ARWR insider transactions

Chief Financial Officer Apel Daniel Joseph sold $934,285 worth of shares (13,095 units at $71.35) as part of a pre-agreed trading plan, decreasing direct ownership by 7% to 162,905 units (SEC Form 4) (withholding obligation)

Chief Medical Officer Hamilton James C sold $750,000 worth of shares (10,000 units at $75.00) as part of a pre-agreed trading plan, decreasing direct ownership by 4% to 226,958 units (SEC Form 4)

Chief Medical Officer Hamilton James C sold $641,900 worth of shares (10,000 units at $64.19), decreasing direct ownership by 4% to 236,958 units (SEC Form 4)

Chief Medical Officer Hamilton James C was granted 75,000 shares, increasing direct ownership by 44% to 246,958 units (SEC Form 4)

COO O'Brien Patrick gifted 2,500 shares and was granted 75,000 shares, increasing direct ownership by 15% to 547,408 units (SEC Form 4)

Chief Financial Officer Apel Daniel Joseph was granted 75,000 shares, increasing direct ownership by 74% to 176,200 units (SEC Form 4)

COO O'Brien Patrick gifted 2,800 shares and sold $3,123,349 worth of shares (49,493 units at $63.11), decreasing direct ownership by 10% to 474,908 units (SEC Form 4)

Chief Medical Officer Hamilton James C sold $2,534,661 worth of shares (40,164 units at $63.11), decreasing direct ownership by 19% to 171,958 units (SEC Form 4)

Chief Executive Officer Anzalone Christopher Richard sold $871,703 worth of shares (13,187 units at $66.10), decreasing direct ownership by 0.35% to 3,792,739 units (SEC Form 4)

Chief Executive Officer Anzalone Christopher Richard sold $3,575,575 worth of shares (51,726 units at $69.13) and exercised 51,726 shares at a strike of $6.15 (SEC Form 4)

Director Ferrari Mauro sold $527,100 worth of shares (7,530 units at $70.00), decreasing direct ownership by 10% to 69,053 units (SEC Form 4)

Director Olukotun Adeoye Y sold $676,623 worth of shares (10,000 units at $67.66), decreasing direct ownership by 23% to 33,600 units (SEC Form 4)

Director Waddill William D. sold $566,038 worth of shares (8,367 units at $67.65), decreasing direct ownership by 13% to 56,563 units (SEC Form 4)

Chief Executive Officer Anzalone Christopher Richard sold $1,771,022 worth of shares (26,031 units at $68.04), decreasing direct ownership by 0.68% to 3,805,926 units (SEC Form 4)

Director Vakiener Victoria sold $679,491 worth of shares (10,040 units at $67.68), decreasing direct ownership by 22% to 35,723 units (SEC Form 4)

Chief Executive Officer Anzalone Christopher Richard sold $5,443,462 worth of shares (85,000 units at $64.04), decreasing direct ownership by 2% to 3,831,957 units (SEC Form 4)

Director Ferrari Mauro was granted 7,819 shares, increasing direct ownership by 11% to 76,583 units (SEC Form 4)

Director Lu Hongbo was granted 7,819 shares, increasing direct ownership by 17% to 54,982 units (SEC Form 4)

Director Perry Michael S was granted 7,819 shares, increasing direct ownership by 7% to 123,059 units (SEC Form 4)

Director Vakiener Victoria was granted 7,819 shares, increasing direct ownership by 21% to 45,763 units (SEC Form 4)

Director Olukotun Adeoye Y was granted 7,819 shares, increasing direct ownership by 22% to 43,600 units (SEC Form 4)

Director Ingram Douglas S was granted 7,819 shares, increasing direct ownership by 20% to 46,215 units (SEC Form 4)

Director Waddill William D. was granted 7,819 shares, increasing direct ownership by 14% to 64,930 units (SEC Form 4)

Chief Executive Officer Anzalone Christopher Richard was granted 180,000 shares and sold $12,348,802 worth of shares (184,298 units at $67.00), decreasing direct ownership by 0.11% to 3,916,957 units (SEC Form 4)

Director Perry Michael S sold $991,738 worth of shares (16,250 units at $61.03), decreasing direct ownership by 12% to 115,240 units (SEC Form 4)

Director Ferrari Mauro sold $493,412 worth of shares (8,750 units at $56.39), decreasing direct ownership by 11% to 68,764 units (SEC Form 4)

Chief Medical Officer Hamilton James C sold $700,000 worth of shares (20,000 units at $35.00), decreasing direct ownership by 9% to 212,122 units (SEC Form 4)

Chief Medical Officer Hamilton James C sold $450,000 worth of shares (15,000 units at $30.00), decreasing direct ownership by 6% to 232,122 units (SEC Form 4)

Chief Medical Officer Hamilton James C sold $375,000 worth of shares (15,000 units at $25.00), decreasing direct ownership by 6% to 247,122 units (SEC Form 4)

