ONC insider transactions

President and COO Wu Xiaobin sold $361,997 worth of American Depositary Shares (1,357 units at $266.76), closing all direct ownership in the company (SEC Form 4) to cover taxes

SVP, General Counsel Lee Chan Henry sold $156,925 worth of American Depositary Shares (590 units at $265.98), closing all direct ownership in the company (SEC Form 4) to cover taxes

Chief Executive Officer Oyler John sold $980,686 worth of American Depositary Shares (3,693 units at $265.55), closing all direct ownership in the company (SEC Form 4) to satisfy tax liability

President, Global Head of R&D Wang Lai sold $310,236 worth of American Depositary Shares (1,169 units at $265.39), closing all direct ownership in the company (SEC Form 4) (tax liability)

Principal Accounting Officer Ball Titus B. was granted 31,213 units of Ordinary Shares and sold $43,467 worth of American Depositary Shares (169 units at $257.20), closing all direct ownership in the company (SEC Form 4) (for tax liability)

President, Global Head of R&D Wang Lai was granted 118,625 units of Ordinary Shares and sold $197,318 worth of American Depositary Shares (756 units at $261.00), closing all direct ownership in the company (SEC Form 4) (tax liability)

Chief Financial Officer Rosenberg Aaron was granted 71,175 units of Ordinary Shares and sold $162,637 worth of American Depositary Shares (631 units at $257.74), closing all direct ownership in the company (SEC Form 4) (for withholding tax)

SVP, General Counsel Lee Chan Henry was granted 45,071 units of Ordinary Shares and sold $110,268 worth of American Depositary Shares (428 units at $257.63), closing all direct ownership in the company (SEC Form 4) (tax withholding)

President and COO Wu Xiaobin was granted 118,625 units of Ordinary Shares and sold $163,512 worth of American Depositary Shares (626 units at $261.20), closing all direct ownership in the company (SEC Form 4) (tax withholding)

Chair, Scientific Advisory Brd Wang Xiaodong was granted 99,892 units of Ordinary Shares, increasing direct ownership by 2% to 4,682,493 units (SEC Form 4)

Chief Executive Officer Oyler John was granted 177,931 units of Ordinary Shares and sold $501,355 worth of American Depositary Shares (1,949 units at $257.24), closing all direct ownership in the company (SEC Form 4) to satisfy withholding tax

Director Brandicourt Olivier was granted 18,980 units of Ordinary Shares, increasing direct ownership by 69% to 46,306 units (SEC Form 4)

Director Hooper Anthony C was granted 18,980 units of Ordinary Shares, increasing direct ownership by 29% to 83,720 units (SEC Form 4)

Director Mooney Elizabeth Fisher was granted 18,980 units of Ordinary Shares (SEC Form 4)

Director Dugan Margaret was granted 18,980 units of Ordinary Shares, increasing direct ownership by 35% to 73,164 units (SEC Form 4)

Director Sawyers Charles Lazelle was granted 18,980 units of Ordinary Shares, increasing direct ownership by 474,500% to 18,984 units (SEC Form 4)

Director Sharp Shalini was granted 18,980 units of Ordinary Shares, increasing direct ownership by 99% to 38,116 units (SEC Form 4)

Director Riva Alessandro was granted 18,980 units of Ordinary Shares, increasing direct ownership by 35% to 73,164 units (SEC Form 4)

New insider Sawyers Charles Lazelle claimed ownership of 4 units of Ordinary Shares and claimed ownership of 1,946 units of American Depositary Shares (SEC Form 3)

SEC Form 3 filed by new insider Mooney Elizabeth Fisher

Director Baker Bros. Advisors Lp was granted 37,960 units of Ordinary Shares (SEC Form 4)

Principal Accounting Officer Ball Titus B. sold $36,901 worth of American Depositary Shares (136 units at $271.33), closing all direct ownership in the company (SEC Form 4) to cover taxes

SVP, General Counsel Lee Chan Henry sold $235,539 worth of American Depositary Shares (871 units at $270.42), closing all direct ownership in the company (SEC Form 4) (withholding obligation)

President, Global Head of R&D Wang Lai sold $368,247 worth of American Depositary Shares (1,367 units at $269.38), closing all direct ownership in the company (SEC Form 4) to satisfy tax liability

President and COO Wu Xiaobin sold $399,738 worth of American Depositary Shares (1,484 units at $269.37), closing all direct ownership in the company (SEC Form 4) to satisfy withholding tax

Chief Executive Officer Oyler John sold $1,336,548 worth of American Depositary Shares (4,940 units at $270.56), closing all direct ownership in the company (SEC Form 4) (tax withholding)

Director Yi Qingqing sold $65,596 worth of American Depositary Shares (235 units at $279.13), closing all direct ownership in the company (SEC Form 4) (for withholding tax)

Director Riva Alessandro sold $65,617 worth of American Depositary Shares (212 units at $309.51), closing all direct ownership in the company (SEC Form 4) (tax liability)

Director Dugan Margaret sold $65,636 worth of American Depositary Shares (212 units at $309.60), closing all direct ownership in the company (SEC Form 4) to cover taxes

Director Sanders Corazon (Corsee) D. sold $65,633 worth of American Depositary Shares (212 units at $309.59), closing all direct ownership in the company (SEC Form 4) to cover taxes

Director Baker Bros. Advisors Lp sold $261,981 worth of Ordinary Shares (10,998 units at $23.82) (SEC Form 4) to satisfy withholding tax

