RVMD insider transactions

Chief Development Officer Sandler Alan B. sold $67,941 worth of shares (341 units at $199.24) as part of a pre-agreed trading plan, decreasing direct ownership by 0.64% to 52,868 units (SEC Form 4) to satisfy withholding tax

Officer Mancini Anthony sold $353,449 worth of shares (1,774 units at $199.24) as part of a pre-agreed trading plan, decreasing direct ownership by 4% to 42,116 units (SEC Form 4) (for tax liability)

Officer Kelsey Stephen Michael sold $1,109,554 worth of shares (5,569 units at $199.24) as part of a pre-agreed trading plan, decreasing direct ownership by 2% to 286,307 units (SEC Form 4) to satisfy withholding obligation

Chief Operating Officer Horn Margaret A sold $989,613 worth of shares (4,967 units at $199.24) as part of a pre-agreed trading plan, decreasing direct ownership by 3% to 149,680 units (SEC Form 4) (withholding tax)

Officer Goldsmith Mark A sold $2,786,938 worth of shares (13,988 units at $199.24) as part of a pre-agreed trading plan, decreasing direct ownership by 5% to 253,342 units (SEC Form 4) (for withholding tax)

SVP & General Counsel Cislini Jeff sold $670,631 worth of shares (3,366 units at $199.24) as part of a pre-agreed trading plan, decreasing direct ownership by 6% to 52,541 units (SEC Form 4) (tax liability)

Chief Financial Officer Anders Jack sold $807,513 worth of shares (4,053 units at $199.24) as part of a pre-agreed trading plan, decreasing direct ownership by 3% to 119,216 units (SEC Form 4) to satisfy withholding obligation

Officer Kelsey Stephen Michael exercised 92,531 shares at a strike of $41.71 and sold $18,724,767 worth of shares (92,531 units at $202.36) as part of a pre-agreed trading plan (SEC Form 4)

Officer Mancini Anthony exercised 9,363 shares at a strike of $33.62 and sold $3,153,807 worth of shares (15,448 units at $204.16) as part of a pre-agreed trading plan, decreasing direct ownership by 12% to 43,890 units (SEC Form 4)

Director Kim Lorence H. sold $3,585,837 worth of shares (17,090 units at $209.82) as part of a pre-agreed trading plan (SEC Form 4)

Director Kim Lorence H. sold $11,381,288 worth of shares (56,000 units at $203.24) as part of a pre-agreed trading plan (SEC Form 4)

General Counsel Cislini Jeff exercised 56,280 shares at a strike of $20.00 and sold $11,904,247 worth of shares (56,894 units at $209.24) as part of a pre-agreed trading plan, decreasing direct ownership by 1% to 55,907 units (SEC Form 4)

Officer Goldsmith Mark A exercised 80,000 shares at a strike of $4.73 and sold $17,991,107 worth of shares (86,000 units at $209.20) as part of a pre-agreed trading plan (SEC Form 4)

Director Patel Sushil exercised 2,955 shares at a strike of $37.54 and sold $1,048,967 worth of shares (5,580 units at $187.99) as part of a pre-agreed trading plan, decreasing direct ownership by 11% to 21,656 units (SEC Form 4)

Chief Financial Officer Anders Jack exercised 20,000 shares at a strike of $18.56 and sold $3,366,604 worth of shares (20,000 units at $168.33) as part of a pre-agreed trading plan (SEC Form 4)

Director Kim Lorence H. was granted 1,191 shares, increasing direct ownership by 2% to 74,281 units (SEC Form 4)

Director Borisy Alexis was granted 1,191 shares, increasing direct ownership by 0.05% to 2,340,075 units (SEC Form 4)

Director Anderson Elizabeth M was granted 1,191 shares, increasing direct ownership by 14% to 9,406 units (SEC Form 4)

Director Horning Sandra was granted 1,191 shares, increasing direct ownership by 1% to 97,765 units (SEC Form 4)

Director Clyburn Frank was granted 1,191 shares, increasing direct ownership by 12% to 10,929 units (SEC Form 4)

Director Patel Sushil was granted 1,191 shares, increasing direct ownership by 5% to 24,281 units (SEC Form 4)

Director Borellini Flavia was granted 1,191 shares, increasing direct ownership by 5% to 26,215 units (SEC Form 4)

Officer Mancini Anthony sold $720,490 worth of shares (4,615 units at $156.12), decreasing direct ownership by 8% to 49,975 units (SEC Form 4) to satisfy withholding tax

Officer Goldsmith Mark A sold $1,564,310 worth of shares (10,020 units at $156.12) as part of a pre-agreed trading plan, decreasing direct ownership by 4% to 267,330 units (SEC Form 4) to satisfy withholding tax

General Counsel Cislini Jeff sold $336,749 worth of shares (2,157 units at $156.12) as part of a pre-agreed trading plan, decreasing direct ownership by 4% to 56,521 units (SEC Form 4) (for tax liability)