Chief Medical Officer Hamilton James C sold $200,000 worth of shares (10,000 units at $20.00), decreasing direct ownership by 4% to 262,122 units (SEC Form 4)

New insider Apel Daniel Joseph claimed ownership of 101,200 shares (SEC Form 3)

Chief Executive Officer Anzalone Christopher Richard sold $1,533,337 worth of shares (141,122 units at $10.87), decreasing direct ownership by 3% to 3,921,255 units (SEC Form 4)

Chief Executive Officer Anzalone Christopher Richard was granted 340,000 shares and sold $774,975 worth of shares (51,425 units at $15.07), increasing direct ownership by 8% to 4,062,377 units (SEC Form 4)

Chief Executive Officer Anzalone Christopher Richard sold $5,274,334 worth of shares (300,000 units at $17.58) and exercised 300,000 shares at a strike of $7.75 (SEC Form 4)

Chief Executive Officer Anzalone Christopher Richard was granted 9,550 shares, increasing direct ownership by 0.25% to 3,773,802 units (SEC Form 4)

Director Ingram Douglas S was granted 38,396 shares (SEC Form 4)

New insider Ingram Douglas S claimed no ownership of stock in the company (SEC Form 3)

Director Olukotun Adeoye Y sold $20,139 worth of shares (959 units at $21.00), decreasing direct ownership by 3% to 35,781 units (SEC Form 4)

Chief Discovery/Trans Medicine Hamilton James C was granted 100,000 shares and sold $648,824 worth of shares (32,729 units at $19.82), increasing direct ownership by 33% to 272,122 units (SEC Form 4)

COO and General Counsel O'Brien Patrick was granted 100,000 shares and sold $736,059 worth of shares (37,184 units at $19.80), increasing direct ownership by 14% to 527,201 units (SEC Form 4)

Chief Financial Officer Myszkowski Kenneth Allen was granted 100,000 shares and sold $893,095 worth of shares (45,167 units at $19.77), increasing direct ownership by 14% to 455,433 units (SEC Form 4)

Chief Executive Officer Anzalone Christopher Richard sold $219,456 worth of shares (11,520 units at $19.05), decreasing direct ownership by 0.31% to 3,764,252 units (SEC Form 4)

Director Olukotun Adeoye Y sold $57,000 worth of shares (2,850 units at $20.00), decreasing direct ownership by 7% to 36,740 units (SEC Form 4)

Chief Executive Officer Anzalone Christopher Richard sold $246,109 worth of shares (12,563 units at $19.59), decreasing direct ownership by 0.33% to 3,775,772 units (SEC Form 4)

Director Vakiener Victoria was granted 16,733 shares, increasing direct ownership by 79% to 37,944 units (SEC Form 4)

Director Olukotun Adeoye Y was granted 16,733 shares, increasing direct ownership by 73% to 39,590 units (SEC Form 4)

Director Waddill William D. was granted 16,733 shares, increasing direct ownership by 41% to 57,111 units (SEC Form 4)

Director Ferrari Mauro was granted 16,733 shares, increasing direct ownership by 28% to 77,514 units (SEC Form 4)

Director Perry Michael S was granted 16,733 shares, increasing direct ownership by 15% to 131,490 units (SEC Form 4)

Director Lu Hongbo was granted 16,733 shares, increasing direct ownership by 55% to 47,163 units (SEC Form 4)

Chief Executive Officer Anzalone Christopher Richard sold $567,486 worth of shares (26,712 units at $21.24) and was granted 100,000 shares, increasing direct ownership by 2% to 3,788,335 units (SEC Form 4)

Director Waddill William D. sold $164,665 worth of shares (7,495 units at $21.97), decreasing direct ownership by 16% to 40,378 units (SEC Form 4)

Director Given Douglas B sold $121,556 worth of shares (5,547 units at $21.91), decreasing direct ownership by 4% to 124,167 units (SEC Form 4)

Director Vakiener Victoria sold $197,059 worth of shares (8,994 units at $21.91), decreasing direct ownership by 30% to 21,211 units (SEC Form 4)

Lu Hongbo increased direct ownership by 7% to 36,080 units (SEC Form 5)

Chief Commercial Officer Oliver Tracie sold $237,480 worth of shares (9,394 units at $25.28), decreasing direct ownership by 7% to 127,107 units (SEC Form 4)

Vakiener Victoria sold $41,935 worth of shares (1,799 units at $23.31), decreasing direct ownership by 6% to 30,205 units (SEC Form 4)

Hamilton James C sold $168,180 worth of shares (6,000 units at $28.03), decreasing direct ownership by 3% to 204,851 units (SEC Form 4)

Lu Hongbo bought $82,990 worth of shares (3,000 units at $27.66), increasing direct ownership by 10% to 33,680 units (SEC Form 4)

New insider Lu Hongbo claimed ownership of 30,680 shares (SEC Form 3)