MPLT insider transactions

Chief Discovery Officer Kreitzer Anatol sold $1,345,894 worth of Voting Common Stock (36,284 units at $37.09) as part of a pre-agreed trading plan, decreasing direct ownership by 17% to 174,906 units (SEC Form 4) to cover withholding tax

CAO and Interim CFO Gillis Jonathan sold $1,372,668 worth of Voting Common Stock (36,979 units at $37.12) as part of a pre-agreed trading plan, decreasing direct ownership by 20% to 144,240 units (SEC Form 4) to satisfy tax liability

Chief Executive Officer Kroeger Christopher A. sold $5,443,722 worth of Voting Common Stock (147,639 units at $36.87), decreasing direct ownership by 11% to 1,246,455 units (SEC Form 4) to satisfy withholding obligation

Chief Scientific Officer Lillie James Woodruff sold $673,636 worth of Voting Common Stock (18,267 units at $36.88), decreasing direct ownership by 8% to 224,462 units (SEC Form 4) to satisfy withholding obligation

General Counsel Hanson Kristopher sold $607,870 worth of Voting Common Stock (16,508 units at $36.82), decreasing direct ownership by 10% to 145,823 units (SEC Form 4) to cover taxes

Chief Medical Officer Foff Erin Pennock sold $1,734,490 worth of Voting Common Stock (47,158 units at $36.78) as part of a pre-agreed trading plan, decreasing direct ownership by 14% to 298,901 units (SEC Form 4) (withholding obligation)

Director Cox Troy was granted 7,864 units of Voting Common Stock (SEC Form 4)

Director Babler Martin was granted 7,864 units of Voting Common Stock (SEC Form 4)

Director Garnett Timothy John was granted 3,932 units of Voting Common Stock, increasing direct ownership by 8% to 53,457 units (SEC Form 4)

Director Luneborg Nanna Liebach was granted 3,932 units of Voting Common Stock (SEC Form 4)

Director Pavlov George was granted 3,932 units of Voting Common Stock, increasing direct ownership by 16% to 28,932 units (SEC Form 4)

Director Walker Maria C was granted 3,932 units of Voting Common Stock, increasing direct ownership by 7% to 62,703 units (SEC Form 4)

SEC Form 3 filed by new insider Cox Troy

SEC Form 3 filed by new insider Babler Martin

Chief Executive Officer Kroeger Christopher A. sold $3,215,000 worth of Voting Common Stock (118,235 units at $27.19) as part of a pre-agreed trading plan, decreasing direct ownership by 8% to 1,394,094 units (SEC Form 4)

Chief Medical Officer Foff Erin Pennock sold $126,640 worth of Voting Common Stock (4,438 units at $28.54) as part of a pre-agreed trading plan, decreasing direct ownership by 1% to 346,059 units (SEC Form 4)

General Counsel Hanson Kristopher sold $419,263 worth of Voting Common Stock (13,917 units at $30.13) as part of a pre-agreed trading plan, decreasing direct ownership by 8% to 162,331 units (SEC Form 4)

Chief Executive Officer Kroeger Christopher A. sold $1,949,634 worth of Voting Common Stock (68,491 units at $28.47) as part of a pre-agreed trading plan, decreasing direct ownership by 4% to 1,512,329 units (SEC Form 4)

Chief Scientific Officer Lillie James Woodruff sold $20,390 worth of Voting Common Stock (721 units at $28.28) as part of a pre-agreed trading plan, decreasing direct ownership by 0.30% to 242,729 units (SEC Form 4)

Chief Executive Officer Kroeger Christopher A. sold $1,412,235 worth of Voting Common Stock (49,744 units at $28.39) as part of a pre-agreed trading plan, decreasing direct ownership by 3% to 1,580,820 units (SEC Form 4)

General Counsel Hanson Kristopher sold $388,177 worth of Voting Common Stock (13,917 units at $27.89) as part of a pre-agreed trading plan, decreasing direct ownership by 7% to 176,248 units (SEC Form 4)

Chief Financial Officer Setia Vishwas sold $1,024,719 worth of Voting Common Stock (36,371 units at $28.17) as part of a pre-agreed trading plan, decreasing direct ownership by 9% to 356,256 units (SEC Form 4)

Chief Medical Officer Foff Erin Pennock sold $1,427,594 worth of Voting Common Stock (50,280 units at $28.39) as part of a pre-agreed trading plan, decreasing direct ownership by 13% to 350,497 units (SEC Form 4)

Chief Scientific Officer Lillie James Woodruff sold $1,468,251 worth of Voting Common Stock (51,707 units at $28.40) as part of a pre-agreed trading plan, decreasing direct ownership by 18% to 243,450 units (SEC Form 4)

Chief Discovery Officer Kreitzer Anatol sold $1,347,066 worth of Voting Common Stock (45,422 units at $29.66) as part of a pre-agreed trading plan, decreasing direct ownership by 18% to 211,190 units (SEC Form 4)

CAAO and PAO Gillis Jonathan sold $2,087,687 worth of Voting Common Stock (69,835 units at $29.89) as part of a pre-agreed trading plan, decreasing direct ownership by 28% to 181,219 units (SEC Form 4)

SEC Form 4 filed by Foff Erin Pennock

SEC Form 4 filed by Lillie James Woodruff

SEC Form 4 filed by Hanson Kristopher

SEC Form 4 filed by Gillis Jonathan

SEC Form 4 filed by Kreitzer Anatol

SEC Form 4 filed by Setia Vishwas

SEC Form 4 filed by Kroeger Christopher A.

