RNA insider transactions

Chief Scientific Officer Younis Husam covered exercise/tax liability with 11,216 shares, decreasing direct ownership by 21% to 41,441 units (SEC Form 4) to cover taxes

Chief Medical Officer Hughes Steven George covered exercise/tax liability with 21,459 shares, decreasing direct ownership by 29% to 51,638 units (SEC Form 4) to satisfy withholding tax

Director Boyce Sarah covered exercise/tax liability with 126,418 shares, decreasing direct ownership by 48% to 138,668 units (SEC Form 4) (withholding obligation)

Director Flanagan W. Michael covered exercise/tax liability with 22,812 shares, decreasing direct ownership by 42% to 31,974 units (SEC Form 4) to satisfy withholding tax

Officer Kenney Stephanie covered exercise/tax liability with 2,375 shares, decreasing direct ownership by 7% to 33,085 units (SEC Form 4) to satisfy withholding tax

Chief Financial Officer Winslow Brendan R. covered exercise/tax liability with 6,742 shares, decreasing direct ownership by 15% to 36,859 units (SEC Form 4) (for withholding tax)

Officer Gallagher Kathleen P. covered exercise/tax liability with 11,632 shares, decreasing direct ownership by 9% to 119,729 units (SEC Form 4) (for tax liability)

Chief Strategy Officer Hoyos Rocio Martin covered exercise/tax liability with 8,320 shares, decreasing direct ownership by 18% to 38,340 units (SEC Form 4) to satisfy withholding obligation

SEC Form 4 filed by Kenney Stephanie

SEC Form 4 filed by Hughes Steven George

SEC Form 4 filed by Winslow Brendan R.

SEC Form 4 filed by Gallagher Kathleen P.

SEC Form 4 filed by Hoyos Rocio Martin

SEC Form 4 filed by Younis Husam

Chief Medical Officer Hughes Steven George sold $354,643 worth of shares (4,895 units at $72.45), decreasing direct ownership by 13% to 31,599 units (SEC Form 4)

President and CEO Boyce Sarah sold $1,042,338 worth of shares (14,387 units at $72.45), decreasing direct ownership by 5% to 269,007 units (SEC Form 4)

Chief Scientific Officer Flanagan W. Michael sold $473,388 worth of shares (6,534 units at $72.45), decreasing direct ownership by 7% to 85,093 units (SEC Form 4)

Chief Financial Officer Maclean Michael F sold $329,068 worth of shares (4,542 units at $72.45), decreasing direct ownership by 7% to 59,290 units (SEC Form 4)

Director Levin Arthur A sold $127,367 worth of shares (1,758 units at $72.45), decreasing direct ownership by 10% to 16,562 units (SEC Form 4)

Chief Human Resources Officer Mccarthy Teresa sold $212,206 worth of shares (2,929 units at $72.45), decreasing direct ownership by 3% to 113,938 units (SEC Form 4)

President and CEO Boyce Sarah sold $619,444 worth of shares (8,576 units at $72.23), decreasing direct ownership by 3% to 283,394 units (SEC Form 4)

Chief Technical Officer Calderaro Charles Iii sold $269,201 worth of shares (3,727 units at $72.23), decreasing direct ownership by 7% to 49,797 units (SEC Form 4)

Chief Legal Officer Moriarty John B sold $171,474 worth of shares (2,374 units at $72.23), decreasing direct ownership by 3% to 74,557 units (SEC Form 4)

Chief Human Resources Officer Mccarthy Teresa sold $141,932 worth of shares (1,965 units at $72.23), decreasing direct ownership by 2% to 116,867 units (SEC Form 4)

Chief Financial Officer Maclean Michael F sold $142,582 worth of shares (1,974 units at $72.23), decreasing direct ownership by 3% to 63,832 units (SEC Form 4)

Chief Scientific Officer Flanagan W. Michael sold $171,402 worth of shares (2,373 units at $72.23), decreasing direct ownership by 3% to 91,627 units (SEC Form 4)

Chief Medical Officer Hughes Steven George sold $171,402 worth of shares (2,373 units at $72.23), decreasing direct ownership by 6% to 36,494 units (SEC Form 4)

Director Levin Arthur A gifted 1,330 shares, decreasing direct ownership by 7% to 18,320 units (SEC Form 4)

Chief Technical Officer Calderaro Charles Iii was granted 23,250 shares and covered exercise/tax liability with 9,726 shares, increasing direct ownership by 34% to 53,524 units (SEC Form 4)

Chief Scientific Officer Flanagan W. Michael was granted 27,500 shares and covered exercise/tax liability with 13,695 shares, increasing direct ownership by 17% to 94,000 units (SEC Form 4)

Chief Commercial Officer Mosbrooker Eric covered exercise/tax liability with 47,990 shares and was granted 72,000 shares, increasing direct ownership by 44% to 79,010 units (SEC Form 4)

President and CEO Boyce Sarah covered exercise/tax liability with 15,742 shares, gifted 29,159 shares and was granted 31,000 shares, decreasing direct ownership by 5% to 291,970 units (SEC Form 4)

