PHVS - SEC Form 4 insider transactions

Director Monges Viviane exercised 11,969 shares at a strike of $8.05 and sold $395,524 worth of shares (11,969 units at $33.05) (SEC Form 4)

President Lu Peng exercised 45,308 shares at a strike of $2.59, increasing direct ownership by 70% to 110,261 units (SEC Form 4)

Director Schikan Johannes Gerardus Christiaan Petrus exercised 800 shares at a strike of $20.00 and sold $28,952 worth of shares (800 units at $36.19) (SEC Form 4)

CFO / CLO Nassif David W. sold $218,801 worth of shares (6,000 units at $36.47) and gifted 500 shares, decreasing direct ownership by 5% to 113,800 units (SEC Form 4)

President Lu Peng exercised 100,000 shares at a strike of $2.59 and sold $3,500,000 worth of shares (100,000 units at $35.00) (SEC Form 4)

Director Schikan Johannes Gerardus Christiaan Petrus sold $7,000,000 worth of shares (200,000 units at $35.00), decreasing direct ownership by 63% to 115,167 units (SEC Form 4)

Director Bjork Elisabeth sold $1,989,409 worth of shares (52,500 units at $37.89) and exercised 52,500 shares at a strike of $15.64 (SEC Form 4)

Director Glassman Robert exercised 14,493 shares at a strike of $18.14 and sold $558,812 worth of shares (14,493 units at $38.56) as part of a pre-agreed trading plan (SEC Form 4)

Chief Early Development Lesage Anne sold $765,466 worth of shares (20,000 units at $38.27) (SEC Form 4)

SEC Form 4 filed by Chief Executive Officer Modig Berndt

Chief Technical Ops Officer Abele Stefan Andreas exercised 45,000 shares at a strike of $16.40 and sold $1,771,125 worth of shares (46,400 units at $38.17), decreasing direct ownership by 3% to 39,068 units (SEC Form 4)

Director Glassman Robert exercised 8,667 shares at a strike of $22.31 and sold $331,716 worth of shares (8,667 units at $38.27) as part of a pre-agreed trading plan (SEC Form 4)

Chief Commercial Officer Souverijns Wim exercised 20,000 shares at a strike of $17.43 and sold $1,023,575 worth of shares (26,090 units at $39.23) as part of a pre-agreed trading plan, decreasing direct ownership by 14% to 39,021 units (SEC Form 4)

President Lu Peng covered exercise/tax liability with 226 shares, exercised 15,000 shares at a strike of $2.59 and sold $601,947 worth of shares (15,000 units at $40.13) as part of a pre-agreed trading plan, decreasing direct ownership by 0.35% to 64,953 units (SEC Form 4) (withholding obligation)

Chief Executive Officer Modig Berndt sold $90,276 worth of shares (2,291 units at $39.40) as part of a pre-agreed trading plan, decreasing direct ownership by 2% to 128,334 units (SEC Form 4)

Chief Early Development Lesage Anne exercised 30,000 shares at a strike of $8.05 and sold $1,149,084 worth of shares (30,000 units at $38.30) as part of a pre-agreed trading plan (SEC Form 4)

Director Glassman Robert exercised 8,000 shares at a strike of $20.00 and sold $300,396 worth of shares (8,000 units at $37.55) as part of a pre-agreed trading plan (SEC Form 4)

President Lu Peng exercised 15,000 shares at a strike of $2.59 and sold $610,134 worth of shares (15,000 units at $40.68) as part of a pre-agreed trading plan (SEC Form 4)

Chief Executive Officer Modig Berndt sold $79,686 worth of shares (2,292 units at $34.77) as part of a pre-agreed trading plan, decreasing direct ownership by 2% to 130,625 units (SEC Form 4)

President Lu Peng covered exercise/tax liability with 226 shares, decreasing direct ownership by 0.35% to 65,179 units (SEC Form 4) to satisfy tax liability

Chief Executive Officer Modig Berndt sold $80,154 worth of shares (2,292 units at $34.97) as part of a pre-agreed trading plan, decreasing direct ownership by 2% to 132,917 units (SEC Form 4)

Chief Medical Officer Lu Peng covered exercise/tax liability with 226 shares, decreasing direct ownership by 0.34% to 65,405 units (SEC Form 4) (tax withholding)

Director Schikan Johannes Gerardus Christiaan Petrus sold $1,331,496 worth of shares (37,600 units at $35.41) as part of a pre-agreed trading plan, decreasing direct ownership by 11% to 315,167 units (SEC Form 4)

Chief Early Development Lesage Anne exercised 38,472 shares at a strike of $6.85 and sold $2,695,452 worth of shares (76,172 units at $35.39) as part of a pre-agreed trading plan, increasing direct ownership by 4% to 58,750 units (SEC Form 4)

Chief Early Development Lesage Anne exercised 2,300 shares at a strike of $4.73 and sold $161,560 worth of shares (4,600 units at $35.12) as part of a pre-agreed trading plan (SEC Form 4)

