KYMR insider transactions

Chief Executive Officer Mainolfi Nello exercised 50,000 shares at a strike of $2.08 and sold $5,950,000 worth of shares (50,000 units at $119.00) as part of a pre-agreed trading plan (SEC Form 4)

Chief Business Officer Goodman Noah sold $387,329 worth of shares (3,389 units at $114.29) as part of a pre-agreed trading plan, decreasing direct ownership by 7% to 47,179 units (SEC Form 4)

Chief Financial Officer Jacobs Bruce N. exercised 61,378 shares at a strike of $5.33 and sold $8,864,829 worth of shares (77,109 units at $114.96) as part of a pre-agreed trading plan, decreasing direct ownership by 6% to 244,883 units (SEC Form 4)

Chief Executive Officer Mainolfi Nello sold $9,223,527 worth of shares (80,000 units at $115.29) as part of a pre-agreed trading plan and exercised 80,000 shares at a strike of $2.08 (SEC Form 4)

Amendment: Director Booth Bruce sold $8,281,905 worth of shares (76,650 units at $108.05) as part of a pre-agreed trading plan (SEC Form 4)

Director Booth Bruce sold $3,424,800 worth of shares (31,283 units at $109.48) as part of a pre-agreed trading plan (SEC Form 4)

Director Booth Bruce sold $56,460,136 worth of shares (513,245 units at $110.01) as part of a pre-agreed trading plan (SEC Form 4)

Director Bvf Partners L P/Il sold $173,665,077 worth of shares (1,630,658 units at $106.50) (SEC Form 4)

Director Booth Bruce sold $34,812,909 worth of shares (285,684 units at $121.86) as part of a pre-agreed trading plan (SEC Form 4)

Director Booth Bruce sold $43,987,355 worth of shares (398,765 units at $110.31) as part of a pre-agreed trading plan (SEC Form 4)

SEC Form 4 filed by Director Bvf Partners L P/Il

SEC Form 4 filed by Director Booth Bruce

Chief Business Officer Goodman Noah exercised 5,000 shares at a strike of $21.05 and sold $570,000 worth of shares (5,000 units at $114.00) as part of a pre-agreed trading plan (SEC Form 4)

SEC Form 4 filed by Director Albers Jeffrey W.

SEC Form 4 filed by Director Hrustanovic Gorjan

SEC Form 4 filed by Director Esposito Pamela

SEC Form 4 filed by Director Maraganore John

SEC Form 4 filed by Director Sandor Victor

SEC Form 4 filed by Director Ridloff Elena

SEC Form 4 filed by Director Baker Bros. Advisors Lp

Director Booth Bruce sold $3,299,037 worth of shares (31,798 units at $103.75) as part of a pre-agreed trading plan (SEC Form 4)

Director Booth Bruce exercised 11,741 shares at a strike of $20.00 and sold $45,293,294 worth of shares (478,198 units at $94.72) as part of a pre-agreed trading plan (SEC Form 4)

Chief Business Officer Goodman Noah exercised 2,500 shares at a strike of $21.05 and sold $247,500 worth of shares (2,500 units at $99.00) as part of a pre-agreed trading plan (SEC Form 4)

Chief Financial Officer Jacobs Bruce N. exercised 12,653 shares at a strike of $2.08, increasing direct ownership by 5% to 260,241 units (SEC Form 4)

Chief Operating Officer Chadwick Jeremy G sold $1,373,290 worth of shares (17,184 units at $79.92) as part of a pre-agreed trading plan, decreasing direct ownership by 28% to 44,018 units (SEC Form 4) to satisfy withholding obligation

Director Esposito Pamela exercised 1,000 shares at a strike of $31.20 (SEC Form 4)

Chief Financial Officer Jacobs Bruce N. exercised 15,000 shares at a strike of $2.08, increasing direct ownership by 6% to 247,588 units (SEC Form 4)

Director Ridloff Elena exercised 3,000 shares at a strike of $31.20 and sold $261,000 worth of shares (3,000 units at $87.00) as part of a pre-agreed trading plan (SEC Form 4)

Chief Executive Officer Mainolfi Nello exercised 30,000 shares at a strike of $2.08 and sold $2,435,377 worth of shares (30,000 units at $81.18) as part of a pre-agreed trading plan (SEC Form 4)

