Who owns TYRA?
Institutional ownership of Tyra Biosciences Inc. from Form 13F, Q2 2026
170 institutional managers reported holding Tyra Biosciences Inc. (TYRA) in Form 13F filings for Q2 2026, with 69,420,427 shares worth $2.2B. The largest reported holder was Ra Capital Management, L.p. Managers that filed both quarters added a net 2,754,129 shares (+4.4%). 31 opened new positions and 25 sold out.
- Funds holding
- 170
- Value held
- $2.2B
- New / sold out
- 31 / 25
- Net shares, same filers
- +4.4%
Holdings as of June 30, 2026, the end of Q2 2026. Managers have 45 days after a quarter ends to file Form 13F (by August 14, 2026 for Q2 2026), so positions may have changed since.
Largest holders of TYRA
| Fund | Value | Share of 13F holdings | Shares | Move |
|---|---|---|---|---|
| Ra Capital Management, L.p. | $390M | 17.6% | 12,198,625 | Unchanged |
| FMR LLC | $285M | 12.8% | 8,920,513 | Added |
| Jupiter Topco LLC | $139M | 6.3% | 4,352,448 | First report |
| Alta Partners Management Company, L.P. | $122M | 5.5% | 3,823,425 | Unchanged |
| Nextech Invest Ltd. | $114M | 5.1% | 3,553,585 | Trimmed |
| TCG Crossover Management, LLC | $104M | 4.7% | 3,248,980 | Unchanged |
| BlackRock, Inc. | $96.8M | 4.4% | 3,031,972 | Added |
| Price T Rowe Associates Inc | $88.9M | 4.0% | 2,782,567 | Added |
| State Street Corp | $68.4M | 3.1% | 2,140,368 | Added |
| Commodore Capital LP | $59.9M | 2.7% | 1,875,000 | Trimmed |
| Paradigm Biocapital Advisors LP | $58.4M | 2.6% | 1,828,607 | Trimmed |
| Vanguard Capital Management LLC | $48.2M | 2.2% | 1,508,447 | Added |
| BVF Inc | $47.1M | 2.1% | 1,476,196 | Trimmed |
| 5AM Venture Management, LLC | $32.9M | 1.5% | 1,029,298 | Unchanged |
| Deerfield Management Company, L.p. | $32.5M | 1.5% | 1,017,000 | Added |
| Hood River Capital Management LLC | $32.5M | 1.5% | 1,016,775 | New |
| Geode Capital Management, LLC | $31.0M | 1.4% | 970,734 | Added |
| Caligan Partners LP | $25.8M | 1.2% | 806,986 | Trimmed |
| Canaan Partners XI LLC | $24.0M | 1.1% | 750,000 | Unchanged |
| Siren, L.L.C. | $23.2M | 1.0% | 725,000 | New |
| Sio Capital Management, LLC | $22.2M | 1.0% | 695,315 | Added |
| Stempoint Capital LP | $20.2M | 0.9% | 632,754 | Added |
| Marshall Wace, LLP | $18.6M | 0.8% | 583,133 | Added |
| Goldman Sachs Group Inc | $14.8M | 0.7% | 463,477 | Trimmed |
| Jennison Associates LLC | $14.4M | 0.6% | 450,964 | Trimmed |
Share of 13F holdings is each fund's shares as a share of the 69,420,427 TYRA shares all 13F filers reported, not of shares outstanding.
Biggest buyers in Q2 2026
- Price T Rowe Associates Inc Added+$57.4M
- FMR LLC Added+$37.5M
- Hood River Capital Management LLC New+$32.5M
- State Street Corp Added+$29.5M
- BlackRock, Inc. Added+$26.0M
- Siren, L.L.C. New+$23.2M
- Deerfield Management Company, L.p. Added+$14.9M
- Marshall Wace, LLP Added+$12.3M
- Vanguard Capital Management LLC Added+$12.2M
- Defilade Capital Management, L.P. New+$12.0M
Biggest sellers in Q2 2026
- Farallon Capital Management, L.l.c. Sold out-$137M
- Logos Global Management LP Sold out-$32.6M
- Barclays PLC Trimmed-$26.0M
- Commodore Capital LP Trimmed-$19.2M
- Nextech Invest Ltd. Trimmed-$16.0M
- BVF Inc Trimmed-$16.0M
- Caligan Partners LP Trimmed-$15.0M
- Balyasny Asset Management L.P. Sold out-$13.5M
- Elmind Capital, LP Trimmed-$10.5M
- Seven Fleet Capital Management LP Sold out-$7.5M
The change in shares since the quarter before, adjusted for stock splits and priced at the Q2 2026 value per share. Funds bought $409M and sold $356M; 73 added and 43 trimmed.
Schedule 13D and 13G filings on TYRA
Owners of more than 5% must file within days, so these can be newer than the 13F data.
- 2026-09-21BIOTECHNOLOGY VALUE FUND L P SCHEDULE 13G filed by Tyra Biosciences Inc.Schedule 13G
- 2026-09-17Paradigm Biocapital Advisors LP SCHEDULE 13G filed by Tyra Biosciences Inc.Schedule 13G
- 2026-07-30BlackRock, Inc. SCHEDULE 13G filed by BlackRock Inc.Schedule 13G
- 2026-04-07FMR LLC SCHEDULE 13G filed by Tyra Biosciences Inc.Schedule 13G
- 2026-02-20Farallon Capital Partners, L.P. SCHEDULE 13G filed by Tyra Biosciences Inc.Schedule 13G
- 2026-02-13Harris Todd SCHEDULE 13G filed by Tyra Biosciences Inc.Schedule 13G
- 2025-05-14COMMODORE CAPITAL LP SCHEDULE 13G filed by Tyra Biosciences Inc.Schedule 13G
- 2025-05-14JANUS HENDERSON GROUP PLC SCHEDULE 13G filed by Tyra Biosciences Inc.Schedule 13G
- 2025-03-06TCG Crossover GP I, LLC SCHEDULE 13G filed by Tyra Biosciences Inc.Schedule 13G
Questions about TYRA ownership
- Who owns TYRA stock?
- 170 institutional investment managers reported TYRA positions in their Form 13F filings for Q2 2026, holding 69,420,427 shares worth $2.2B in total. Ra Capital Management, L.p. reported the largest position.
- Are funds buying or selling TYRA?
- In Q2 2026, 31 managers opened new TYRA positions, 73 added, 43 trimmed and 25 sold out. Managers that filed in both quarters added a net 2,754,129 shares.
- How current is this TYRA institutional ownership data?
- It covers holdings as of the end of Q2 2026. Managers have 45 days after the quarter ends to file Form 13F (by August 14, 2026 for Q2 2026), so positions may have changed since.
From the SEC's Form 13F data sets for Q2 2026: every 13F holdings report, matched to TYRA by CUSIP. Options are left out. TYRA news and filings · TYRA insider trades · Top funds