63 institutional investment managers reported SPRB positions in their Form 13F filings for Q2 2026, holding 2,002,949 shares worth $108M in total. AIGH Capital Management LLC reported the largest position.

Are funds buying or selling SPRB?

In Q2 2026, 35 managers opened new SPRB positions, 16 added, 3 trimmed and 4 sold out. Managers that filed in both quarters added a net 1,256,824 shares.

How current is this SPRB institutional ownership data?

It covers holdings as of the end of Q2 2026. Managers have 45 days after the quarter ends to file Form 13F (by August 14, 2026 for Q2 2026), so positions may have changed since.

Funds · SPRB

Who owns SPRB?

Institutional ownership of Spruce Biosciences Inc. from Form 13F, Q2 2026

63 institutional managers reported holding Spruce Biosciences Inc. (SPRB) in Form 13F filings for Q2 2026, with 2,002,949 shares worth $108M. The largest reported holder was AIGH Capital Management LLC. Managers that filed both quarters added a net 1,256,824 shares (+168.4%). 35 opened new positions and 4 sold out.

Funds holding: 63
Value held: $108M
New / sold out: 35 / 4
Net shares, same filers: +168.4%

Holdings as of June 30, 2026, the end of Q2 2026. Managers have 45 days after a quarter ends to file Form 13F (by August 14, 2026 for Q2 2026), so positions may have changed since.

Largest holders of SPRB

Fund	Value	Share of 13F holdings	Shares	Move
AIGH Capital Management LLC	$13.5M	12.5%	250,000	New
Orbimed Advisors LLC	$10.8M	10.0%	200,000	New
BlackRock, Inc.	$10.1M	9.4%	187,836	Added
Millennium Management LLC	$8.7M	8.0%	160,981	Added
Ikarian Capital, LLC	$6.6M	6.1%	121,356	Unchanged
Vanguard Capital Management LLC	$6.4M	6.0%	119,331	Added
Alyeska Investment Group, L.P.	$4.4M	4.1%	81,671	Added
Geode Capital Management, LLC	$3.8M	3.5%	70,548	Added
ADAR1 Capital Management, LLC	$3.7M	3.4%	67,717	Added
Cable Car Capital, LP	$3.2M	3.0%	60,000	New
Citadel Advisors LLC	$2.8M	2.6%	51,905	Trimmed
State Street Corp	$2.7M	2.5%	50,450	Added
Boothbay Fund Management, LLC	$2.3M	2.1%	42,080	Unchanged
Stempoint Capital LP	$2.2M	2.1%	41,388	Added
Eversept Partners, LP	$2.2M	2.0%	40,000	New
Carlyle Group Inc.	$2.1M	1.9%	38,620	Unchanged
Goldman Sachs Group Inc	$1.7M	1.6%	32,348	Added
Diadema Partners LP	$1.6M	1.5%	30,000	Added
Affinity Asset Advisors, LLC	$1.6M	1.5%	30,000	New
Stonepine Capital Management, LLC	$1.6M	1.4%	28,795	New
Point72 Asset Management, L.P.	$1.5M	1.4%	28,278	New
Quinn Opportunity Partners LLC	$1.4M	1.3%	26,810	Unchanged
UBS Group AG	$1.3M	1.2%	23,381	Added
ExodusPoint Capital Management, LP	$1.2M	1.1%	22,000	Unchanged
Northern Trust Corp	$1.1M	1.1%	21,083	New

Share of 13F holdings is each fund's shares as a share of the 2,002,949 SPRB shares all 13F filers reported, not of shares outstanding.

Biggest buyers in Q2 2026

AIGH Capital Management LLC New+$13.5M
Orbimed Advisors LLC New+$10.8M
BlackRock, Inc. Added+$9.2M
Vanguard Capital Management LLC Added+$5.5M
Cable Car Capital, LP New+$3.2M
Geode Capital Management, LLC Added+$3.1M
Millennium Management LLC Added+$2.7M
State Street Corp Added+$2.4M
Eversept Partners, LP New+$2.2M
Alyeska Investment Group, L.P. Added+$1.6M

Biggest sellers in Q2 2026

Wellington Management Group LLP Sold out-$3.2M
Balyasny Asset Management L.P. Trimmed-$1.5M
Citadel Advisors LLC Trimmed-$977K
Squadron Capital Management LLC Sold out-$797K
Resolute Capital Asset Partners LLC Sold out-$261K
Sound Income Strategies, LLC Sold out-$14K
Jones Financial Companies LLLP Trimmed-$9K

The change in shares since the quarter before, adjusted for stock splits and priced at the Q2 2026 value per share. Funds bought $73.9M and sold $6.8M; 16 added and 3 trimmed.

Schedule 13D and 13G filings on SPRB

Owners of more than 5% must file within days, so these can be newer than the 13F data.

2026-08-14ORBIMED ADVISORS LLC SCHEDULE 13G filed by Spruce Biosciences Inc.Schedule 13G
2026-08-14AWM Investment Company, Inc. SCHEDULE 13G filed by Spruce Biosciences Inc.Schedule 13G
2026-07-30BlackRock, Inc. SCHEDULE 13G filed by BlackRock Inc.Schedule 13G
2026-07-27HIRSCHMAN ORIN SCHEDULE 13G filed by Spruce Biosciences Inc.Schedule 13G
2026-04-28ExodusPoint Capital Management, LP SCHEDULE 13G filed by Spruce Biosciences Inc.Schedule 13G
2026-02-24INTEGRATED CORE STRATEGIES (US) LLC SCHEDULE 13G filed by Spruce Biosciences Inc.Schedule 13G
2026-02-17Alyeska Investment Group, L.P. SCHEDULE 13G filed by Spruce Biosciences Inc.Schedule 13G
2026-02-10WELLINGTON MANAGEMENT GROUP LLP SCHEDULE 13G filed by Spruce Biosciences Inc.Schedule 13G
2025-10-16CITADEL ADVISORS LLC SCHEDULE 13G filed by Spruce Biosciences Inc.Schedule 13G

Questions about SPRB ownership

Who owns SPRB stock?: 63 institutional investment managers reported SPRB positions in their Form 13F filings for Q2 2026, holding 2,002,949 shares worth $108M in total. AIGH Capital Management LLC reported the largest position.
Are funds buying or selling SPRB?: In Q2 2026, 35 managers opened new SPRB positions, 16 added, 3 trimmed and 4 sold out. Managers that filed in both quarters added a net 1,256,824 shares.
How current is this SPRB institutional ownership data?: It covers holdings as of the end of Q2 2026. Managers have 45 days after the quarter ends to file Form 13F (by August 14, 2026 for Q2 2026), so positions may have changed since.

From the SEC's Form 13F data sets for Q2 2026: every 13F holdings report, matched to SPRB by CUSIP. Options are left out. SPRB news and filings · SPRB insider trades · Top funds