For the twelve months ended Jun 30, 2026, Spero Therapeutics Inc. reported $47.00M of revenue and $7.38M of net income.
SPRO revenue was $0 in fiscal Q2 2026 (ended Jun 30, 2026), down 100.0% from a year earlier and down 100.0% from the prior quarter. For the full fiscal 2025 it was $66.80M, up 39.2% from fiscal 2024. Compound annual growth was +48.2% over 5 years. It rose in 7 of the last 9 fiscal years.
SPRO net income was -$9.55M in fiscal Q2 2026 (ended Jun 30, 2026), compared with -$1.70M a year earlier. For the full fiscal 2025 it was $8.57M, compared with -$68.57M in fiscal 2024.
SPRO diluted EPS was -$0.16 in fiscal Q2 2026 (ended Jun 30, 2026), compared with -$0.03 a year earlier. For the full fiscal 2025 it was $0.15, compared with -$1.27 in fiscal 2024.
| Line item | Dec 31, 2025 | Dec 31, 2024 | Dec 31, 2023 | Dec 31, 2022 | Dec 31, 2021 | Dec 31, 2020 | Dec 31, 2019 | Dec 31, 2018 | Dec 31, 2017 | Dec 31, 2016 |
|---|---|---|---|---|---|---|---|---|---|---|
| Revenue | $66.80M | $47.98M | $103.78M | $53.51M | $18.26M | $9.33M | $18.15M | $3.97M | $1.98M | $335.0K |
| Research and development | $38.47M | $96.76M | $51.44M | $47.59M | $64.53M | $67.00M | $65.78M | $33.88M | $32.87M | $26.33M |
| Selling, general and admin | $21.18M | $23.70M | $25.55M | $36.48M | $41.70M | $21.44M | $15.59M | $12.89M | $10.84M | $7.22M |
| Operating income | $6.31M | -$73.36M | $21.48M | -$42.20M | -$87.97M | -$79.11M | -$63.22M | -$42.81M | -$41.73M | -$33.22M |
| Pre-tax income | $8.83M | -$68.57M | $25.40M | -$46.41M | -$89.76M | -$78.28M | -$60.92M | -$41.66M | -$39.89M | -$32.64M |
| Income tax | $261.0K | $0 | $2.60M | $0 | $0 | $0 | $0 | $0 | $0 | $0 |
| Net income | $8.57M | -$68.57M | $22.81M | -$46.41M | -$89.76M | -$78.30M | -$60.90M | -$41.70M | -$38.74M | -$25.49M |
| EPS, basic | $0.15 | -$1.27 | $0.43 | -$1.23 | -$2.91 | -$3.52 | -$3.35 | -$2.60 | -$17.82 | -$95.87 |
| EPS, diluted | $0.15 | -$1.27 | $0.43 | -$1.23 | -$2.91 | -$3.52 | -$3.35 | -$2.60 | -$17.82 | -$95.87 |
| Diluted shares | 59.0M | 54.0M | 53.0M | 37.6M | 30.9M | 22.4M | 18.2M | 16.0M | 2.6M | 312,169 |
| Line item | Dec 31, 2025 | Dec 31, 2024 | Dec 31, 2023 | Dec 31, 2022 | Dec 31, 2021 | Dec 31, 2020 | Dec 31, 2019 | Dec 31, 2018 | Dec 31, 2017 | Dec 31, 2016 |
|---|---|---|---|---|---|---|---|---|---|---|
| Cash and equivalents | $40.27M | $52.89M | $76.33M | $109.11M | $112.58M | $85.21M | $29.73M | $34.08M | $87.29M | $10.37M |
| Short-term investments | - | - | - | $0 | $33.82M | $41.70M | $52.31M | $81.36M | - | - |
| Current assets | $67.29M | $107.28M | $131.21M | $113.57M | $157.87M | $139.15M | $95.41M | $124.22M | $92.06M | $11.87M |
| Total assets | $68.92M | $110.54M | $182.39M | $124.80M | $171.07M | $153.45M | $106.10M | $129.01M | $93.48M | $13.77M |
| Current liabilities | $8.87M | $49.07M | $37.15M | $21.65M | $18.67M | $14.34M | $26.66M | $12.32M | $8.16M | $6.92M |
| Total liabilities | $9.90M | $64.42M | $75.50M | $48.87M | $82.78M | $21.41M | $31.53M | $13.15M | $8.52M | $7.41M |
| Shareholders' equity | $59.02M | $46.12M | $106.89M | $75.93M | $88.29M | $132.04M | $74.57M | $115.86M | $84.96M | -$49.25M |
| Line item | Dec 31, 2025 | Dec 31, 2024 | Dec 31, 2023 | Dec 31, 2022 | Dec 31, 2021 | Dec 31, 2020 | Dec 31, 2019 | Dec 31, 2018 | Dec 31, 2017 | Dec 31, 2016 |
|---|---|---|---|---|---|---|---|---|---|---|
