TBPH insider transactions

CHIEF EXECUTIVE OFFICER Winningham Rick E covered exercise/tax liability with 20,038 units of Ordinary Shares, decreasing direct ownership by 1% to 1,631,056 units (SEC Form 4) to cover withholding tax

SVP & CHIEF FINANCIAL OFFICER Sawaf Aziz covered exercise/tax liability with 8,670 units of Ordinary Shares, decreasing direct ownership by 2% to 344,953 units (SEC Form 4) (withholding obligation)

SVP, DEV & HEAD OF IRE OFFICE Miller Aine covered exercise/tax liability with 6,827 units of Ordinary Shares, decreasing direct ownership by 4% to 177,334 units (SEC Form 4) to satisfy withholding obligation

SVP, GEN COUNSEL AND SECRETARY Grimaud Brett A. covered exercise/tax liability with 8,829 units of Ordinary Shares, decreasing direct ownership by 2% to 363,120 units (SEC Form 4) (withholding tax)

SVP, COMM & MEDICAL AFFAIRS Farnum Rhonda covered exercise/tax liability with 5,678 units of Ordinary Shares, decreasing direct ownership by 2% to 245,771 units (SEC Form 4) (withholding tax)

SEC Form 4 filed by Winningham Rick E

SEC Form 4 filed by Sawaf Aziz

SEC Form 4 filed by Grimaud Brett A.

SEC Form 4 filed by Farnum Rhonda

SEC Form 4 filed by Farnum Rhonda

CHIEF EXECUTIVE OFFICER Winningham Rick E covered exercise/tax liability with 74,975 units of Ordinary Shares, decreasing direct ownership by 5% to 1,576,094 units (SEC Form 4)

SVP & CHIEF FINANCIAL OFFICER Sawaf Aziz covered exercise/tax liability with 20,672 units of Ordinary Shares, decreasing direct ownership by 6% to 316,123 units (SEC Form 4)

SVP, DEV & HEAD OF IRE OFFICE Miller Aine covered exercise/tax liability with 16,851 units of Ordinary Shares, decreasing direct ownership by 8% to 184,161 units (SEC Form 4)

SVP, GEN COUNSEL AND SECRETARY Grimaud Brett A. covered exercise/tax liability with 20,833 units of Ordinary Shares, decreasing direct ownership by 6% to 334,449 units (SEC Form 4)

SVP, COMM & MEDICAL AFFAIRS Farnum Rhonda covered exercise/tax liability with 13,929 units of Ordinary Shares, decreasing direct ownership by 5% to 263,766 units (SEC Form 4)

SVP, COMM & MEDICAL AFFAIRS Farnum Rhonda sold $582,501 worth of Ordinary Shares (31,067 units at $18.75), decreasing direct ownership by 10% to 277,695 units (SEC Form 4)

Director Broshy Eran sold $590,020 worth of Ordinary Shares (29,501 units at $20.00), decreasing direct ownership by 40% to 44,703 units (SEC Form 4)

SVP & CHIEF FINANCIAL OFFICER Sawaf Aziz covered exercise/tax liability with 18,627 units of Ordinary Shares, decreasing direct ownership by 5% to 336,795 units (SEC Form 4)

SVP, DEV & HEAD OF IRE OFFICE Miller Aine covered exercise/tax liability with 6,989 units of Ordinary Shares, decreasing direct ownership by 3% to 201,012 units (SEC Form 4)

SVP, GEN COUNSEL AND SECRETARY Grimaud Brett A. covered exercise/tax liability with 19,024 units of Ordinary Shares, decreasing direct ownership by 5% to 355,282 units (SEC Form 4)

SVP, COMM & MEDICAL AFFAIRS Farnum Rhonda covered exercise/tax liability with 9,060 units of Ordinary Shares, decreasing direct ownership by 3% to 308,762 units (SEC Form 4)

