BCYC insider transactions

SEC Form 4 filed by Chief Financial Officer Thompson Travis Alvin

SEC Form 4 filed by CHIEF PROD & SUPPLY CHAIN OFF Hannay Michael Charles Ferguson

SEC Form 4 filed by Chief Operating Officer Perry Jennifer Scott

SEC Form 4 filed by CHIEF SCIENTIFIC OFFICER Skynner Michael

Chief Operating Officer Perry Jennifer Scott sold $6,054 worth of Ordinary Shares (1,412 units at $4.29) as part of a pre-agreed trading plan, decreasing direct ownership by 2% to 91,052 units (SEC Form 4) to cover taxes

Chief Financial Officer Thompson Travis Alvin sold $3,945 worth of Ordinary Shares (923 units at $4.27), decreasing direct ownership by 1% to 64,441 units (SEC Form 4) (tax liability)

CHIEF SCIENTIFIC OFFICER Skynner Michael sold $10,231 worth of Ordinary Shares (2,391 units at $4.28), decreasing direct ownership by 1% to 157,171 units (SEC Form 4) (tax withholding)

CHIEF EXECUTIVE OFFICER Lee Kevin sold $32,701 worth of Ordinary Shares (7,642 units at $4.28), decreasing direct ownership by 1% to 603,671 units (SEC Form 4) (for tax liability)

CHIEF PROD & SUPPLY CHAIN OFF Hannay Michael Charles Ferguson sold $7,530 worth of Ordinary Shares (1,761 units at $4.28), decreasing direct ownership by 2% to 94,375 units (SEC Form 4) (withholding obligation)

SEC Form 4 filed by Skynner Michael

SEC Form 4 filed by Lee Kevin

SEC Form 4 filed by Perry Jennifer Scott

SEC Form 4 filed by Thompson Travis Alvin

SEC Form 4 filed by Hannay Michael Charles Ferguson

SEC Form 3 filed by new insider Perry Jennifer Scott

SEC Form 4 filed by Chief Financial Officer Thompson Travis Alvin

CHIEF ACCOUNTING OFFICER Thompson Travis Alvin was granted 37,500 units of Ordinary Shares and sold $16,147 worth of Ordinary Shares (2,432 units at $6.64), increasing direct ownership by 112% to 66,265 units (SEC Form 4)

CHIEF TECHNOLOGY OFFICER Skynner Michael was granted 50,000 units of Ordinary Shares and sold $41,804 worth of Ordinary Shares (6,311 units at $6.62), increasing direct ownership by 37% to 161,966 units (SEC Form 4)

CHIEF OPERATING OFFICER Milnes Alistair was granted 50,000 units of Ordinary Shares and sold $44,127 worth of Ordinary Shares (6,660 units at $6.63), increasing direct ownership by 46% to 136,717 units (SEC Form 4)

CHIEF EXECUTIVE OFFICER Lee Kevin was granted 165,000 units of Ordinary Shares and sold $141,199 worth of Ordinary Shares (21,314 units at $6.62), increasing direct ownership by 30% to 618,996 units (SEC Form 4)

Director Riva Alessandro was granted 7,380 units of Ordinary Shares, increasing direct ownership by 59% to 19,880 units (SEC Form 4)

CHIEF PROD & SUPPLY CHAIN OFF Hannay Michael Charles Ferguson sold $34,491 worth of Ordinary Shares (5,194 units at $6.64) and was granted 50,000 units of Ordinary Shares, increasing direct ownership by 84% to 97,908 units (SEC Form 4)

Chief Financial Officer Young Alethia sold $50,489 worth of Ordinary Shares (7,623 units at $6.62) and was granted 50,000 units of Ordinary Shares, increasing direct ownership by 95% to 87,081 units (SEC Form 4)

Director Sands Stephen H. was granted 9,500 units of Ordinary Shares, increasing direct ownership by 55% to 26,893 units (SEC Form 4)

Director Winter Gregory Paul was granted 9,500 units of Ordinary Shares, increasing direct ownership by 5% to 196,427 units (SEC Form 4)

Director Hoppenot Herve was granted 3,032 units of Ordinary Shares, increasing direct ownership by 24% to 15,532 units (SEC Form 4)

Director Bourque Janice was granted 9,500 units of Ordinary Shares, increasing direct ownership by 41% to 32,500 units (SEC Form 4)

Director Gutierrez-Ramos Jose-Carlos was granted 9,500 units of Ordinary Shares, increasing direct ownership by 41% to 32,500 units (SEC Form 4)

Director Dansey Roger D was granted 3,032 units of Ordinary Shares, increasing direct ownership by 24% to 15,532 units (SEC Form 4)

Director Swanton Robert Charles was granted 3,726 units of Ordinary Shares, increasing direct ownership by 24% to 19,213 units (SEC Form 4)

Director Baker Bros. Advisors Lp was granted 38,000 units of American Depositary Shares (SEC Form 4)