Director Booth Bruce exercised 5,900 shares at a strike of $14.44 and sold $539,772 worth of shares (6,000 units at $89.96) as part of a pre-agreed trading plan (SEC Form 4)

Chief Operating Officer Chadwick Jeremy G sold $27,000 worth of shares (300 units at $90.00) as part of a pre-agreed trading plan and exercised 300 shares at a strike of $39.06 (SEC Form 4)

SEC Form 4 filed by Goodman Noah

SEC Form 4 filed by Chadwick Jeremy G

SEC Form 4 filed by Booth Bruce

SEC Form 4 filed by Goodman Noah

SEC Form 4 filed by Chadwick Jeremy G

SEC Form 4 filed by Ridloff Elena

SEC Form 4 filed by Chadwick Jeremy G

SEC Form 4 filed by Esposito Pamela

Chief Operating Officer Chadwick Jeremy G exercised 20,000 shares at a strike of $43.50 and sold $2,145,673 worth of shares (25,758 units at $83.30), decreasing direct ownership by 8% to 68,052 units (SEC Form 4)

SEC Form 4 filed by Chief Executive Officer Mainolfi Nello

Chief Operating Officer Chadwick Jeremy G was granted 12,575 shares and sold $515,594 worth of shares (5,958 units at $86.54), increasing direct ownership by 10% to 73,810 units (SEC Form 4)

Chief Financial Officer Jacobs Bruce N. was granted 17,650 shares and sold $1,091,231 worth of shares (12,471 units at $87.50), increasing direct ownership by 2% to 232,588 units (SEC Form 4)

Chief Medical Officer Gollob Jared was granted 17,650 shares and sold $916,669 worth of shares (10,508 units at $87.24), increasing direct ownership by 6% to 117,134 units (SEC Form 4)

Chief Business Officer Goodman Noah was granted 9,225 shares, increasing direct ownership by 18% to 59,306 units (SEC Form 4)

Chief Legal Officer Adams Brian was granted 4,125 shares, increasing direct ownership by 8% to 56,625 units (SEC Form 4)

Director Booth Bruce sold $7,378,583 worth of shares (81,866 units at $90.13) (SEC Form 4)

Chief Executive Officer Mainolfi Nello sold $2,707,813 worth of shares (30,000 units at $90.26) and exercised 30,000 shares at a strike of $2.08 (SEC Form 4)

Director Esposito Pamela exercised 2,500 shares at a strike of $49.10 and sold $218,270 worth of shares (2,500 units at $87.31) (SEC Form 4)

Director Esposito Pamela exercised 5,500 shares at a strike of $39.34 and sold $373,521 worth of shares (5,500 units at $67.91) (SEC Form 4)

Chief Executive Officer Mainolfi Nello exercised 3,118 shares at a strike of $32.07, increasing direct ownership by 0.47% to 666,195 units (SEC Form 4)

Chief Executive Officer Mainolfi Nello exercised 30,000 shares at a strike of $2.08 and sold $2,341,939 worth of shares (30,000 units at $78.06) (SEC Form 4)

Chief Executive Officer Mainolfi Nello exercised 2,595 shares at a strike of $38.53, increasing direct ownership by 0.39% to 663,077 units (SEC Form 4)

Director Esposito Pamela exercised 27,563 shares at a strike of $37.82 and sold $2,264,480 worth of shares (27,563 units at $82.16) (SEC Form 4)

Director Booth Bruce sold $21,699,044 worth of shares (236,588 units at $91.72) (SEC Form 4)

Director Baker Bros. Advisors Lp bought $172,499,918 worth of shares (2,005,813 units at $86.00) (SEC Form 4)

Director Albers Jeffrey W. exercised 5,000 shares at a strike of $14.18 and sold $448,823 worth of shares (5,000 units at $89.76) (SEC Form 4)

Chief Executive Officer Mainolfi Nello exercised 100,000 shares at a strike of $2.08 and sold $8,917,000 worth of shares (100,000 units at $89.17) (SEC Form 4)

Chief Medical Officer Gollob Jared exercised 49,307 shares at a strike of $5.33 and sold $4,371,833 worth of shares (49,307 units at $88.67) (SEC Form 4)

Chief Executive Officer Mainolfi Nello exercised 30,000 shares at a strike of $2.08 and sold $1,829,737 worth of shares (30,000 units at $60.99) (SEC Form 4)