SEC Form 4 filed by Malenka Robert C.

Director Malenka Robert C. sold $260,398 worth of Voting Common Stock (14,195 units at $18.34), decreasing direct ownership by 4% to 325,059 units (SEC Form 4)

Director Pavlov George bought $441,168 worth of Voting Common Stock (25,000 units at $17.65) (SEC Form 4)

Director Malenka Robert C. sold $220,632 worth of Voting Common Stock (12,116 units at $18.21), decreasing direct ownership by 3% to 339,254 units (SEC Form 4)

Director Malenka Robert C. sold $124,329 worth of Voting Common Stock (6,863 units at $18.12), decreasing direct ownership by 2% to 351,370 units (SEC Form 4)

Director Garnett Timothy John bought $252,678 worth of Voting Common Stock (14,124 units at $17.89) (SEC Form 4)

CAAO and PAO Gillis Jonathan was granted 6,020 units of Voting Common Stock, increasing direct ownership by 2% to 254,523 units (SEC Form 4)

Chief Scientific Officer Lillie James Woodruff was granted 7,730 units of Voting Common Stock, increasing direct ownership by 3% to 298,862 units (SEC Form 4)

Chief Financial Officer Setia Vishwas was granted 7,730 units of Voting Common Stock, increasing direct ownership by 2% to 395,549 units (SEC Form 4)

Chief Discovery Officer Kreitzer Anatol was granted 6,020 units of Voting Common Stock, increasing direct ownership by 2% to 259,928 units (SEC Form 4)

General Counsel Hanson Kristopher was granted 7,730 units of Voting Common Stock, increasing direct ownership by 4% to 191,582 units (SEC Form 4)

Chief Executive Officer Kroeger Christopher A. was granted 23,145 units of Voting Common Stock, increasing direct ownership by 1% to 1,649,751 units (SEC Form 4)

Chief Medical Officer Foff Erin Pennock was granted 13,360 units of Voting Common Stock, increasing direct ownership by 3% to 403,835 units (SEC Form 4)

Director Malenka Robert C. sold $126,861 worth of Voting Common Stock (7,040 units at $18.02), decreasing direct ownership by 2% to 358,233 units (SEC Form 4)

Director Malenka Robert C. sold $635,857 worth of Voting Common Stock (34,398 units at $18.49), decreasing direct ownership by 9% to 365,273 units (SEC Form 4)

Chief Financial Officer Setia Vishwas covered exercise/tax liability with 33,382 units of Voting Common Stock, decreasing direct ownership by 8% to 387,819 units (SEC Form 4)

CAAO and PAO Gillis Jonathan covered exercise/tax liability with 22,050 units of Voting Common Stock, decreasing direct ownership by 8% to 248,503 units (SEC Form 4)

Chief Scientific Officer Lillie James Woodruff covered exercise/tax liability with 45,055 units of Voting Common Stock, decreasing direct ownership by 13% to 291,132 units (SEC Form 4)

Chief Discovery Officer Kreitzer Anatol covered exercise/tax liability with 42,099 units of Voting Common Stock, decreasing direct ownership by 14% to 253,908 units (SEC Form 4)

Chief Executive Officer Kroeger Christopher A. covered exercise/tax liability with 204,146 units of Voting Common Stock, decreasing direct ownership by 11% to 1,626,606 units (SEC Form 4)

General Counsel Hanson Kristopher covered exercise/tax liability with 26,007 units of Voting Common Stock, decreasing direct ownership by 12% to 183,852 units (SEC Form 4)

Chief Medical Officer Foff Erin Pennock covered exercise/tax liability with 44,616 units of Voting Common Stock, decreasing direct ownership by 10% to 390,475 units (SEC Form 4)

Amendment: SEC Form 3 filed by new insider Pavlov George

Large owner Novo Holdings A/S converted options into 2,733,681 units of Voting Common Stock and bought $16,199,997 worth of Voting Common Stock (952,941 units at $17.00) (SEC Form 4)

Large owner Catalyst4, Inc. converted options into 14,256,288 units of Voting Common Stock and bought $92,499,992 worth of Voting Common Stock (5,441,176 units at $17.00) (SEC Form 4)