| Operating cash flow | -$12.62M | -$23.44M | -$32.99M | -$7.73M | -$64.35M | -$85.87M | -$50.02M | -$39.63M | -$39.11M | -$28.96M |
| Capital expenditures | - | - | - | - | - | $157.0K | $314.0K | $2.44M | $27.0K | $830.0K |
| Free cash flow | - | - | - | - | - | -$86.03M | -$50.33M | -$42.06M | -$39.14M | -$29.79M |
| Investing cash flow | - | - | $0 | $33.81M | $7.67M | $10.47M | $29.53M | -$83.16M | -$27.0K | -$830.0K |
| Financing cash flow | - | $0 | $221.0K | -$29.55M | $84.05M | $130.88M | $16.14M | $69.52M | $116.11M | $34.41M |
| Stock-based compensation | $4.33M | $7.79M | $7.93M | $9.12M | $9.43M | $4.89M | $3.78M | $2.75M | $1.43M | $180.0K |
| Depreciation and amortization | $0 | $2.0K | $367.0K | $869.0K | $646.0K | $761.0K | $750.0K | $409.0K | $363.0K | $279.0K |
| Line item | Dec 31, 2025 | Dec 31, 2024 | Dec 31, 2023 | Dec 31, 2022 | Dec 31, 2021 | Dec 31, 2020 | Dec 31, 2019 | Dec 31, 2018 | Dec 31, 2017 | Dec 31, 2016 |
|---|---|---|---|---|---|---|---|---|---|---|
| Revenue growth, YoY | 39.2% | -53.8% | 94.0% | 193.1% | 95.7% | -48.6% | 357.6% | 100.4% | 490.7% | - |
| Operating margin | 9.5% | -152.9% | 20.7% | -78.9% | -481.9% | -847.9% | -348.4% | -1079.3% | -2108.6% | -9916.7% |
| Net margin | 12.8% | -142.9% | 22.0% | -86.7% | -491.7% | -839.2% | -335.6% | -1051.4% | -1957.7% | -7609.3% |
| Free cash flow margin | - | - | - | - | - | -922.1% | -277.4% | -1060.5% | -1977.7% | -8892.2% |
| Return on equity | 14.5% | -148.7% | 21.3% | -61.1% | -101.7% | -59.3% | -81.7% | -36.0% | -45.6% | - |
| Return on assets | 12.4% | -62.0% | 12.5% | -37.2% | -52.5% | -51.0% | -57.4% | -32.3% | -41.4% | -185.1% |
| Current ratio | 7.59 | 2.19 | 3.53 | 5.25 | 8.46 | 9.70 | 3.58 | 10.08 | 11.29 | 1.72 |
| Line item | Jun 30, 2026 | Mar 31, 2026 | Dec 31, 2025 | Sep 30, 2025 | Jun 30, 2025 | Mar 31, 2025 | Dec 31, 2024 | Sep 30, 2024 | Jun 30, 2024 | Mar 31, 2024 | Dec 31, 2023 | Sep 30, 2023 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Revenue | $0 | $258.0K | $41.30M | $5.44M | $14.19M | $5.87M | $15.04M | $13.47M | $10.20M | $9.27M | $73.52M | $25.47M |
| Research and development | $3.43M | $2.91M | $5.59M | $8.60M | $10.67M | $13.61M | $28.84M | $26.86M | $23.73M | $17.33M | $16.56M | $16.39M |
| Selling, general and admin | $6.49M | $4.89M | $4.30M | $4.17M | $5.88M | $6.82M | $7.06M | $5.20M | $5.53M | $5.92M | $6.43M | $5.71M |
| Operating income | -$9.93M | -$7.54M | $31.41M | -$7.92M | -$2.44M | -$14.73M | -$21.73M | -$18.59M | -$19.06M | -$13.98M | $50.53M | -$1.93M |
| Income tax | - | - | $261.0K | $0 | - | - | -$290.0K | $290.0K | - | - | $387.0K | $2.21M |
| Net income | -$9.55M | -$7.20M | $31.52M | -$7.38M | -$1.70M | -$13.87M | -$20.89M | -$17.15M | -$17.86M | -$12.67M | $51.19M | -$3.21M |
| EPS, basic | -$0.16 | -$0.13 | $0.56 | -$0.13 | -$0.03 | -$0.25 | -$0.38 | -$0.32 | -$0.33 | -$0.24 | $0.97 | -$0.06 |
| EPS, diluted | -$0.16 | -$0.13 | $0.56 | -$0.13 | -$0.03 | -$0.25 | -$0.38 | -$0.32 | -$0.33 | -$0.24 | $0.97 | -$0.06 |
| Diluted shares | 58.0M | 57.3M | - | 56.3M | 56.0M | 55.4M | - | 54.1M | 54.0M | 53.5M | - | 52.7M |
| Line item | Jun 30, 2026 | Mar 31, 2026 | Dec 31, 2025 | Sep 30, 2025 | Jun 30, 2025 | Mar 31, 2025 | Dec 31, 2024 | Sep 30, 2024 | Jun 30, 2024 | Mar 31, 2024 | Dec 31, 2023 | Sep 30, 2023 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cash and equivalents | $50.77M | $56.13M | $40.27M | $48.62M | $31.19M | $48.89M | $52.89M | $76.29M | $63.53M | $82.27M | $76.33M | $93.83M |