Chief Financial Officer Anders Jack sold $424,956 worth of shares (2,722 units at $156.12) as part of a pre-agreed trading plan, decreasing direct ownership by 2% to 123,269 units (SEC Form 4) to satisfy withholding tax

Officer Kelsey Stephen Michael sold $651,798 worth of shares (4,175 units at $156.12) as part of a pre-agreed trading plan, decreasing direct ownership by 1% to 291,876 units (SEC Form 4) (withholding tax)

Chief Operating Officer Horn Margaret A exercised 90,000 shares at a strike of $30.82 and sold $14,972,110 worth of shares (93,575 units at $160.00) as part of a pre-agreed trading plan, decreasing direct ownership by 2% to 154,647 units (SEC Form 4) to cover taxes

Chief Operating Officer Horn Margaret A exercised 10,000 shares at a strike of $40.93 and sold $1,480,139 worth of shares (10,000 units at $148.01) as part of a pre-agreed trading plan (SEC Form 4)

Officer Mancini Anthony exercised 3,121 shares at a strike of $33.62 and sold $480,611 worth of shares (3,121 units at $153.99) as part of a pre-agreed trading plan (SEC Form 4)

Officer Mancini Anthony exercised 3,120 shares at a strike of $33.62 and sold $413,129 worth of shares (3,120 units at $132.41) as part of a pre-agreed trading plan (SEC Form 4)

SEC Form 4 filed by Goldsmith Mark A

SEC Form 4 filed by Mancini Anthony

SEC Form 3 filed by new insider Mancini Anthony

SEC Form 3 filed by new insider Sandler Alan B.

SEC Form 4 filed by Wei Lin

SEC Form 4 filed by Kelsey Stephen Michael

SEC Form 4 filed by Goldsmith Mark A

SEC Form 4 filed by Horn Margaret A

SEC Form 4 filed by Anders Jack

SEC Form 4 filed by Cislini Jeff

SEC Form 4 filed by Wang Xiaolin

Director Anderson Elizabeth M received a gift of 15,000 shares and gifted 15,000 shares, decreasing direct ownership by 65% to 8,215 units (SEC Form 4)

Officer Wang Xiaolin was granted 15,100 shares, increasing direct ownership by 15% to 118,073 units (SEC Form 4)

Chief Medical Officer Wei Lin was granted 15,100 shares, increasing direct ownership by 17% to 103,439 units (SEC Form 4)

Officer Kelsey Stephen Michael was granted 21,100 shares, increasing direct ownership by 8% to 299,700 units (SEC Form 4)

Officer Goldsmith Mark A was granted 57,100 shares, exercised 30,000 shares at a strike of $4.09 and sold $3,644,354 worth of shares (36,000 units at $101.23), increasing direct ownership by 25% to 289,569 units (SEC Form 4)

Chief Operating Officer Horn Margaret A was granted 21,100 shares, increasing direct ownership by 15% to 162,153 units (SEC Form 4)

General Counsel Cislini Jeff was granted 14,500 shares, increasing direct ownership by 31% to 61,476 units (SEC Form 4)

Chief Financial Officer Anders Jack was granted 20,200 shares, increasing direct ownership by 19% to 128,265 units (SEC Form 4)

Officer Goldsmith Mark A exercised 24,010 shares at a strike of $0.54, increasing direct ownership by 10% to 256,479 units (SEC Form 4)

General Counsel Cislini Jeff sold $104,965 worth of shares (908 units at $115.60), decreasing direct ownership by 2% to 46,976 units (SEC Form 4)

Chief Operating Officer Horn Margaret A exercised 75,000 shares at a strike of $38.47 and sold $7,542,023 worth of shares (75,000 units at $100.56) (SEC Form 4)

Chief Financial Officer Anders Jack exercised 10,000 shares at a strike of $42.45 and sold $980,000 worth of shares (10,000 units at $98.00) (SEC Form 4)

Officer Goldsmith Mark A sold $1,182,526 worth of shares (15,394 units at $76.82), decreasing direct ownership by 6% to 232,469 units (SEC Form 4)

General Counsel Cislini Jeff sold $206,484 worth of shares (2,688 units at $76.82), decreasing direct ownership by 5% to 47,884 units (SEC Form 4)

Officer Kelsey Stephen Michael sold $418,423 worth of shares (5,447 units at $76.82), decreasing direct ownership by 2% to 278,600 units (SEC Form 4)

Chief Operating Officer Horn Margaret A sold $372,333 worth of shares (4,847 units at $76.82), decreasing direct ownership by 3% to 141,053 units (SEC Form 4)

Chief Financial Officer Anders Jack sold $239,289 worth of shares (3,104 units at $77.09), decreasing direct ownership by 3% to 108,065 units (SEC Form 4)

Chief Financial Officer Anders Jack exercised 5,418 shares at a strike of $17.00 and sold $400,932 worth of shares (5,418 units at $74.00) (SEC Form 4)