anti-inflammatory implantable drug matrix for the treatment of chronic rhinosinusitis (CRS), which is in Phase II clinical trial; and LYR-220 for CRS patients with and without nasal polyps. The company was formerly known as 480 Biomedical, Inc. and changed its name to Lyra Therapeutics, Inc. in July 2018. Lyra Therapeutics, Inc. was incorporated in 2005 and is headquartered in Watertown, Massachusetts.

SYK

Stryker Corporation

Stryker Corporation operates as a medical technology company. The company operates through three segments: Orthopaedics, MedSurg, and Neurotechnology and Spine. The Orthopaedics segment provides implants for use in hip and knee joint replacements, and trauma and extremities surgeries. The MedSurg segment offers surgical equipment and surgical navigation systems, endoscopic and communications systems, patient handling, emergency medical equipment and intensive care disposable products, reprocessed and remanufactured medical devices, and other medical device products that are used in various medical specialties. The Neurotechnology and Spine segment provides neurotechnology products, which include products used for minimally invasive endovascular techniques; products for brain and open skull based surgical procedures; orthobiologic and biosurgery products, such as synthetic bone grafts and vertebral augmentation products; and minimally invasive products for the treatment of acute ischemic and hemorrhagic stroke. This segment also offers spinal implant products comprising cervical, thoracolumbar, and interbody systems that are used in spinal injury, deformity, and degenerative therapies. The company sells its products to doctors, hospitals, and other healthcare facilities through company-owned subsidiaries and branches, as well as third-party dealers and distributors in approximately 75 countries. Stryker Corporation was founded in 1941 and is headquartered in Kalamazoo, Michigan.