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Financials · SEPN

Septerna Inc. (SEPN) financials

For the twelve months ended Jun 30, 2026, Septerna Inc. reported $98.88M of revenue and -$24.24M of net income.

Revenue, TTM
$98.88M
Revenue growth, YoY
+13520.1%
Net income, TTM
-$24.24M
Net margin
-24.5%
Free cash flow, TTM
$105.10M
EPS, diluted, TTM
-$0.53
Cash
$84.66M
P/S
23.06
Market cap
$2.28B
Annual revenue$45.95M
FY2023FY2025
Annual net income-$48.88M
FY2023FY2025
Annual free cash flow$109.67M
FY2023FY2025

SEPN revenue and earnings growth

SEPN revenueQ2 2026$26.75M

Quarter YoY
225x
QoQ
+0.8%
FY YoY
43x

SEPN revenue was $26.75M in fiscal Q2 2026 (ended Jun 30, 2026), up about 225-fold from a year earlier and up 0.8% from the prior quarter. For the full fiscal 2025 it was $45.95M, up about 43-fold from fiscal 2024.

SEPN net incomeQ2 2026-$13.03M

SEPN net income was -$13.03M in fiscal Q2 2026 (ended Jun 30, 2026), compared with -$24.84M a year earlier. For the full fiscal 2025 it was -$48.88M, compared with -$71.80M in fiscal 2024.

SEPN EPSQ2 2026-$0.29

SEPN diluted EPS was -$0.29 in fiscal Q2 2026 (ended Jun 30, 2026), compared with -$0.56 a year earlier. For the full fiscal 2025 it was -$1.10.

SEPN free cash flowQ2 2026-$22.18M

SEPN free cash flow was -$22.18M in fiscal Q2 2026 (ended Jun 30, 2026), compared with -$20.34M a year earlier. For the full fiscal 2025 it was $109.67M, compared with -$69.57M in fiscal 2024.

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Income statement

Income statement
Line item
FY2025
Dec 31, 2025
FY2024
Dec 31, 2024
FY2023
Dec 31, 2023
Revenue$45.95M$1.07M$151.0K
Research and development$97.58M$65.34M$35.98M
Selling, general and admin$29.16M$16.56M$9.72M
Operating income-$68.30M-$80.82M$2.08M
Pre-tax income-$48.87M-$72.30M-$48.87M
Income tax$12.0K-$498.0K$691.0K
Net income-$48.88M-$71.80M$4.18M
EPS, basic-$1.10-$7.26$0.29
EPS, diluted-$1.10-$7.26$0.29
Diluted shares44.3M9.9M2.2M

Balance sheet

Balance sheet
Line item
FY2025
Dec 31, 2025
FY2024
Dec 31, 2024
FY2023
Dec 31, 2023
Cash and equivalents$120.72M$238.20M$88.48M
Short-term investments$270.37M$112.73M$0
Receivables$10.36M$171.0K$151.0K
Current assets$410.96M$356.82M$112.68M
Total assets$596.19M$456.55M$130.87M
Current liabilities$86.93M$12.85M$6.91M
Total liabilities$214.26M$36.51M$20.03M
Shareholders' equity$381.93M$420.05M-$38.37M

Cash flow

Cash flow
Line item
FY2025
Dec 31, 2025
FY2024
Dec 31, 2024
FY2023
Dec 31, 2023
Operating cash flow$110.19M-$67.47M-$38.72M
Capital expenditures$518.0K$2.10M$2.88M
Free cash flow$109.67M-$69.57M-$41.60M
Investing cash flow-$229.35M-$160.60M$22.12M
Financing cash flow$1.69M$377.78M$74.52M
Stock-based compensation$8.48M$3.15M$1.62M
Depreciation and amortization$1.60M$1.40M$800.0K

Key ratios

Key ratios
Line item
FY2025
Dec 31, 2025
FY2024
Dec 31, 2024
FY2023
Dec 31, 2023
Revenue growth, YoY4174.5%611.9%-
Operating margin-148.6%-7518.4%1374.2%
Net margin-106.4%-6678.9%2768.2%
Free cash flow margin238.7%-6471.9%-27550.3%
Return on equity-12.8%-17.1%-
Return on assets-8.2%-15.7%3.2%
Current ratio4.7327.7716.30

Source: XBRL data Septerna Inc. files with the SEC, latest filing dated Aug 10, 2026 (see filings on SEC EDGAR). Provided for information only, not investment advice. Check the filing before relying on a number.

* Worked out from the filings rather than stated in them: Q4 is the full year less the first nine months.

Per-share figures are as filed. The filings show no stock split in these periods.

EPS growth is left out where the share count moved enough to suggest a split the filings do not show. Growth rates need a positive starting figure. CAGR is compound annual growth between fiscal years. The CSV holds every period on file, in full figures, from the same SEC filings.

SEPN peers

CompanyRevenueGrowthNet incomeNet marginMarket cap
SEPN$98.88M+13520.1%-$24.24M-24.5%$2.28B
LLY$86.46B+45.5%$27.58B31.9%$1.27T
JNJ$99.33B+7.8%$16.09B16.2%$664.95B
ABBV$66.01B+10.7%$10.34B15.7%$514.92B
MRK$67.38B+4.9%$2.45B3.6%$361.71B
NVS$54.53B+8.4%$13.98B25.6%$310.17B
AZN$58.74B+8.6%$10.22B17.4%$289.10B
ABT$48.23B+10.0%$4.70B9.7%$190.39B
NVODKK 309.06B+6.4%DKK 102.43B33.1%$178.51B

SEPN FAQ

8 questions
  • What is SEPN revenue?
    Septerna Inc. (SEPN) reported $98.88M of revenue for the twelve months ended Jun 30, 2026. That is up 13520.1% from the year before. Revenue for fiscal 2025 was $45.95M.
  • Is SEPN profitable?
    No. Septerna Inc. reported a net loss of $24.24M for the twelve months ended Jun 30, 2026.
  • How much cash and debt does SEPN have?
    Septerna Inc. reported $84.66M in cash and cash equivalents on its most recent balance sheet in SEC filings.
  • How fast is SEPN revenue growing?
    Septerna Inc.'s revenue changed 43x in fiscal 2025, to $45.95M.
  • What is SEPN free cash flow?
    Septerna Inc. generated $105.10M of free cash flow for the twelve months ended Jun 30, 2026, which is operating cash flow of $106.01M less capital expenditures.
  • What is SEPN earnings per share?
    Diluted earnings per share were -$0.53 for the twelve months ended Jun 30, 2026, from SEC filings, restated for any stock split those filings show.
  • When did SEPN last report financial results?
    The latest statements here come from Septerna Inc.'s 10-Q filed on Aug 10, 2026, covering the period ended Jun 30, 2026.
  • Where does this SEPN financial data come from?
    Quantisnow builds these statements from the structured XBRL data Septerna Inc. files with the SEC. It is provided for information only and is not investment advice.