PTCT insider transactions

CHIEF EXECUTIVE OFFICER Klein Matthew B. sold $202,094 worth of shares (2,850 units at $70.91), decreasing direct ownership by 0.72% to 394,070 units (SEC Form 4) to satisfy withholding tax

SEC Form 4 filed by Boulding Mark Elliott

SEC Form 4 filed by Golden Lee Scott

SEC Form 4 filed by Almstead Neil Gregory

SEC Form 4 filed by Chutter Jessica Caroline

SEC Form 3 filed by new insider Chutter Jessica Caroline

CHIEF EXECUTIVE OFFICER Klein Matthew B. was granted 12,500 shares and sold $170,581 worth of shares (2,662 units at $64.08), increasing direct ownership by 3% to 396,920 units (SEC Form 4)

Director Okey Stephanie exercised 15,167 shares at a strike of $33.63 and sold $1,061,690 worth of shares (15,167 units at $70.00) (SEC Form 4)

CHIEF TECHNICAL OPS OFFICER Almstead Neil Gregory sold $252,823 worth of shares (3,989 units at $63.38) (SEC Form 4)

EVP & CHIEF MEDICAL OFFICER Golden Lee Scott sold $633,800 worth of shares (10,000 units at $63.38), decreasing direct ownership by 11% to 79,944 units (SEC Form 4)

Director Okey Stephanie sold $401,386 worth of shares (6,333 units at $63.38), decreasing direct ownership by 44% to 8,000 units (SEC Form 4)

EXEC. VP AND CLO Boulding Mark Elliott sold $209,763 worth of shares (3,019 units at $69.48), decreasing direct ownership by 3% to 105,212 units (SEC Form 4)

CHIEF BUSINESS OFFICER Pauwels Eric sold $209,398 worth of shares (3,019 units at $69.36), decreasing direct ownership by 4% to 77,122 units (SEC Form 4)

CHIEF EXECUTIVE OFFICER Klein Matthew B. sold $511,253 worth of shares (7,371 units at $69.36), decreasing direct ownership by 2% to 387,082 units (SEC Form 4)

SVP, CHIEF ACCOUNTING OFFICER Utter Christine Marie sold $172,984 worth of shares (2,494 units at $69.36), decreasing direct ownership by 3% to 70,199 units (SEC Form 4)

CHIEF FINANCIAL OFFICER Gravier Pierre sold $207,525 worth of shares (2,992 units at $69.36), decreasing direct ownership by 3% to 87,318 units (SEC Form 4)

EVP & CHIEF MEDICAL OFFICER Golden Lee Scott sold $172,290 worth of shares (2,484 units at $69.36), decreasing direct ownership by 3% to 89,944 units (SEC Form 4)

CHIEF TECHNICAL OPS OFFICER Almstead Neil Gregory sold $216,473 worth of shares (3,121 units at $69.36), decreasing direct ownership by 3% to 112,140 units (SEC Form 4)

EXEC. VP AND CLO Boulding Mark Elliott exercised 2,813 shares at a strike of $25.69 and sold $408,613 worth of shares (5,894 units at $69.33), decreasing direct ownership by 3% to 108,231 units (SEC Form 4)

SVP, CHIEF ACCOUNTING OFFICER Utter Christine Marie sold $79,049 worth of shares (1,034 units at $76.45), decreasing direct ownership by 1% to 72,693 units (SEC Form 4)

EXEC. VP AND CLO Boulding Mark Elliott sold $489,081 worth of shares (6,347 units at $77.06), decreasing direct ownership by 5% to 111,312 units (SEC Form 4)

EVP & CHIEF MEDICAL OFFICER Golden Lee Scott sold $66,206 worth of shares (866 units at $76.45), decreasing direct ownership by 0.93% to 92,428 units (SEC Form 4)

CHIEF EXECUTIVE OFFICER Klein Matthew B. sold $192,195 worth of shares (2,514 units at $76.45), decreasing direct ownership by 0.63% to 394,453 units (SEC Form 4)

CHIEF BUSINESS OFFICER Pauwels Eric sold $565,946 worth of shares (7,348 units at $77.02), decreasing direct ownership by 8% to 80,141 units (SEC Form 4)

CHIEF TECHNICAL OPS OFFICER Almstead Neil Gregory sold $71,863 worth of shares (940 units at $76.45), decreasing direct ownership by 0.76% to 115,196 units (SEC Form 4)

SVP, CHIEF ACCOUNTING OFFICER Utter Christine Marie sold $201,919 worth of shares (2,616 units at $77.19), decreasing direct ownership by 3% to 73,727 units (SEC Form 4)

CHIEF FINANCIAL OFFICER Gravier Pierre sold $164,596 worth of shares (2,139 units at $76.95), decreasing direct ownership by 2% to 90,310 units (SEC Form 4)

CHIEF EXECUTIVE OFFICER Klein Matthew B. sold $629,895 worth of shares (8,165 units at $77.15), decreasing direct ownership by 2% to 396,967 units (SEC Form 4)

CHIEF BUSINESS OFFICER Pauwels Eric sold $242,417 worth of shares (3,141 units at $77.18), decreasing direct ownership by 3% to 87,489 units (SEC Form 4)

EVP & CHIEF MEDICAL OFFICER Golden Lee Scott sold $152,855 worth of shares (1,982 units at $77.12), decreasing direct ownership by 2% to 93,294 units (SEC Form 4)