| Current assets | $51.58M | $57.61M | $67.29M | $52.32M | $59.40M | $74.71M | $107.28M | $131.63M | $122.22M | $140.15M | $131.21M | $102.22M |
| Total assets | $52.77M | $59.02M | $68.92M | $54.17M | $62.12M | $77.71M | $110.54M | $135.16M | $149.88M | $167.70M | $182.39M | $107.10M |
| Current liabilities | $8.43M | $5.49M | $8.87M | $13.65M | $14.95M | $29.16M | $49.07M | $49.10M | $45.63M | $41.82M | $37.15M | $25.46M |
| Total liabilities | $8.56M | $6.09M | $9.90M | $27.68M | $29.29M | $43.90M | $64.42M | $69.65M | $69.38M | $71.45M | $75.50M | $53.40M |
| Shareholders' equity | $44.20M | $52.93M | $59.02M | $26.49M | $32.83M | $33.81M | $46.12M | $65.51M | $80.50M | $96.25M | $106.89M | $53.70M |
| Line item | Jun 30, 2026 | Mar 31, 2026 | Dec 31, 2025 | Sep 30, 2025 | Jun 30, 2025 | Mar 31, 2025 | Dec 31, 2024 | Sep 30, 2024 | Jun 30, 2024 | Mar 31, 2024 | Dec 31, 2023 | Sep 30, 2023 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Operating cash flow | -$5.36M | $15.86M | -$8.35M | $17.42M | -$17.69M | -$4.00M | -$23.40M | $12.76M | -$18.74M | $5.94M | -$17.49M | $15.91M |
| Investing cash flow | - | - | - | - | - | - | - | - | - | - | $0 | $0 |
| Financing cash flow | - | - | - | - | - | - | $0 | - | - | - | $1.0K | $220.0K |
| Stock-based compensation | $822.0K | $1.11M | $1.01M | $1.05M | $714.0K | $1.56M | $1.50M | $2.15M | $2.11M | $2.02M | $2.00M | $1.91M |
| Depreciation and amortization | - | - | $0 | $0 | - | - | $0 | $0 | $2.0K | $0 | $38.0K | $108.0K |
| Line item | Jun 30, 2026 | Mar 31, 2026 | Dec 31, 2025 | Sep 30, 2025 | Jun 30, 2025 | Mar 31, 2025 | Dec 31, 2024 | Sep 30, 2024 | Jun 30, 2024 | Mar 31, 2024 | Dec 31, 2023 | Sep 30, 2023 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Revenue growth, YoY | -100.0% | -95.6% | 174.5% | -59.6% | 39.1% | -36.6% | -79.5% | -47.1% | 275.4% | 347.9% | 55.0% | 1169.8% |
| Net income growth, YoY | - | - | - | - | - | - | - | - | - | - | 91.1% | - |
| Operating margin | - | -2921.7% | 76.0% | -145.5% | -17.2% | -250.8% | -144.4% | -138.0% | -186.9% | -150.9% | 68.7% | -7.6% |
| Net margin | - | -2791.9% | 76.3% | -135.6% | -12.0% | -236.1% | -138.8% | -127.3% | -175.2% | -136.7% | 69.6% | -12.6% |
| Current ratio | 6.12 | 10.50 | 7.59 | 3.83 | 3.97 | 2.56 | 2.19 | 2.68 | 2.68 | 3.35 | 3.53 | 4.01 |
Source: XBRL data Spero Therapeutics Inc. files with the SEC, latest filing dated Aug 12, 2026 (see filings on SEC EDGAR). Provided for information only, not investment advice. Check the filing before relying on a number.
* Worked out from the filings rather than stated in them: Q4 is the full year less the first nine months.
Per-share figures are as filed. The filings show no stock split in these periods.
EPS growth is left out where the share count moved enough to suggest a split the filings do not show. Growth rates need a positive starting figure. CAGR is compound annual growth between fiscal years. The CSV holds every period on file, in full figures, from the same SEC filings.
| Company | Revenue | Growth | Net income | Net margin | Market cap |
|---|---|---|---|---|---|
| SPRO | $47.00M | -3.3% | $7.38M | 15.7% | $62.3M |
| INVA | $438.32M | +12.8% | $193.44M | 44.1% | $1.35B |