Director Schikan Johannes Gerardus Christiaan Petrus sold $84,250 worth of shares (2,400 units at $35.10) as part of a pre-agreed trading plan, decreasing direct ownership by 0.68% to 352,767 units (SEC Form 4)

Chief Medical Officer Lu Peng exercised 29,700 shares at a strike of $2.59 and sold $1,018,832 worth of shares (29,700 units at $34.30) as part of a pre-agreed trading plan (SEC Form 4)

Chief Medical Officer Lu Peng exercised 300 shares at a strike of $2.59 and sold $10,200 worth of shares (300 units at $34.00) as part of a pre-agreed trading plan (SEC Form 4)

Chief Executive Officer Modig Berndt sold $71,173 worth of shares (2,291 units at $31.07) as part of a pre-agreed trading plan, decreasing direct ownership by 2% to 135,209 units (SEC Form 4)

Chief Medical Officer Lu Peng covered exercise/tax liability with 117 shares, decreasing direct ownership by 0.18% to 65,631 units (SEC Form 4) (withholding obligation)

Chief Medical Officer Lu Peng covered exercise/tax liability with 109 shares, decreasing direct ownership by 0.17% to 65,748 units (SEC Form 4) to cover withholding tax

Principal Accounting Officer Nijdam Anna sold $82,425 worth of shares (2,670 units at $30.87), decreasing direct ownership by 5% to 46,275 units (SEC Form 4)

Director Monges Viviane sold $292,853 worth of shares (9,667 units at $30.29), decreasing direct ownership by 64% to 5,500 units (SEC Form 4) to satisfy tax liability

Principal Accounting Officer Nijdam Anna exercised 7,330 shares at a strike of $20.00 and sold $225,055 worth of shares (7,330 units at $30.70) (SEC Form 4) to satisfy withholding obligation

CFO / CLO Nassif David W. sold $303,076 worth of shares (10,000 units at $30.31), decreasing direct ownership by 8% to 120,300 units (SEC Form 4) to satisfy withholding obligation

Director Bjork Elisabeth exercised 10,000 shares at a strike of $8.05 and sold $293,166 worth of shares (10,000 units at $29.32) as part of a pre-agreed trading plan (SEC Form 4)

Amendment: SEC Form 4 filed by Chief Executive Officer Modig Berndt

Chief Executive Officer Modig Berndt sold $66,977 worth of shares (2,292 units at $29.22) as part of a pre-agreed trading plan, decreasing direct ownership by 2% to 137,500 units (SEC Form 4)

Director Glassman Robert exercised 5,333 shares at a strike of $22.31 and sold $298,245 worth of shares (10,000 units at $29.82), decreasing direct ownership by 31% to 10,500 units (SEC Form 4)

Chief Technical Ops Officer Abele Stefan Andreas sold $260,864 worth of shares (8,748 units at $29.82), decreasing direct ownership by 20% to 35,194 units (SEC Form 4)

Chief Commercial Officer Souverijns Wim sold $299,163 worth of shares (10,000 units at $29.92) as part of a pre-agreed trading plan, decreasing direct ownership by 18% to 45,111 units (SEC Form 4)

Chief Medical Officer Lu Peng covered exercise/tax liability with 226 shares, decreasing direct ownership by 0.34% to 65,857 units (SEC Form 4) (for withholding tax)

Chief Medical Officer Lu Peng exercised 14,166 shares at a strike of $2.59 and sold $427,419 worth of shares (14,166 units at $30.17) as part of a pre-agreed trading plan (SEC Form 4)

Director Schikan Johannes Gerardus Christiaan Petrus sold $996,545 worth of shares (32,900 units at $30.29) as part of a pre-agreed trading plan, decreasing direct ownership by 8% to 355,167 units (SEC Form 4)

Chief Early Development Lesage Anne exercised 25,400 shares at a strike of $6.46 and sold $1,459,970 worth of shares (48,300 units at $30.23) as part of a pre-agreed trading plan (SEC Form 4)

Chief Medical Officer Lu Peng sold $565,859 worth of shares (18,733 units at $30.21) as part of a pre-agreed trading plan and exercised 18,733 shares at a strike of $2.59 (SEC Form 4)

Director Schikan Johannes Gerardus Christiaan Petrus sold $213,382 worth of shares (7,100 units at $30.05) as part of a pre-agreed trading plan, decreasing direct ownership by 2% to 388,067 units (SEC Form 4)

Chief Early Development Lesage Anne exercised 7,600 shares at a strike of $7.62 and sold $441,726 worth of shares (14,700 units at $30.05) as part of a pre-agreed trading plan (SEC Form 4)

Chief Medical Officer Lu Peng exercised 7,101 shares at a strike of $2.59 and sold $213,405 worth of shares (7,101 units at $30.05) as part of a pre-agreed trading plan (SEC Form 4)

SEC Form 4 filed by Lu Peng

SEC Form 4 filed by Modig Berndt

SEC Form 4 filed by Nijdam Anna

SEC Form 4 filed by Modig Berndt

SEC Form 4 filed by Nijdam Anna

SEC Form 4 filed by Nijdam Anna