EXEC. VP AND CLO Boulding Mark Elliott sold $511,641 worth of shares (6,618 units at $77.31) and exercised 3,376 shares at a strike of $38.10, decreasing direct ownership by 3% to 117,659 units (SEC Form 4)

CHIEF TECHNICAL OPS OFFICER Almstead Neil Gregory sold $186,098 worth of shares (2,411 units at $77.19), decreasing direct ownership by 2% to 116,077 units (SEC Form 4)

Director Smith Mary L. was granted 4,000 shares, increasing direct ownership by 22% to 21,813 units (SEC Form 4)

CHIEF TECHNICAL OPS OFFICER Almstead Neil Gregory was granted 18,020 shares, increasing direct ownership by 17% to 118,382 units (SEC Form 4)

CHIEF BUSINESS OFFICER Pauwels Eric was granted 20,000 shares, increasing direct ownership by 28% to 90,630 units (SEC Form 4)

SVP, CHIEF ACCOUNTING OFFICER Utter Christine Marie was granted 13,250 shares, increasing direct ownership by 21% to 76,343 units (SEC Form 4)

EVP & CHIEF MEDICAL OFFICER Golden Lee Scott was granted 18,750 shares, increasing direct ownership by 25% to 95,276 units (SEC Form 4)

Director Young Alethia was granted 4,000 shares, increasing direct ownership by 23% to 21,067 units (SEC Form 4)

Director Reeve Emma was granted 4,000 shares, exercised 734 shares at a strike of $46.54 and sold $55,784 worth of shares (734 units at $76.00), increasing direct ownership by 60% to 10,666 units (SEC Form 4)

Director Zeldis Jerome B was granted 4,000 shares, increasing direct ownership by 22% to 22,500 units (SEC Form 4)

Director Southwell David P was granted 4,000 shares, increasing direct ownership by 24% to 20,850 units (SEC Form 4)

Director Okey Stephanie was granted 4,000 shares, increasing direct ownership by 50% to 12,000 units (SEC Form 4)

EXEC. VP AND CLO Boulding Mark Elliott was granted 17,000 shares, exercised 2,266 shares at a strike of $39.42 and sold $171,192 worth of shares (2,266 units at $75.55), increasing direct ownership by 16% to 120,901 units (SEC Form 4)

Director Jacobson Allan Steven was granted 4,000 shares, increasing direct ownership by 23% to 21,451 units (SEC Form 4)

CHIEF EXECUTIVE OFFICER Klein Matthew B. was granted 63,000 shares, increasing direct ownership by 18% to 405,132 units (SEC Form 4)

CHIEF FINANCIAL OFFICER Gravier Pierre was granted 20,000 shares, increasing direct ownership by 28% to 92,449 units (SEC Form 4)

Director Schmertzler Michael was granted 8,000 shares, increasing direct ownership by 5% to 163,266 units (SEC Form 4)

Director Steele Glenn Jr Md Phd exercised 12,000 shares at a strike of $30.86, sold $916,200 worth of shares (12,000 units at $76.35) and was granted 4,000 shares, increasing direct ownership by 22% to 22,500 units (SEC Form 4)

CHIEF EXECUTIVE OFFICER Klein Matthew B. sold $619,941 worth of shares (8,089 units at $76.64), decreasing direct ownership by 2% to 341,875 units (SEC Form 4)

CHIEF BUSINESS OFFICER Pauwels Eric exercised 20,508 shares at a strike of $65.15 and sold $1,584,350 worth of shares (20,508 units at $77.26) (SEC Form 4)

CHIEF BUSINESS OFFICER Pauwels Eric exercised 43,492 shares at a strike of $62.10 and sold $3,279,275 worth of shares (43,492 units at $75.40), decreasing direct ownership by 3% to 70,373 units (SEC Form 4)

Director Schmertzler Michael exercised 24,000 shares at a strike of $30.86, increasing direct ownership by 18% to 155,266 units (SEC Form 4)

Director Reeve Emma exercised 733 shares at a strike of $46.54 and sold $57,628 worth of shares (733 units at $78.62) (SEC Form 4)

CHIEF EXECUTIVE OFFICER Klein Matthew B. was granted 15,625 shares and sold $271,052 worth of shares (3,428 units at $79.07), increasing direct ownership by 4% to 349,964 units (SEC Form 4)

CHIEF TECHNICAL OPS OFFICER Almstead Neil Gregory exercised 71,928 shares at a strike of $30.75 and sold $6,001,932 worth of shares (71,928 units at $83.44) (SEC Form 4)

Director Jacobson Allan Steven exercised 26,000 shares at a strike of $14.88 and sold $2,132,018 worth of shares (26,000 units at $82.00) (SEC Form 4)

CHIEF TECHNICAL OPS OFFICER Almstead Neil Gregory exercised 35,572 shares at a strike of $30.23 and sold $2,852,031 worth of shares (35,572 units at $80.18) (SEC Form 4)

Director Reeve Emma exercised 10,000 shares at a strike of $51.16 and sold $795,000 worth of shares (10,000 units at $79.50) (SEC Form 4)

Director Okey Stephanie gifted 867 shares, decreasing direct ownership by 10% to 8,000 units (SEC Form 4)

EXEC. VP AND CLO Boulding Mark Elliott exercised 2,812 shares at a strike of $25.69 and sold $213,687 worth of shares (2,812 units at $75.99) (SEC Form 4)