CHIEF EXECUTIVE OFFICER Winningham Rick E gifted 9,900 units of Ordinary Shares, received a gift of 9,900 units of Ordinary Shares and covered exercise/tax liability with 56,817 units of Ordinary Shares, decreasing direct ownership by 4% to 1,651,069 units (SEC Form 4)

Amendment: Director Broshy Eran sold $809,250 worth of Ordinary Shares (45,000 units at $17.98), decreasing direct ownership by 34% to 60,204 units (SEC Form 4)

Director Broshy Eran sold $1,068,250 worth of Ordinary Shares (59,000 units at $18.11), decreasing direct ownership by 49% to 46,204 units (SEC Form 4)

CHIEF EXECUTIVE OFFICER Winningham Rick E covered exercise/tax liability with 15,394 units of Ordinary Shares, decreasing direct ownership by 0.89% to 1,717,786 units (SEC Form 4)

SVP & CHIEF FINANCIAL OFFICER Sawaf Aziz covered exercise/tax liability with 9,368 units of Ordinary Shares, decreasing direct ownership by 3% to 355,422 units (SEC Form 4)

SVP, DEV & HEAD OF IRE OFFICE Miller Aine covered exercise/tax liability with 6,989 units of Ordinary Shares, decreasing direct ownership by 3% to 208,001 units (SEC Form 4)

SVP, GEN COUNSEL AND SECRETARY Grimaud Brett A. covered exercise/tax liability with 9,762 units of Ordinary Shares, decreasing direct ownership by 3% to 374,306 units (SEC Form 4)

SVP, COMM & MEDICAL AFFAIRS Farnum Rhonda covered exercise/tax liability with 9,096 units of Ordinary Shares, decreasing direct ownership by 3% to 317,822 units (SEC Form 4)

SVP, COMM & MEDICAL AFFAIRS Farnum Rhonda sold $113,870 worth of Ordinary Shares (10,000 units at $11.39), decreasing direct ownership by 3% to 326,918 units (SEC Form 4)

CHIEF EXECUTIVE OFFICER Winningham Rick E gifted 20,000 units of Ordinary Shares, decreasing direct ownership by 1% to 1,733,180 units (SEC Form 4)

CHIEF EXECUTIVE OFFICER Winningham Rick E gifted 9,600 units of Ordinary Shares and received a gift of 9,600 units of Ordinary Shares, decreasing direct ownership by 0.54% to 1,753,180 units (SEC Form 4)

SVP, COMM & MEDICAL AFFAIRS Farnum Rhonda sold $264,000 worth of Ordinary Shares (24,000 units at $11.00), decreasing direct ownership by 7% to 336,918 units (SEC Form 4)

CHIEF EXECUTIVE OFFICER Winningham Rick E covered exercise/tax liability with 15,364 units of Ordinary Shares, decreasing direct ownership by 0.86% to 1,762,780 units (SEC Form 4)

SVP & CHIEF FINANCIAL OFFICER Sawaf Aziz covered exercise/tax liability with 9,348 units of Ordinary Shares, decreasing direct ownership by 2% to 364,790 units (SEC Form 4)

SVP, GEN COUNSEL AND SECRETARY Grimaud Brett A. covered exercise/tax liability with 9,743 units of Ordinary Shares, decreasing direct ownership by 2% to 384,068 units (SEC Form 4)

SVP, COMM & MEDICAL AFFAIRS Farnum Rhonda covered exercise/tax liability with 9,120 units of Ordinary Shares, decreasing direct ownership by 2% to 360,918 units (SEC Form 4)

SVP, DEV & HEAD OF IRE OFFICE Miller Aine was granted 10,430 units of Ordinary Shares and covered exercise/tax liability with 9,701 units of Ordinary Shares, increasing direct ownership by 0.34% to 214,990 units (SEC Form 4)

Director Pakianathan Deepika was granted 10,649 units of Ordinary Shares, increasing direct ownership by 22% to 58,065 units (SEC Form 4)

Director O'Connor Donal was granted 10,649 units of Ordinary Shares, increasing direct ownership by 17% to 74,204 units (SEC Form 4)