Chief Legal Officer Moriarty John B was granted 56,000 shares and covered exercise/tax liability with 26,824 shares, increasing direct ownership by 61% to 76,931 units (SEC Form 4)

Chief Program Officer Gallagher Kathleen P. was granted 72,000 shares and covered exercise/tax liability with 41,366 shares, increasing direct ownership by 61% to 80,838 units (SEC Form 4)

Chief Human Resources Officer Mccarthy Teresa was granted 39,000 shares and covered exercise/tax liability with 17,298 shares, increasing direct ownership by 22% to 118,832 units (SEC Form 4)

Chief Medical Officer Hughes Steven George exercised 2,209 shares at a strike of $10.16 and sold $105,015 worth of shares (2,209 units at $47.54) (SEC Form 4)

Chief Human Resources Officer Mccarthy Teresa exercised 20,000 shares at a strike of $22.34 and sold $1,003,058 worth of shares (20,000 units at $50.15) (SEC Form 4)

Chief Commercial Officer Mosbrooker Eric exercised 6,562 shares at a strike of $9.05 and sold $297,771 worth of shares (6,562 units at $45.38) (SEC Form 4)

Chief Medical Officer Hughes Steven George exercised 2,208 shares at a strike of $10.16 and sold $89,601 worth of shares (2,208 units at $40.58) (SEC Form 4)

Chief Human Resources Officer Mccarthy Teresa exercised 15,000 shares at a strike of $22.34 and sold $621,142 worth of shares (15,000 units at $41.41) (SEC Form 4)

Chief Medical Officer Hughes Steven George exercised 1,542 shares at a strike of $6.57 and sold $70,022 worth of shares (1,542 units at $45.41) (SEC Form 4)

Chief Scientific Officer Flanagan W. Michael sold $778,702 worth of shares (20,000 units at $38.94) and exercised 20,000 shares at a strike of $14.22 (SEC Form 4)

Director Wilson Troy Edward exercised 14,500 shares at a strike of $12.48 and sold $1,475,000 worth of shares (29,500 units at $50.00), decreasing direct ownership by 22% to 54,425 units (SEC Form 4)

President and CEO Boyce Sarah exercised 50,000 shares at a strike of $1.24 and sold $2,497,435 worth of shares (50,000 units at $49.95) (SEC Form 4)

Chief Commercial Officer Mosbrooker Eric exercised 6,563 shares at a strike of $9.05 and sold $308,936 worth of shares (6,563 units at $47.07) (SEC Form 4)

Chief Program Officer Gallagher Kathleen P. sold $8,915 worth of shares (188 units at $47.42), decreasing direct ownership by 0.37% to 50,204 units (SEC Form 4)

President and CEO Boyce Sarah exercised 25,000 shares at a strike of $1.24 and sold $1,234,700 worth of shares (25,000 units at $49.39) (SEC Form 4)

Chief Medical Officer Hughes Steven George sold $102,462 worth of shares (2,208 units at $46.40) and exercised 2,208 shares at a strike of $10.16 (SEC Form 4)

Chief Human Resources Officer Mccarthy Teresa exercised 10,000 shares at a strike of $22.34 and sold $465,632 worth of shares (10,000 units at $46.56) (SEC Form 4)

Chief Financial Officer Maclean Michael F sold $1,320,844 worth of shares (30,914 units at $42.73), decreasing direct ownership by 32% to 65,806 units (SEC Form 4)

Chief Medical Officer Hughes Steven George exercised 1,542 shares at a strike of $6.57 and sold $71,950 worth of shares (1,542 units at $46.66) (SEC Form 4)

Chief Commercial Officer Mosbrooker Eric exercised 124,687 shares at a strike of $9.05 and sold $5,763,697 worth of shares (130,807 units at $44.06), decreasing direct ownership by 10% to 55,000 units (SEC Form 4)

Director Wilson Troy Edward exercised 29,500 shares at a strike of $12.14 and sold $4,277,430 worth of shares (95,054 units at $45.00) (SEC Form 4)

Director Levin Arthur A exercised 107,500 shares at a strike of $22.34 and sold $5,118,881 worth of shares (107,500 units at $47.62) (SEC Form 4)

Chief Medical Officer Hughes Steven George exercised 47,451 shares at a strike of $12.21 and sold $3,480,269 worth of shares (81,434 units at $42.74), decreasing direct ownership by 47% to 38,867 units (SEC Form 4)

Chief Legal Officer Moriarty John B sold $81,291 worth of shares (2,245 units at $36.21), decreasing direct ownership by 4% to 47,755 units (SEC Form 4)

Chief Program Officer Gallagher Kathleen P. sold $27,549 worth of shares (911 units at $30.24), decreasing direct ownership by 2% to 50,392 units (SEC Form 4)

Director Henig Noreen was granted 6,692 shares (SEC Form 4)

Director Boess Carsten was granted 6,692 shares (SEC Form 4)

Director Kaye Edward M. Md was granted 6,692 shares (SEC Form 4)