Amendment: New insider Sharp Shalini claimed ownership of 9 units of American Depositary Shares (SEC Form 3)

SVP, General Counsel Lee Chan Henry exercised 332 units of American Depositary Shares at a strike of $191.56 and sold $103,159 worth of American Depositary Shares (332 units at $310.72) as part of a pre-agreed trading plan (SEC Form 4)

SEC Form 4 filed by Lee Chan Henry

SVP, General Counsel Lee Chan Henry sold $102,300 worth of American Depositary Shares (341 units at $300.00) and exercised 341 units of American Depositary Shares at a strike of $191.64 (SEC Form 4)

Chief Executive Officer Oyler John was granted 444,912 units of Ordinary Shares, increasing direct ownership by 9% to 5,609,275 units (SEC Form 4)

President, Global Head of R&D Wang Lai was granted 167,635 units of Ordinary Shares, increasing direct ownership by 12% to 1,619,059 units (SEC Form 4)

President and COO Wu Xiaobin was granted 247,546 units of Ordinary Shares, increasing direct ownership by 26% to 1,216,524 units (SEC Form 4)

Chief Financial Officer Rosenberg Aaron was granted 119,587 units of Ordinary Shares, increasing direct ownership by 56% to 334,919 units (SEC Form 4)

SVP, General Counsel Lee Chan Henry was granted 95,264 units of Ordinary Shares, increasing direct ownership by 43% to 318,370 units (SEC Form 4)

SVP, General Counsel Lee Chan Henry sold $580,197 worth of American Depositary Shares (1,660 units at $349.52) and exercised 1,660 units of American Depositary Shares at a strike of $191.40 (SEC Form 4)

SVP, General Counsel Lee Chan Henry exercised 664 units of American Depositary Shares at a strike of $191.56 and sold $220,289 worth of American Depositary Shares (664 units at $331.76) (SEC Form 4)

President, Global Head of R&D Wang Lai was granted 427,895 units of Ordinary Shares, increasing direct ownership by 42% to 1,451,424 units (SEC Form 4)

Chief Executive Officer Oyler John sold $30,659,419 worth of American Depositary Shares (100,000 units at $306.59), closing all direct ownership in the company (SEC Form 4)

SVP, General Counsel Lee Chan Henry exercised 664 units of American Depositary Shares at a strike of $191.56 and sold $213,569 worth of American Depositary Shares (664 units at $321.64) (SEC Form 4)

Director Sanders Corazon (Corsee) D. exercised 2,627 units of American Depositary Shares at a strike of $159.03 and sold $895,534 worth of American Depositary Shares (2,627 units at $340.90) (SEC Form 4)

President and COO Wu Xiaobin sold $1,518,303 worth of American Depositary Shares (3,991 units at $380.43), closing all direct ownership in the company (SEC Form 4)

President and COO Wu Xiaobin sold $5,846,820 worth of American Depositary Shares (16,009 units at $365.22), closing all direct ownership in the company (SEC Form 4)

SVP, General Counsel Lee Chan Henry exercised 996 units of American Depositary Shares at a strike of $191.47 and sold $347,770 worth of American Depositary Shares (996 units at $349.17) (SEC Form 4)

Chief Executive Officer Oyler John gifted 1,009,853 units of Ordinary Shares, decreasing direct ownership by 14% to 6,441,041 units (SEC Form 4)

Chair, Scientific Advisory Brd Wang Xiaodong gifted 424,073 units of Ordinary Shares, decreasing direct ownership by 8% to 4,582,601 units (SEC Form 4)

SVP, General Counsel Lee Chan Henry sold $3,739,108 worth of American Depositary Shares (10,671 units at $350.40) and exercised 9,559 units of American Depositary Shares at a strike of $211.04, closing all direct ownership in the company (SEC Form 4)

Chief Executive Officer Oyler John sold $9,055,694 worth of American Depositary Shares (27,803 units at $325.71), closing all direct ownership in the company (SEC Form 4)

SVP, General Counsel Lee Chan Henry sold $3,257,289 worth of American Depositary Shares (10,006 units at $325.53) and exercised 8,894 units of American Depositary Shares at a strike of $197.10, closing all direct ownership in the company (SEC Form 4)

Chair, Scientific Advisory Brd Wang Xiaodong gifted 148,096 units of Ordinary Shares, decreasing direct ownership by 3% to 5,006,674 units (SEC Form 4)

Global Head of R&D Wang Lai sold $1,750,312 worth of American Depositary Shares (5,000 units at $350.06) (SEC Form 4)

Director Sanders Corazon (Corsee) D. exercised 2,665 units of American Depositary Shares at a strike of $155.68 and sold $898,105 worth of American Depositary Shares (2,665 units at $337.00) (SEC Form 4)

Principal Accounting Officer Ball Titus B. sold $39,865 worth of American Depositary Shares (122 units at $326.76), closing all direct ownership in the company (SEC Form 4)

President and COO Wu Xiaobin exercised 89,794 units of American Depositary Shares at a strike of $160.78 and sold $27,347,635 worth of American Depositary Shares (89,794 units at $304.56) (SEC Form 4)

SVP, General Counsel Lee Chan Henry sold $3,308,877 worth of American Depositary Shares (11,013 units at $300.45) and exercised 8,230 units of American Depositary Shares at a strike of $177.90, closing all direct ownership in the company (SEC Form 4)