CHIEF EXECUTIVE OFFICER Lee Kevin sold $46,182 worth of Ordinary Shares (5,494 units at $8.41), decreasing direct ownership by 1% to 475,310 units (SEC Form 4)

CHIEF OPERATING OFFICER Milnes Alistair sold $17,860 worth of Ordinary Shares (2,125 units at $8.40), decreasing direct ownership by 2% to 93,377 units (SEC Form 4)

CHIEF PROD & SUPPLY CHAIN OFF Hannay Michael Charles Ferguson sold $6,076 worth of Ordinary Shares (723 units at $8.40), decreasing direct ownership by 1% to 53,102 units (SEC Form 4)

Director Swanton Robert Charles sold $872 worth of Ordinary Shares (102 units at $8.55), decreasing direct ownership by 0.65% to 15,487 units (SEC Form 4)

CHIEF TECHNOLOGY OFFICER Skynner Michael sold $15,147 worth of Ordinary Shares (1,802 units at $8.41), decreasing direct ownership by 2% to 118,277 units (SEC Form 4)

CHIEF ACCOUNTING OFFICER Thompson Travis Alvin sold $2,723 worth of Ordinary Shares (324 units at $8.40), decreasing direct ownership by 1% to 31,197 units (SEC Form 4)

Chief Financial Officer Young Alethia sold $4,103 worth of Ordinary Shares (482 units at $8.51), decreasing direct ownership by 1% to 44,704 units (SEC Form 4)

Director Hoppenot Herve was granted 12,500 units of Ordinary Shares (SEC Form 4)

Director Dansey Roger D was granted 12,500 units of Ordinary Shares (SEC Form 4)

SEC Form 3 filed by new insider Hoppenot Herve

SEC Form 3 filed by new insider Dansey Roger D

Director Swanton Robert Charles was granted 12,500 units of Ordinary Shares, increasing direct ownership by 405% to 15,589 units (SEC Form 4)

New insider Swanton Robert Charles claimed ownership of 3,089 units of Ordinary Shares (SEC Form 3)

CHIEF EXECUTIVE OFFICER Lee Kevin sold $39,836 worth of Ordinary Shares (5,461 units at $7.29), decreasing direct ownership by 1% to 480,804 units (SEC Form 4)

Chief Financial Officer Young Alethia sold $1,446 worth of Ordinary Shares (204 units at $7.09), decreasing direct ownership by 0.45% to 45,186 units (SEC Form 4)

CHIEF ACCOUNTING OFFICER Thompson Travis Alvin sold $2,205 worth of Ordinary Shares (306 units at $7.20), decreasing direct ownership by 0.96% to 31,521 units (SEC Form 4)

CHIEF TECHNOLOGY OFFICER Skynner Michael sold $13,036 worth of Ordinary Shares (1,791 units at $7.28), decreasing direct ownership by 1% to 120,079 units (SEC Form 4)

CHIEF PROD & SUPPLY CHAIN OFF Hannay Michael Charles Ferguson sold $5,206 worth of Ordinary Shares (722 units at $7.21), decreasing direct ownership by 1% to 53,825 units (SEC Form 4)

CHIEF OPERATING OFFICER Milnes Alistair sold $15,333 worth of Ordinary Shares (2,115 units at $7.25), decreasing direct ownership by 2% to 95,502 units (SEC Form 4)

Chief Financial Officer Young Alethia sold $1,724 worth of Ordinary Shares (215 units at $8.02), decreasing direct ownership by 0.47% to 45,390 units (SEC Form 4)

CHIEF TECHNOLOGY OFFICER Skynner Michael sold $14,293 worth of Ordinary Shares (1,852 units at $7.72), decreasing direct ownership by 1% to 121,870 units (SEC Form 4)

CHIEF EXECUTIVE OFFICER Lee Kevin sold $43,612 worth of Ordinary Shares (5,669 units at $7.69), decreasing direct ownership by 1% to 486,265 units (SEC Form 4)

CHIEF ACCOUNTING OFFICER Thompson Travis Alvin sold $2,500 worth of Ordinary Shares (319 units at $7.84), decreasing direct ownership by 0.99% to 31,827 units (SEC Form 4)

CHIEF PROD & SUPPLY CHAIN OFF Hannay Michael Charles Ferguson sold $5,735 worth of Ordinary Shares (733 units at $7.82), decreasing direct ownership by 1% to 54,547 units (SEC Form 4)

CHIEF OPERATING OFFICER Milnes Alistair sold $16,851 worth of Ordinary Shares (2,171 units at $7.76), decreasing direct ownership by 2% to 97,617 units (SEC Form 4)

Director Riva Alessandro was granted 12,500 units of Ordinary Shares (SEC Form 4)

SEC Form 3 filed by new insider Riva Alessandro

SEC Form 4 filed by Chief Medical Officer Westin Eric

New insider Westin Eric claimed ownership of 2,305 units of Ordinary Shares (SEC Form 3)