Director Mitchell Dean J was granted 10,649 units of Ordinary Shares, increasing direct ownership by 13% to 91,204 units (SEC Form 4)

Director Gray Susannah was granted 10,649 units of Ordinary Shares, increasing direct ownership by 34% to 42,137 units (SEC Form 4)

Director Grant Jeremy T was granted 10,649 units of Ordinary Shares, increasing direct ownership by 48% to 32,954 units (SEC Form 4)

Director Broshy Eran was granted 10,649 units of Ordinary Shares, increasing direct ownership by 13% to 91,204 units (SEC Form 4)

Director Smaldone Alsup Laurie was granted 10,649 units of Ordinary Shares, increasing direct ownership by 17% to 74,980 units (SEC Form 4)

SVP, COMM & MEDICAL AFFAIRS Farnum Rhonda sold $36,000 worth of Ordinary Shares (4,000 units at $9.00), decreasing direct ownership by 1% to 370,038 units (SEC Form 4)

CHIEF EXECUTIVE OFFICER Winningham Rick E was granted 2,178 units of Ordinary Shares, increasing direct ownership by 0.12% to 1,778,144 units (SEC Form 4)

SVP & CHIEF FINANCIAL OFFICER Sawaf Aziz was granted 75,000 units of Ordinary Shares, increasing direct ownership by 25% to 374,138 units (SEC Form 4)

SVP, DEV & HEAD OF IRE OFFICE Miller Aine was granted 75,000 units of Ordinary Shares, increasing direct ownership by 54% to 214,261 units (SEC Form 4)

SVP, GEN COUNSEL AND SECRETARY Grimaud Brett A. was granted 75,000 units of Ordinary Shares, increasing direct ownership by 24% to 393,811 units (SEC Form 4)

SVP, COMM & MEDICAL AFFAIRS Farnum Rhonda was granted 75,000 units of Ordinary Shares, increasing direct ownership by 25% to 374,038 units (SEC Form 4)

CHIEF EXECUTIVE OFFICER Winningham Rick E covered exercise/tax liability with 35,129 units of Ordinary Shares, decreasing direct ownership by 2% to 1,775,966 units (SEC Form 4)

SVP & CHIEF FINANCIAL OFFICER Sawaf Aziz covered exercise/tax liability with 13,751 units of Ordinary Shares, decreasing direct ownership by 4% to 299,138 units (SEC Form 4)

SVP, DEV & HEAD OF IRE OFFICE Miller Aine covered exercise/tax liability with 11,295 units of Ordinary Shares, decreasing direct ownership by 8% to 139,261 units (SEC Form 4)

SVP, GEN COUNSEL AND SECRETARY Grimaud Brett A. covered exercise/tax liability with 14,534 units of Ordinary Shares, decreasing direct ownership by 4% to 318,811 units (SEC Form 4)

SVP, COMM & MEDICAL AFFAIRS Farnum Rhonda was granted 5,283 units of Ordinary Shares and covered exercise/tax liability with 15,810 units of Ordinary Shares, decreasing direct ownership by 3% to 299,038 units (SEC Form 4)

SVP, COMM & MEDICAL AFFAIRS Farnum Rhonda sold $36,000 worth of Ordinary Shares (4,000 units at $9.00), decreasing direct ownership by 1% to 309,565 units (SEC Form 4)

CHIEF EXECUTIVE OFFICER Winningham Rick E covered exercise/tax liability with 15,997 units of Ordinary Shares, decreasing direct ownership by 0.88% to 1,811,095 units (SEC Form 4)

SVP & CHIEF FINANCIAL OFFICER Sawaf Aziz covered exercise/tax liability with 8,477 units of Ordinary Shares, decreasing direct ownership by 3% to 312,889 units (SEC Form 4)

SVP, DEV & HEAD OF IRE OFFICE Miller Aine covered exercise/tax liability with 10,076 units of Ordinary Shares, decreasing direct ownership by 6% to 150,556 units (SEC Form 4)