GPCR insider transactions

COO & GC Lang Matthew was granted 184,614 units of Ordinary Shares (SEC Form 4)

SEC Form 3 filed by new insider Lang Matthew

SEC Form 4 filed by Fmr Llc

SEC Form 4 filed by Hall Ashley

SEC Form 4 filed by Lin Xichen

SEC Form 4 filed by Ma Yingli

SEC Form 4 filed by Coll Crespo Blas

SEC Form 4 filed by Yoon Jun

SEC Form 4 filed by Stevens Raymond C

CHIEF TECHNOLOGY OFFICER Ma Yingli covered exercise/tax liability with 11,313 units of Ordinary Shares, decreasing direct ownership by 10% to 107,391 units (SEC Form 4)

CHIEF MEDICAL OFFICER Coll Crespo Blas covered exercise/tax liability with 11,826 units of Ordinary Shares, decreasing direct ownership by 5% to 204,981 units (SEC Form 4)

CHIEF EXECUTIVE OFFICER Stevens Raymond C covered exercise/tax liability with 53,454 units of Ordinary Shares, decreasing direct ownership by 4% to 1,141,376 units (SEC Form 4)

CHIEF SCIENTIFIC OFFICER Lin Xichen covered exercise/tax liability with 18,735 units of Ordinary Shares, decreasing direct ownership by 9% to 185,592 units (SEC Form 4)

Chief Development Officer Hall Ashley covered exercise/tax liability with 4,836 units of Ordinary Shares, decreasing direct ownership by 4% to 107,481 units (SEC Form 4)

CHIEF FINANCIAL OFFICER Yoon Jun covered exercise/tax liability with 22,305 units of Ordinary Shares, decreasing direct ownership by 2% to 1,297,571 units (SEC Form 4)

SEC Form 4 filed by See Remark 1 Fmr Llc

SEC Form 4 filed by See Remark 1 Fmr Llc

CHIEF MEDICAL OFFICER Coll Crespo Blas covered exercise/tax liability with 8,106 units of Ordinary Shares, decreasing direct ownership by 4% to 216,807 units (SEC Form 4)

Chief Development Officer Hall Ashley covered exercise/tax liability with 6,021 units of Ordinary Shares, decreasing direct ownership by 5% to 112,317 units (SEC Form 4)

CHIEF SCIENTIFIC OFFICER Lin Xichen covered exercise/tax liability with 12,846 units of Ordinary Shares, decreasing direct ownership by 6% to 204,327 units (SEC Form 4)

CHIEF TECHNOLOGY OFFICER Ma Yingli covered exercise/tax liability with 4,470 units of Ordinary Shares, decreasing direct ownership by 4% to 118,704 units (SEC Form 4)

SEC Form 4 filed by See Remark 1 Fmr Llc

CHIEF TECHNOLOGY OFFICER Ma Yingli covered exercise/tax liability with 1,824 units of Ordinary Shares and was granted 24,459 units of Ordinary Shares, increasing direct ownership by 23% to 123,174 units (SEC Form 4)

CHIEF MEDICAL OFFICER Coll Crespo Blas was granted 7,992 units of Ordinary Shares and covered exercise/tax liability with 2,667 units of Ordinary Shares, increasing direct ownership by 2% to 224,913 units (SEC Form 4)

CHIEF SCIENTIFIC OFFICER Lin Xichen covered exercise/tax liability with 6,441 units of Ordinary Shares and was granted 57,078 units of Ordinary Shares, increasing direct ownership by 30% to 217,173 units (SEC Form 4)

CHIEF FINANCIAL OFFICER Yoon Jun covered exercise/tax liability with 13,029 units of Ordinary Shares and was granted 39,606 units of Ordinary Shares, increasing direct ownership by 2% to 1,319,876 units (SEC Form 4)

CHIEF EXECUTIVE OFFICER Stevens Raymond C covered exercise/tax liability with 28,545 units of Ordinary Shares and was granted 89,697 units of Ordinary Shares, increasing direct ownership by 5% to 1,194,830 units (SEC Form 4)

SEC Form 4 filed by Director Love Ted W

SEC Form 4 filed by Director Russell Angus C.

SEC Form 4 filed by Director Waldstreicher Joanne

SEC Form 4 filed by Director Tetlow Sharon

SEC Form 4 filed by Director Dobmeier Eric

SEC Form 4 filed by Director Welch Daniel G

Chief Development Officer Hall Ashley was granted 51,048 units of Ordinary Shares, increasing direct ownership by 76% to 118,338 units (SEC Form 4)

CHIEF TECHNOLOGY OFFICER Ma Yingli was granted 63,810 units of Ordinary Shares, increasing direct ownership by 174% to 100,539 units (SEC Form 4)

Chief Medical Officer Coll Crespo Blas was granted 116,988 units of Ordinary Shares, increasing direct ownership by 114% to 219,588 units (SEC Form 4)

CHIEF EXECUTIVE OFFICER Stevens Raymond C was granted 340,332 units of Ordinary Shares, increasing direct ownership by 43% to 1,133,678 units (SEC Form 4)

CHIEF SCIENTIFIC OFFICER Lin Xichen was granted 80,829 units of Ordinary Shares, increasing direct ownership by 94% to 166,536 units (SEC Form 4)

CHIEF FINANCIAL OFFICER Yoon Jun was granted 170,166 units of Ordinary Shares, increasing direct ownership by 15% to 1,293,299 units (SEC Form 4)

SEC Form 4 filed by See Remark 1 Fmr Llc

Chief Development Officer Hall Ashley was granted 67,290 units of Ordinary Shares (SEC Form 4)

SEC Form 3 filed by new insider Hall Ashley

Chief Medical Officer Coll Crespo Blas was granted 90,600 units of Ordinary Shares, increasing direct ownership by 755% to 102,600 units (SEC Form 4)

New insider Coll Crespo Blas claimed ownership of 12,000 units of Ordinary Shares (SEC Form 3)

SEC Form 4 filed by Director Russell Angus C.

SEC Form 3 filed by new insider Russell Angus C.

SEC Form 4 filed by Director Dobmeier Eric

SEC Form 4 filed by Director Welch Daniel G

SEC Form 4 filed by Director Waldstreicher Joanne

SEC Form 4 filed by Director Love Ted W

SEC Form 4 filed by Director Tetlow Sharon

CHIEF EXECUTIVE OFFICER Stevens Raymond C exercised 150,000 units of Ordinary Shares at a strike of $0.42, increasing direct ownership by 23% to 793,346 units (SEC Form 4)

New insider Fmr Llc claimed ownership of 575,934 units of Ordinary Shares (SEC Form 3)

CHIEF EXECUTIVE OFFICER Stevens Raymond C decreased direct ownership by 46% to 643,346 units (SEC Form 4)

Lin Xichen exercised 106,200 units of Ordinary Shares at a strike of $0.34 (SEC Form 4)

SEC Form 4 filed by Fmr Llc

SEC Form 4 filed by Lin Xichen (Amendment)

SEC Form 4 filed by Bach Mark Allen (Amendment)

SEC Form 4 filed by Ma Yingli (Amendment)

SEC Form 4 filed by Yoon Jun (Amendment)